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  1. Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer deaths worldwide. Besides common therapeutic approaches, such as surgery, chemotherapy, and radiotherapy, novel th...

    Authors: Ke-Tao Jin, Bo Chen, Yu-Yao Liu, H uan-Rong Lan and Jie-Ping Yan
    Citation: Cancer Cell International 2021 21:83
  2. Liver cancer (LC) is one of the most fatal cancers throughout the world. More efficient and sensitive gene signatures that could accurately predict survival in LC patients are vitally needed to promote a bette...

    Authors: Wenjing Zhu, Qiliang Zhang, Min Liu, Meixing Yan, Xiao Chu and Yongchun Li
    Citation: Cancer Cell International 2021 21:81
  3. UCEC is the most common gynecological malignancy in many countries, and its mechanism of occurrence and development is related to tumor mutation burden (TMB) and immune cell infiltration. Therefore, it is nece...

    Authors: Ling Zhao, Xueshu Fu, Xiling Han, Yanjun Yu, Yaping Ye and Jun Gao
    Citation: Cancer Cell International 2021 21:80
  4. Prostate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs...

    Authors: Zeeshan Javed, Khushbukhat Khan, Amna Rasheed, Haleema Sadia, Muhammad Naeem Shahwani, Asma Irshad, Shahid Raza, Bahare Salehi, Javad Sharifi-Rad, Hafiz A. R. Suleria, Natália Cruz-Martins and Cristina Quispe
    Citation: Cancer Cell International 2021 21:77
  5. Glioblastoma (GBM) is the most common and malignant Grade IV primary craniocerebral tumor caused by glial cell carcinogenesis with an extremely poor median survival of 12–18 months. The current standard treatm...

    Authors: Xin Xu, Wenli Chen, Wenjun Zhu, Jing Chen, Bin Ma, Jianxia Ding, Zaichuan Wang, Yifei Li, Yeming Wang and Xiaochun Zhang
    Citation: Cancer Cell International 2021 21:76
  6. The regulator of cullins-1 (ROC1) is an essential subunit in the cullin-RING ligase (CRL) protein complex and has been shown to be critical in bladder cancer cell survival and progression. This study aimed to ...

    Authors: W. Wang, J. Qiu, P. Qu, H. Chen, J. Lan, H. Chen, L. Li and M. Gu
    Citation: Cancer Cell International 2021 21:75
  7. Lung cancer is one of the important health threats worldwide, of which 5-year survival rate is less than 15%. Non-small-cell lung cancer (NSCLC) accounts for about 80% of all lung cancer with high metastasis a...

    Authors: Yuxin Qi, Wenping Yang, Shuang Liu, Fanjie Han, Haibin Wang, Yonghong Zhao, Yufa Zhou and Daijun Zhou
    Citation: Cancer Cell International 2021 21:74
  8. Non-small cell lung cancer (NSCLC) is a threat to human health. Circular RNAs (circRNAs) have been proved to function in NSCLC development. In this study, the role of circRNA hsa_circ_0010235 in NSCLC progress...

    Authors: Furui Zhang, Ruirui Cheng, Ping Li, Chunya Lu and Guojun Zhang
    Citation: Cancer Cell International 2021 21:73
  9. The regulatory roles of circular RNAs (circRNAs) in tumorigenesis have attracted increasing attention. However, novel circRNAs with the potential to be used as serum/plasma biomarkers and their regulatory mech...

    Authors: Lianghai Wang, Lisha Zhou, Jun Hou, Jin Meng, Ke Lin, Xiangwei Wu and Xueling Chen
    Citation: Cancer Cell International 2021 21:72

    The Correction to this article has been published in Cancer Cell International 2021 21:86

  10. Recent studies have established the roles of microRNAs (miRNAs) in cancer progression. The aberrant expression of miR-335-5p has been reported in many cancers, including gastric cancer (GC). In this study, the...

    Authors: Yi Gao, Yanfeng Wang, Xiaofei Wang, Changan Zhao, Fenghui Wang, Juan Du, Huahua Zhang, Haiyan Shi, Yun Feng, Dan Li, Jing Yan, Yan Yao, Weihong Hu, Ruxin Ding, Mengjie Zhang, Lumin Wang…
    Citation: Cancer Cell International 2021 21:71
  11. Gastric cancer is one of the most prevalent and deadly malignancies without efficient treatment option. This study aimed to investigate the effect of hydrogen gas on the behavior of gastric cancer cells.

