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  1. Up-regulation of heat shock protein 70 (HSP70) could be elicited primarily by heat in former studies, and this was proved to be associated with cancer progression. Burkitt's lymphoma is one of highly aggressiv...

    Authors: Xiaosheng Fang, Yujie Jiang, Lili Feng, Haiping Chen, Changqing Zhen, Mei Ding and Xin Wang

    Citation: Cancer Cell International 2013 13:48

    Content type: Primary research

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  2. Cranial radiation therapy has been used for the treatment of primary and metastatic brain tumors. A prominent feature of brain injury induced by the radiation therapy is hippocampal dysfunction, characterized ...

    Authors: Ai-Min Sun, Chuan-Gang Li, Yong-Qing Han, Que-Ling Liu, Qiong Xia and Ya-Wei Yuan

    Citation: Cancer Cell International 2013 13:47

    Content type: Primary research

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  3. The multidrug resistance (MDR) 1 gene encodes a 170-kDa membrane transporter called P-glycoprotein, which plays an important role in protecting cells against lipophilic xenobiotics by the way of an ATP-dependent ...

    Authors: Ling-Hui Wang, Yan-Bin Song, Wen-Ling Zheng, Ling Jiang and Wen-Li Ma

    Citation: Cancer Cell International 2013 13:46

    Content type: Primary research

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  4. MicroRNAs are small RNA molecules that negatively regulate gene expression by translational inhibition or mRNA cleavage. The discovery that abnormal expression of particular miRNAs contributes to human disease...

    Authors: Sanja Jurcevic, Björn Olsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2013 13:45

    Content type: Primary research

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  5. Endometrial cancer (EC) is the most common gynecologic malignancy, but the molecular events involved in the development and progression of EC remain unclear. This study aimed to explore epigenetic modification...

    Authors: Bi-Lan Li, Wen Lu, Cong Lu, Jun-jie Qu, Ting-ting Yang, Qin Yan and Xiao-ping Wan

    Citation: Cancer Cell International 2013 13:44

    Content type: Primary research

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  6. We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53,...

    Authors: Michael Jelínek, Kamila Balušíková, Dana Kopperová, Vlasta Němcová-Fürstová, Jan Šrámek, Julie Fidlerová, Ilaria Zanardi, Iwao Ojima and Jan Kovář

    Citation: Cancer Cell International 2013 13:42

    Content type: Primary research

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  7. Nowadays, we believe that cancer is a genetic disease. We focus on the genetic targets and epigenetic changes in a tumor. Remarkably, many crucial signal pathways in a malignant cell involve “stem-ness” genes....

    Authors: Shi-Ming Tu

    Citation: Cancer Cell International 2013 13:40

    Content type: Hypothesis

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  8. The cancer stem cell (CSC) theory proposes that tumours arise from and are sustained by a subpopulation of cells with both cancer and stem cell properties. One of the key hallmarks of CSCs is the ability to gr...

    Authors: Jo-Anne de la Mare, Jason N Sterrenberg, Mugdha G Sukhthankar, Maynard T Chiwakata, Denzil R Beukes, Gregory L Blatch and Adrienne L Edkins

    Citation: Cancer Cell International 2013 13:39

    Content type: Primary research

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  9. Lung cancer often exhibits molecular changes, such as the overexpression of the ErbB1 gene. ErbB1 encodes epidermal growth factor receptor (EGFR), a tyrosine kinase receptor, involved mainly in cell proliferat...

    Authors: Camila Lauand, Paula Rezende-Teixeira, Beatriz Araújo Cortez, Evandro Luís de Oliveira Niero and Gláucia Maria Machado-Santelli

    Citation: Cancer Cell International 2013 13:38

    Content type: Primary research

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  10. To elucidate the characteristics of T-cell receptor (TCR) signal transduction in T-cells from acute myeloid leukemia (AML), the mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1 (MALT1), A20, NF-...

    Authors: Li Shi, Shaohua Chen, Yuhong Lu, Xu Wang, Ling Xu, Fan Zhang, Lijian Yang, Xiuli Wu, Bo Li and Yangqiu Li

    Citation: Cancer Cell International 2013 13:37

    Content type: Primary research

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  11. Hypoxia inducible factor-1 α (HIF-1α) has been identified as an important novel target in apoptosis resistance of pediatric tumors such as Rhabdomyosarcoma (RMS) and Ewing’s sarcoma (ES). Evidence suggests tha...

    Authors: Mehtap Kilic-Eren, Tulin Boylu and Vedrana Tabor

    Citation: Cancer Cell International 2013 13:36

    Content type: Primary research

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  12. T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy. Immune tolerance induced by CD4+CD25+ regulatory T cells (Tregs) with high expression of Foxp3 is an important hypothesis...

    Authors: Xiaodan Luo, Huo Tan, Yueqiao Zhou, Tiantian Xiao, Chunyan Wang and Yangqiu Li

    Citation: Cancer Cell International 2013 13:34

    Content type: Primary research

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  13. Ovarian cancer constitutes nearly 4% of all cancers among women and is the leading cause of death from gynecologic malignancies in the Western world. Standard first line adjuvant chemotherapy treatments includ...

