Skip to main content

Articles

Page 33 of 39

  1. Without doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical ...

    Authors: Afef Dellai, Monia Deghrigue, Audrey Laroche-Clary, Hedi Ben Masour, Nabil Chouchane, Jacques Robert and Abderrahman Bouraoui

    Citation: Cancer Cell International 2012 12:18

    Content type: Primary research

    Published on:

  2. Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1 and it...

    Authors: Casey M Turk, Katerina D Fagan-Solis, Kristin E Williams, Joseph M Gozgit, Sallie Smith-Schneider, Sharon A Marconi, Christopher N Otis, Giovanna M Crisi, Douglas L Anderton, Manfred W Kilimann and Kathleen F Arcaro

    Citation: Cancer Cell International 2012 12:17

    Content type: Primary research

    Published on:

  3. This study progresses in the direction of identifying component(s) from the Mediterranean sponge, Spongia officinalis with anticonvulsant and analgesic activities. We investigated the efficacy of crude extract an...

    Authors: Afef Dellai, Hedi Ben Mansour, Audrey Clary-Laroche, Monia Deghrigue and Abderrahman Bouraoui

    Citation: Cancer Cell International 2012 12:15

    Content type: Primary research

    Published on:

  4. Glioblastoma is the most aggressive form of brain tumors showing resistance to treatment with various chemotherapeutic agents. The most effective way to eradicate glioblastoma requires the concurrent inhibitio...

    Authors: Hiroko Tabunoki, Naoki Saito, Khanit Suwanborirux, Kornvika Charupant and Jun-ichi Satoh

    Citation: Cancer Cell International 2012 12:14

    Content type: Primary research

    Published on:

  5. The Notch signaling pathway is crucial in T-cell development, Notch 1 mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL). To investigate the feature of Notch 1 mutation and its corres...

    Authors: Chunlan Lin, Haitao Zheng, Chunyan Wang, Lijian Yang, Shaohua Chen, Bo Li, Yubing Zhou, Huo Tan and Yangqiu Li

    Citation: Cancer Cell International 2012 12:13

    Content type: Primary research

    Published on:

  6. GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) and PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid) are tumour metabolism inhibitors that target adenine nucleotide translocase (ANT...

    Authors: Danielle Park, Joyce Chiu, Gabriel G Perrone, Pierre J Dilda and Philip J Hogg

    Citation: Cancer Cell International 2012 12:11

    Content type: Primary research

    Published on:

  7. Although the primary risk factors for developing oral cancers are well understood, less is known about the relationship among the secondary factors that may modulate the progression of oral cancers, such as hi...

    Authors: Michael Moody, Oanh Le, Megan Rickert, Jeremy Manuele, Sarah Chang, Gary Robinson, Jeffrey Hajibandeh, John Silvaroli, Mark A Keiserman, Christine J Bergman and Karl Kingsley

    Citation: Cancer Cell International 2012 12:10

    Content type: Primary research

    Published on:

  8. Recently electroporation using biphasic pulses was successfully applied in clinical developments for treating tumours in humans and animals. We evaluated the effects of electrical treatment on cell adhesion be...

    Authors: Viktoria N Pehlivanova, Iana H Tsoneva and Rumiana D Tzoneva

    Citation: Cancer Cell International 2012 12:9

    Content type: Primary research

    Published on:

  9. The effect of cell injury and apoptosis induced by ultrasound with contrast agent has been verified. Contrast agent enhanced apoptosis and expression of genes that related to apoptosis and are responsive to ul...

    Authors: Zao Jiang, Wei Wu and Meng-lu Qian

    Citation: Cancer Cell International 2012 12:8

    Content type: Primary research

    Published on:

  10. A potential strategy for the diagnosis of lung cancer is to exploit the distinct metabolic signature of this disease by way of biomarkers found in different sample types. In this study, we investigated whether...

