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  1. The altered expression of prolactin (PRL) and its receptor (PRLR) has been implicated in breast and other types of cancer. There are few studies that have focused on the analysis of PRL/PRLR in cervical cancer...

    Authors: Edgar I Lopez-Pulido, José F Muñoz-Valle, Susana Del Toro-Arreola, Luis F Jave-Suárez, Miriam R Bueno-Topete, Ciro Estrada-Chávez and Ana Laura Pereira-Suárez

    Citation: Cancer Cell International 2013 13:103

    Content type: Primary research

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  2. Homeobox (HOX) genes deregulation has been largely implicated in the development of human leukemia. Among the HOXB cluster, HOXB1 was silent in a number of analyzed acute myeloid leukemia (AML) primary cells a...

    Authors: Marina Petrini, Federica Felicetti, Lisabianca Bottero, Maria Cristina Errico, Ornella Morsilli, Alessandra Boe, Alessandra De Feo and Alessandra Carè

    Citation: Cancer Cell International 2013 13:101

    Content type: Primary research

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  3. The incidence and mortality associated with intrahepatic cholangiocarcinoma is increasing in many countries and documentation of disease outcome is sparse. The present study was undertaken to investigate the p...

    Authors: Rui-qing Liu, Shu-jing Shen, Xiu-feng Hu, Jie Liu, Li-juan Chen and Xing-ya Li

    Citation: Cancer Cell International 2013 13:99

    Content type: Primary research

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  4. Recent evidence suggests that vascular endothelial growth factor-C (VEGF-C)- dependent tumour production promotes lymphangiogenesis, while membrane-type matrix 1 metalloproteinase (MT1-MMP) is involved in the ...

    Authors: Guangyu Yao, Ping He, Lujia Chen, Xiaolei Hu, Fan Gu and Changsheng Ye

    Citation: Cancer Cell International 2013 13:98

    Content type: Primary research

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  5. Human epidermal growth factor receptor-2 (Her-2) is over expressed in approximately 25-30% of all primary breast tumors resulting in a distinctive breast cancer subtype associated with a poor prognosis and a d...

    Authors: Tracey Hurrell and Kim Outhoff

    Citation: Cancer Cell International 2013 13:97

    Content type: Primary research

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  6. MicroRNAs are a class of endogenous single strand non-coding RNAs that are involved in many important physiological and pathological processes. The purpose of this study was to examine the expression levels of...

    Authors: Qifeng Luo, Xiaoyu Li, Yan Gao, Yin Long, Lei Chen, Yixiang Huang and Lin Fang

    Citation: Cancer Cell International 2013 13:95

    Content type: Primary research

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  7. Angiogenesis represents a highly multi-factorial and multi-cellular complex (patho-) physiologic event involving endothelial cells, tumor cells in malignant conditions, as well as bone marrow derived cells and...

    Authors: Melanie Hein and Shannon Graver

    Citation: Cancer Cell International 2013 13:94

    Content type: Primary research

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  8. Somatostatin receptors (SSTRs) and opioid receptors (ORs) belong to the superfamily of G-protein coupled receptors and function as negative regulators of cell proliferation in breast cancer. In the present stu...

    Authors: Geetanjali Kharmate, Padmesh S Rajput, Yu-Chen Lin and Ujendra Kumar

    Citation: Cancer Cell International 2013 13:93

    Content type: Primary research

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  9. Ras association domain family 1A gene (RASSFlA) is a candidate suppressor gene, Lack of RASSF1A expression was found in lung cancer. High DNA methylation at the promoter region is the main reason for inactivat...

    Authors: Duan Mengxi, Wang Qian, Wang Nan, Xiao Xiaoguang and Li Shijun

    Citation: Cancer Cell International 2013 13:91

    Content type: Primary research

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  10. Our recent evidence showed that Toll like receptor 9 (TLR9) signaling could enhance the growth and metastatic potential of human lung cancer cells through repressing microRNA-7 (miR-7) expression. Human antige...

