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  1. Cancer begins with multiple cumulative epigenetic and genetic alterations that sequencially transform a cell, or a group of cells in a particular organ. The early genetic events might lead to clonal expansion ...

    Authors: Gabriel D Dakubo, John P Jakupciak, Mark A Birch-Machin and Ryan L Parr

    Citation: Cancer Cell International 2007 7:2

    Content type: Review

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  2. Prolactinoma is the most frequent pituitary tumor in humans. The dopamine D2 receptor agonist bromocriptine has been widely used clinically to treat human breast tumor and prolactinoma through inhibition of hyper...

    Authors: Yan-Nian Jiang, Yi-Hung Li, Meng-Wei Ke, Ting-Yu Tseng, Yueh-Bih Tang, Mu-Chiou Huang, Winston Teng-Kuei Cheng and Yu-Ten Ju

    Citation: Cancer Cell International 2007 7:1

    Content type: Primary research

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  3. Mucosal squamous cell carcinoma of the head and neck is a disease of high mortality and morbidity. Interactions between the squamous cell carcinoma and the host's local immunity, and how the latter contributes...

    Authors: Sydney Ch'ng, Michael Sullivan, Lan Yuan, Paul Davis and Swee T Tan

    Citation: Cancer Cell International 2006 6:28

    Content type: Primary research

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  4. It is widely assumed that genotoxin-induced damage (e.g., G-to-T transversions) to the tumor suppressor gene, p53, is a direct cause of cancer. However, genotoxins also induce the stress response, which upregulat...

    Authors: Barbara Wright, Jacqueline Reimers, Karen Schmidt, Evan Burkala, Nick Davis and Ping Wei

    Citation: Cancer Cell International 2006 6:27

    Content type: Hypothesis

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  5. Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, and nearly 40% of UM will develop metastasis that will ultimately lead to death. The Epithelial Cell Adhesion Molecule (EpC...

    Authors: Danilo N Odashiro, Alexandre N Odashiro, Patrícia R Pereira, Katyanne Godeiro, Emilia Antecka, Sebastian Di Cesare and Miguel N Burnier Jr

    Citation: Cancer Cell International 2006 6:26

    Content type: Primary research

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  6. We describe the basic tenets of the current concepts of cancer biology, and review the recent advances on the suppressor role of senescence in tumor growth and the breakdown of this barrier during the origin o...

    Authors: Rengaswami Rajaraman, Duane L Guernsey, Murali M Rajaraman and Selva R Rajaraman

    Citation: Cancer Cell International 2006 6:25

    Content type: Hypothesis

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  7. Reports showing susceptibility of multidrug resistant (MDR) cancer cells to immune effectors, together with P-glycoprotein (P-gp) expression in immune effector subsets, including immature natural killer (NK) c...

    Authors: Burhan Savas, Pauline E Kerr and Hugh F Pross

    Citation: Cancer Cell International 2006 6:24

    Content type: Primary research

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  8. The blood plasma and other intertissue fluids usually contain a certain amount of DNA, getting there due to a natural cell death in the organism. Cells of this organism can capture the extracellular DNA, where...

    Authors: Vladimir A Rogachev, Anastasia Likhacheva, Oksana Vratskikh, Lyudmila V Mechetina, Tamara E Sebeleva, Sergei S Bogachev, Leonid A Yakubov and Mikhail A Shurdov

    Citation: Cancer Cell International 2006 6:23

    Content type: Primary research

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  9. Despite significant achievements in the treatment of cervical cancer, it is still a deadly disease; hence newer therapeutical modalities are needed. Preliminary investigations suggest that platelet-derived gro...

    Authors: Lucia Taja-Chayeb, Alma Chavez-Blanco, Jorge Martínez-Tlahuel, Aurora González-Fierro, Myrna Candelaria, Jose Chanona-Vilchis, Elizabeth Robles and Alfonso Dueñas-Gonzalez

    Citation: Cancer Cell International 2006 6:22

    Content type: Primary research

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  10. p27(Kip1) is a cyclin-dependent kinase inhibitor. When up-regulated, p27 inhibits G1-to-S phase transition of the cell cycle. This report addresses the question of whether various nutritional and chemopreventi...

    Authors: Isao Eto

    Citation: Cancer Cell International 2006 6:20

    Content type: Primary research

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  11. Human papillomavirus type 16 (HPV-16) E5 protein co-operates with epidermal growth factor to stimulate mitogenesis of murine fibroblasts. Currently, little is known about which viral amino acids are involved i...

