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  1. The most common genetic changes identified in human NSCLC are Kras mutations (10–30 %) and p53 mutation or loss (50–70 %). Moreover, NSCLC with mutations in Kras and p53 poorly respond to current therapies, so...

    Authors: Huanan Wang, Lei Wang, Yingjie Zhang, Ji Wang, Yibin Deng and Degui Lin

    Citation: Cancer Cell International 2016 16:9

    Content type: Primary research

    Published on:

    The Erratum to this article has been published in Cancer Cell International 2016 16:38

  2. Through research carried out in the last 25 years about the breast cancer etiology, it has been possible to estimate that less than 10 % of patients who are diagnosed with the condition are carriers of some ge...

    Authors: Marco Allán Pérez-Solis, Guadalupe Maya-Nuñez, Patricia Casas-González, Aleida Olivares and Arturo Aguilar-Rojas

    Citation: Cancer Cell International 2016 16:7

    Content type: Review

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  3. This last decade, a lot of emphasis has been placed on developing new cancer cell culture models, closer to in vivo condition, in order to test new drugs and therapies. In the case of colorectal cancer, the us...

    Authors: Sébastien Relier, Laura Yazdani, Oualid Ayad, Armelle Choquet, Jean-François Bourgaux, Michel Prudhomme, Julie Pannequin, Françoise Macari and Alexandre David

    Citation: Cancer Cell International 2016 16:6

    Content type: Primary research

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  4. Despite the fact that melatonin treatment shows some promise in gastric cancer, the molecular mechanisms of gastric cancer cells in response to melatonin remains to be determined.

    Authors: Wenjie Deng, Yujie Zhang, Luo Gu, Jie Cui, Biao Duan, Yueyuan Wang and Jun Du

    Citation: Cancer Cell International 2016 16:5

    Content type: Primary research

    Published on:

  5. Alterations in cellular metabolism are considered as hallmarks of cancers, however, to recognize these alterations and understand their mechanisms appropriate techniques are required. Our hypothesis was to det...

    Authors: A. Jeney, Z. Hujber, N. Szoboszlai, A. Fullár, J. Oláh, É. Pap, Á. Márk, Cs. Kriston, J. Kralovánszky, I. Kovalszky, K. Vékey and A. Sebestyén

    Citation: Cancer Cell International 2016 16:4

    Content type: Primary research

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  6. Breast cancer is the most prevalent malignancies among the women that have a high mortality. Previous studies demonstrated that hypericin, a bioactive component of Hypericum perforatum have a cytotoxic effect on ...

    Authors: Seyed Abbas Mirmalek, Mohammad Amin Azizi, Ehsan Jangholi, Soheila Yadollah-Damavandi, Mohammad Amin Javidi, Yekta Parsa, Tina Parsa, Seyed Alireza Salimi-Tabatabaee, Hossein Ghasemzadeh kolagar and Reza Alizadeh-Navaei

    Citation: Cancer Cell International 2016 16:3

    Content type: Primary Research

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  7. Mutation rates are consistently varied in cancer genome and play an important role in tumorigenesis, however, little has been known about their function potential and impact on the distribution of functional m...

    Authors: Chuance Du, Xiaoyuan Wu and Jia Li

    Citation: Cancer Cell International 2016 16:2

    Content type: Primary Research

    Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2017 17:67

  8. Development of alternative cancer-specific drugs would be of paramount importance to overcome toxicity toward normal tissues and tumor resistance. Here, we investigated the potential anti-tumoral effect of pee...

    Authors: Ichrak Riahi-Chebbi, Meriam Haoues, Makram Essafi, Ons Zakraoui, Sami Fattouch, Habib Karoui and Khadija Essafi-Benkhadir

    Citation: Cancer Cell International 2016 16:1

    Content type: Primary research

    Published on:

  9. The resulting clinical impact of the combined use of G-CSF with chemotherapy as a chemosensitizing strategy for treatment of acute myeloid leukemia (AML) patients is still controversial. In this study, the eff...

    Authors: Meritxell Nomdedeu, María Carmen Lara-Castillo, Amaia Etxabe, Josep María Cornet-Masana, Marta Pratcorona, Marina Díaz-Beyá, Xavier Calvo, María Rozman, Dolors Costa, Jordi Esteve and Ruth M. Risueño

    Citation: Cancer Cell International 2015 15:122

    Content type: Primary research

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  10. Cisplatin causes male infertility but the exact mechanism have not been clarified, yet. MOTILIPERM has been implicated in alleviation of infertility in Sprague–Dawley rats caused by cisplatin. We evaluated re...

