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  1. Diverse functions of microRNAs (miRNAs), including effects on tumorigenesis, proliferation, and differentiation, have been reported, and several miRNAs have also been demonstrated to play an important role in ...

    Authors: Keiichiro Iida, Jun-ichi Fukushi, Yoshihiro Matsumoto, Yoshinao Oda, Yusuke Takahashi, Toshifumi Fujiwara, Yuko Fujiwara-Okada, Mihoko Hatano, Akira Nabashima, Satoshi Kamura and Yukihide Iwamoto

    Citation: Cancer Cell International 2013 13:21

    Content type: Primary research

    Published on:

  2. Clear cell renal cell carcinoma (ccRCC) cell lines with distinct metastatic potential are essential to study the mechanism of ccRCC metastasis. However, none of them originated from Chinese.

    Authors: Xiaojie Tan, Songqin He, Yifang Han, Yongwei Yu, Jianru Xiao, Danfeng Xu, Guoping Wang, Yan Du, Wenjun Chang, Jianhua Yin, Tong Su, Jianguo Hou and Guangwen Cao

    Citation: Cancer Cell International 2013 13:20

    Content type: Primary research

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  3. Malignant mesothelioma is an asbestos-related fatal disease with no effective cure. We studied whether a green tea polyphenol, epigallocathechin-3-gallate (EGCG), could induce cell death in five human mesothel...

    Authors: Motohiko Satoh, Yukitoshi Takemura, Hironobu Hamada, Yoshitaka Sekido and Shunichiro Kubota

    Citation: Cancer Cell International 2013 13:19

    Content type: Primary research

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  4. The loss of tumor suppressor gene expression is involved in the carcinogenesis of gastric cancer (GC). Klotho is a recently identified tumor suppressor gene that epigenetically inactivated in gastric cancer. Howe...

    Authors: Biao Xie, Jianping Zhou, Guoshun Shu, Dong-cai Liu, Jiapeng Zhou, Jinhui Chen and Lianwen Yuan

    Citation: Cancer Cell International 2013 13:18

    Content type: Primary research

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  5. A fribotic tumor microenvironment promotes progression of cancer. In this study, we utilize a reconstituted basement membrane mimics Matrigel based three-dimensional organotypic culture (rBM 3-D) to investigat...

    Authors: Hong T Nguyen, Yan Zhuang, Lichun Sun, Steven P Kantrow, Jay K Kolls, Zongbing You, Ying Zhuo and Bin Shan

    Citation: Cancer Cell International 2013 13:16

    Content type: Primary research

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  6. Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G...

    Authors: Ling Wang, Fubiao Kang, Jie Li, Jing Zhang and Baoen Shan

    Citation: Cancer Cell International 2013 13:14

    Content type: Primary research

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  7. Natural products, including plants, microorganisms and marines, have been considered as valuable sources for anticancer drug discovery. Many Chinese herbs have been discovered to be potential sources of antitu...

    Authors: Shengjie Yang, Qi Zhao, Hongmei Xiang, Minjie Liu, Qiuyun Zhang, Wei Xue, Baoan Song and Song Yang

    Citation: Cancer Cell International 2013 13:12

    Content type: Primary research

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  8. Geldanamycin (GA) can be considered a relatively new component with a promising mode of action against human malignancies. It specifically targets heat shock protein 90 (Hsp90) and interferes with its function...

    Authors: Panagiotis K Karkoulis, Dimitrios J Stravopodis, Eumorphia G Konstantakou and Gerassimos E Voutsinas

    Citation: Cancer Cell International 2013 13:11

    Content type: Primary research

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  9. This study examined whether combining paclitaxel (taxol) with a novel epigenetic agent phenethyl isothiocyanate (PEITC) will yield a synergistic effect on inhibiting breast cancer cells. Two drug-resistant bre...

    Authors: Katherine Liu, Shundong Cang, Yuehua Ma and Jen Wei Chiao

    Citation: Cancer Cell International 2013 13:10

    Content type: Primary research

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  10. Senescence in the population of cells is often described as a program of restricted proliferative capacity, which is manifested by broad morphological and biochemical changes including a metabolic shift toward...

    Authors: Anna Litwiniec, Lidia Gackowska, Anna Helmin-Basa, Agnieszka Żuryń and Alina Grzanka

    Citation: Cancer Cell International 2013 13:9

    Content type: Primary research

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  11. Small cell lung cancer (SCLC) is a special kind of lung cancers, lymph or blood metastasis of SCLC usually occurs in early stage. Studies in breast and colon cancer showed over expression of SATB1 could promot...

    Authors: Bo Huang, Hongli Zhou, Xiaodong Wang and Zhiliang Liu

    Citation: Cancer Cell International 2013 13:8

    Content type: Primary research

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  12. MicroRNAs (miRNAs) are small, non-coding RNAs (20–24 nucleotides) that post-transcriptionally modulate gene expression by negatively regulating the stability or translational efficiency of their target mRNAs. ...