    Authors: Baocheng Zhu, Hengguan Cui and Weiqiang Xu
    Citation: Cancer Cell International 2021 21:70
  12. Colorectal cancer (CRC) is among the deadliest cancers, wherein early dissemination of tumor cells, and consequently, metastasis formation, are the main causes of mortality and poor prognosis. Cofilin-1 (CFL-1...

    Authors: Annie Cristhine Moraes Sousa-Squiavinato, Renata Ivo Vasconcelos, Adriana Sartorio Gehren, Priscila Valverde Fernandes, Ivanir Martins de Oliveira, Mariana Boroni and Jose Andrés Morgado-Díaz
    Citation: Cancer Cell International 2021 21:69
  13. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) could interact with each other to play a vital role in the pathogenesis of cancers. We aimed to examine the expression profile, clinical significance and r...

    Authors: Jingjing Jing, Xu Zhao, Jiannan Wang and Tan Li
    Citation: Cancer Cell International 2021 21:68
  14. Bladder cancer (BCa) is a malignant tumor that occurs on the mucosa of the bladder, in which dysregulated long non-coding RNAs (lncRNAs) are involved. This study investigated the effect of lncRNA small nucleol...

    Authors: Rui Feng, Zhongxing Li, Xing Wang, Guangcheng Ge, Yuejun Jia, Dan Wu, Yali Ji and Chenghao Wang
    Citation: Cancer Cell International 2021 21:67
  15. Gastric cancer (GC) is one of the most common cancers with high malignancy. In spite of the great development in diagnostic tools and application of anti-tumor drugs, we have not witnessed a significant increa...

    Authors: Milad Ashrafizadeh, Hossein Rafiei, Reza Mohammadinejad, Tahereh Farkhondeh and Saeed Samarghandian
    Citation: Cancer Cell International 2021 21:66
  16. Lung cancer is the most common malignant tumor. Identification of novel diagnostic and prognostic biomarkers for lung cancer is a key research imperative. The role of centromere protein K (CENPK) in cancer is ...

    Authors: Jiayu Ma, Xiaochuan Chen, Mingqiang Lin, Zhiping Wang, Yahua Wu and Jiancheng Li
    Citation: Cancer Cell International 2021 21:65
  17. Hedgehog (Hh) signaling pathway, which is essential for cell proliferation and differentiation, is noted to be aberrantly activated in tumor from increasing studies in recent years. MicroRNAs (miRNAs) as an im...

    Authors: Jiong Ma, Chunxia Zhou and Xuejun Chen
    Citation: Cancer Cell International 2021 21:64
  18. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can induce substantial cytotoxicity in tumor cells but rarely exert cytotoxic activity on non-transformed cells. In the present study, we therefo...

    Authors: Shihai Liu, Jing Qiu, Guifang He, Weitai He, Changchang Liu, Duo Cai and Huazheng Pan
    Citation: Cancer Cell International 2021 21:63
  19. Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels suppl...

    Authors: Asieh Emami Nejad, Simin Najafgholian, Alireza Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard, Marjan Taherian, Mojtaba Ahmadlou, Rasoul Salehi, Bahman Sadeghi and Mostafa Manian
    Citation: Cancer Cell International 2021 21:62
  20. Studies have shown the value of subtypes and distribution of gastric intestinal metaplasia (GIM) for prediction of gastric cancer. We aim to combine GIM subtypes and distribution to form a new scoring system f...

    Authors: Ning Wei, Zhiheng Zhong and Ruihua Shi
    Citation: Cancer Cell International 2021 21:61

    The Correction to this article has been published in Cancer Cell International 2021 21:132

  21. Interferon regulatory factor 4 (IRF4) is a transcription factor from the IRF factor family that exerts regulatory functions in the immune system and oncogenesis. However, the biological role of IRF4 in colon c...

    Authors: Jiwei Wang, Song Li, Honglang Li, Xiaoshuang Zhou, Huabin Wen and Bin Lai
    Citation: Cancer Cell International 2021 21:58
  22. Drug resistance and metastasis involving hypoxic tumor environments and persistent stem cell populations are detrimental to the survival of patients with non-small cell lung carcinoma (NSCLC). Tie1 is upregula...

    Authors: Chaojie Li, Nannan Yang, Zhijin Chen, Ning Xia, Qungang Shan, Ziyin Wang, Jian Lu, Mingyi Shang and Zhongmin Wang
    Citation: Cancer Cell International 2021 21:57
  23. Increasing evidence has demonstrated that snoRNAs play crucial roles in tumorigenesis of various cancer types. However, researches on snoRNAs in ccRCC were very little. This study mainly aimed to validate the ...