    Authors: Kiran Kumar Soni, Li Tao Zhang, Jae Hyung You, Sung Won Lee, Chul Young Kim, Wan Shou Cui, Han Jung Chae, Hye Kyung Kim and Jong Kwan Park

    Citation: Cancer Cell International 2015 15:121

    Content type: Primary research

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  11. DIXDC1 (Dishevelled-Axin domain containing 1) is a positive regulator of the Wnt pathway. In the field of cancer research, the role of DIXDC1 is unclear. Our previous in vitro study showed that DIXDC1 enhances...

    Authors: Lei Wang, Cong Tan, Fan Qiao, Weige Wang, Xiangnan Jiang, Peng Lian, Bin Chang and Weiqi Sheng

    Citation: Cancer Cell International 2015 15:120

    Content type: Primary research

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  12. Alizarin and purpurin are di- and trihydroxyanthraquinones derived from Rubia tinctorum L. Previous pharmacological studies have demonstrated that they exhibit certain degree of selective inhibitory effects towar...

    Authors: Eszter Lajkó, Péter Bányai, Zsófia Zámbó, László Kursinszki, Éva Szőke and László Kőhidai

    Citation: Cancer Cell International 2015 15:119

    Content type: Primary research

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  13. In this study, we aim to evaluate the balance of interleukin (IL)-33 and its soluble receptor sST2 in patients with aplastic anemia (AA).

    Authors: Ming Sun, Hai-feng Ma, Ye-yun Che and Xin Cui

    Citation: Cancer Cell International 2015 15:118

    Content type: Primary research

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  14. Advances in surgical and medical treatments for ovarian cancer have improved prognoses. Platinum drugs in particular are pivotal for the medical treatment of ovarian cancer. However, previous studies have reve...

    Authors: Shinya Matsuzaki, Kiyoshi Yoshino, Yutaka Ueda, Satoko Matsuzaki, Mamoru Kakuda, Akiko Okazawa, Tomomi Egawa-Takata, Eiji Kobayashi and Tadashi Kimura

    Citation: Cancer Cell International 2015 15:117

    Content type: Review

    Published on:

  15. Multidrug resistance is one of the major reasons chemotherapy-based treatments failed in hepatitis B virus (HBV) related hepatocellular carcinoma (HCC). Hypoxia is generally associated with tumor chemo-resista...

    Authors: Guifang Yu, Xuezhu Chen, Shudi Chen, Weipeng Ye, Kailian Hou and Min Liang

    Citation: Cancer Cell International 2015 15:116

    Content type: Primary research

    Published on:

  16. The incidence of gastric cancer is high in Chinese Tibetan. This study aimed to identify the differentially expressed microRNAs (miRNAs) and further explore their potential roles in Tibetan with gastric cancer...

    Authors: Yushuang Luo, Chengwu Zhang, Feng Tang, Junhui Zhao, Cunfang Shen, Cheng Wang, Pengjie Yu, Miaozhou Wang, Yan Li, J. I. Di, Rong Chen and Ge Rili

    Citation: Cancer Cell International 2015 15:115

    Content type: Primary research

    Published on:

  17. Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme

    Authors: Xiao-Ni Liu, Shuang Wang, Qing Yang, Ya-Jie Wang, De-Xi Chen and Xiao-Xin Zhu

    Citation: Cancer Cell International 2015 15:114

    Content type: Primary research

    Published on:

  18. Thyroid-derived cell models are commonly used to investigate the characteristics of thyroid cancers. It is noteworthy that each in vitro single cell model system imitates only a few characteristics of thyroid ...

    Authors: Francesca Cammarota, Francesco Fiscardi, Tiziana Esposito, Gabriella de Vita, Marco Salvatore and Mikko O. Laukkanen

    Citation: Cancer Cell International 2015 15:113

    Content type: Primary research

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  19. The factors driving the onset and progression of ovarian cancer are not well understood. Recent reports have identified cell lines that are representative of the genomic pattern of high-grade serous ovarian ca...

    Authors: Danielle L. Bourgeois, Karl A. Kabarowski, Veronica L. Porubsky and Pamela K. Kreeger

    Citation: Cancer Cell International 2015 15:112

    Content type: Primary research

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  20. Aberrant STAT1 signaling is observed in human hepatocellular carcinoma (HCC) and has been associated with the modulation of cell proliferation and survival. However, the role of STAT1 signaling in HCC and its...