    Authors: Yong-Ju Li, Chun-Hong Wang, Ya Zhou, Zheng-Yuan Liao, Shun-Fei Zhu, Yan Hu, Chao Chen, Jun-Min Luo, Zhen-Ke Wen and Lin Xu

    Citation: Cancer Cell International 2013 13:90

    Content type: Primary research

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  11. Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being primarily considered to be due to lactate secretion from anaerobic glycolysis. Clinicopathological evidence shows t...

    Authors: Yasumasa Kato, Shigeyuki Ozawa, Chihiro Miyamoto, Yojiro Maehata, Atsuko Suzuki, Toyonobu Maeda and Yuh Baba

    Citation: Cancer Cell International 2013 13:89

    Content type: Review

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  12. The multiple tyrosine kinase inhibitors SU6668 have a promising therapeutic effect on the progression of hematological malignancies and some solid tumors. Here, we determined its effect on triple negative brea...

    Authors: Lu Wang, Zhaozhe Liu, Dongchu Ma, Ying Piao, Fang Guo, Yaling Han and Xiaodong Xie

    Citation: Cancer Cell International 2013 13:88

    Content type: Primary research

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  13. 2-Methoxyestradiol has been shown to induce both autophagy and apoptosis in various carcinogenic cell lines. Although a promising anti-cancer agent, it has poor bioavailability and rapid in vivo metabolism which ...

    Authors: Anne E Theron, Elsie M Nolte, Laurence Lafanechère and Annie M Joubert

    Citation: Cancer Cell International 2013 13:87

    Content type: Primary research

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  14. Despite advances in detection and therapy, epithelial ovarian cancer (EOC) still represents the most lethal gynecologic malignancy in women worldwide. The high mortality of EOC is mainly due to late-stage diag...

    Authors: Ying Chen, Lei Zhang and Quan Hao

    Citation: Cancer Cell International 2013 13:86

    Content type: Review

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  15. Glioblastoma stem-like cells (GSC) have been shown to promote tumor growth, tumor-associated neovascularization, therapeutic resistance, and metastasis. CXCR4 receptors have been found involved in the prolifer...

    Authors: Chin-Cheng Lee, Jin-Huei Lai, Dueng-Yang Hueng, Hsin-I Ma, Yuan- Chiang Chung, Ya-yun Sun, Yih-Ju Tsai, Wen-Ben Wu and Chih-Li Chen

    Citation: Cancer Cell International 2013 13:85

    Content type: Primary research

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  16. The prognosis of oral squamous cell carcinoma is very poor due to local recurrence and metastasis. This study explores the molecular events involved in oral carcinoma with the goal of developing novel therapeu...

    Authors: Bin Zhang, Ke Yi Li, Hai Ying Chen, Shao Dong Pan, Li Cheng Jiang, Ya Ping Wu and Shu Wei Liu

    Citation: Cancer Cell International 2013 13:83

    Content type: Primary research

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  17. It has been shown that proteasome inhibition leads to growth arrest in the G1 phase of the cell cycle and/or induction of apoptosis. However, it was found that some of these inhibitors do not induce apoptosis ...

    Authors: Khaled Y Orabi, Mohamed S Abaza, Khalid A El Sayed, Ahmed Y Elnagar, Rajaa Al-Attiyah and Radhika P Guleri

    Citation: Cancer Cell International 2013 13:82

    Content type: Primary research

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  18. B7-H3 and matrix metalloproteinases 2 (MMP-2) are reported highly expressed in malignant tumor, we investigate the relationship between B7-H3 expression and MMP-2 on malignant behavior and prognosis predictabl...

    Authors: Lihua Xu, Xiangmin Ding, Huo Tan and Jianjun Qian

    Citation: Cancer Cell International 2013 13:81

    Content type: Primary research

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  19. Citation: Cancer Cell International 2013 13:80

    Content type: Erratum

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    The original article was published in Cancer Cell International 2012 12:2

  20. The human “Elston and Ellis grading method” was utilized in dogs with mammary tumor to examine its relation to prognosis in this species, based on a 2-year follow-up period. Although cytopathology is widely us...