    Authors: Rahul Nath, Christine A Mant, Barbara Kell, John Cason and Jon M Bible

    Citation: Cancer Cell International 2006 6:19

    Content type: Primary research

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  12. Hepatitis C (HCV) viral infection is a serious medical problem in Egypt and it has a devastating impact on the Egyptian economy. It is estimated that over 15% of Egyptians are infected by the virus and thus fi...

    Authors: Mostafa K El Awady, Noha G Badr El Din, Wael T El Garf, Samar S Youssef, Moataza H Omran, Jasmin El Abd and Said A Goueli

    Citation: Cancer Cell International 2006 6:18

    Content type: Primary research

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  13. Cationic (positively charged) liposomes have been tested in various gene therapy clinical trials for neoplastic and other diseases. They have demonstrated selectivity for tumour vascular endothelial cells rais...

    Authors: Crispin R Dass and Peter FM Choong

    Citation: Cancer Cell International 2006 6:17

    Content type: Review

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  14. Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. ...

    Authors: Britny J Candia, William C Hines, Christopher M Heaphy, Jeffrey K Griffith and Robert A Orlando

    Citation: Cancer Cell International 2006 6:16

    Content type: Primary research

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  15. Immortalization is a key step in malignant transformation, but immortalization alone is insufficient for transformation. Human mammary epithelial cell (HMEC) transformation is a complex process that requires a...

    Authors: Krishna Rao, Özge Alper, Kent E Opheim, George Bonnet, Kristine Wolfe, Eileen Bryant, Siobhan O'Hara Larivee, Peggy Porter and James K McDougall

    Citation: Cancer Cell International 2006 6:15

    Content type: Primary research

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  16. Human papillomavirus has been implicated in virtually all cervical cancers and is believed to be the primary etiological factor that transforms cervical epithelia. The presence of HPV in oral cancers suggests ...

    Authors: Karl Kingsley, Devin Johnson and Susan O'Malley

    Citation: Cancer Cell International 2006 6:14

    Content type: Primary research

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  17. Integrin-linked kinase (ILK) is a ubiquitously expressed protein kinase that has emerged as one of the points of convergence between integrin- and growth factor-signalling pathways.

    Authors: Glenn A Driver and Robin B Veale

    Citation: Cancer Cell International 2006 6:12

    Content type: Primary research

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  18. We have demonstrated that in some human cancer cells both chronic mild heat and ionizing radiation exposures induce a transient block in S and G2 phases of the cell cycle. During this delay, cyclin B1 protein ...

    Authors: Fiorenza Ianzini, Alessandro Bertoldo, Elizabeth A Kosmacek, Stacia L Phillips and Michael A Mackey

    Citation: Cancer Cell International 2006 6:11

    Content type: Primary research

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  19. Zinc plays important roles in maintaining normal function of the prostate and in development of prostate malignancy. It has been demonstrated that prostate malignant epithelial cells contain much less cellular...

    Authors: Liping Huang, Catherine P Kirschke and Yunfan Zhang

    Citation: Cancer Cell International 2006 6:10

    Content type: Primary research

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  20. Lovastatin and other statins may reduce the development of melanomas. The effects on melanoma cells and their ability to enhance angiogenesis in a co-culture system presented an opportunity to assess whether L...

    Authors: Ivan Depasquale and Denys N Wheatley

    Citation: Cancer Cell International 2006 6:9

    Content type: Primary research

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  21. Plasminogen activators are known to play a key role in the remodeling of bone matrix which occurs during tumor progression, bone metastasis and bone growth. Dysfunctional remodeling of bone matrix gives rise t...

    Authors: Daniel Vial, Elizabeth Monaghan-Benson and Paula J McKeown-Longo

    Citation: Cancer Cell International 2006 6:8

    Content type: Primary research

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  22. Chlorogenic acid (CHL), the most potent functional inhibitor of the microsomal glucose-6-phosphate translocase (G6PT), is thought to possess cancer chemopreventive properties. It is not known, however, whether...

    Authors: Anissa Belkaid, Jean-Christophe Currie, Julie Desgagnés and Borhane Annabi

    Citation: Cancer Cell International 2006 6:7

    Content type: Primary research

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  23. In order to explore a pre-clinical method to evaluate if [18F]FDG is valid for monitoring early response, we investigated the uptake of FDG in Multicellular tumour spheroids (MTS) without and with treatment with ...

