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  1. Emodin is a natural anthraquinone derivative isolated from the Rheum palmatum L. Aim: The aim of the present study was to investigate the effect of emodin on the apoptosis of the human cervical cancer line HeL...

    Authors: Wang Yaoxian, Yu Hui, Zhang Yunyan, Liu Yanqin, Ge Xin and Wu Xiaoke

    Citation: Cancer Cell International 2013 13:71

    Content type: Primary research

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  2. The breast and ovarian cancer susceptibility gene (BRCA1) encodes a tumor suppressor. The BRCA1 protein is found primarily in cell nuclei and plays an important role in the DNA damage response and transcriptional...

    Authors: Natalie Tulchin, Leonard Ornstein, Steven Dikman, James Strauchen, Shabnam Jaffer, Chandandeep Nagi, Ira Bleiweiss, Ruth Kornreich, Lisa Edelmann, Karen Brown, Carol Bodian, Venugopalan D Nair, Monique Chambon, Nicholas T Woods and Alvaro NA Monteiro

    Citation: Cancer Cell International 2013 13:70

    Content type: Primary research

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  3. Angiogenesis has been an attractive target for drug therapy. Aloin (AL), an natural compound derived from Aloe barbadensis Miller leaves, has been shown to possess anti-cancer potential activities. However, its r...

    Authors: Qin Pan, Hongming Pan, Haizhou Lou, Yinghua Xu and Lu Tian

    Citation: Cancer Cell International 2013 13:69

    Content type: Primary research

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  4. MicroRNAs are a class of small non-coding RNAs that play an important role in various human tumor initiation and progression by regulating gene expression negatively. The aim of this study was to investigate t...

    Authors: Ting-Song Yang, Xiao-Hu Yang, Xu-Dong Wang, Yi-Ling Wang, Bo Zhou and Zhen-Shun Song

    Citation: Cancer Cell International 2013 13:68

    Content type: Primary research

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  5. In order to search for new structural modification strategies on fluoroquinolones, we have designed and synthesized a series of fluoroquinolone derivatives by linking various hydrazine compounds to the C-3 car...

    Authors: Jin-ping Sun, Zhen-yu Shi, Shi-meng Liu, Yu-hua Kang, Guo-qiang Hu, Chao-shen Huangfu, Jin-bo Deng and Bin Liu

    Citation: Cancer Cell International 2013 13:67

    Content type: Primary research

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  6. Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast propo...

    Authors: Arnaud Guille, Max Chaffanet and Daniel Birnbaum

    Citation: Cancer Cell International 2013 13:66

    Content type: Hypothesis

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  7. Folate-nanoliposomes delivery system has emerged recently as a specific and safety delivery method and gradually used as the carrier of a variety kinds of drugs including compounds, plasmids and siRNAs.

    Authors: Qiqi Zhu, Chen Feng, Weiwei Liao, Yan Zhang and Suoqin Tang

    Citation: Cancer Cell International 2013 13:65

    Content type: Primary research

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  8. Gallbladder carcinoma is a malignant tumor with a very low 5-year survival rate because of the difficulty with its early diagnosis and the very poor prognosis of the advanced cancer state. The aims of this stu...

    Authors: Tian-Yu Liu, Zhu-Jun Tan, Lin Jiang, Jian-Feng Gu, Xiang-Song Wu, Yang Cao, Mao-Lan Li, Ke-Jin Wu and Ying-Bin Liu

    Citation: Cancer Cell International 2013 13:64

    Content type: Primary research

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  9. Apoptosis is a major target and treatment effect of multiple chemotherapeutical agents in cancer. A soybean isoflavone, genistein, is a well-studied chemopreventive agent and has been reported to potentiate th...

    Authors: Xin Xie, Shan Shan Wang, Timothy Chung Sing Wong and Ming Chiu Fung

    Citation: Cancer Cell International 2013 13:63

    Content type: Primary research

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  10. Identification of cancer stem cells (CSCs) and their behaviors will provide insightful information for the future control of human cancers. This study investigated CD44 and CD24 cell surface markers as breast ...

    Authors: Wenxing Yan, Yubing Chen, Yueliang Yao, Hongmei Zhang and Tiejun Wang

    Citation: Cancer Cell International 2013 13:62

    Content type: Primary research

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  11. The specific mechanism underlying the contribution of the Aldehyde dehydrogenase 1 (ALDH1) phenotype to metastatic behavior and early tumor relapse in breast cancer is currently unclear.

