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  1. Cellular FLICE-Inhibitory Protein (long form, c-FLIPL) is a critical negative regulator of death receptor-mediated apoptosis. Overexpression of c-FLIPL has been reported in many cancer cell lines and is associate...

    Authors: Qilin Wang, Wendong Sun, Xuexi Hao, Tianliang Li, Ling Su and Xiangguo Liu

    Citation: Cancer Cell International 2012 12:54

    Content type: Primary research

    Published on:

  2. Cyclooxygenase-2(COX-2) promotes carcinogenesis, tumor proliferation, angiogenesis, prevention of apoptosis, and immunosuppression. Meanwhile, COX-2 over-expression has been associated with tumor behavior and ...

    Authors: Zhi-Jun Dai, Xiao-Bin Ma, Hua-Feng Kang, Jie Gao, Wei-Li Min, Hai-Tao Guan, Yan Diao, Wang-Feng Lu and Xi-Jing Wang

    Citation: Cancer Cell International 2012 12:53

    Content type: Primary research

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  3. In malignant melanoma, it has been published that up to 40% of cancer patients will suffer from brain metastasis. The prognosis for these patients is poor, with a life expectancy of 4 to 6 months. Calcium exch...

    Authors: Abraham Embi, Benjamin J Scherlag, Peter J Embi, Manuel Menes and Sunny S Po

    Citation: Cancer Cell International 2012 12:51

    Content type: Hypothesis

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  4. There is an overwhelmingly increasing trend of analysis of naturally occurring ingredients in treatment of prostate cancer. Substantial fraction of information has been added that highlights activity at variou...

    Authors: Ammad Ahmad Farooqi, Ghazala Butt and Zubia Razzaq

    Citation: Cancer Cell International 2012 12:50

    Content type: Review

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  5. Lycorine, a natural alkaloid extracted from Amaryllidaceae, has shown various pharmacological effects. Recent studies have focused on the potential antitumor activity of lycorine. In our previous study, we found ...

    Authors: Lv Li, Hong-Juan Dai, Mao Ye, Shu-Ling Wang, Xiao-Juan Xiao, Jie Zheng, Hui-Yong Chen, Yu-hao Luo and Jing Liu

    Citation: Cancer Cell International 2012 12:49

    Content type: Primary research

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  6. Zoledronic acid is used to treat bone metastases and has been shown to reduce skeletal-related events and exert antitumor activity. The present in vitro study investigates the mechanism of action of Zoledronic Ac...

    Authors: Toni Ibrahim, Laura Mercatali, Emanuele Sacanna, Anna Tesei, Silvia Carloni, Paola Ulivi, Chiara Liverani, Francesco Fabbri, Michele Zanoni, Wainer Zoli and Dino Amadori

    Citation: Cancer Cell International 2012 12:48

    Content type: Primary research

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  7. Breast cancer is the most common cancer in the Arab world and it ranked first among Saudi females. Doxorubicin (DOX), an anthracycline antibiotic is one of the most effective anticancer agents used to treat br...

    Authors: Abdel-Moneim M Osman, Hadeel M Bayoumi, Sameer E Al-Harthi, Zoheir A Damanhouri and Mohamed F ElShal

    Citation: Cancer Cell International 2012 12:47

    Content type: Primary research

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  8. Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cance...

    Authors: Henry I C Lowe, Charah T Watson, Simone Badal, Ngeh J Toyang and Joseph Bryant

    Citation: Cancer Cell International 2012 12:46

    Content type: Primary research

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  9. Inhibition of kinases involved in the DNA damage response sensitizes cells to genotoxic agents by abrogating checkpoint-induced cell cycle arrest. CHK1 and WEE1 act in a pathway upstream of CDK1 to inhibit cel...

    Authors: Amy D Guertin, Melissa M Martin, Brian Roberts, Melissa Hurd, Xianlu Qu, Nathan R Miselis, Yaping Liu, Jing Li, Igor Feldman, Yair Benita, Andrew Bloecher, Carlo Toniatti and Stuart D Shumway

    Citation: Cancer Cell International 2012 12:45

    Content type: Primary research

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  10. Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently,...

    Authors: Fan Zhang, Lijiang Yang and Yangqiu Li

    Citation: Cancer Cell International 2012 12:44

    Content type: Review

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  11. Breast cancer is one of the most common cancers among women throughout the world. Therefore, established cell lines are widely used as in vitro experimental models in cancer research.

    Authors: Behnam Kamalidehghan, Massoud Houshmand, Fereydoun Kamalidehghan, Narges Jafarzadeh, Shahram Azari, Sharifah Noor Akmal and Rozita Rosli

    Citation: Cancer Cell International 2012 12:43

    Content type: Primary research

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  12. In order to characterize the expression pattern of SALL4, BMI-1 and ABCA3 genes in patients with myeloid leukemia and those who achieved complete remission (CR) after chemotherapy. Real-time PCR was used to deter...

