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  1. Pancreatic cancer is an extremely dismal malignance. Chemotherapy has been widely applied to treat this intractable tumor. It has exclusive tumor microenvironment (TME), characterized by dense desmoplasia and ...

    Authors: Qiaofei Liu, Quan Liao and Yupei Zhao

    Citation: Cancer Cell International 2017 17:68

    Content type: Review

    Published on:

  2. 6-Chloro-2-methoxy-N-(phenylmethyl)-9-acridinamine (BA), a novel sponge-derived compound, has been reported to elicit a cytotoxic effect by inhibiting cell proliferation.

    Authors: Yun Huang, Guohua Liu, Feng Yang, Xiaowei Xing, Ying Li, Zhijun Huang and Hong Yuan

    Citation: Cancer Cell International 2017 17:66

    Content type: Primary Research

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  3. Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can inter...

    Authors: Jing Li, Jing Wang, Yan Zhong, Ruixia Guo, Danxia Chu, Haifeng Qiu and Zhongfu Yuan

    Citation: Cancer Cell International 2017 17:65

    Content type: Review

    Published on:

  4. Recent studies have verified that long noncoding RNAs (lncRNAs) involved in many biological functions and play crucial roles in human cancers progression, the study aimed to detect the association between long...

    Authors: Jian-Hui Chen, Li-Yang Zhou, Suo Xu, Yu-Long Zheng, Yu-Feng Wan and Cheng-Ping Hu

    Citation: Cancer Cell International 2017 17:64

    Content type: Primary Research

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  5. Recent evidence indicated that the aberrant expression of microRNA plays a crucial role in the development of cervical cancer. The overall shorter survival was strongly related to the abnormal expression of mi...

    Authors: Ai-Hua Chen, Yu-E Qin, Wen-Fan Tang, Jing Tao, Hua-mei Song and Manzhen Zuo

    Citation: Cancer Cell International 2017 17:63

    Content type: Primary Research

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  6. To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived exosomes.

    Authors: Quanfeng Wu, Xiaoli Wu, Xiang Ying, Qinyi Zhu, Xinjing Wang, Lu Jiang, Xin Chen, Yueqian Wu and Xipeng Wang

    Citation: Cancer Cell International 2017 17:62

    Content type: Primary Research

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  7. The completion of the human genome project and the accomplished milestones in the human proteome project; as well as the progress made so far in computational bioinformatics and “big data” processing have cont...

    Authors: Henry A. Adeola, Olujide O. Soyele, Anthonio O. Adefuye, Sikiru A. Jimoh and Azeez Butali

    Citation: Cancer Cell International 2017 17:61

    Content type: Review

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  8. Hepatocellular carcinoma (HCC) is the seventh most common malignancy and the third leading cause of cancer-related death worldwide with an extremely grim prognosis. Berberine (BBR) has been found to inhibit pr...

    Authors: Tung-Yueh Chuang, Hsiao-Li Wu, Jie Min, Michael Diamond, Ricardo Azziz and Yen-Hao Chen

    Citation: Cancer Cell International 2017 17:59

    Content type: Primary Research

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  9. The DMD gene encoding dystrophin is mutated in Duchenne muscular dystrophy, a fatal progressive muscle wasting disease. DMD has also been shown to act as a tumor suppressor gene. Rhabdomyosarcoma (RMS) is a mesod...

    Authors: Emma Tabe Eko Niba, Ryo Yamanaka, Abdul Qawee Mahyoob Rani, Hiroyuki Awano, Masaaki Matsumoto, Hisahide Nishio and Masafumi Matsuo

    Citation: Cancer Cell International 2017 17:58

    Content type: Research article

    Published on:

  10. Breast cancer negatively affects women’s health worldwide. The tumour microenvironment plays a critical role in tumour initiation, proliferation, and metastasis. Cancer cells are traditionally grown in two-dim...

    Authors: Hejing Wang, Junmin Qian, Yaping Zhang, Weijun Xu, Juxiang Xiao and Aili Suo

    Citation: Cancer Cell International 2017 17:55

    Content type: Primary Research

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  11. Intra-tumoral hypoxia and increases in extracellular level of transforming growth factor β1 (TGF-β1), which are common findings in cancer, are associated with an increased risk of metastasis and mortality. Mor...

