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  1. The purpose of the present study is to investigate the direct biological effects of the epidermal growth factor receptor (EGFR) inhibitor C225 on the radiosensitivity of human lung squamous cancer cell-H520. H...

    Authors: Yingdong Zhang, Junjie Wang, Feng Liu, Zhenyu You, Ruijie Yang and Yong Zhao

    Citation: Cancer Cell International 2010 10:39

    Content type: Primary research

    Published on:

  2. Survivin is a member of the inhibitor-of-apoptosis (IAP) family which is widely expressed by many different cancers. Overexpression of survivin is associated with drug resistance in cancer cells, and reduced p...

    Authors: Chun Hei Antonio Cheung, Xueying Sun, Jagat R Kanwar, Ji-Zhong Bai, LiTing Cheng and Geoffrey W Krissansen

    Citation: Cancer Cell International 2010 10:36

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2010 10:43

  3. Purinergic receptor-mediated signaling plays an important role in the function of glial cells, including glial tumor cells. Bradykinin is also an important paracrine mediator which is highly expressed in brain...

    Authors: Héctor E López-Valdés, Luis Beltran-Parrazal, Kevin C Brennan and Andrew C Charles

    Citation: Cancer Cell International 2010 10:35

    Content type: Primary research

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  4. Cytoglobin (Cygb) and neuroglobin (Ngb) are recently identified globin molecules that are expressed in vertebrate tissues. Upregulation of Cygb and Ngb under hypoxic and/or ischemic conditions in vitro and in viv...

    Authors: Marwan Emara, A Robert Turner and Joan Allalunis-Turner

    Citation: Cancer Cell International 2010 10:33

    Content type: Primary research

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  5. Activating Transcription Factor (ATF) 3 is a key regulator of the cellular integrated stress response whose expression has also been correlated with pro-apoptotic activities in tumour cell models. Combination ...

    Authors: Carly St Germain, Anna O'Brien and Jim Dimitroulakos

    Citation: Cancer Cell International 2010 10:32

    Content type: Primary research

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  6. Colorectal cancer is the third most-common cancer and the second most-common cause of cancer related death in UK. Although chemotherapy plays significant role in the treatment of colorectal cancer, morbidity a...

    Authors: Jayesh Sagar, Kevin Sales, Jan-Willem Taanman, Sas Dijk and Marc Winslet

    Citation: Cancer Cell International 2010 10:31

    Content type: Primary research

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  7. MCF-10A, immortalized but non-transformed human breast epithelial cells, are widely used in research examining carcinogenesis. The studies presented here were initiated with the observation that MCF-10A cells ...

    Authors: Rita Yusuf and Krystyna Frenkel

    Citation: Cancer Cell International 2010 10:30

    Content type: Primary research

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  8. Melanoma differentiation associated gene-7 (MDA-7), also known as interleukin (IL)-24, is a tumour suppressor gene associated with differentiation, growth and apoptosis. However, the mechanisms underlying its ...

    Authors: Neill Patani, Anthony Douglas-Jones, Robert Mansel, Wen Jiang and Kefah Mokbel

    Citation: Cancer Cell International 2010 10:29

    Content type: Primary research

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  9. Young women diagnosed with breast cancer are known to have a higher mortality rate from the disease than older patients. Specific risk factors leading to this poorer outcome have not been identified. In the pr...

    Authors: Jonathan Eckard, Jisen Dai, Jing Wu, Jinlong Jian, Qing Yang, Haobin Chen, Max Costa, Krystyna Frenkel and Xi Huang

    Citation: Cancer Cell International 2010 10:28

    Content type: Primary research

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  10. D-glucuronyl C5-epimerase (GLCE) is one of the key enzymes in the biosynthesis of heparansulfate proteoglycans. Down-regulation of GLCE expression in human breast tumours suggests a possible involvement of the ge...