    Authors: Radmehr Shafiee, Javad Javanbakht, Nahid Atyabi, Pegah Kheradmand, Danial Kheradmand, Alimohammad Bahrami, Hasti Daraei and Farshid Khadivar

    Citation: Cancer Cell International 2013 13:469

    Content type: Primary research

    Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2016 16:83

  21. Recent evidence suggests a subset of cells within a tumor with "stem-like" characteristics. These cells are able to transplant tumors in immunodeficient hosts. Distinct from non-malignant stem cells, cancer st...

    Authors: Rüdiger M Zimmerer, Philippe Korn, Philippe Demougin, Andreas Kampmann, Horst Kokemüller, André M Eckardt, Nils-Claudius Gellrich and Frank Tavassol

    Citation: Cancer Cell International 2013 13:78

    Content type: Primary research

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  22. Taxol is a powerful chemotherapy agent leading to mitotic arrest and cell death; however, its clinical efficacy has been hampered due to the development of drug resistance. Taxol specifically targets the cell ...

    Authors: Xueqing Wang, Lingya Pan, Ning Mao, Lifang Sun, Xiangjuan Qin and Jie Yin

    Citation: Cancer Cell International 2013 13:77

    Content type: Primary research

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  23. Epithelial-mesenchymal transition (EMT) is a process implicated in cancer metastasis that involves the conversion of epithelial cells to a more mesenchymal and invasive cell phenotype. In breast cancer cells E...

    Authors: Felicity M Davis, Michelle T Parsonage, Peter J Cabot, Marie-Odile Parat, Erik W Thompson, Sarah J Roberts-Thomson and Gregory R Monteith

    Citation: Cancer Cell International 2013 13:76

    Content type: Primary research

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  24. One of the most popular and versatile model of murine melanoma is by inoculating B16 cells in the syngeneic C57BL6J mouse strain. A characterization of different B16 modified cell sub-lines will be of real pra...

    Authors: Corina Danciu, Alexandra Falamas, Cristina Dehelean, Codruta Soica, Heinfried Radeke, Lucian Barbu-Tudoran, Florina Bojin, Simona Cîntă Pînzaru and Melania F Munteanu

    Citation: Cancer Cell International 2013 13:75

    Content type: Primary research

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  25. Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland during involution and by radiation. While TGFβ normally has a tumour suppressor role, prolonged exposure to TGFβ can induce ...

    Authors: Karen A Dunphy, Jae-Hong Seo, Daniel J Kim, Amy L Roberts, Luwei Tao, James DiRenzo, Amanda L Balboni, Giovanna M Crisi, Mary J Hagen, Thiruppavai Chandrasekaran, Kelly J Gauger, Sallie Smith Schneider and D Joseph Jerry

    Citation: Cancer Cell International 2013 13:74

    Content type: Primary research

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  26. Volatile organic compounds (VOCs) emitted by human body offer a unique insight into biochemical processes ongoing in healthy and diseased human organisms. Unfortunately, in many cases their origin and metaboli...

    Authors: Paweł Mochalski, Andreas Sponring, Julian King, Karl Unterkofler, Jakob Troppmair and Anton Amann

    Citation: Cancer Cell International 2013 13:72

    Content type: Primary research

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  27. Emodin is a natural anthraquinone derivative isolated from the Rheum palmatum L. Aim: The aim of the present study was to investigate the effect of emodin on the apoptosis of the human cervical cancer line HeL...

    Authors: Wang Yaoxian, Yu Hui, Zhang Yunyan, Liu Yanqin, Ge Xin and Wu Xiaoke

    Citation: Cancer Cell International 2013 13:71

    Content type: Primary research

    Published on:

  28. The breast and ovarian cancer susceptibility gene (BRCA1) encodes a tumor suppressor. The BRCA1 protein is found primarily in cell nuclei and plays an important role in the DNA damage response and transcriptional...