    Authors: Feifei Xu, Jialu Zhang, Guolin Hu, Lei Liu and Weijiang Liang

    Citation: Cancer Cell International 2017 17:54

    Content type: Primary Research

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  12. For every six men, one will be diagnosed with prostate cancer (PCa) in their lifetime. Estrogen receptors (ERs) are known to play a role in prostate carcinogenesis. However, it is unclear whether the estrogeni...

    Authors: Shaneabbas Raza, Megan Meyer, Casey Goodyear, Kimberly D. P. Hammer, Bin Guo and Othman Ghribi

    Citation: Cancer Cell International 2017 17:52

    Content type: Primary Research

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  13. Oral reactive lesions are the most common lesions of oral cavity. Phospholipases and fatty acids play key roles in the creation of inflammation by change in metabolic activities and production of lipid mediato...

    Authors: Ali Hossein Mesgarzadeh, Abolfazl Akbarzadeh, Ali Rasipour, Tannaz Rasipour, Amir Mehdizadeh and Maghsod Shaaker

    Citation: Cancer Cell International 2017 17:50

    Content type: Primary Research

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  14. Tumour radiosensitivity would be particularly useful in optimizing the radiation dose during radiotherapy. The aim of the current study was to evaluate the potential value of phosphorylated H2AX (γH2AX) and AT...

    Authors: Jin Zhao, Zhong Guo, Shuyan Pei, Lei Song, Chenjing Wang, Jianxiu Ma, Long Jin, Yanqing Ma, Renke He, Jianbin Zhong, Ying Ma and Hong Zhang

    Citation: Cancer Cell International 2017 17:49

    Content type: Primary Research

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  15. The mechanisms and prevention of progression of hepatocellular carcinoma (HCC) after insufficient radiofrequency ablation (RFA) has been preliminarily investigated, therefore, new strategy needs to be investig...

    Authors: Qingyun Zhang, Jian Kong, Shuying Dong, Wenlei Xu and Wenbing Sun

    Citation: Cancer Cell International 2017 17:48

    Content type: Primary Research

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  16. Pancreatic ductal adenocarcinomas are among the most malignant neoplasms and have very poor prognosis. Our understanding of various cancers has recently improved the survival of patients with cancer, except fo...

    Authors: Mi-Ju Kim, Min-Sun Kim, Sung Joo Kim, Soyeon An, Jin Park, Hosub Park, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, Suhwan Chang, Kyu-pyo Kim, Seong-Yun Jeong, Song Cheol Kim and Seung-Mo Hong

    Citation: Cancer Cell International 2017 17:47

    Content type: Primary Research

    Published on:

  17. Lung cancer is the major cause of cancer-related death worldwide, and 80% patients of lung cancer are non-small-cell lung cancer (NSCLC) cases. MicroRNAs are important gene regulators with critical roles in di...

    Authors: Guowei Zhang, Hao Zheng, Guojun Zhang, Ruirui Cheng, Chunya Lu, Yijie Guo and Guoqiang Zhao

    Citation: Cancer Cell International 2017 17:46

    Content type: Primary Research

    Published on:

  18. Ras-related protein 25 (Rab25) functions either as an oncogene or a tumor suppressor with a cancer type-dependent manner. We aimed to investigate clinical significance of Rab25 in prostate cancer (PCa).

    Authors: Chunhui Hu, Beibei Chen, Yibin Zhou and Yuxi Shan

    Citation: Cancer Cell International 2017 17:45

    Content type: Primary Research

    Published on:

  19. Emerging evidences have verified that long non-coding RNAs (lncRNAs) play important regulatory roles in the pathogenesis and progression of cancers. lncRNAs metastasis associated lung adenocarcinoma transcript...

    Authors: Jijun Li, Jinghua Gao, Wen Tian, Yongsheng Li and Jinghua Zhang

    Citation: Cancer Cell International 2017 17:44

    Content type: Primary Research

    Published on:

  20. MYCN gene amplification is related to risk stratification. Therefore it is important to identify accurately the level of the MYCN gene as early as possible in neuroblastoma (NB); howev...

    Authors: Zhi-Xia Yue, Cheng Huang, Chao Gao, Tian-Yu Xing, Shu-Guang Liu, Xing-Jun Li, Qian Zhao, Xi-Si Wang, Wen Zhao, Mei Jin and Xiao-Li Ma

    Citation: Cancer Cell International 2017 17:43

    Content type: Primary Research

    Published on:

  21. Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths worldwide. Up to 80% of cancer patients are classified as non-small-cell lung cancer (NSCLC) and cisplatin rem...

