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  1. Cancer and Alzheimer's disease (AD) are two seemingly distinct diseases and rarely occur simultaneously in patients. To explore molecular determinants differentiating pathogenic routes towards AD or cancer, we...

    Authors: Hong Zhao, Jinmin Zhu, Kemi Cui, Xiaoyin Xu, Megan O'Brien, Kelvin K Wong, Santosh Kesari, Weiming Xia and Stephen TC Wong

    Citation: Cancer Cell International 2009 9:15

    Content type: Primary research

    Published on:

  2. Recent evidence suggests that several human cancers are capable of uncoupling of mitochondrial ATP generation in the presence of intact tricarboxylic acid (TCA) enzymes. The goal of the current study was to te...

    Authors: Eugene J Fine, Anna Miller, Edward V Quadros, Jeffrey M Sequeira and Richard D Feinman

    Citation: Cancer Cell International 2009 9:14

    Content type: Primary research

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  3. Metabolic states of neoplastic cells are increasingly being relied upon for diagnostic and prognostic assessment of neoplastic conditions. The nucleic acid distribution pattern of cells in general, in terms of...

    Authors: Godwin N Isitor, Mervyn Campbell and Shivananda B Nayak

    Citation: Cancer Cell International 2009 9:13

    Content type: Primary research

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  4. In the Western world, endometrial cancers are the most common gynaecological neoplastic disorders among women. Initial symptoms are often vague and may be confused with several other conditions or disorders. T...

    Authors: Sandra Karlsson, Björn Olsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2009 9:12

    Content type: Primary research

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  5. The Wnt family of secreted proteins is implicated in the regulation of cell fate during development, as well as in cell proliferation, morphology, and migration. Aberrant activation of the Wnt/β-catenin signal...

    Authors: Kelly J Gauger, Jeremy M Hugh, Melissa A Troester and Sallie Smith Schneider

    Citation: Cancer Cell International 2009 9:11

    Content type: Primary research

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  6. DNA methylation is an epigenetic phenomenon known to play an important role in the development of cancers, including colorectal cancer (CRC). Aberrant methylation of promoter regions of genes is potentially re...

    Authors: Sylwia Flis, Agnieszka Gnyszka, Irena Misiewicz-Krzemińska and Jacek Spławiński

    Citation: Cancer Cell International 2009 9:10

    Content type: Primary research

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  7. Protein used in medicine, e.g. interferon, are immunogenic and quickly broken down by the body. Pegylation is a recognized way of preserving their integrity and reducing immune reactions, and works well with e...

    Authors: Sam-Mui Tsui, Wai-Man Lam, Tin-Lun Lam, Hiu-Chi Chong, Pui-Kin So, Sui-Yi Kwok, Simon Arnold, Paul Ning-Man Cheng, Denys N Wheatley, Wai-Hung Lo and Yun-Chung Leung

    Citation: Cancer Cell International 2009 9:9

    Content type: Primary research

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  8. MCF-10A cells are near diploid and normal human mammary epithelial cells. In three-dimensional reconstituted basement membrane culture, they undergo a well-defined program of proliferation, differentiation, an...

    Authors: Karen M Imbalzano, Iva Tatarkova, Anthony N Imbalzano and Jeffrey A Nickerson

    Citation: Cancer Cell International 2009 9:7

    Content type: Primary research

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  9. Piper sarmentosum, locally known as kaduk is belonging to the family of Piperaceae. It is our interest to evaluate their effect on human hepatoma cell line (HepG2) for the potential of anticarcinogenic activity.

    Authors: Shahrul Hisham Zainal Ariffin, Wan Haifa Haryani Wan Omar, Zaidah Zainal Ariffin, Muhd Fauzi Safian, Sahidan Senafi and Rohaya Megat Abdul Wahab

    Citation: Cancer Cell International 2009 9:6

    Content type: Primary research

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  10. The prototypical antiprogestin mifepristone exhibits potent growth inhibition activity towards ovarian cancer cells in vitro and in vivo. The aim of this research was to establish whether mifepristone is capable ...