    Authors: Yosuke Hanai, Ken Shimono, Hiroaki Oka, Yoshinobu Baba, Kunio Yamazaki and Gary K Beauchamp

    Citation: Cancer Cell International 2012 12:7

    Content type: Primary research

    Published on:

  11. Caveolin-1 is a scaffolding protein found in plasma membrane invaginations known as caveolae. Caveolin-1 can regulate a number of intracellular processes such as signal transduction, cholesterol metabolism and...

    Authors: Devan E Thompson, Megan D Siwicky and Roger A Moorehead

    Citation: Cancer Cell International 2012 12:6

    Content type: Primary research

    Published on:

  12. Statins may have therapeutic effects on hepatocarcinoma (HCC). This type of disorder is the most common malignant primary tumour in the liver. Our objective was to determine whether pravastatin had a therapeut...

    Authors: Elizabeth Hijona, Jesús María Banales, Lander Hijona, Juan Francisco Medina, Juan Arenas, Marta Herreros-Villanueva, Pablo Aldazabal and Luis Bujanda

    Citation: Cancer Cell International 2012 12:5

    Content type: Primary research

    Published on:

  13. Removal of numerous classes of chemical pollutants from the industrial wastewater such as textile, pharmaceutical and olive mill using conventional wastewater treatment, is incomplete and several studies sugge...

    Authors: Hedi Ben Mansour, Afef Dellai and Yosra Ayed

    Citation: Cancer Cell International 2012 12:4

    Content type: Primary research

    Published on:

  14. The aim of this study was to evaluate the biological and pharmaceutical activities of 14 amphiphilic liquid-crystalline compounds (LCs), i.e, phenylpyrimidine derivatives possessing D-glucamine and cyanobiphenyl ...

    Authors: Junya Ishikawa, Yuuka Takahashi, Masaharu Hazawa, Yukako Fukushi, Atsushi Yoshizawa and Ikuo Kashiwakura

    Citation: Cancer Cell International 2012 12:3

    Content type: Primary research

    Published on:

  15. Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administra...

    Authors: Micaela Martinez, Nadia Ono, Marina Planutiene, Kestutis Planutis, Edward L Nelson and Randall F Holcombe

    Citation: Cancer Cell International 2012 12:2

    Content type: Editorial

    Published on:

    The Erratum to this article has been published in Cancer Cell International 2013 13:80

  16. Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection and lack of efficient treatments. Identifying novel drug targets for this indicat...

    Authors: Friedrich G Kapp, Anette Sommer, Thomas Kiefer, Gottfried Dölken and Bernard Haendler

    Citation: Cancer Cell International 2012 12:1

    Content type: Primary research

    Published on:

  17. Currently, Atypical Teratoid Rhabdoid Tumor (AT/RT) constitutes one of the most difficult to treat malignancies in pediatrics. Hence, new knowledge of potential targets for therapeutics and the development of ...

    Authors: Aarthi Jayanthan, Delphine Bernoux, Pinaki Bose, Karl Riabowol and Aru Narendran

    Citation: Cancer Cell International 2011 11:44

    Content type: Primary research

    Published on:

  18. In the search for anticancer agents, a promising 17-β-estradiol metabolite, 2-methoxyestradiol (2ME2) was found that exerts antiproliferative in vitro and in vivo activity. Since 2ME2 has limited biological acces...

    Authors: Michelle H Visagie and Anna M Joubert

    Citation: Cancer Cell International 2011 11:43

    Content type: Primary research

    Published on:

  19. Dysregulation of many apoptotic related genes and androgens are critical in the development, progression, and treatment of prostate cancer. The differential sensitivity of tumour cells to TRAIL-induced apoptos...

    Authors: David Vindrieux, Marie Réveiller, Jacqueline Chantepie, Sadok Yakoub, Catherine Deschildre, Alain Ruffion, Marian Devonec, Mohamed Benahmed and Renée Grataroli

    Citation: Cancer Cell International 2011 11:42

    Content type: Primary research

    Published on:

  20. Neuron specific enolase (ENO2, γ-enolase) has been used as a biomarker to help identify neuroendocrine differentiation in breast cancer. The goal of the present study was to determine if ENO2 expression in the...