    Authors: Azita Monazzam, Pasha Razifar, Martin Simonsson, Fredrik Qvarnström, Raymond Josephsson, Carl Blomqvist, Bengt Långström and Mats Bergström

    Citation: Cancer Cell International 2006 6:6

    Content type: Primary research

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  24. Cancer is one of the most complex dynamic human disease. Despite rapid advances in the fields of molecular and cell biology, it is still widely debated as to how neoplastic cells progress through carcinogenesi...

    Authors: Fabio Grizzi and Maurizio Chiriva-Internati

    Citation: Cancer Cell International 2006 6:4

    Content type: Review

    Published on:

  25. The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein Phosphatase 1 (PP1). At mitotic exit, all three PP1 isoforms, α, γ1 and δ, bind to pRb and dephosphorylate its Ser/Thr sit...

    Authors: Michele Vietri, Mariarita Bianchi, John W Ludlow, Sibylle Mittnacht and Emma Villa-Moruzzi

    Citation: Cancer Cell International 2006 6:3

    Content type: Primary research

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  26. Among the epigenetic alterations occurring in cancer, DNA hypermethylation and histone hypoacetylation are the focus of intense research because their pharmacological inhibition has shown to produce antineopla...

    Authors: Alma Chavez-Blanco, Carlos Perez-Plasencia, Enrique Perez-Cardenas, Claudia Carrasco-Legleu, Edgar Rangel-Lopez, Blanca Segura-Pacheco, Lucia Taja-Chayeb, Catalina Trejo-Becerril, Aurora Gonzalez-Fierro, Myrna Candelaria, Gustavo Cabrera and Alfonso Duenas-Gonzalez

    Citation: Cancer Cell International 2006 6:2

    Content type: Primary research

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  27. Pluripotent mouse embryonic stem (ES) cells can be induced in vitro to become neural progenitors. Upon transplantation, neural progenitors migrate toward areas of damage and inflammation in the CNS. We tested whe...

    Authors: Peter Serfozo, Maggie S Schlarman, Chris Pierret, Bernard L Maria and Mark D Kirk

    Citation: Cancer Cell International 2006 6:1

    Content type: Primary research

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  28. Mitochondrial DNA (mtDNA) is known for high mutation rates caused by lack of protective histones, inefficient DNA repair systems, and continuous exposure to mutagenic effects of oxygen radicals. Alterations in...

    Authors: Himani Sharma, Archna Singh, Chandresh Sharma, Sunesh Kumar Jain and Neeta Singh

    Citation: Cancer Cell International 2005 5:34

    Content type: Primary research

    Published on:

  29. Clinicians will argue that cancer can only really receive the treatment that is needed through thorough understanding of medicine. However, even empirical approaches to therapy result in experimental analysis ...

    Authors: Denys N Wheatley Editor-in-Chief, Cancer Cell International

    Citation: Cancer Cell International 2005 5:33

    Content type: Editorial

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  30. Considering the width and importance of using Multicellular Tumor Spheroids (MTS) in oncology research, size determination of MTSs by an accurate and fast method is essential. In the present study an effective...

    Authors: Azita Monazzam, Pasha Razifar, Örjan Lindhe, Raymond Josephsson, Bengt Långström and Mats Bergström

    Citation: Cancer Cell International 2005 5:32

    Content type: Primary research

    Published on:

  31. It is known that aurora B, a chromosomal passenger protein responsible for the proper progression of mitosis and cytokinesis, is overexpressed throughout the cell cycle in cancer cells. Overexpression of auror...

    Authors: Ash-shafie Abdullah, Charlene Foong and Maki Murata-Hori

    Citation: Cancer Cell International 2005 5:31

    Content type: Primary research

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  32. The p23.2 region of human chromosome 8 is frequently deleted in several types of epithelial cancer and those deletions appear to be associated with poor prognosis. Cub and Sushi Multiple Domains 1 (CSMD1) was pos...

    Authors: Toni M Richter, Benton D Tong and Steven B Scholnick

    Citation: Cancer Cell International 2005 5:29

    Content type: Primary research

    Published on:

  33. Many anticancer agents and carcinogens are DNA damaging chemicals and exposure to such chemicals results in the deregulation of cell cycle progression. The molecular mechanisms of DNA damage-induced cell cycle...

    Authors: Huijun Zhu, Catherine Smith, Charles Ansah and Nigel J Gooderham

    Citation: Cancer Cell International 2005 5:28

    Content type: Primary research

    Published on:

  34. p53 is important in the development of hepatocellular carcinoma (HCC) and in therapeutic approaches, but the mechanism whereby it inhibits HCC growth is still unclear. The aim of the present study was to estab...