    Authors: Qi Shen, Sichu Liu, Junyan Hu, Shaohua Chen, Lijian Yang, Bo Li, Xiuli Wu, Yu Ma, Jianchang Yang, Yupo Ma and Yangqiu Li

    Citation: Cancer Cell International 2012 12:42

    Content type: Primary research

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  13. The cancer stem cell (CSC) hypothesis posits that deregulated neural stem cells (NSCs) form the basis of brain tumors such as glioblastoma multiforme (GBM). GBM, however, usually forms in the cerebral white ma...

    Authors: Shengwen Calvin Li, Long T Vu, Hector W Ho, Hong Zhen Yin, Vic Keschrumrus, Qiang Lu, Jun Wang, Heying Zhang, Zhiwei Ma, Alexander Stover, John H Weiss, Philip H Schwartz and William G Loudon

    Citation: Cancer Cell International 2012 12:41

    Content type: Primary research

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  14. The Real-time PCR Array System is the ideal tool for analyzing the expression of a focused panel of genes. In this study, we will analyze the gene expression profile of pediatric acute myeloid leukemia with re...

    Authors: Tao Yan-Fang, Wu Dong, Pang Li, Zhao Wen-Li, Lu Jun, Wang Na, Wang Jian, Feng Xing, Li Yan-Hong, Ni Jian and Pan Jian

    Citation: Cancer Cell International 2012 12:40

    Content type: Primary research

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  15. To globally characterize the cancer stroma expression profile of muscle-invasive transitional cell carcinoma and to discuss the cancer biology as well as biomarker discovery from stroma. Laser capture micro di...

    Authors: Haitao Niu, Haiping Jiang, Bo Cheng, Xinhui Li, Qian Dong, Leping Shao, Shiguo Liu and Xinsheng Wang

    Citation: Cancer Cell International 2012 12:39

    Content type: Primary research

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  16. Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitot...

    Authors: Michelle H Visagie and Anna M Joubert

    Citation: Cancer Cell International 2012 12:37

    Content type: Primary research

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  17. Lycopene, a major carotenoid component of tomato, has a potential anticancer activity in many types of cancer. Epidemiological and clinical trials rarely provide evidence for mechanisms of the compound’s actio...

    Authors: Anderson Junger Teodoro, Felipe Leite Oliveira, Nathalia Balthazar Martins, Guilherme de Azevedo Maia, Renata Brum Martucci and Radovan Borojevic

    Citation: Cancer Cell International 2012 12:36

    Content type: Primary research

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  18. Cisplatin resistance is a serious problem in cancer treatment. To overcome it, alternative approaches including virotherapy are being pursued. One of the candidates for anticancer virotherapy is the Newcastle ...

    Authors: Mohd-Hafifi Jamal, Wei-Choong Ch’ng, Khatijah Yusoff and Norazizah Shafee

    Citation: Cancer Cell International 2012 12:35

    Content type: Primary research

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  19. Nasopharyngeal carcinoma (NPC) is a unique tumour of epithelial origin with a distinct geographical distribution, genetic predisposition and environmental as well as dietary influence as aetiological factors. ...

    Authors: Maelinda Daker, Munirah Ahmad and Alan SB Khoo

    Citation: Cancer Cell International 2012 12:34

    Content type: Primary research

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  20. Although the peptidyl-prolyl isomerase, cyclophilin-A (peptidyl-prolyl isomerase, PPIA), has been studied for decades in the context of its intracellular functions, its extracellular roles as a major contribut...

    Authors: Karim Bahmed, Curtis Henry, Michael Holliday, Jasmina Redzic, Madalina Ciobanu, Fengli Zhang, Colin Weekes, Robert Sclafani, James DeGregori and Elan Eisenmesser

    Citation: Cancer Cell International 2012 12:19

    Content type: Primary research

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  21. ZIP8 functions endogenously as a Zn+2/HCO3- symporter that can also bring cadmium (Cd+2) into the cell. It has also been proposed that ZIP8 participates in Cd-induced testicular necrosis and renal disease. In thi...

    Authors: Amornpan Ajjimaporn, Tom Botsford, Scott H Garrett, Mary Ann Sens, Xu Dong Zhou, Jane R Dunlevy, Donald A Sens and Seema Somji

    Citation: Cancer Cell International 2012 12:16

    Content type: Primary research

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  22. The purpose of this study was to investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and correlate it with OPN expression and function in squamous carcinoma of ton...