    Authors: Ying Zhong, Yan Lin, Songjie Shen, Yidong Zhou, Feng Mao, Jinghong Guan and Qiang Sun

    Citation: Cancer Cell International 2013 13:60

    Content type: Primary research

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  12. The aim of this study was to clarify the clinicopathological outcome of serum relaxin-2 and tissues relaxin-2 expression levels in human primary osteosarcoma (OS), and to explore the roles of relaxin-2 inhibit...

    Authors: Jinfeng Ma, Min Niu, Wenjiu Yang, Lina Zang and Yongming Xi

    Citation: Cancer Cell International 2013 13:59

    Content type: Primary research

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  13. R-CHOP has significantly improved survival rates of patients with diffuse large B cell lymphoma (DLBCL) by ~20% as compared to CHOP. CD20 antigen, highly expressed on more than 80% of B-cell lymphomas, is the ...

    Authors: Huirong Ding, Xuan Jin, Ning Ding, Zhiying Fu, Yuqin Song and Jun Zhu

    Citation: Cancer Cell International 2013 13:58

    Content type: Primary research

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  14. Epigenetic control using histone deacetylase (HDAC) inhibitors is a promising therapy for lymphomas. Insights into the anti-proliferative effects of HDAC inhibitors on diffuse large B-cell lymphoma (DLBCL) and...

    Authors: Ying Cai, Wenli Cui, Weixiang Chen, Ping Wei, Yayun Chi, Ping Zhang, Rui Bi and Xiaoyan Zhou

    Citation: Cancer Cell International 2013 13:57

    Content type: Primary research

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  15. Nowadays it remains a controversial issue whether a correlation exists between the apoptosis rate of tumor tissue and the prognosis of the patients. We aimed to explore the prognostic significance of apoptosis...

    Authors: Xing Wu, Biao Cheng, Zheng-dong Cai and Lie-ming Lou

    Citation: Cancer Cell International 2013 13:56

    Content type: Primary research

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  16. For their various bioactivities, biomaterials derived from marine algae are important ingredients in many products, such as cosmetics and drugs for treating cancer and other diseases. This mini-review comprehe...

    Authors: Jin-Ching Lee, Ming-Feng Hou, Hurng-Wern Huang, Fang-Rong Chang, Chi-Chen Yeh, Jen-Yang Tang and Hsueh-Wei Chang

    Citation: Cancer Cell International 2013 13:55

    Content type: Review

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  17. Apigenin (4’,5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell li...

    Authors: Yi Zhu, Yeqing Mao, Hong Chen, Yiwei Lin, Zhenghui Hu, Jian Wu, Xin Xu, Xianglai Xu, Jie Qin and Liping Xie

    Citation: Cancer Cell International 2013 13:54

    Content type: Primary research

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  18. The pro-apoptotic Bcl-2 protein BAD initiated apoptosis in human cells and has been identified as a prognostic marker in non-small cell lung cancer (NSCLC). In this study, we aimed to explore the functions of ...

    Authors: Li Jiang, Man Luo, Dan Liu, Bojiang Chen, Wen Zhang, Lin Mai, Jing Zeng, Na Huang, Yi Huang, Xianming Mo and Weimin Li

    Citation: Cancer Cell International 2013 13:53

    Content type: Primary research

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  19. Doxorubicin (DOX), an anthracycline antibiotic is one of the most effective anticancer drug used in the treatment of variety of cancers .Its use is limited by its cardiotoxicity. The present study was designed...

    Authors: Abdel-Moneim M Osman, Sameer E Al-Harthi, Ohoud M AlArabi, Mohamed F Elshal, Wafaa S Ramadan, Mohamed N Alaama, Huda M Al-Kreathy, Zoheir A Damanhouri and Osman H Osman

    Citation: Cancer Cell International 2013 13:52

    Content type: Primary research

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  20. MicroRNAs (miRNAs) are a large group of negative gene regulators that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-145 acts a tumor suppressor in numerous human can...

    Authors: Yuan Shao, Yiping Qu, Siwen Dang, Bowen Yao and Meiju Ji

    Citation: Cancer Cell International 2013 13:51

    Content type: Primary research

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  21. Celastrol, a plant triterpene, is known to play important role in inhibiting proliferation and inducing apoptosis of gastric cancer cells. In the present study, the mechanism of celastrol on gastric cancer cel...

    Authors: Min Sha, Jun Ye, Li-xin Zhang, Zheng-yun Luan and Ya-bao Chen

    Citation: Cancer Cell International 2013 13:50

    Content type: Primary research

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  22. Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinase (RTK) family. Epidermal growth factor induces its dimerization and stimulates phosphorylation of intracellular tyrosine resid...