    Authors: Jia Li, Xiangjie Kong, Junfeng Zhang, Qifeng Luo, Xiaoyu Li and Lin Fang

    Citation: Cancer Cell International 2013 13:7

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2013 13:17

  13. To evaluate the impacts of the negative lymph nodes (NLNs) count on the prognostic prediction of the ratio of positive and removed lymph nodes (RPL) in cervical cancer patients after radical hysterectomy and p...

    Authors: Ying Chen, Lei Zhang, Jing Tian, Xiubao Ren and Quan Hao

    Citation: Cancer Cell International 2013 13:6

    Content type: Primary research

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  14. Metastatic brain tumours are a common end stage of breast cancer progression, with significant associated morbidity and high mortality. Walker 256 is a rat breast carcinoma cell line syngeneic to Wistar rats a...

    Authors: Kate M Lewis, Elizabeth Harford-Wright, Robert Vink and Mounir N Ghabriel

    Citation: Cancer Cell International 2013 13:5

    Content type: Primary research

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  15. TWIST1 plays a key role in EMT-mediated tumor invasion and metastasis. Since bone metastasis is a hallmark of advanced prostate cancer and is detected in at least 85% of patients who die of this disease, it is...

    Authors: Turid Eide, Håkon Ramberg, Carlotta Glackin, Donald Tindall and Kristin Austlid Taskén

    Citation: Cancer Cell International 2013 13:4

    Content type: Primary research

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  16. Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activatio...

    Authors: Shibo Lin, Katrin Hoffmann, Zhi Xiao, Nan Jin, Uwe Galli, Elvira Mohr, Markus W Büchler and Peter Schemmer

    Citation: Cancer Cell International 2013 13:3

    Content type: Primary research

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  17. Mirk/Dyrk1B contributes to G0 arrest by destabilization of cyclin D1 and stabilization of p27kip1 to maintain the viability of quiescent human cancer cells, and it could be negatively regulated by mitogenic-ac...

    Authors: Jingchun Gao, Yi Zhao, Yunyi Lv, Yamin Chen, Bing Wei, Jianxin Tian, Zhihai Yang, Fandou Kong, Jian Pang, Jiwei Liu and Hong Shi

    Citation: Cancer Cell International 2013 13:2

    Content type: Primary research

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  18. Cellular FLICE-Inhibitory Protein (long form, c-FLIPL) is a critical negative regulator of death receptor-mediated apoptosis. Overexpression of c-FLIPL has been reported in many cancer cell lines and is associate...

    Authors: Qilin Wang, Wendong Sun, Xuexi Hao, Tianliang Li, Ling Su and Xiangguo Liu

    Citation: Cancer Cell International 2012 12:54

    Content type: Primary research

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  19. Cyclooxygenase-2(COX-2) promotes carcinogenesis, tumor proliferation, angiogenesis, prevention of apoptosis, and immunosuppression. Meanwhile, COX-2 over-expression has been associated with tumor behavior and ...

    Authors: Zhi-Jun Dai, Xiao-Bin Ma, Hua-Feng Kang, Jie Gao, Wei-Li Min, Hai-Tao Guan, Yan Diao, Wang-Feng Lu and Xi-Jing Wang

    Citation: Cancer Cell International 2012 12:53

    Content type: Primary research

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  20. In malignant melanoma, it has been published that up to 40% of cancer patients will suffer from brain metastasis. The prognosis for these patients is poor, with a life expectancy of 4 to 6 months. Calcium exch...

    Authors: Abraham Embi, Benjamin J Scherlag, Peter J Embi, Manuel Menes and Sunny S Po

    Citation: Cancer Cell International 2012 12:51

    Content type: Hypothesis

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  21. There is an overwhelmingly increasing trend of analysis of naturally occurring ingredients in treatment of prostate cancer. Substantial fraction of information has been added that highlights activity at variou...

    Authors: Ammad Ahmad Farooqi, Ghazala Butt and Zubia Razzaq

    Citation: Cancer Cell International 2012 12:50

    Content type: Review

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  22. Lycorine, a natural alkaloid extracted from Amaryllidaceae, has shown various pharmacological effects. Recent studies have focused on the potential antitumor activity of lycorine. In our previous study, we found ...

    Authors: Lv Li, Hong-Juan Dai, Mao Ye, Shu-Ling Wang, Xiao-Juan Xiao, Jie Zheng, Hui-Yong Chen, Yu-hao Luo and Jing Liu

    Citation: Cancer Cell International 2012 12:49

    Content type: Primary research

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  23. Zoledronic acid is used to treat bone metastases and has been shown to reduce skeletal-related events and exert antitumor activity. The present in vitro study investigates the mechanism of action of Zoledronic Ac...