    Authors: Stéfano M. Cirigliano, María I. Díaz Bessone, Damián E. Berardi, Carolina Flumian, Elisa D. Bal de Kier Joffé, Silvio E. Perea, Hernán G. Farina, Laura B. Todaro and Alejandro J. Urtreger

    Citation: Cancer Cell International 2017 17:42

    Content type: Primary Research

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  22. Medulloblastoma is one of the most common types of pediatric brain tumor characterized by the subpopulation of cells that exhibit high invasive potential and radioresistant properties. In addition, dysregulate...

    Authors: Shilpa Bhatia, Kellen Hirsch, Sanjana Bukkapatnam, Nimrah A. Baig, Ayman Oweida, Anastacia Griego, Dylan Calame, Jaspreet Sharma, Andrew Donson, Nicholas Foreman, Christopher Albanese, Sujatha Venkataraman, Rajeev Vibhakar and Sana D. Karam

    Citation: Cancer Cell International 2017 17:41

    Content type: Primary Research

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  23. Non-small cell lung cancer comprises the majority of lung cancer cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid,...

    Authors: Ling-Yun Ye, Song Hu, Hua-E Xu, Rong-Rong Xu, Hui Kong, Xiao-Ning Zeng, Wei-Ping Xie and Hong Wang

    Citation: Cancer Cell International 2017 17:40

    Content type: Primary Research

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  24. Previous reports have revealed that down-regulation of miR-34a expression can promote colorectal cancer (CRC) cell growth by targeting cell cycle-related transcriptional factor E2F1. To date, the function of t...

    Authors: Haiqiang Jiang, Fengyuan Ge, Beina Hu, Lamei Wu, Huijian Yang and Huiyun Wang

    Citation: Cancer Cell International 2017 17:39

    Content type: Primary research

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  25. The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, ef...

    Authors: Henry I. C. Lowe, Ngeh J. Toyang, Charah T. Watson, Kenneth N. Ayeah and Joseph Bryant

    Citation: Cancer Cell International 2017 17:38

    Content type: Primary research

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  26. 2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinoline-11-one (BPIQ), is a synthetic quinoline analog. A previous study showed the anti-cancer potential of BPIQ thr...

    Authors: Yao Fong, Chang-Yi Wu, Kuo-Feng Chang, Bing-Hung Chen, Wan-Ju Chou, Chih-Hua Tseng, Yen-Chun Chen, Hui-Min David Wang, Yeh-Long Chen and Chien-Chih Chiu

    Citation: Cancer Cell International 2017 17:37

    Content type: Primary research

    Published on:

  27. Overexpression of cyclin D1 dependent kinases 4 and 6 (CDK4/6) is a common feature of many human cancers including leukemia. LEE011 is a novel inhibitor of both CDK4 and 6. To date, the molecular function of L...

    Authors: Yan-Fang Tao, Na-Na Wang, Li-Xiao Xu, Zhi-Heng Li, Xiao-Lu Li, Yun-Yun Xu, Fang Fang, Mei Li, Guang-Hui Qian, Yan-Hong Li, Yi-Ping Li, Yi Wu, Jun-Li Ren, Wei-Wei Du, Jun Lu, Xing Feng…

    Citation: Cancer Cell International 2017 17:35

    Content type: Primary research

    Published on:

  28. G protein–coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with patholo...

    Authors: Shuli Liu, Dongxia Ye, Tong Wang, Wenzheng Guo, Hongyong Song, Yueling Liao, Dongliang Xu, Hanguang Zhu, Zhiyuan Zhang and Jiong Deng

    Citation: Cancer Cell International 2017 17:34

    Content type: Primary Research

    Published on:

  29. Absence of the estrogen receptor-α (ER) is perhaps the most distinctive pathological feature of breast cancers arising in women who inherit a mutation in BRCA1. Two hypotheses, not necessarily mutually exclusi...

    Authors: William B. Archey and Bradley A. Arrick

    Citation: Cancer Cell International 2017 17:33

    Content type: Primary research

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  30. MicroRNAs are 22–24 nt non-coding RNAs that bind to the 3′ UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptio...

    Authors: Weizhong Wu, Sanguang Liu, Yunfei Liang, Zegao Zhou and Xueqing Liu

    Citation: Cancer Cell International 2017 17:31

    Content type: Primary research

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  31. Curcumin is a lead compound of the rhizomes of Curcuma longa and possess a broad range of pharmacological activities. Chemically, curcumin is 1,3-dicarbonyl class of compound, which exhibits keto-enol tautomerism...