    Authors: Jiayu Chen, Haihe Wang, Jing Wang, Shishun Huang and Wei Zhang

    Citation: Cancer Cell International 2015 15:111

    Content type: Primary research

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  21. The estrogen receptor-positive M13SV1 breast epithelial cell line was proposed to be a suitable in vitro model for breast cancer research since two derivatives with graduated tumorigenicity—M13SV1-R2-2 and M13...

    Authors: Sandra Stempin, Anika Engel, Nora Winkler, Thorsten Buhrke and Alfonso Lampen

    Citation: Cancer Cell International 2015 15:110

    Content type: Primary research

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  22. Chemoresistance is a major obstacle to successful chemotherapy for colorectal cancer. Eukaryotic translation initiation factor 5A2 (eIF5A2), one of the two isoforms in the eIF5A family, has been reported to be...

    Authors: Ying Bao, Yongliang Lu, Xiang Wang, Wenming Feng, Xinrong Sun, Huihui Guo, Chengwu Tang, Xiaojing Zhang, Qilin Shi and Hongbin Yu

    Citation: Cancer Cell International 2015 15:109

    Content type: Primary research

    Published on:

  23. Genome-wide miRNA expression profile has identified microRNA (miR)-96 as one of upregulated miRNAs in clinical bladder cancer (BC) tissues compared to normal bladder tissues. The aim of this study was to confi...

    Authors: Ziyu Wu, Kun Liu, Yunyan Wang, Zongyuan Xu, Junsong Meng and Shuo Gu

    Citation: Cancer Cell International 2015 15:107

    Content type: Primary research

    Published on:

  24. Over expression of Bcl-2 is frequently observed in several types of cancers and it is one of the prognostic markers in breast cancer. The importance of the Bcl-2 protein as ideal therapeutic target is the dual...

    Authors: Abdolhassan Talaiezadeh, Fateme jalali, Hamid Galehdari and Ali Khodadadi

    Citation: Cancer Cell International 2015 15:105

    Content type: Primary research

    Published on:

  25. Cisplatin (CIS) is a potent antineoplastic agent with high therapeutic efficacy against many kinds of tumors. Its use is limited by its nephrotoxicity. The aim of this work was to minimize cisplatin effective ...

    Authors: Abdel-Moneim M. Osman, Ali A. Alqahtani, Zoheir A. Damanhouri, Sameer E. Al-Harthy, Mohamed F. ElShal, Wafaa S. Ramadan, Fatemah Kamel, Mohamed A. M. Osman and Lateef M. Khan

    Citation: Cancer Cell International 2015 15:104

    Content type: Primary research

    Published on:

  26. The incidence of tumors with life-threatening effects has increased gradually over time; however, the mechanisms involved in tumor development have not been fully elucidated. Recent studies have shown that mic...

    Authors: Juanjuan Zhao, Yijing Tao, Ya Zhou, Nalin Qin, Chao Chen, Dan Tian and Lin Xu

    Citation: Cancer Cell International 2015 15:103

    Content type: Review

    Published on:

  27. The central nervous system (CNS) is protected by several barriers, including the blood–brain (BBB) and blood-cerebrospinal fluid (BCSFB) barriers. Understanding how cancer cells circumvent these protective bar...

    Authors: Elodie Vandenhaute, Carolin Stump-Guthier, María Lasierra Losada, Tobias Tenenbaum, Henriette Rudolph, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Matthias Dürken, Martin März and Michael Karremann

    Citation: Cancer Cell International 2015 15:102

    Content type: Primary research

    Published on:

  28. Celastrol has anti-cancer effects by increase of apoptosis of gastric cancer cells. However, its role in gastric cancer cell cycle is still unclear. The aim of this study was to investigate the effect and mec...

    Authors: Min Sha, Jun Ye, Zheng-yun Luan, Ting Guo, Bian Wang and Jun-xing Huang

    Citation: Cancer Cell International 2015 15:101

    Content type: Primary research

    Published on:

  29. Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. It has been well established to possess a variety of biological activities such as anticancer, antimicro...

    Authors: Seok Fang Oon, Meenakshii Nallappan, Thiam Tsui Tee, Shamarina Shohaimi, Nur Kartinee Kassim, Mohd Shazrul Fazry Sa’ariwijaya and Yew Hoong Cheah

    Citation: Cancer Cell International 2015 15:100

    Content type: Review

    Published on:

  30. LIN28B is a conserved RNA-binding protein critically involved in development, cellular metabolism and tumorigenesis. It is frequently overexpressed in human cancers and correlates with tumor aggressiveness as ...