    Authors: Fan Zhang, Xu Jin Liu, Xun Qu, Zhen Sheng Hu, Yong Mei Yang, Ling Ma, Pei Liu, Ping Shi and Feng Cai Wei

    Citation: Cancer Cell International 2012 12:33

    Content type: Primary research

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  23. EPCs were isolated primarily in 1997 by Asahara et al. and recent studies indicated that bone-marrow-derived EPCs contributed little to the endothelium of tumor vessels. Tumors of the CNS system demonstrate va...

    Authors: She-Hong Zhang, Ping Xiang, He-Yong Wang, You-Yi Lu, Yan-Li Luo and Hao Jiang

    Citation: Cancer Cell International 2012 12:32

    Content type: Primary research

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  24. Upregulation of nuclear factor kappa B (NFκB) activity and neuroendocrine differentiation are two mechanisms known to be involved in prostate cancer (PC) progression to castration resistance. We have observed ...

    Authors: Anna Patrikidou, Panagiotis J Vlachostergios, Ioannis A Voutsadakis, Eleana Hatzidaki, Rosalia-Maria Valeri, Chariklia Destouni, Effie Apostolou and Christos N Papandreou

    Citation: Cancer Cell International 2012 12:31

    Content type: Primary research

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  25. RNA interference (RNAi) is a powerful approach in functional genomics to selectively silence messenger mRNA (mRNA) expression and can be employed to rapidly develop potential novel drugs against a complex dise...

    Authors: Anthony Stanislaus, Athirah Bakhtiar, Diyana Salleh, Snigdha Tiash, Tahereh Fatemian, Sharif Hossain, Toshihiro Akaike and Ezharul Hoque Chowdhury

    Citation: Cancer Cell International 2012 12:30

    Content type: Primary research

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  26. While breast cancer (BC) is the major cause of death among women worldwide, there is no guarantee of better patient survival because many of these patients develop primarily metastases, despite efforts to dete...

    Authors: Vivian Labovsky, Valeria B Fernández Vallone, Leandro M Martinez, Julian Otaegui and Norma A Chasseing

    Citation: Cancer Cell International 2012 12:29

    Content type: Primary research

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  27. Kaiso protein has been identified as a new member of the POZ-ZF subfamily of transcription factors that are involved in development and cancer. There is consistent evidence of the role of Kaiso and its involve...

    Authors: Jaime Cofre, João R L Menezes, Luciana Pizzatti and Eliana Abdelhay

    Citation: Cancer Cell International 2012 12:28

    Content type: Primary research

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  28. Head and neck squamous cell carcinoma (HNSCC) is the 5th most common cancer worldwide. Locally advanced HNSCC are treated with either radiation or chemo-radiotherapy, but still associated with high mortality r...

    Authors: Nehad M Alajez, Joseph D Mocanu, Tiffany Krushel, John C Bell and Fei-Fei Liu

    Citation: Cancer Cell International 2012 12:27

    Content type: Primary research

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  29. We have investigated the role of erythroid transcription factors mRNA expression in patients with acute myeloid leukemia (AML) in the context of cytogenetic and other prognostic molecular markers, such as FMS-...

    Authors: Rosa Ayala, Joaquin Martínez-López and Florinda Gilsanz

    Citation: Cancer Cell International 2012 12:25

    Content type: Primary research

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  30. Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal tra...

    Authors: Liviu Feller, Beverley Kramer and Johan Lemmer

    Citation: Cancer Cell International 2012 12:24

    Content type: Review

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  31. Our previous work found that mouse embryos could invade malignant cancer cells. In the process of implantation, embryo trophoblast cells express matrix metalloproteinases and the invasive ability of trophoblas...

    Authors: Xiaoyan Ding, Liaoqiong Fang, Hong Zhang, Hai Qiao and Zhi-biao Wang

    Citation: Cancer Cell International 2012 12:23

    Content type: Primary research

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  32. The outcome of chemotherapy in breast cancer is strongly influenced by multidrug resistance (MDR). Several surrogate markers of chemoresistance have been identified including - CD24 (cluster differentiation 24...

    Authors: Neil D Jelly, Issam I Hussain, Jennifer Eremin, Oleg Eremin and Mohamed El-Sheemy

    Citation: Cancer Cell International 2012 12:21

    Content type: Primary research

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    The Retraction Note to this article has been published in Cancer Cell International 2013 13:96

  33. Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects. ...

    Authors: Johan Kjellström, Stina M Oredsson and Johan Wennerberg

    Citation: Cancer Cell International 2012 12:20

    Content type: Primary research

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  34. Without doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical ...