    Authors: Elizabeth M Freeburg, Alicia A Goyeneche, Erin E Seidel and Carlos M Telleria

    Citation: Cancer Cell International 2009 9:4

    Content type: Primary research

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  11. Resistance of cholangiocarcinoma to chemotherapy is a major problem in cancer treatment. The mechanism of resistance is believed to involve phosphoinositide-3- kinase (PI3K)/Akt activation. Although the platin...

    Authors: Kawin Leelawat, Siriluck Narong, Wandee Udomchaiprasertkul, Surang Leelawat and Sumalee Tungpradubkul

    Citation: Cancer Cell International 2009 9:3

    Content type: Primary research

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  12. Breast cancer is a major malignancy affecting females worldwide. It is the most common cause of death from cancer in women. Cell lines are widely used in laboratory research and particularly as in vitro models in...

    Authors: Chao Shen, Meijia Gu, Dan Liang, Lixia Miao, Liu Hu, Congyi Zheng and Jiakuan Chen

    Citation: Cancer Cell International 2009 9:2

    Content type: Primary research

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  13. It has been suggested that combined effect of natural products may improve the treatment effectiveness in combating proliferation of cancer cells. The present study was undertaken to evaluate the possibility t...

    Authors: Yew Hoong Cheah, Fariza Juliana Nordin, Rozie Sarip, Thiam Tsui Tee, Hawariah Lope Pihie Azimahtol, Hasnah M Sirat, Badrul Amini Abd Rashid, Noor Rain Abdullah and Zakiah Ismail

    Citation: Cancer Cell International 2009 9:1

    Content type: Primary research

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  14. Cancer expansion depends on host organ conditions that permit growth. Since such microenvironmental nourishment is limited we argue here that an autologous, therapeutically engineered and faster metabolizing cell...

    Authors: Thomas S Deisboeck and Zhihui Wang

    Citation: Cancer Cell International 2008 8:19

    Content type: Hypothesis

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  15. ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have ...

    Authors: Philippe O Gannon, Ismaël Hervé Koumakpayi, Cécile Le Page, Pierre I Karakiewicz, Anne-Marie Mes-Masson and Fred Saad

    Citation: Cancer Cell International 2008 8:18

    Content type: Primary research

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  16. The aim of this work was to confirm the existence of volatile organic compounds (VOCs) specifically released or consumed by lung cancer cells.

    Authors: Wojciech Filipiak, Andreas Sponring, Tomas Mikoviny, Clemens Ager, Jochen Schubert, Wolfram Miekisch, Anton Amann and Jakob Troppmair

    Citation: Cancer Cell International 2008 8:17

    Content type: Primary research

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  17. Most patients with advanced Ewing's sarcoma (EWS) respond poorly to conventional chemotherapy, indicating the need for new treatment approaches. Epigenetic events, such as promoter hypermethylation and chromat...

    Authors: Annie Hurtubise, Mark L Bernstein and Richard L Momparler

    Citation: Cancer Cell International 2008 8:16

    Content type: Primary research

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  18. Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper...

    Authors: Hideo Watanabe, Kenzo Soejima, Hiroyuki Yasuda, Ichiro Kawada, Ichiro Nakachi, Satoshi Yoda, Katsuhiko Naoki and Akitoshi Ishizaka

    Citation: Cancer Cell International 2008 8:15

    Content type: Primary research

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  19. Human herpesvirus (HHV)-8 associated oncogenesis, a state of immune impairment, a local inflammatory environment, angiogenesis and HIV infection occurring concurrently are important factors for the development...

    Authors: Neil H Wood and Liviu Feller

    Citation: Cancer Cell International 2008 8:14

    Content type: Review

    Published on:

  20. Aberrations in DNA methylation patterns promote changes in gene expression patterns and are invariably associated with neoplasia. DNA methylation is carried out and maintained by several DNA methyltransferases...

    Authors: Ahmed Yaqinuddin, Sohail A Qureshi, Romena Qazi and Farhat Abbas

    Citation: Cancer Cell International 2008 8:13

    Content type: Primary research

    Published on:

  21. Breast cancer is the most common cancer and cause of deaths in women around the world. Oncogene amplification usually occurs late in tumor progression and correlates well with aggressiveness of tumor. In fact ...