    Authors: Norlaily Mohd Ali, Swee Keong Yeap, Nadiah Abu, Kian Lam Lim, Huynh Ky, Ahmad Zaim Mat Pauzi, Wan Yong Ho, Sheau Wei Tan, Han Kiat Alan-Ong, Seema Zareen, Noorjahan Banu Alitheen and M. Nadeem Akhtar

    Citation: Cancer Cell International 2017 17:30

    Content type: Primary research

    Published on:

  32. MicroRNAs have been suggested to play a vital role in regulating carcinogenesis, tumor progression and invasion. MiR-335 is involved in suppressing metastasis and invasion in various human cancers. However, th...

    Authors: Jia-kui Zhang, Yong-shuang Li, Chun-dong Zhang and Dong-qiu Dai

    Citation: Cancer Cell International 2017 17:28

    Content type: Primary research

    Published on:

  33. We have reported that the phosphatidylinositol-3 kinase (PI3K)/Akt signaling pathway mediated Wnt5a-induced osteosarcoma cell migration. However, the signaling pathways regulating Wnt5a/PI3K/Akt-mediated cell ...

    Authors: Ailiang Zhang, Ting Yan, Kun Wang, Zhihui Huang and Jinbo Liu

    Citation: Cancer Cell International 2017 17:27

    Content type: Primary research

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  34. Increased expression of suppressor of zest 12 (SUZ12), a core component of the polycomb repressive complex 2, contributes to human tumorigenesis and associates with patient prognosis. In the present study, we ...

    Authors: Huijun Hu, Yi Wang, Zhongwu Li, Yumin Zhu, Wei Zhang, Dongmiao Wang, Tangyi Lin, Jianrong Yang, Yanling Wang and Jie Cheng

    Citation: Cancer Cell International 2017 17:26

    Content type: Primary research

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  35. Cancer stem cells (CSCs), a subpopulation in tumors, are known to cause drug resistance, tumor recurrence and metastasis. Based on the characteristic formation of mammospheres in in vitro conditions, the mammo...

    Authors: Hack Sun Choi, Dal-Ah Kim, Heesung Chung, In Ho Park, Bo Hye Kim, Eok-Soo Oh and Duk-Hee Kang

    Citation: Cancer Cell International 2017 17:25

    Content type: Primary research

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  36. Glioblastoma (GBM) is one of the most lethal tumors with a poor prognosis. Its inevitable recurrence is frequently explained by the presence of cancer stem cells. We aimed to show that human GBM cells with ste...

    Authors: Se-Jeong Oh, Jung-In Yang, Ok Kim, Eun-Jung Ahn, Woo Dae Kang, Jae-Hyuk Lee, Kyung-Sub Moon, Kyung-Hwa Lee and Duck Cho

    Citation: Cancer Cell International 2017 17:22

    Content type: Primary research

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  37. Eph receptors are a subfamily of receptor tyrosine kinases. Eph receptor-mediated forward and ephrin ligand-mediated reverse signalings are termed bidirectional signaling. Increasing evidence shows that Eph/ep...

    Authors: Wenqiang Wei, Hongju Wang and Shaoping Ji

    Citation: Cancer Cell International 2017 17:21

    Content type: Review

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  38. Human gallbladder cancer (GBC) is an aggressive malignant neoplasm with a poor prognosis. The development of ideal tools for example tumor cell lines for investigating biological behavior, metastatic mechanism...

    Authors: Zhong-Yan Liu, Guo-Li Xu, Hui-Hong Tao, Yao-Qin Yang and Yue-Zu Fan

    Citation: Cancer Cell International 2017 17:20

    Content type: Primary research

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  39. To investigate the influence of polymorphisms in the receptor for advanced glycation end products (RAGE) gene and circulating soluble RAGE (sRAGE) levels on susceptibility to gastric cancer, and identify wheth...

    Authors: Taijie Li, Weijuan Qin, Yanqiong Liu, Shan Li, Xue Qin and Zhiming Liu

    Citation: Cancer Cell International 2017 17:19

    Content type: Primary research

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  40. Human basonuclin 2 (BNC2) acts as a tumor suppressor in multiple cancers in an as yet unidentified manner. The role and expression of the BNC2 gene in lung cancer has not yet been investigated.

    Authors: Egon Urgard, Anu Reigo, Eva Reinmaa, Ana Rebane and Andres Metspalu

    Citation: Cancer Cell International 2017 17:18

    Content type: Primary research

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