    Authors: Xiaoling Shang, Xingguo Song, Kangyu Wang, Miao Yu, Shanshan Ding, Xiaohan Dong, Li Xie and Xianrang Song
    Citation: Cancer Cell International 2021 21:56
  24. Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces th...

    Authors: Jianhui Liu, Shaoliang Zhu, Wei Tang, Qinghua Huang, Yan Mei and Huawei Yang
    Citation: Cancer Cell International 2021 21:55

    The Correction to this article has been published in Cancer Cell International 2021 21:673

    The Correction to this article has been published in Cancer Cell International 2021 21:240

  25. Increasing evidence manifested that circular RNAs (circRNAs) acted as crucial regulators in human cancers by targeting the miRNA/mRNA axis, including cervical cancer (CC). Circ_0007534 was reported to promote ...

    Authors: Qiang Sun, Xiangying Qi, Wenyan Zhang and Xiaoyu Li
    Citation: Cancer Cell International 2021 21:54
  26. Acute myeloid leukemia (AML) remains a devastating disease with a 5-year survival rate of less than 30%. AML treatment has undergone significant changes in recent years, incorporating novel targeted therapies ...

    Authors: May Levin, Michal Stark, Yishai Ofran and Yehuda G. Assaraf
    Citation: Cancer Cell International 2021 21:53
  27. Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hin...

    Authors: Heena Saini, Harshita Sharma, Sudeshna Mukherjee, Shibasish Chowdhury and Rajdeep Chowdhury
    Citation: Cancer Cell International 2021 21:52
  28. It has been reported that the lncRNA SNHG16 has significantly increased expression in pancreatic adenocarcinoma (PC). However, the functions and mechanisms of SNHG16 are not clear. The aim of this study was to...

    Authors: Hao Xu, Xin Miao, Xin Li, Haofei Chen, Bo Zhang and Wence Zhou
    Citation: Cancer Cell International 2021 21:51
  29. The exosomal nucleic acid (exoNA) from the plasma and pleural fluid can potentially provide means to identify genomic changes in non-small cell lung cancer (NSCLC) patients who develop resistance to targeted e...

    Authors: Yoonjung Kim, Saeam Shin and Kyung-A Lee
    Citation: Cancer Cell International 2021 21:50
  30. Serum Deprivation Protein Response (SDPR) plays an important role in formation of pulmonary alveoli. However, the functions and values of SDPR in lung cancer remain unknown. We explored prognostic value, expre...

    Authors: Xiaoqing Luo, Shunli Peng, Sijie Ding, Qin Zeng, Rong Wang, Yueyun Ma, ShiYu Chen, Yanxia Wang and Wei Wang
    Citation: Cancer Cell International 2021 21:49
  31. Cell division cycle associated 4 (CDCA4) has been reported to be engaged into the progression of several cancers. The function of CDCA4 in Non-small cell lung cancer (NSCLC) was unknown. We aimed to explore th...

    Authors: Chenxin Xu, Haixia Cao, Ying Sui, Hui Zhang, Chen Shi, Jianzhong Wu, Rong Ma and Jifeng Feng
    Citation: Cancer Cell International 2021 21:48
  32. The incidence of multiple primary malignant tumors (MPMTs) is rising due to the development of screening technologies, significant treatment advances and increased aging of the population. For patients with a ...

    Authors: Yu Zheng, Yifeng Sun, Yue Kuai, Guoxiang Fu, Huimin An, Jinyun Chen, Jinying Chen, Jiajun Zhu, Yixin Wo, Yiwang Wu, Kaibin Song, Qinghua Xu, Di Wu, Deshuang Huang, Qifeng Wang and Hongming Pan
    Citation: Cancer Cell International 2021 21:47
  33. METTL14, as one of N6-methyladenosine (m6A) related genes, has been found to be associated with promoting tumorigenesis in different types of cancers. This study was aimed to investigate the prognostic value o...

    Authors: Yi Wang, Rong Cong, Shouyong Liu, Bingye Zhu, Xing Wang and Qianwei Xing
    Citation: Cancer Cell International 2021 21:46
  34. Castration-resistant prostate cancer (CRPC) remains prostate cancer research and treatment bottleneck. Abnormal androgen receptor (AR) activation still has a pivotal role in CRPC. Multiple mechanisms involve t...