    Authors: Mi Jeong Jo, Seong Ja Bae, Byeng Wha Son, Chi Yeon Kim and Gun Do Kim

    Citation: Cancer Cell International 2013 13:49

    Content type: Primary research

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  23. Up-regulation of heat shock protein 70 (HSP70) could be elicited primarily by heat in former studies, and this was proved to be associated with cancer progression. Burkitt's lymphoma is one of highly aggressiv...

    Authors: Xiaosheng Fang, Yujie Jiang, Lili Feng, Haiping Chen, Changqing Zhen, Mei Ding and Xin Wang

    Citation: Cancer Cell International 2013 13:48

    Content type: Primary research

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  24. Cranial radiation therapy has been used for the treatment of primary and metastatic brain tumors. A prominent feature of brain injury induced by the radiation therapy is hippocampal dysfunction, characterized ...

    Authors: Ai-Min Sun, Chuan-Gang Li, Yong-Qing Han, Que-Ling Liu, Qiong Xia and Ya-Wei Yuan

    Citation: Cancer Cell International 2013 13:47

    Content type: Primary research

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  25. The multidrug resistance (MDR) 1 gene encodes a 170-kDa membrane transporter called P-glycoprotein, which plays an important role in protecting cells against lipophilic xenobiotics by the way of an ATP-dependent ...

    Authors: Ling-Hui Wang, Yan-Bin Song, Wen-Ling Zheng, Ling Jiang and Wen-Li Ma

    Citation: Cancer Cell International 2013 13:46

    Content type: Primary research

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  26. MicroRNAs are small RNA molecules that negatively regulate gene expression by translational inhibition or mRNA cleavage. The discovery that abnormal expression of particular miRNAs contributes to human disease...

    Authors: Sanja Jurcevic, Björn Olsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2013 13:45

    Content type: Primary research

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  27. Endometrial cancer (EC) is the most common gynecologic malignancy, but the molecular events involved in the development and progression of EC remain unclear. This study aimed to explore epigenetic modification...

    Authors: Bi-Lan Li, Wen Lu, Cong Lu, Jun-jie Qu, Ting-ting Yang, Qin Yan and Xiao-ping Wan

    Citation: Cancer Cell International 2013 13:44

    Content type: Primary research

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  28. We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53,...

    Authors: Michael Jelínek, Kamila Balušíková, Dana Kopperová, Vlasta Němcová-Fürstová, Jan Šrámek, Julie Fidlerová, Ilaria Zanardi, Iwao Ojima and Jan Kovář

    Citation: Cancer Cell International 2013 13:42

    Content type: Primary research

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  29. Nowadays, we believe that cancer is a genetic disease. We focus on the genetic targets and epigenetic changes in a tumor. Remarkably, many crucial signal pathways in a malignant cell involve “stem-ness” genes....

    Authors: Shi-Ming Tu

    Citation: Cancer Cell International 2013 13:40

    Content type: Hypothesis

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  30. The cancer stem cell (CSC) theory proposes that tumours arise from and are sustained by a subpopulation of cells with both cancer and stem cell properties. One of the key hallmarks of CSCs is the ability to gr...

    Authors: Jo-Anne de la Mare, Jason N Sterrenberg, Mugdha G Sukhthankar, Maynard T Chiwakata, Denzil R Beukes, Gregory L Blatch and Adrienne L Edkins

    Citation: Cancer Cell International 2013 13:39

    Content type: Primary research

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  31. Lung cancer often exhibits molecular changes, such as the overexpression of the ErbB1 gene. ErbB1 encodes epidermal growth factor receptor (EGFR), a tyrosine kinase receptor, involved mainly in cell proliferat...

    Authors: Camila Lauand, Paula Rezende-Teixeira, Beatriz Araújo Cortez, Evandro Luís de Oliveira Niero and Gláucia Maria Machado-Santelli

    Citation: Cancer Cell International 2013 13:38

    Content type: Primary research

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  32. To elucidate the characteristics of T-cell receptor (TCR) signal transduction in T-cells from acute myeloid leukemia (AML), the mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), A20, NF-...

    Authors: Li Shi, Shaohua Chen, Yuhong Lu, Xu Wang, Ling Xu, Fan Zhang, Lijian Yang, Xiuli Wu, Bo Li and Yangqiu Li

    Citation: Cancer Cell International 2013 13:37

    Content type: Primary research

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  33. Hypoxia inducible factor-1 α (HIF-1α) has been identified as an important novel target in apoptosis resistance of pediatric tumors such as Rhabdomyosarcoma (RMS) and Ewing’s sarcoma (ES). Evidence suggests tha...

    Authors: Mehtap Kilic-Eren, Tulin Boylu and Vedrana Tabor

    Citation: Cancer Cell International 2013 13:36

    Content type: Primary research

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  34. T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy. Immune tolerance induced by CD4+CD25+ regulatory T cells (Tregs) with high expression of Foxp3 is an important hypothesis...