    Authors: Nawfal I Ismail, Gurjeet Kaur, Hasnah Hashim and Mohammed S Hassan

    Citation: Cancer Cell International 2008 8:12

    Content type: Primary research

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  22. A localized hypoxic environment occurs during tumor growth necessitating an angiogenic response or tumor necrosis results. Novel cancer treatment strategies take advantage of tumor-induced vascularisation by c...

    Authors: Jamie M Heinzman, Stacey L Brower and Jason E Bush

    Citation: Cancer Cell International 2008 8:11

    Content type: Primary research

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  23. Brain tumors are now the leading cause of cancer-related deaths in children under age 15. Malignant gliomas are, for all practical purposes, incurable and new therapeutic approaches are desperately needed. One...

    Authors: Shengwen Calvin Li and William Gunter Loudon

    Citation: Cancer Cell International 2008 8:9

    Content type: Hypothesis

    Published on:

  24. 4-Hydroxycoumarin (4-HC) is a coumarin that lacks anticoagulant activity. 4-HC affects the cytoskeletal stability and decreases cell adhesion and motility of the melanoma cell line B16-F10. Together with integ...

    Authors: Marco A Velasco-Velázquez, Nohemí Salinas-Jazmín, Nicandro Mendoza-Patiño and Juan J Mandoki

    Citation: Cancer Cell International 2008 8:8

    Content type: Primary research

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  25. Breast cancer is the most common cause of cancer death in the western world. The expression differences of many proteins are associated with breast cancer progression or suppression. The purpose of the study w...

    Authors: Nawfal I Ismail, Gurjeet Kaur, Hasnah Hashim and Mohammed S Hassan

    Citation: Cancer Cell International 2008 8:6

    Content type: Primary research

    Published on:

  26. c-kit is expressed in various cell types during development and it has been linked to the promotion of cellular migration, proliferation and/or survival of melanoblasts, hematopoietic progenitors and primordial g...

    Authors: Maricel V Maffini, Ana M Soto, Carlos Sonnenschein, Nikoletta Papadopoulos and Theoharis C Theoharides

    Citation: Cancer Cell International 2008 8:5

    Content type: Primary research

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  27. Truncated variants of Ku86 protein have previously been detected in 86% to 100% of freshly isolated patient multiple myeloma (MM) cells. Since, the Ku70/Ku86 heterodimer functions as the regulatory subunit of ...

    Authors: Charles A Gullo, Feng Ge, Geraline Cow and Gerrard Teoh

    Citation: Cancer Cell International 2008 8:4

    Content type: Primary research

    Published on:

  28. Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged an...

    Authors: Greg Shaw and David M Prowse

    Citation: Cancer Cell International 2008 8:3

    Content type: Primary research

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  29. Tyrosine kinase inhibitors (TKIs) have gained much attention in recent years as targeted agents for the treatment of a wide range of human cancers. We have investigated the effect of the TKIs gefitinib and van...

    Authors: Mattias K Andersson and Pierre Åman

    Citation: Cancer Cell International 2008 8:1

    Content type: Primary research

    Published on:

  30. Glucocorticoids (GC's) play an integral role in treatment strategies designed to combat various forms of hematological malignancies. GCs also are powerful inhibitors of the immune system, through regulation of...

    Authors: Aaron L Miller, Spogmai Komak, M Scott Webb, Edward H Leiter and E Brad Thompson

    Citation: Cancer Cell International 2007 7:18

    Content type: Primary research

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  31. The CXCR4/CXCL12 chemokine axis may play a critical role in guiding CXCR4+ circulating malignant cells to organ specific locations that actively secrete its ligand CXCL12 (SDF-1) such as bone, brain, liver, an...

    Authors: Sebastian Di Cesare, Jean-Claude Marshall, Bruno F Fernandes, Patrick Logan, Emilia Antecka, Vasco Bravo Filho and Miguel N Burnier Jr

    Citation: Cancer Cell International 2007 7:17

    Content type: Primary research

    Published on:

  32. Integrins are transmembrane adhesion receptors that provide the physical link between the actin cytoskeleton and the extracellular matrix. It has been well established that integrins play a major role in vario...