    Authors: Dali Tong
    Citation: Cancer Cell International 2021 21:45

    The Correction to this article has been published in Cancer Cell International 2021 21:301

  35. Gastric cancer (GC) is one of the most common cancers in the world. Due to the lack of specific symptoms, more than 80% of patients are diagnosed as the advanced stage with a high mortality rate, so the early ...

    Authors: Shuo Ma, Shan Kong, Xinliang Gu, Yanhua Xu, Mei Tao, Lei Shen, Xianjuan Shen and Shaoqing Ju
    Citation: Cancer Cell International 2021 21:44
  36. Ectopic expression of transcription elongation factor A (SII)-like 7 (TCEAL7) has been observed in several kinds of cancers, but its role in melanoma is still unclear. This study was carried out to investigate...

    Authors: Xilin Liu, Xianji Song and Hong Li
    Citation: Cancer Cell International 2021 21:43
  37. Clinical management of triple-negative breast cancer (TNBC) patients remain challenging because of the development of chemo-resistance. Identification of biomarkers for risk stratification of chemo-resistance ...

    Authors: Shan Zhu, Yulin Xu, Lijun Wang, Shichong Liao, Yuan Wang, Manman Shi, Yi Tu, Yurong Zhou and Wen Wei
    Citation: Cancer Cell International 2021 21:42
  38. Renal cell carcinoma (RCC) is a clinically common tumor in the urinary system, showing an upward trend of both incidence and mortality. Apolipoprotein C1 (APOC1) has been identified as a vital regulator in tum...

    Authors: Hao Jiang, Jing-Yuan Tang, Dong Xue, Yi-Meng Chen, Ting-Chun Wu, Qian-Feng Zhuang and Xiao-Zhou He
    Citation: Cancer Cell International 2021 21:41
  39. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01759-5.

    Authors: Jin Gao, Yuan Yuan, Lili Zhang, Shaorong Yu, Jianwei Lu, Jifeng Feng and Sainan Hu
    Citation: Cancer Cell International 2021 21:40

    The original article was published in Cancer Cell International 2020 20:90

  40. LncRNA HOXA-AS2 has been found in the literature to deteriorate glioblastoma. However, its regulatory mechanism is yet to be fully investigated. Our study focused chiefly on the interaction and role of the HOX...

    Authors: Jixin Shou, Haidong Gao, Sen Cheng, Bingbing Wang and Haibo Guan
    Citation: Cancer Cell International 2021 21:39
  41. Breast cancer is the first killer leading to female death, and tumor metastasis is one of the important factors leading to the death of patients, but the specific mechanism of breast cancer metastasis is not v...

    Authors: Bowen Li, Liying Mu, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Bashir Ahmad, Shujing Li and Huijian Wu
    Citation: Cancer Cell International 2021 21:38
  42. Oral squamous cell carcinoma (OSCC) has been one of the most malignant cancers in head and neck region. Anlotinib is a tyrosine kinase inhibitor targeting several receptors such as vascular endothelial growth ...

    Authors: Zhaoming Deng, Wei Liao, Wei Wei, Guihua Zhong, Chao He, Hongbo Zhang, Qiaodan Liu, Xiwei Xu, Jun Liang and Zhigang Liu
    Citation: Cancer Cell International 2021 21:37
  43. Long non-coding RNAs (lncRNAs) are pervasively transcribed in genome and emerging as a new player in tumorigenesis due to their functions in transcriptional, posttranscriptional and epigenetic mechanisms of ge...

    Authors: Min Hou, Nannan Wu and Lili Yao
    Citation: Cancer Cell International 2021 21:36
  44. Triple-negative breast cancer (TNBC) is the most challenging breast cancer subtype to treat, because it is so aggressive with shorter survival. Chemotherapy remains the standard treatment due to the lack of sp...

    Authors: Yuanyuan Cheng, Lishuang Lin, Xiaoyan Li, Aiqi Lu, Chenjian Hou, Qian Wu, Xiaomu Hu, Zhongwen Zhou, Zhongqing Chen and Feng Tang
    Citation: Cancer Cell International 2021 21:32
  45. Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene ...

    Authors: Yue Chang, Min Hao, Ru Jia, Yihui Zhao, Yixuan Cai and Yun Liu
    Citation: Cancer Cell International 2021 21:29
  46. Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates...

    Authors: Jing Han, Nannan Han, Zhimin Xu, Chunye Zhang, Jiannan Liu and Min Ruan
    Citation: Cancer Cell International 2021 21:28

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