    Authors: Xiaodan Luo, Huo Tan, Yueqiao Zhou, Tiantian Xiao, Chunyan Wang and Yangqiu Li

    Citation: Cancer Cell International 2013 13:34

    Content type: Primary research

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  35. Ovarian cancer constitutes nearly 4% of all cancers among women and is the leading cause of death from gynecologic malignancies in the Western world. Standard first line adjuvant chemotherapy treatments includ...

    Authors: Ilenia Pellicciotta, Chia-Ping Huang Yang, Charis A Venditti, Gary L Goldberg and Shohreh Shahabi

    Citation: Cancer Cell International 2013 13:33

    Content type: Primary research

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  36. The use of imatinib, an ABL tyrosine kinase inhibitor, has led to a dramatic change in the management of BCR-ABL-positive leukemia patients. However, resistance to imatinib mediated by mutations in the BCR-ABL...

    Authors: Seiichi Okabe, Tetsuzo Tauchi, Yuko Tanaka, Shinya Kimura, Taira Maekawa and Kazuma Ohyashiki

    Citation: Cancer Cell International 2013 13:32

    Content type: Primary research

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  37. Liver cancer is one of the most frequent cancers in the world. Targeted therapy of cancer with specific inhibitors is developing and has shown promising antitumor efficacy. CCI-779 (temsirolimus), a specific i...

    Authors: Shuyu Li, Yan Liang, Manlin Wu, Xiaojing Wang, Haixia Fu, Yuhao Chen and Zhigang Wang

    Citation: Cancer Cell International 2013 13:30

    Content type: Primary research

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  38. We have investigated the ability of Mifepristone, an anti-progestin and anti-glucocorticoid drug, to modulate the antitumor effect of current standard clinical treatment in glioblastoma xenografts.

    Authors: Monserrat Llaguno-Munive, Luis Alberto Medina, Rafael Jurado, Mario Romero-Piña and Patricia Garcia-Lopez

    Citation: Cancer Cell International 2013 13:29

    Content type: Primary research

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  39. Macrophage migration inhibitory factor (MIF) is important in regulating cell proliferation and apoptosis in both normal and cancerous cells, and may be important in cancer progression and metastasis. In human ...

    Authors: Yubiao Guo, Junna Hou, Yifeng Luo and Dujuan Wang

    Citation: Cancer Cell International 2013 13:28

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2013 13:84

  40. The editor and editorial board of Cancer Cell International would like to thank Angela Panther for her continued hard work throughout 2012 in keeping the journal going as our managing editor. We take this opportu...

    Authors: Denys Wheatley

    Citation: Cancer Cell International 2013 13:22

    Content type: Reviewer acknowledgement

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  41. β-elemene, a natural sesquiterpene extracted from the essential oils of Curcuma aromatica Salisb, has been shown to be effective against a wide range of tumors. In this study, the antitumor effect of β-elemene on...

    Authors: Zhi-Jun Dai, Wei Tang, Wang-Feng Lu, Jie Gao, Hua-Feng Kang, Xiao-Bin Ma, Wei-Li Min, Xi-Jing Wang and Wen-Ying Wu

    Citation: Cancer Cell International 2013 13:27

    Content type: Primary research

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  42. Beclin1 is a well-known key regulator of autophagy, which is also a haploinsufficient tumor suppressor. Current studies revealed that down-regulation or monoallelic deletions of Beclin1 were frequently found i...

    Authors: Xiaoshu Li, Jun Yan, Lisheng Wang, Fengjun Xiao, Yuefeng Yang, Xiaozhong Guo and Hua Wang

    Citation: Cancer Cell International 2013 13:26

    Content type: Primary research

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  43. Arsenic Trioxide (ATO) has shown remarkable efficacy for the treatment of multiple myeloma (MM). However, the mechanism by which ATO exerts its inhibitory effect on the proliferation of myeloma cells remains t...

    Authors: Jiasheng Hu, Xiao Huang, Xiuli Hong, Quanyi Lu and Xiongpeng Zhu

    Citation: Cancer Cell International 2013 13:25

    Content type: Primary research

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  44. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Although much is known about both the cellular changes that lead to HCC and the etiological agents responsible for the majority of HCC ca...

    Authors: Yan Zhao, Wang Jian, Wei Gao, Ya-Xin Zheng, Yong-Kun Wang, Zhu-Qing Zhou, Hui Zhang and Cong-Jun Wang

    Citation: Cancer Cell International 2013 13:23

    Content type: Primary research

    Published on:

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