    Authors: Tatiana Y Prudnikova, Liudmila A Mostovich, Natalia V Domanitskaya, Tatiana V Pavlova, Vladimir I Kashuba, Eugene R Zabarovsky and Elvira V Grigorieva

    Citation: Cancer Cell International 2010 10:27

    Content type: Primary research

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  11. The cell microenvironment, especially extracellular matrix proteins, plays an important role in tumor cell response to chemotherapeutic drugs. The present study was designed to investigate whether this microen...

    Authors: Emilie Millerot-Serrurot, Marie Guilbert, Nicolas Fourré, Wojciech Witkowski, Georges Said, Laurence Van Gulick, Christine Terryn, Jean-Marie Zahm, Roselyne Garnotel and Pierre Jeannesson

    Citation: Cancer Cell International 2010 10:26

    Content type: Primary research

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  12. We have shown that the microtopography (mT) underlying colon cancer changes as a tumor de-differentiates. We distinguish the well-differentiated mT based on the increasing number of "pits" and poorly different...

    Authors: Rebecca Rapier, Jameela Huq, Ramana Vishnubhotla, Marinka Bulic, Cecile M Perrault, Vitali Metlushko, Michael Cho, Roger Tran Son Tay and Sarah C Glover

    Citation: Cancer Cell International 2010 10:24

    Content type: Primary research

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  13. Recent advances in oncology have lead to identification of a plethora of alterations in signaling pathways that are critical to oncogenesis and propagation of malignancy. Among the biomarkers identified, dysre...

    Authors: Shyam Nyati, Brian D Ross, Alnawaz Rehemtulla and Mahaveer S Bhojani

    Citation: Cancer Cell International 2010 10:23

    Content type: Review

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  14. The association between the wnt signaling pathway and apoptosis has become more firmly established in the recent scientific literature. Many reports indicate that the wnt signaling pathway regulates apoptosis ...

    Authors: Nives Pećina-Šlaus

    Citation: Cancer Cell International 2010 10:22

    Content type: Review

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  15. Intravesical immunotherapy with Mycobacterium bovis bacillus Calmette-Guérin has been established as the most effective adjuvant treatment for high risk non-muscle-invasive bladder cancer (NMIBC). We investigated...

    Authors: Katja Schwarzer, Martin Foerster, Thomas Steiner, Inge-Marie Hermann and Eberhard Straube

    Citation: Cancer Cell International 2010 10:21

    Content type: Primary research

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  16. Blockade of the angiotensin (ANG) II type 1 receptor (AT1R) inhibits tumour growth in several cancers, including colorectal cancer (CRC) liver metastases. While AT1R blockade has been extensively studied, the ...

    Authors: Eleanor I Ager, Way W Chong, Shu-wen Wen and Christopher Christophi

    Citation: Cancer Cell International 2010 10:19

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2010 10:37

  17. In this study the effect of myenteric denervation induced by benzalconium chloride (BAC) on distribution of fibrillar components of extracellular matrix (ECM) and inflammatory cells was investigated in gastric...

    Authors: Cássia F Estofolete, Carla Botelho-Machado, Sebastião R Taboga, Sérgio Zucoloto, Ana Cláudia Polli-Lopes and Cristiane D Gil

    Citation: Cancer Cell International 2010 10:18

    Content type: Primary research

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  18. Ovarian cancer is one of the most significant malignancies in the western world. Studies showed that Ovarian cancers tend to grow resistance to cisplatin treatment. Therefore, new approaches are needed in ovar...

    Authors: Haitao Luo, Matthew K Daddysman, Gary O Rankin, Bing-Hua Jiang and Yi C Chen

    Citation: Cancer Cell International 2010 10:16

    Content type: Primary research

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  19. Micro(mi)RNAs are a class of small non-coding RNAs that play critical roles in the induction of various cancers, including lymphomas induced by oncogenic viruses. While some of the miRNAs are oncogenic, miRNAs...

    Authors: Hongtao Xu, Yongxiu Yao, Lorraine P Smith and Venugopal Nair

    Citation: Cancer Cell International 2010 10:15

    Content type: Primary research

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  20. Hydnophytum formicarium Jack is an epyphytic shrub that belongs to the family of Rubiaceae and is native to the tropical rain forests of the Asean region, which includes Malaysia. A flavanoid derivative, 7, 3', 5...