    Authors: Toni Ibrahim, Laura Mercatali, Emanuele Sacanna, Anna Tesei, Silvia Carloni, Paola Ulivi, Chiara Liverani, Francesco Fabbri, Michele Zanoni, Wainer Zoli and Dino Amadori

    Citation: Cancer Cell International 2012 12:48

    Content type: Primary research

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  24. Breast cancer is the most common cancer in the Arab world and it ranked first among Saudi females. Doxorubicin (DOX), an anthracycline antibiotic is one of the most effective anticancer agents used to treat br...

    Authors: Abdel-Moneim M Osman, Hadeel M Bayoumi, Sameer E Al-Harthi, Zoheir A Damanhouri and Mohamed F ElShal

    Citation: Cancer Cell International 2012 12:47

    Content type: Primary research

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  25. Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cance...

    Authors: Henry I C Lowe, Charah T Watson, Simone Badal, Ngeh J Toyang and Joseph Bryant

    Citation: Cancer Cell International 2012 12:46

    Content type: Primary research

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  26. Inhibition of kinases involved in the DNA damage response sensitizes cells to genotoxic agents by abrogating checkpoint-induced cell cycle arrest. CHK1 and WEE1 act in a pathway upstream of CDK1 to inhibit cel...

    Authors: Amy D Guertin, Melissa M Martin, Brian Roberts, Melissa Hurd, Xianlu Qu, Nathan R Miselis, Yaping Liu, Jing Li, Igor Feldman, Yair Benita, Andrew Bloecher, Carlo Toniatti and Stuart D Shumway

    Citation: Cancer Cell International 2012 12:45

    Content type: Primary research

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  27. Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently,...

    Authors: Fan Zhang, Lijiang Yang and Yangqiu Li

    Citation: Cancer Cell International 2012 12:44

    Content type: Review

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  28. Breast cancer is one of the most common cancers among women throughout the world. Therefore, established cell lines are widely used as in vitro experimental models in cancer research.

    Authors: Behnam Kamalidehghan, Massoud Houshmand, Fereydoun Kamalidehghan, Narges Jafarzadeh, Shahram Azari, Sharifah Noor Akmal and Rozita Rosli

    Citation: Cancer Cell International 2012 12:43

    Content type: Primary research

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  29. In order to characterize the expression pattern of SALL4, BMI-1 and ABCA3 genes in patients with myeloid leukemia and those who achieved complete remission (CR) after chemotherapy. Real-time PCR was used to deter...

    Authors: Qi Shen, Sichu Liu, Junyan Hu, Shaohua Chen, Lijian Yang, Bo Li, Xiuli Wu, Yu Ma, Jianchang Yang, Yupo Ma and Yangqiu Li

    Citation: Cancer Cell International 2012 12:42

    Content type: Primary research

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  30. The cancer stem cell (CSC) hypothesis posits that deregulated neural stem cells (NSCs) form the basis of brain tumors such as glioblastoma multiforme (GBM). GBM, however, usually forms in the cerebral white ma...

    Authors: Shengwen Calvin Li, Long T Vu, Hector W Ho, Hong Zhen Yin, Vic Keschrumrus, Qiang Lu, Jun Wang, Heying Zhang, Zhiwei Ma, Alexander Stover, John H Weiss, Philip H Schwartz and William G Loudon

    Citation: Cancer Cell International 2012 12:41

    Content type: Primary research

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  31. The Real-time PCR Array System is the ideal tool for analyzing the expression of a focused panel of genes. In this study, we will analyze the gene expression profile of pediatric acute myeloid leukemia with re...

    Authors: Tao Yan-Fang, Wu Dong, Pang Li, Zhao Wen-Li, Lu Jun, Wang Na, Wang Jian, Feng Xing, Li Yan-Hong, Ni Jian and Pan Jian

    Citation: Cancer Cell International 2012 12:40

    Content type: Primary research

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  32. To globally characterize the cancer stroma expression profile of muscle-invasive transitional cell carcinoma and to discuss the cancer biology as well as biomarker discovery from stroma. Laser capture micro di...

    Authors: Haitao Niu, Haiping Jiang, Bo Cheng, Xinhui Li, Qian Dong, Leping Shao, Shiguo Liu and Xinsheng Wang

    Citation: Cancer Cell International 2012 12:39

    Content type: Primary research

    Published on:

  33. Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitot...

    Authors: Michelle H Visagie and Anna M Joubert

    Citation: Cancer Cell International 2012 12:37

    Content type: Primary research

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  34. Lycopene, a major carotenoid component of tomato, has a potential anticancer activity in many types of cancer. Epidemiological and clinical trials rarely provide evidence for mechanisms of the compound’s actio...