    Authors: Natalie Tulchin, Leonard Ornstein, Steven Dikman, James Strauchen, Shabnam Jaffer, Chandandeep Nagi, Ira Bleiweiss, Ruth Kornreich, Lisa Edelmann, Karen Brown, Carol Bodian, Venugopalan D Nair, Monique Chambon, Nicholas T Woods and Alvaro NA Monteiro

    Citation: Cancer Cell International 2013 13:70

    Content type: Primary research

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  29. Angiogenesis has been an attractive target for drug therapy. Aloin (AL), an natural compound derived from Aloe barbadensis Miller leaves, has been shown to possess anti-cancer potential activities. However, its r...

    Authors: Qin Pan, Hongming Pan, Haizhou Lou, Yinghua Xu and Lu Tian

    Citation: Cancer Cell International 2013 13:69

    Content type: Primary research

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  30. MicroRNAs are a class of small non-coding RNAs that play an important role in various human tumor initiation and progression by regulating gene expression negatively. The aim of this study was to investigate t...

    Authors: Ting-Song Yang, Xiao-Hu Yang, Xu-Dong Wang, Yi-Ling Wang, Bo Zhou and Zhen-Shun Song

    Citation: Cancer Cell International 2013 13:68

    Content type: Primary research

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  31. In order to search for new structural modification strategies on fluoroquinolones, we have designed and synthesized a series of fluoroquinolone derivatives by linking various hydrazine compounds to the C-3 car...

    Authors: Jin-ping Sun, Zhen-yu Shi, Shi-meng Liu, Yu-hua Kang, Guo-qiang Hu, Chao-shen Huangfu, Jin-bo Deng and Bin Liu

    Citation: Cancer Cell International 2013 13:67

    Content type: Primary research

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  32. Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast propo...

    Authors: Arnaud Guille, Max Chaffanet and Daniel Birnbaum

    Citation: Cancer Cell International 2013 13:66

    Content type: Hypothesis

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  33. Folate-nanoliposomes delivery system has emerged recently as a specific and safety delivery method and gradually used as the carrier of a variety kinds of drugs including compounds, plasmids and siRNAs.

    Authors: Qiqi Zhu, Chen Feng, Weiwei Liao, Yan Zhang and Suoqin Tang

    Citation: Cancer Cell International 2013 13:65

    Content type: Primary research

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  34. Gallbladder carcinoma is a malignant tumor with a very low 5-year survival rate because of the difficulty with its early diagnosis and the very poor prognosis of the advanced cancer state. The aims of this stu...

    Authors: Tian-Yu Liu, Zhu-Jun Tan, Lin Jiang, Jian-Feng Gu, Xiang-Song Wu, Yang Cao, Mao-Lan Li, Ke-Jin Wu and Ying-Bin Liu

    Citation: Cancer Cell International 2013 13:64

    Content type: Primary research

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  35. Apoptosis is a major target and treatment effect of multiple chemotherapeutical agents in cancer. A soybean isoflavone, genistein, is a well-studied chemopreventive agent and has been reported to potentiate th...

    Authors: Xin Xie, Shan Shan Wang, Timothy Chung Sing Wong and Ming Chiu Fung

    Citation: Cancer Cell International 2013 13:63

    Content type: Primary research

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  36. Identification of cancer stem cells (CSCs) and their behaviors will provide insightful information for the future control of human cancers. This study investigated CD44 and CD24 cell surface markers as breast ...

    Authors: Wenxing Yan, Yubing Chen, Yueliang Yao, Hongmei Zhang and Tiejun Wang

    Citation: Cancer Cell International 2013 13:62

    Content type: Primary research

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  37. The specific mechanism underlying the contribution of the Aldehyde dehydrogenase 1 (ALDH1) phenotype to metastatic behavior and early tumor relapse in breast cancer is currently unclear.