    Authors: Maureen A Soh, Scott H Garrett, Seema Somji, Jane R Dunlevy, Xu Dong Zhou, Mary Ann Sens, Chandra S Bathula, Christina Allen and Donald A Sens

    Citation: Cancer Cell International 2011 11:41

    Content type: Primary research

    Published on:

  21. Hepatocellular carcinoma (HCC) is a molecular complex tumor with high intrinsic drug resistance. Recent evidence suggests an involvement of the tyrosine kinase pathway in the regulation of ATP-binding cassette...

    Authors: Katrin Hoffmann, Zhi Xiao, Clemens Franz, Elvira Mohr, Susanne Serba, Markus W Büchler and Peter Schemmer

    Citation: Cancer Cell International 2011 11:40

    Content type: Primary research

    Published on:

  22. During cell division, replication of the genomic DNA is performed by high-fidelity DNA polymerases but these error-free enzymes can not synthesize across damaged DNA. Specialized DNA polymerases, so called DNA...

    Authors: Philip A Knobel and Thomas M Marti

    Citation: Cancer Cell International 2011 11:39

    Content type: Review

    Published on:

  23. This study was designed to evaluate the potential chemopreventive activities of Ginkgo biloba extract (EGb) and Silybum marianum extract (silymarin) against hepatocarcinogenesis induced by N-nitrosodiethylamine (...

    Authors: Hala O El Mesallamy, Nadia S Metwally, Mahmoud S Soliman, Kawkab A Ahmed and Mai M Abdel Moaty

    Citation: Cancer Cell International 2011 11:38

    Content type: Primary research

    Published on:

  24. In this report the phytochemical profile of Nitraria. Retusa (N. Retusa) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated.

    Authors: Jihed Boubaker, Wissem Bhouri, Mohamed Ben Sghaier, Ines Bouhlel, Ines Skandrani, Kamel Ghedira and Leila Chekir-Ghedira

    Citation: Cancer Cell International 2011 11:37

    Content type: Primary research

    Published on:

  25. Hepatocellular carcinoma (HCC) accounts for majority of liver cancers and is the leading cause of cancer related death in Asia. Like any other cancer, HCC develops when there is a mutation to the cellular mach...

    Authors: SNCVL Pushpavalli, M Janaki Ramaiah, Ch Srinivas, Debasmita Mukhopadhya, JL Aditya, Ravindra M Kumbhare, Utpal Bhadra and Manika Pal Bhadra

    Citation: Cancer Cell International 2011 11:36

    Content type: Primary research

    Published on:

  26. The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT)...

    Authors: Jessica T Li, Ka Bian, Alan L Zhang, Dong H Kim, William W Ashley, Rahul Nath, Ian McCutcheon, Bingliang Fang and Ferid Murad

    Citation: Cancer Cell International 2011 11:35

    Content type: Primary research

    Published on:

  27. Rhabdoid tumors (RTs) are aggressive pediatric malignancies with poor prognosis. N-(4-hydroxy phenyl) retinamide (4-HPR or fenretinide) is a potential chemotherapeutic for RTs with activity correlated to its a...

    Authors: Melissa E Smith, Bhaskar C Das and Ganjam V Kalpana

    Citation: Cancer Cell International 2011 11:34

    Content type: Primary research

    Published on:

  28. Multiple innate and adaptive immune effector cells and molecules partake in the recognition and destruction of cancer cells to protect against growing tumors, a concept that is known as cancer immunosurveillan...

    Authors: Heba A Alshaker and Khalid Z Matalka

    Citation: Cancer Cell International 2011 11:33

    Content type: Review

    Published on:

  29. Cell fusion induced by polyethylene glycol (PEG) is an efficient but poorly controlled procedure for obtaining somatic cell hybrids used in gene mapping, monoclonal antibody production, and tumour immunotherap...