    Authors: Hasmah Abdullah, Azimahtol Hawariah Lope Pihie, Judit Hohmann and Joseph Molnár

    Citation: Cancer Cell International 2010 10:14

    Content type: Primary research

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  21. MLL2, an epigenetic regulator in mammalian cells, mediates histone 3 lysine 4 tri-methylation (H3K4me3) through the formation of a multiprotein complex. MLL2 shares a high degree of structural similarity with ...

    Authors: Thanemozhi G Natarajan, Bhaskar V Kallakury, Christine E Sheehan, Margaret B Bartlett, Natarajan Ganesan, Anju Preet, Jeffrey S Ross and Kevin T FitzGerald

    Citation: Cancer Cell International 2010 10:13

    Content type: Primary research

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  22. The DNA enzyme Dz13, targeted against the oncogene c-Jun, is capable of inhibiting various model tumours in mice albeit in ectopic models of neoplasia. In previous studies using orthotopic models of disease, t...

    Authors: Mei Lin Tan, Peter FM Choong and Crispin R Dass

    Citation: Cancer Cell International 2010 10:9

    Content type: Primary research

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  23. The interaction between viral oncoproteins such as Simian virus 40 TAg, adenovirus E1A, and human papilloma virus E7, and the retinoblastoma protein (pRB) occurs through a well characterized peptide sequence, ...

    Authors: Shauna A Henley, Sarah M Francis, Jordan Demone, Peter Ainsworth and Frederick A Dick

    Citation: Cancer Cell International 2010 10:8

    Content type: Primary research

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  24. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expression of PADI4 in various malignant tumour tissues. PADI4 is also ex...

    Authors: Xiaotian Chang and Kehua Fang

    Citation: Cancer Cell International 2010 10:7

    Content type: Review

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  25. Pancratistatin, a natural compound extracted from Hymenocallis littoralis, can selectively induce apoptosis in several cancer cell lines. In this ex vivo study, we evaluated the effect of pancratistatin on periph...

    Authors: Carly Griffin, Caroline Hamm, James McNulty and Siyaram Pandey

    Citation: Cancer Cell International 2010 10:6

    Content type: Primary research

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  26. Most cancer researchers regularly practice the responsible conduct of research (RCR) without consciously considering it. As professional scientists, we simply do what we are trained to do. However, as we train...

    Authors: Mark A Brown, Richard J Ablin and Denys N Wheatley

    Citation: Cancer Cell International 2010 10:5

    Content type: Editorial

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  27. Simian Virus 40 (SV40) immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC) has been used to elicit tumors in athymic mice. 3-MC carcinogenesis has been thoroughly studied, however g...

    Authors: Lynn M Crosby, Tanya M Moore, Michael George, Lawrence W Yoon, Marilyn J Easton, Hong Ni, Kevin T Morgan and Anthony B DeAngelo

    Citation: Cancer Cell International 2010 10:4

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2010 10:10

  28. Lung cancers are the most common type of human malignancy and are intractable. Lung cancers are generally classified into four histopathological subtypes: adenocarcinoma (AD), squamous cell carcinoma (SQ), lar...

    Authors: Takashi Watanabe, Tomohiro Miura, Yusuke Degawa, Yuna Fujita, Masaaki Inoue, Makoto Kawaguchi and Chie Furihata

    Citation: Cancer Cell International 2010 10:2

    Content type: Primary research

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  29. ASPM (Abnormal Spindle-like Microcephaly associated) over-expression was recently implicated in the development of malignant gliomas.

    Authors: Sandra-Nadia Ngwabyt Bikeye, Carole Colin, Yannick Marie, Raphaël Vampouille, Philippe Ravassard, Audrey Rousseau, Blandine Boisselier, Ahmed Idbaih, Charles Félix Calvo, Pascal Leuraud, Myriam Lassalle, Soufiane El Hallani, Jean-Yves Delattre and Marc Sanson

    Citation: Cancer Cell International 2010 10:1

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2011 11:10

  30. Intravesical BCG immunotherapy is effective for preventing recurrence and progression in none muscle-invasive bladder cancer but the dosing schedule and duration of treatment remain empirical. The mechanisms b...