    Authors: Ying Zhong, Yan Lin, Songjie Shen, Yidong Zhou, Feng Mao, Jinghong Guan and Qiang Sun

    Citation: Cancer Cell International 2013 13:60

    Content type: Primary research

    Published on:

  38. The aim of this study was to clarify the clinicopathological outcome of serum relaxin-2 and tissues relaxin-2 expression levels in human primary osteosarcoma (OS), and to explore the roles of relaxin-2 inhibit...

    Authors: Jinfeng Ma, Min Niu, Wenjiu Yang, Lina Zang and Yongming Xi

    Citation: Cancer Cell International 2013 13:59

    Content type: Primary research

    Published on:

  39. R-CHOP has significantly improved survival rates of patients with diffuse large B cell lymphoma (DLBCL) by ~20% as compared to CHOP. CD20 antigen, highly expressed on more than 80% of B-cell lymphomas, is the ...

    Authors: Huirong Ding, Xuan Jin, Ning Ding, Zhiying Fu, Yuqin Song and Jun Zhu

    Citation: Cancer Cell International 2013 13:58

    Content type: Primary research

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  40. Epigenetic control using histone deacetylase (HDAC) inhibitors is a promising therapy for lymphomas. Insights into the anti-proliferative effects of HDAC inhibitors on diffuse large B-cell lymphoma (DLBCL) and...

    Authors: Ying Cai, Wenli Cui, Weixiang Chen, Ping Wei, Yayun Chi, Ping Zhang, Rui Bi and Xiaoyan Zhou

    Citation: Cancer Cell International 2013 13:57

    Content type: Primary research

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  41. Nowadays it remains a controversial issue whether a correlation exists between the apoptosis rate of tumor tissue and the prognosis of the patients. We aimed to explore the prognostic significance of apoptosis...

    Authors: Xing Wu, Biao Cheng, Zheng-dong Cai and Lie-ming Lou

    Citation: Cancer Cell International 2013 13:56

    Content type: Primary research

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  42. For their various bioactivities, biomaterials derived from marine algae are important ingredients in many products, such as cosmetics and drugs for treating cancer and other diseases. This mini-review comprehe...

    Authors: Jin-Ching Lee, Ming-Feng Hou, Hurng-Wern Huang, Fang-Rong Chang, Chi-Chen Yeh, Jen-Yang Tang and Hsueh-Wei Chang

    Citation: Cancer Cell International 2013 13:55

    Content type: Review

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  43. Apigenin (4’,5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell li...

    Authors: Yi Zhu, Yeqing Mao, Hong Chen, Yiwei Lin, Zhenghui Hu, Jian Wu, Xin Xu, Xianglai Xu, Jie Qin and Liping Xie

    Citation: Cancer Cell International 2013 13:54

    Content type: Primary research

    Published on:

  44. The pro-apoptotic Bcl-2 protein BAD initiated apoptosis in human cells and has been identified as a prognostic marker in non-small cell lung cancer (NSCLC). In this study, we aimed to explore the functions of ...

    Authors: Li Jiang, Man Luo, Dan Liu, Bojiang Chen, Wen Zhang, Lin Mai, Jing Zeng, Na Huang, Yi Huang, Xianming Mo and Weimin Li

    Citation: Cancer Cell International 2013 13:53

    Content type: Primary research

    Published on:

  45. Doxorubicin (DOX), an anthracycline antibiotic is one of the most effective anticancer drug used in the treatment of variety of cancers .Its use is limited by its cardiotoxicity. The present study was designed...

    Authors: Abdel-Moneim M Osman, Sameer E Al-Harthi, Ohoud M AlArabi, Mohamed F Elshal, Wafaa S Ramadan, Mohamed N Alaama, Huda M Al-Kreathy, Zoheir A Damanhouri and Osman H Osman

    Citation: Cancer Cell International 2013 13:52

    Content type: Primary research

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  46. MicroRNAs (miRNAs) are a large group of negative gene regulators that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-145 acts a tumor suppressor in numerous human can...

    Authors: Yuan Shao, Yiping Qu, Siwen Dang, Bowen Yao and Meiju Ji

    Citation: Cancer Cell International 2013 13:51

    Content type: Primary research

    Published on:

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