    Authors: Filippo Pedrazzoli, Iraklis Chrysantzas, Luca Dezzani, Vittorio Rosti, Massimo Vincitorio and Giammaria Sitar

    Citation: Cancer Cell International 2011 11:32

    Content type: Primary research

    Published on:

  30. The objective of this study was to investigate whether the levels of glucose or certain amino acids could regulate the expression of a cell cycle repressor protein p27(Kip1), thereby dictating the risk of canc...

    Authors: Isao Eto

    Citation: Cancer Cell International 2011 11:31

    Content type: Primary research

    Published on:

  31. The synergic action of KHCO3 and D-ribose is tested on A72 and HTB-126 cell lines proliferation using K:D-Rib solution. Altered Na+/K+ ATPase expression and activity were shown in patients with cancer. Studies in...

    Authors: Simonetta Croci, Luca Bruni, Simona Bussolati, Marianna Castaldo and Maurizio Dondi

    Citation: Cancer Cell International 2011 11:30

    Content type: Primary research

    Published on:

  32. The inhibition of Br east Ca ncer 1 (BRCA1) expression sensitizes breast and ovarian cancer cells to platinum chemotherapy. However, therapeutically relevant agents that target BRCA1 expression have not been iden...

    Authors: Johanne I Weberpals, Anna M O'Brien, Nima Niknejad, Kyla D Garbuio, Katherine V Clark-Knowles and Jim Dimitroulakos

    Citation: Cancer Cell International 2011 11:29

    Content type: Primary research

    Published on:

  33. Molecular classification of human breast cancers has identified at least 5 distinct tumor subtypes; luminal A, luminal B, Her2-enriched, basal-like and claudin-low. The claudin-low subtype was identified in 20...

    Authors: Craig I Campbell, Devan E Thompson, Megan D Siwicky and Roger A Moorehead

    Citation: Cancer Cell International 2011 11:28

    Content type: Primary research

    Published on:

  34. In this study, we pilot tested an in vitro assay of cancer killing activity (CKA) in circulating leukocytes of 22 cancer cases and 25 healthy controls.

    Authors: Michael J Blanks, John R Stehle Jr, Wei Du, Jonathan M Adams, Mark C Willingham, Glenn O Allen, Jennifer J Hu, James Lovato, Istvan Molnar and Zheng Cui

    Citation: Cancer Cell International 2011 11:26

    Content type: Primary research

    Published on:

  35. Many potassium ion (K+) channels function as oncogenes to sustain growth of solid tumors, but their role in cancer progression is not well understood. Emerging evidence suggests that the early progenitor cancer c...

    Authors: Brandon M Schickling, Nukhet Aykin-Burns, Kimberly K Leslie, Douglas R Spitz and Victoria P Korovkina

    Citation: Cancer Cell International 2011 11:25

    Content type: Primary research

    Published on:

  36. In adults, bone is the preferential target site for metastases from primary cancers of prostate, breast, lungs and thyroid. The tendency of these cancers to metastasize to bone is determined by the anatomical ...

    Authors: Liviu Feller, Beverley Kramer and Johan Lemmer

    Citation: Cancer Cell International 2011 11:24

    Content type: Review

    Published on:

  37. Brain-derived neurotrophic factor (BDNF) has established physiological roles in the development and function of the vertebrate nervous system. BDNF has also been implicated in several human malignancies, inclu...

    Authors: Neill Patani, Wen G Jiang and Kefah Mokbel

    Citation: Cancer Cell International 2011 11:23

    Content type: Primary research

    Published on:

  38. Previously we have shown that oncogenic Ha-Ras stimulated in vivo metastasis through RalGEF-Ral signaling. RalA and RalB are highly homologous small G proteins belonging to Ras superfamily. They can be activated ...

    Authors: Vera A Rybko, Anna V Knizhnik, Andrei V Komelkov, Vasily N Aushev, Lyubov S Trukhanova and Elena M Tchevkina

    Citation: Cancer Cell International 2011 11:22

    Content type: Primary research

    Published on:

  39. Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tis...