    Authors: Afef Dellai, Monia Deghrigue, Audrey Laroche-Clary, Hedi Ben Masour, Nabil Chouchane, Jacques Robert and Abderrahman Bouraoui

    Citation: Cancer Cell International 2012 12:18

    Content type: Primary research

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  35. Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1 and it...

    Authors: Casey M Turk, Katerina D Fagan-Solis, Kristin E Williams, Joseph M Gozgit, Sallie Smith-Schneider, Sharon A Marconi, Christopher N Otis, Giovanna M Crisi, Douglas L Anderton, Manfred W Kilimann and Kathleen F Arcaro

    Citation: Cancer Cell International 2012 12:17

    Content type: Primary research

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  36. This study progresses in the direction of identifying component(s) from the Mediterranean sponge, Spongia officinalis with anticonvulsant and analgesic activities. We investigated the efficacy of crude extract an...

    Authors: Afef Dellai, Hedi Ben Mansour, Audrey Clary-Laroche, Monia Deghrigue and Abderrahman Bouraoui

    Citation: Cancer Cell International 2012 12:15

    Content type: Primary research

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  37. Glioblastoma is the most aggressive form of brain tumors showing resistance to treatment with various chemotherapeutic agents. The most effective way to eradicate glioblastoma requires the concurrent inhibitio...

    Authors: Hiroko Tabunoki, Naoki Saito, Khanit Suwanborirux, Kornvika Charupant and Jun-ichi Satoh

    Citation: Cancer Cell International 2012 12:14

    Content type: Primary research

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  38. The Notch signaling pathway is crucial in T-cell development, Notch 1 mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL). To investigate the feature of Notch 1 mutation and its corres...

    Authors: Chunlan Lin, Haitao Zheng, Chunyan Wang, Lijian Yang, Shaohua Chen, Bo Li, Yubing Zhou, Huo Tan and Yangqiu Li

    Citation: Cancer Cell International 2012 12:13

    Content type: Primary research

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  39. GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) and PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid) are tumour metabolism inhibitors that target adenine nucleotide translocase (ANT...

    Authors: Danielle Park, Joyce Chiu, Gabriel G Perrone, Pierre J Dilda and Philip J Hogg

    Citation: Cancer Cell International 2012 12:11

    Content type: Primary research

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  40. Although the primary risk factors for developing oral cancers are well understood, less is known about the relationship among the secondary factors that may modulate the progression of oral cancers, such as hi...

    Authors: Michael Moody, Oanh Le, Megan Rickert, Jeremy Manuele, Sarah Chang, Gary Robinson, Jeffrey Hajibandeh, John Silvaroli, Mark A Keiserman, Christine J Bergman and Karl Kingsley

    Citation: Cancer Cell International 2012 12:10

    Content type: Primary research

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  41. Recently electroporation using biphasic pulses was successfully applied in clinical developments for treating tumours in humans and animals. We evaluated the effects of electrical treatment on cell adhesion be...

    Authors: Viktoria N Pehlivanova, Iana H Tsoneva and Rumiana D Tzoneva

    Citation: Cancer Cell International 2012 12:9

    Content type: Primary research

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  42. The effect of cell injury and apoptosis induced by ultrasound with contrast agent has been verified. Contrast agent enhanced apoptosis and expression of genes that related to apoptosis and are responsive to ul...

    Authors: Zao Jiang, Wei Wu and Meng-lu Qian

    Citation: Cancer Cell International 2012 12:8

    Content type: Primary research

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  43. A potential strategy for the diagnosis of lung cancer is to exploit the distinct metabolic signature of this disease by way of biomarkers found in different sample types. In this study, we investigated whether...

    Authors: Yosuke Hanai, Ken Shimono, Hiroaki Oka, Yoshinobu Baba, Kunio Yamazaki and Gary K Beauchamp

    Citation: Cancer Cell International 2012 12:7

    Content type: Primary research

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  44. Caveolin-1 is a scaffolding protein found in plasma membrane invaginations known as caveolae. Caveolin-1 can regulate a number of intracellular processes such as signal transduction, cholesterol metabolism and...

    Authors: Devan E Thompson, Megan D Siwicky and Roger A Moorehead

    Citation: Cancer Cell International 2012 12:6

    Content type: Primary research

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  45. Statins may have therapeutic effects on hepatocarcinoma (HCC). This type of disorder is the most common malignant primary tumour in the liver. Our objective was to determine whether pravastatin had a therapeut...

    Authors: Elizabeth Hijona, Jesús María Banales, Lander Hijona, Juan Francisco Medina, Juan Arenas, Marta Herreros-Villanueva, Pablo Aldazabal and Luis Bujanda

    Citation: Cancer Cell International 2012 12:5

    Content type: Primary research

    Published on:

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