    Authors: Sophia Havaki, Mirsini Kouloukoussa, Kawther Amawi, Yiannis Drosos, Leonidas D Arvanitis, Nikos Goutas, Dimitrios Vlachodimitropoulos, Stamatis D Vassilaros, Eleni Z Katsantoni, Irene Voloudakis-Baltatzis, Vassiliki Aleporou-Marinou, Christos Kittas and Evangelos Marinos

    Citation: Cancer Cell International 2007 7:16

    Content type: Primary research

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  33. Methylation-mediated silencing of genes is one epigenetic mechanism implicated in cancer. Studies regarding the role of modulation of gene expression utilizing inhibitors of DNA methylation, such as decitabine...

    Authors: Khaldoun Al-Romaih, Gino R Somers, Jane Bayani, Simon Hughes, Mona Prasad, Jean-Claude Cutz, Hui Xue, Maria Zielenska, Yuzhuo Wang and Jeremy A Squire

    Citation: Cancer Cell International 2007 7:14

    Content type: Primary research

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  34. Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hyp...

    Authors: Michael D Hughes, Erilda Kapllani, Ashlynn E Alexander, Robert D Burk and Alan R Schoenfeld

    Citation: Cancer Cell International 2007 7:13

    Content type: Primary research

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  35. Uncovering the molecular mechanism underlying expansion of hematopoietic stem and progenitor cells is critical to extend current therapeutic applications and to understand how its deregulation relates to leuke...

    Authors: Oswaldo Keith Okamoto, Ana Carolina SR Carvalho, Luciana C Marti, Ricardo Z Vêncio and Carlos A Moreira-Filho

    Citation: Cancer Cell International 2007 7:11

    Content type: Primary research

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  36. Pancratistatin (PST), a compound extracted from an Amaryllidaceae (AMD) family plant, has been shown to specifically induce apoptosis in cancer cells with no/minimal toxic effect on normal cells. A systematic syn...

    Authors: Carly Griffin, Natasha Sharda, Divya Sood, Jerald Nair, James McNulty and Siyaram Pandey

    Citation: Cancer Cell International 2007 7:10

    Content type: Primary research

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  37. For over 30 years, stem cells have been used in the replenishment of blood and immune systems damaged by the cancer cells or during treatment of cancer by chemotherapy or radiotherapy. Apart from their use in ...

    Authors: Jayesh Sagar, Boussad Chaib, Kevin Sales, Marc Winslet and Alexander Seifalian

    Citation: Cancer Cell International 2007 7:9

    Content type: Review

    Published on:

  38. Most cancers express elevated protease levels which contribute to certain aspects of tumor behavior such as growth, metastatic spread, and angiogenesis. Elevation of the cathepsins of the cysteine protease fam...

    Authors: Zhen Yang and James L Cox

    Citation: Cancer Cell International 2007 7:8

    Content type: Primary research

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  39. Fish oil is known to protect from many types of cancers of the colon, liver, breast, prostate and lung [13]. The objective of the present study was to evaluate the role of fish oil [Maxepa, supplemented at a dos...

    Authors: Sangita Manna, Tridib Chakraborty, Suresh Damodaran, Kartick Samanta, Basabi Rana and Malay Chatterjee

    Citation: Cancer Cell International 2007 7:6

    Content type: Primary research

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  40. The pharmacologic modulatory effects of the antibiotic, tunicamycin (TM), on multidrug-resistant human UWOV2 ovarian cancer cells are reported. The UWOV2 cell line was derived from a cystadenocarcinoma in a pa...

    Authors: Donavon C Hiss, Gary A Gabriels and Peter I Folb

    Citation: Cancer Cell International 2007 7:5

    Content type: Primary research

    Published on:

  41. Glucocorticoids are frequently used as a primary chemotherapeutic agent in many types of human lymphoid malignancies because they induce apoptosis through activation of the glucocorticoid receptor, with subseq...

    Authors: Aaron L Miller, Anna S Garza, Betty H Johnson and E Brad Thompson

    Citation: Cancer Cell International 2007 7:3

    Content type: Primary research

    Published on:

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