    Authors: Dongmiao Wang, Yuming Zhu, Yanling Wang, Zhongwu Li, Chunping Yuan, Wei Zhang, Hua Yuan, Jinhai Ye, Jianrong Yang, Hongbing Jiang and Jie Cheng

    Citation: Cancer Cell International 2015 15:99

    Content type: Primary research

    Published on:

  31. Changes in DNA methylation are associated with changes in somatic cell fate without the alteration of coding sequences. In addition to its use as a traceable biomarker, reversible DNA methylation could also se...

    Authors: Chih-Cheng Chen, Kuan-Der Lee, Mei-Yu Pai, Pei-Yi Chu, Chia-Chen Hsu, Chia-Chen Chiu, Li-Tzong Chen, Jang-Yang Chang, Shu-Huei Hsiao and Yu-Wei Leu

    Citation: Cancer Cell International 2015 15:98

    Content type: Primary research

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  32. The indirubin derivative 7-bromoindirubin-3′-oxime (7BIO) has already shown anticancer properties by causing cell death in some tumour cell lines and may be a new therapeutic option for treatment-resistant tum...

    Authors: Martina Broecker-Preuss, Nina Becher-Boveleth, Susanne Gall, Katrin Rehmann, Susann Schenke and Klaus Mann

    Citation: Cancer Cell International 2015 15:97

    Content type: Primary research

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  33. Colorectal cancer is one of the commonest cancers in the world and it is also a common cause of cancer-related death worldwide. Despite advanced treatment strategies, the disease is rarely cured completely due...

    Authors: Thamil Selvee Ramasamy, Ain Zubaidah Ayob, Hsu Hsu Lynn Myint, Sharmanee Thiagarajah and Farahnaz Amini

    Citation: Cancer Cell International 2015 15:96

    Content type: Review

    Published on:

  34. Cancer stem cells (CSCs) constitute 1–2 % of cancer tissue and are a major cause of tumor metastasis and recurrence. The culture environment is important in maintaining CSCs in vitro. Sphere formation is one m...

    Authors: Seon Ok Min, Sang Woo Lee, Seon Young Bak and Kyung Sik Kim

    Citation: Cancer Cell International 2015 15:95

    Content type: Primary research

    Published on:

  35. The article to which this update relates has been retracted. Please see the retraction notice for more detail: http://dx.doi.org/10.1186/s12935-015-0226-9

    Authors: Kaushik Kumar Dey, Siddik Sarkar, Ipsita Pal, Subhasis Das, Goutam Dey, Rashmi Bharti, Payel Banik, Jay Gopal Ray, Sukumar Maity, Indranil kulavi and Mahitosh Mandal

    Citation: Cancer Cell International 2015 15:94

    Content type: Erratum

    Published on:

    The original article was published in Cancer Cell International 2015 15:74

  36. Previous study showed that downregulated BCL11B expression in T cell acute lymphoblastic leukemia (T-ALL) cell line Molt-4 inhibited cell proliferation and induce apoptosis, which may be related to PHTF1 gene ove...

    Authors: Xin Huang, Suxia Geng, Jianyu Weng, Zesheng Lu, Lingji Zeng, Minming Li, Chengxin Deng, Xiuli Wu, Yangqiu Li and Xin Du

    Citation: Cancer Cell International 2015 15:93

    Content type: Primary research

    Published on:

  37. AKT plays a pivotal role in the signal transduction of cancer cells. MK2206, an AKT inhibitor, has been shown to be an effective anti-cancer drug to a variety of cancer cell lines. However, some cancer cells a...

    Authors: Lei Qi, Hidemi Toyoda, Dong-qing Xu, Ye Zhou, Naoto Sakurai, Keishirou Amano, Kentaro Kihira, Hiroki Hori, Eiichi Azuma and Yoshihiro Komada

    Citation: Cancer Cell International 2015 15:91

    Content type: Primary research

    Published on:

    The Erratum to this article has been published in Cancer Cell International 2015 15:108

  38. Conjugated linolenic acids (CLN) refer to the positional and geometric isomers of octadecatrienoic acids with three conjugated double bonds (C18:3). Previous researches have demonstrated that CLN can inhibit t...