    Authors: Anderson Junger Teodoro, Felipe Leite Oliveira, Nathalia Balthazar Martins, Guilherme de Azevedo Maia, Renata Brum Martucci and Radovan Borojevic

    Citation: Cancer Cell International 2012 12:36

    Content type: Primary research

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  35. Cisplatin resistance is a serious problem in cancer treatment. To overcome it, alternative approaches including virotherapy are being pursued. One of the candidates for anticancer virotherapy is the Newcastle ...

    Authors: Mohd-Hafifi Jamal, Wei-Choong Ch’ng, Khatijah Yusoff and Norazizah Shafee

    Citation: Cancer Cell International 2012 12:35

    Content type: Primary research

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  36. Nasopharyngeal carcinoma (NPC) is a unique tumour of epithelial origin with a distinct geographical distribution, genetic predisposition and environmental as well as dietary influence as aetiological factors. ...

    Authors: Maelinda Daker, Munirah Ahmad and Alan SB Khoo

    Citation: Cancer Cell International 2012 12:34

    Content type: Primary research

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  37. Although the peptidyl-prolyl isomerase, cyclophilin-A (peptidyl-prolyl isomerase, PPIA), has been studied for decades in the context of its intracellular functions, its extracellular roles as a major contribut...

    Authors: Karim Bahmed, Curtis Henry, Michael Holliday, Jasmina Redzic, Madalina Ciobanu, Fengli Zhang, Colin Weekes, Robert Sclafani, James DeGregori and Elan Eisenmesser

    Citation: Cancer Cell International 2012 12:19

    Content type: Primary research

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  38. ZIP8 functions endogenously as a Zn+2/HCO3- symporter that can also bring cadmium (Cd+2) into the cell. It has also been proposed that ZIP8 participates in Cd-induced testicular necrosis and renal disease. In thi...

    Authors: Amornpan Ajjimaporn, Tom Botsford, Scott H Garrett, Mary Ann Sens, Xu Dong Zhou, Jane R Dunlevy, Donald A Sens and Seema Somji

    Citation: Cancer Cell International 2012 12:16

    Content type: Primary research

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  39. The purpose of this study was to investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and correlate it with OPN expression and function in squamous carcinoma of ton...

    Authors: Fan Zhang, Xu Jin Liu, Xun Qu, Zhen Sheng Hu, Yong Mei Yang, Ling Ma, Pei Liu, Ping Shi and Feng Cai Wei

    Citation: Cancer Cell International 2012 12:33

    Content type: Primary research

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  40. EPCs were isolated primarily in 1997 by Asahara et al. and recent studies indicated that bone-marrow-derived EPCs contributed little to the endothelium of tumor vessels. Tumors of the CNS system demonstrate va...

    Authors: She-Hong Zhang, Ping Xiang, He-Yong Wang, You-Yi Lu, Yan-Li Luo and Hao Jiang

    Citation: Cancer Cell International 2012 12:32

    Content type: Primary research

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  41. Upregulation of nuclear factor kappa B (NFκB) activity and neuroendocrine differentiation are two mechanisms known to be involved in prostate cancer (PC) progression to castration resistance. We have observed ...

    Authors: Anna Patrikidou, Panagiotis J Vlachostergios, Ioannis A Voutsadakis, Eleana Hatzidaki, Rosalia-Maria Valeri, Chariklia Destouni, Effie Apostolou and Christos N Papandreou

    Citation: Cancer Cell International 2012 12:31

    Content type: Primary research

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  42. RNA interference (RNAi) is a powerful approach in functional genomics to selectively silence messenger mRNA (mRNA) expression and can be employed to rapidly develop potential novel drugs against a complex dise...

    Authors: Anthony Stanislaus, Athirah Bakhtiar, Diyana Salleh, Snigdha Tiash, Tahereh Fatemian, Sharif Hossain, Toshihiro Akaike and Ezharul Hoque Chowdhury

    Citation: Cancer Cell International 2012 12:30

    Content type: Primary research

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  43. While breast cancer (BC) is the major cause of death among women worldwide, there is no guarantee of better patient survival because many of these patients develop primarily metastases, despite efforts to dete...

    Authors: Vivian Labovsky, Valeria B Fernández Vallone, Leandro M Martinez, Julian Otaegui and Norma A Chasseing

    Citation: Cancer Cell International 2012 12:29

    Content type: Primary research

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  44. Kaiso protein has been identified as a new member of the POZ-ZF subfamily of transcription factors that are involved in development and cancer. There is consistent evidence of the role of Kaiso and its involve...

    Authors: Jaime Cofre, João R L Menezes, Luciana Pizzatti and Eliana Abdelhay

    Citation: Cancer Cell International 2012 12:28

    Content type: Primary research

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