    Authors: Tian-Yi Chi, George G Chen, Lok-Kee Ho and Paul BS Lai

    Citation: Cancer Cell International 2005 5:27

    Content type: Primary research

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  35. Sodium weighted images can indicate sodium signal intensities from different features in the tumor before and 24 hours following administration of Taxotere.

    Authors: Rakesh Sharma, Richard P Kline, Ed X Wu and Jose K Katz

    Citation: Cancer Cell International 2005 5:26

    Content type: Primary research

    Published on:

  36. This study was undertaken to examine the relationship between the tumor suppressor gene p53 and the nuclear signaling protein beta-catenin during bone differentiation. Cross talk between p53 and beta-catenin p...

    Authors: Nalini Chandar, Rasleen Saluja, Peter C Lamar, Kevin Kolman and Walter C Prozialeck

    Citation: Cancer Cell International 2005 5:24

    Content type: Primary research

    Published on:

  37. The effects of a rectified semi-sinewave signal (15 mT amplitude, 120 pulses per second, EMF Therapeutics, Inc.) (TEMF) alone and in combination with gamma irradiation (IR) therapy in nude mice bearing a human...

    Authors: Ivan L Cameron, Lu-Zhe Sun, Nicholas Short, W Elaine Hardman and C Douglas Williams

    Citation: Cancer Cell International 2005 5:23

    Content type: Primary research

    Published on:

  38. Multidrug resistance mediated by the multidrug resistance-associated protein 1 (MRP1) decreases cellular drug accumulation. The exact mechanism of MRP1 involved multidrug resistance has not been clarified yet,...

    Authors: Ilhan Akan, Selma Akan, Hakan Akca, Burhan Savas and Tomris Ozben

    Citation: Cancer Cell International 2005 5:22

    Content type: Primary research

    Published on:

  39. A secreted peptide Pep27 initiates the cell death program in S. pneumoniae through signal transduction. This study was undertaken to evaluate the relation between the structure and cytotoxic activity of Pep27 and...

    Authors: Dong Gun Lee, Kyung-Soo Hahm, Yoonkyung Park, Hai-Young Kim, Weontae Lee, Sung-Chul Lim, Youn-Kyung Seo and Cheol-Hee Choi

    Citation: Cancer Cell International 2005 5:21

    Content type: Primary research

    Published on:

  40. Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular sphe...

    Authors: Ponce de León Valeria and Barrera-Rodríguez Raúl

    Citation: Cancer Cell International 2005 5:20

    Content type: Primary research

    Published on:

  41. Insensitivity of advanced-stage prostate cancer to androgen ablation therapy is a serious problem in clinical practice because it is associated with aggressive progression and poor prognosis. Targeted therapeu...

    Authors: Ekwere T Ifon, Alan LY Pang, Warren Johnson, Kathleen Cashman, Sharon Zimmerman, Sumitra Muralidhar, Wai-Yee Chan, John Casey and Leonard Jason Rosenthal

    Citation: Cancer Cell International 2005 5:19

    Content type: Primary research

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  42. A neoplastic tumor cannot grow beyond a millimeter or so in diameter without recruitment of endothelial cells and new blood vessels to supply nutrition and oxygen for tumor cell survival. This study was design...

    Authors: Ivan L Cameron, Nicholas Short, LuZhe Sun and W Elaine Hardman

    Citation: Cancer Cell International 2005 5:17

    Content type: Primary research

    Published on:

  43. Combined effect of vanadium and beta-carotene on rat liver DNA-chain break and Proton induced X-ray emission (PIXE) analysis was studied during a necrogenic dose (200 mg/kg of body weight) of Diethyl Nitrosami...

    Authors: Mitali Basu Chattopadhyay, Sutapa Mukherjee, Indira Kulkarni, V Vijayan, Manika Doloi, NB Kanjilal and Malay Chatterjee

    Citation: Cancer Cell International 2005 5:16

    Content type: Primary research

    Published on:

  44. Multidrug resistance (MDR) phenotype of malignant cells is the major problem in the chemotherapy of neoplasia. The treatment of leukemia with retinoids is aimed on the induction of leukemic cells differentiati...

    Authors: Tatjana P Stromskaya, Ekaterina Y Rybalkina, Tatjana N Zabotina, Alexander A Shishkin and Alla A Stavrovskaya

    Citation: Cancer Cell International 2005 5:15

    Content type: Primary research

    Published on:

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