    Authors: Wai Nam Liu and Kwok Nam Leung

    Citation: Cancer Cell International 2015 15:90

    Content type: Primary research

    Published on:

  39. Cyclin D3, which induces progression through the G1 phase of the cell cycle, is a regulator of Cyclin-dependent kinases 4 and 6. Previous studies revealed that abnormal expression of Cyclin D3 was found in man...

    Authors: Yayun Chi, Sheng Huang, Mengying Liu, Liang Guo, Xuxia Shen and Jiong Wu

    Citation: Cancer Cell International 2015 15:89

    Content type: Primary research

    Published on:

  40. We studied a primary culture developed from a biopsy of a clear cell carcinoma of the ovary (O-CCC) by (a) assessing its capacity to retain in vitro pathological features of the tumor of origin; (b) characteri...

    Authors: Alicia A. Goyeneche, Michael Koch, Maria C. Bell and Carlos M. Telleria

    Citation: Cancer Cell International 2015 15:88

    Content type: Primary research

    Published on:

  41. Dysregulated miRNAs play an important role in many malignant tumors. However, elucidating the roles of miRNAs in cancer biology, especially in epithelial cancers, remains an ongoing process. In this study, we ...

    Authors: Qiang Sun, Shuai Chen, Xue Zhao, Ming Yan, Zheng Fang, Haibin Wang, Junfang Zhao, Minglei Sun, Xinguang Han, Wantao Chen and Xinming Li

    Citation: Cancer Cell International 2015 15:87

    Content type: Primary research

    Published on:

  42. MicroRNAs (miRNAs) play key roles in cancer development and progression. The purpose of the present study was to determine the expression levels of miR-133a and miR-539 in osteosarcoma patients and to further ...

    Authors: Alireza Mirghasemi, Afshin Taheriazam, Seyyed Hasan Karbasy, Ali Torkaman, Mohammadreza Shakeri, Emad Yahaghi and Aram Mokarizadeh

    Citation: Cancer Cell International 2015 15:86

    Content type: Primary research

    Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2016 16:84

  43. Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15–20 %, with a m...

    Authors: Shanshan Chen, Ping Li, Rui Yang, Ruirui Cheng, Furui Zhang, Yuanyuan Wang, Xiaonan Chen, Qianqian Sun, Wenqiao Zang, Yuwen Du, Guoqiang Zhao and Guojun Zhang

    Citation: Cancer Cell International 2015 15:85

    Content type: Primary research

    Published on:

  44. Lung cancer, predominantly non-small-cell lung cancer (NSCLC), is the leading cause of cancer deaths worldwide. There is a great need to identify critical effectors involved in metastasis of NSCLC that will fa...

    Authors: Qinchuan Li, Yang Han, Chunhong Wang, Shan Shan, Yuanyuan Wang, Jingang Zhang and Tao Ren

    Citation: Cancer Cell International 2015 15:84

    Content type: Primary research

    Published on:

  45. Prolactin (PRL) has been implicated in the development of different types of cancer. However, signaling pathways might be activated depending on various forms of prolactin receptor (PRLR). JAK/STAT is an impor...

    Authors: Adrián Ramírez de Arellano, Edgar I. Lopez-Pulido, Priscila A. Martínez-Neri, Ciro Estrada Chávez, Renee González Lucano, Mary Fafutis-Morris, A. Aguilar-Lemarroy, José. F. Muñoz-Valle and Ana Laura Pereira-Suárez

    Citation: Cancer Cell International 2015 15:83

    Content type: Primary research

    Published on:

  46. The purpose of this study was to assess the antitumoral effect of the methanol extract (MeOH) from Nitraria retusa leaves and to investigate its immunomodulatory activity that mediated the prevention of tumor pro...

    Authors: Jihed Boubaker, Fadwa Chaabane, Ahmed Bedoui, Rihab Aloui, Besma Ben Ahmed, Kamel Ghedira and Leila Chekir-Ghedira

    Citation: Cancer Cell International 2015 15:82

    Content type: Primary research

    Published on:

  47. Rhodiola algida var. tangutica is a traditional Tibetan herb. Its root and rhizome have been successfully used as an effective clinical remedy for the prevention and treatment of cance...

    Authors: Yu-juan Qi, Sen Cui, Dian-xiang Lu, Ying-zhong Yang, Yushuang Luo, Lan Ma, Yan Ma, Tana Wuren, Rong Chang, Lei Qi, Ba-ji Ben, Jun Han and Ri-Li Ge

    Citation: Cancer Cell International 2015 15:81

    Content type: Primary research

    Published on:

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