    Authors: Christa Nagler, Cornelia Hardt, Kurt S Zänker and Thomas Dittmar

    Citation: Cancer Cell International 2011 11:21

    Content type: Primary research

    Published on:

  40. Genomic alterations are common features of cancer cells, and some of these changes are proven to be neoplastic-specific. Such alterations may serve as valuable tools for diagnosis and classification of tumors,...

    Authors: Eva Falck, Carola Hedberg, Karin Klinga-Levan and Afrouz Behboudi

    Citation: Cancer Cell International 2011 11:20

    Content type: Primary research

    Published on:

  41. Secondary therapy-related acute lymphoblastic leukemia might emerge following chemotherapy and/or radiotherapy for primary malignancies. Therefore, other alternatives should be pursued to treat leukemia.

    Authors: Angelica R Bonilla-Porras, Marlene Jimenez-Del-Rio and Carlos Velez-Pardo

    Citation: Cancer Cell International 2011 11:19

    Content type: Primary research

    Published on:

  42. Glioblastoma (GBM) develops resistance to the advances in chemotherapy leading to poor prognosis and life quality. Consequently, new treatment modalities are needed. Our aims were to investigate the effects of...

    Authors: Mine Erguven, Ayhan Bilir, Nuray Yazihan, Ezgi Ermis, Akin Sabanci, Esin Aktas, Yavuz Aras and Vehbi Alpman

    Citation: Cancer Cell International 2011 11:18

    Content type: Primary research

    Published on:

  43. Aimed to facilitate candidate biomarkers selection and improve network-based multi-target therapy, we perform comparative proteomics research on muscle-invasive bladder transitional cell carcinoma. Laser captu...

    Authors: Hai Tao Niu, Zhen Dong, Gang Jiang, Ting Xu, Yan Qun Liu, Yan Wei Cao, Jun Zhao and Xin Sheng Wang

    Citation: Cancer Cell International 2011 11:17

    Content type: Primary research

    Published on:

  44. Natural killer (NK) cells are an important resource of the innate immune system directly involved in the spontaneous recognition and lysis of virus-infected and tumor cells. An exquisite balance of inhibitory ...

    Authors: Susana del Toro-Arreola, Naela Arreygue-Garcia, Adriana Aguilar-Lemarroy, Angel Cid-Arregui, Miriam Jimenez-Perez, Jesse Haramati, Patricio Barros-Nuñez, Oscar Gonzalez-Ramella, Alicia del Toro-Arreola, Pablo Ortiz-Lazareno, Georgina Hernandez-Flores, Alejandro Bravo-Cuellar, Adrian Daneri-Navarro and Luis F Jave-Suarez

    Citation: Cancer Cell International 2011 11:15

    Content type: Primary research

    Published on:

  45. MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cance...

    Authors: Jessica Carlsson, Sabina Davidsson, Gisela Helenius, Mats Karlsson, Zelmina Lubovac, Ove Andrén, Björn Olsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2011 11:14

    Content type: Primary research

    Published on:

  46. Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two m...

    Authors: Anna Patrikidou, Panagiotis J Vlachostergios, Ioannis A Voutsadakis, Eleana Hatzidaki, Rosalia-Maria Valeri, Chariklia Destouni, Effie Apostolou, Danai Daliani and Christos N Papandreou

    Citation: Cancer Cell International 2011 11:13

    Content type: Primary research

    Published on:

  47. Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring ole...

    Authors: Zeyad D Nassar, Abdalrahim FA Aisha, Mohamed BK Ahamed, Zhari Ismail, Khalid M Abu-Salah, Salman A Alrokayan and Amin Malik Shah Abdul Majid

    Citation: Cancer Cell International 2011 11:12

    Content type: Primary research

    Published on:

Annual Journal Metrics

Institutional membership

Visit the membership page to check if your institution is a member and learn how you could save on article-processing charges (APCs).

Funding your APC

​​​​​​​Open access funding and policy support by SpringerOpen​​

​​​​We offer a free open access support service to make it easier for you to discover and apply for article-processing charge (APC) funding. Learn more here