    Authors: Akira Kitamura, Sohkichi Mastumoto and Izumi Asahina

    Citation: Cancer Cell International 2009 9:30

    Content type: Primary research

    Published on:

  31. Cancer remains one of the most dreaded diseases causing an astonishingly high death rate, second only to cardiac arrest. The fact that conventional and newly emerging treatment procedures like chemotherapy, ca...

    Authors: Gowhar Shafi, Anjana Munshi, Tarique N Hasan, Ali A Alshatwi, A Jyothy and David KY Lei

    Citation: Cancer Cell International 2009 9:29

    Content type: Primary research

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  32. The gene encoding integrator complex subunit 6 (INTS6), previously known as deleted in cancer cells 1 (DICE1, OMIM 604331) was found to be frequently affected by allelic deletion and promoter hypermethylation in ...

    Authors: Stephanie Filleur, Jennifer Hirsch, Aline Wille, Margarete Schön, Christian Sell, Michael H Shearer, Thomas Nelius and Ilse Wieland

    Citation: Cancer Cell International 2009 9:28

    Content type: Primary research

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  33. Malignant glioma cells are particularly motile and can travel diffusely through the brain parenchyma, apparently without following anatomical structures to guide their migration. The neural adhesion/recognitio...

    Authors: Muhua Yang, Shalini Adla, Murali K Temburni, Vivek P Patel, Errin L Lagow, Owen A Brady, Jing Tian, Magdy I Boulos and Deni S Galileo

    Citation: Cancer Cell International 2009 9:27

    Content type: Primary research

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  34. Osteoprotegerin (OPG), a member of the tumor necrosis factor (TNF) receptor superfamily, contributes determinatively to the bone remodeling as well as to the pathogenetic mechanism of bone malignancies and dis...

    Authors: Sofia Fili, Maria Karalaki and Bernhard Schaller

    Citation: Cancer Cell International 2009 9:26

    Content type: Review

    Published on:

  35. Glucosamine is known as a toxic agent for several malignant cell lines and transplanted tumors with little toxicity to normal host tissues. However, the mechanisms underlying anticancer activity of glucosamine...

    Authors: Viktor Chesnokov, Chao Sun and Keiichi Itakura

    Citation: Cancer Cell International 2009 9:25

    Content type: Primary research

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  36. The Signal Transducer and Activator of Transcription (STAT) proteins comprise a family of latent transcription factors with diverse functions. STAT3 has well established roles in cell proliferation, growth and...

    Authors: Brian Hutzen, William Willis, Sarah Jones, Ling Cen, Stephanie Deangelis, Beng Fuh and Jiayuh Lin

    Citation: Cancer Cell International 2009 9:24

    Content type: Primary research

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  37. Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+. Up regulation of genes which contribute to store operated channel...

    Authors: Ebru Aydar, Syn Yeo, Mustafa Djamgoz and Christopher Palmer

    Citation: Cancer Cell International 2009 9:23

    Content type: Primary research

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  38. Gap junction intercellular communication (GJIC) is considered to play a role in the regulation of homeostasis because it regulates important processes, such as cell proliferation and cell differentiation. A re...

    Authors: Marisa Ionta, Raphael Adolpho Sant'ana Ferreira, Sandra Cristina Pfister and Gláucia Maria Machado-Santelli

    Citation: Cancer Cell International 2009 9:22

    Content type: Primary research

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  39. The human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces apoptosis after cell cycle arrest at the G2 phase in primate cells. We have reported previously that C81, a carboxy-terminally truncat...

    Authors: Mizuho Nonaka, Yoshie Hashimoto, Shin-nosuke Takeshima and Yoko Aida

    Citation: Cancer Cell International 2009 9:20

    Content type: Primary research

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