    Authors: Ilenia Pellicciotta, Chia-Ping Huang Yang, Charis A Venditti, Gary L Goldberg and Shohreh Shahabi

    Citation: Cancer Cell International 2013 13:33

    Content type: Primary research

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  14. The use of imatinib, an ABL tyrosine kinase inhibitor, has led to a dramatic change in the management of BCR-ABL-positive leukemia patients. However, resistance to imatinib mediated by mutations in the BCR-ABL...

    Authors: Seiichi Okabe, Tetsuzo Tauchi, Yuko Tanaka, Shinya Kimura, Taira Maekawa and Kazuma Ohyashiki

    Citation: Cancer Cell International 2013 13:32

    Content type: Primary research

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  15. Liver cancer is one of the most frequent cancers in the world. Targeted therapy of cancer with specific inhibitors is developing and has shown promising antitumor efficacy. CCI-779 (temsirolimus), a specific i...

    Authors: Shuyu Li, Yan Liang, Manlin Wu, Xiaojing Wang, Haixia Fu, Yuhao Chen and Zhigang Wang

    Citation: Cancer Cell International 2013 13:30

    Content type: Primary research

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  16. We have investigated the ability of Mifepristone, an anti-progestin and anti-glucocorticoid drug, to modulate the antitumor effect of current standard clinical treatment in glioblastoma xenografts.

    Authors: Monserrat Llaguno-Munive, Luis Alberto Medina, Rafael Jurado, Mario Romero-Piña and Patricia Garcia-Lopez

    Citation: Cancer Cell International 2013 13:29

    Content type: Primary research

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  17. Macrophage migration inhibitory factor (MIF) is important in regulating cell proliferation and apoptosis in both normal and cancerous cells, and may be important in cancer progression and metastasis. In human ...

    Authors: Yubiao Guo, Junna Hou, Yifeng Luo and Dujuan Wang

    Citation: Cancer Cell International 2013 13:28

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2013 13:84

  18. The editor and editorial board of Cancer Cell International would like to thank Angela Panther for her continued hard work throughout 2012 in keeping the journal going as our managing editor. We take this opportu...

    Authors: Denys Wheatley

    Citation: Cancer Cell International 2013 13:22

    Content type: Reviewer acknowledgement

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  19. β-elemene, a natural sesquiterpene extracted from the essential oils of Curcuma aromatica Salisb, has been shown to be effective against a wide range of tumors. In this study, the antitumor effect of β-elemene on...

    Authors: Zhi-Jun Dai, Wei Tang, Wang-Feng Lu, Jie Gao, Hua-Feng Kang, Xiao-Bin Ma, Wei-Li Min, Xi-Jing Wang and Wen-Ying Wu

    Citation: Cancer Cell International 2013 13:27

    Content type: Primary research

    Published on:

  20. Beclin1 is a well-known key regulator of autophagy, which is also a haploinsufficient tumor suppressor. Current studies revealed that down-regulation or monoallelic deletions of Beclin1 were frequently found i...

    Authors: Xiaoshu Li, Jun Yan, Lisheng Wang, Fengjun Xiao, Yuefeng Yang, Xiaozhong Guo and Hua Wang

    Citation: Cancer Cell International 2013 13:26

    Content type: Primary research

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  21. Arsenic Trioxide (ATO) has shown remarkable efficacy for the treatment of multiple myeloma (MM). However, the mechanism by which ATO exerts its inhibitory effect on the proliferation of myeloma cells remains t...

    Authors: Jiasheng Hu, Xiao Huang, Xiuli Hong, Quanyi Lu and Xiongpeng Zhu

    Citation: Cancer Cell International 2013 13:25

    Content type: Primary research

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  22. Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Although much is known about both the cellular changes that lead to HCC and the etiological agents responsible for the majority of HCC ca...

    Authors: Yan Zhao, Wang Jian, Wei Gao, Ya-Xin Zheng, Yong-Kun Wang, Zhu-Qing Zhou, Hui Zhang and Cong-Jun Wang

    Citation: Cancer Cell International 2013 13:23

    Content type: Primary research

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  23. Diverse functions of microRNAs (miRNAs), including effects on tumorigenesis, proliferation, and differentiation, have been reported, and several miRNAs have also been demonstrated to play an important role in ...

    Authors: Keiichiro Iida, Jun-ichi Fukushi, Yoshihiro Matsumoto, Yoshinao Oda, Yusuke Takahashi, Toshifumi Fujiwara, Yuko Fujiwara-Okada, Mihoko Hatano, Akira Nabashima, Satoshi Kamura and Yukihide Iwamoto

    Citation: Cancer Cell International 2013 13:21

    Content type: Primary research

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  24. Clear cell renal cell carcinoma (ccRCC) cell lines with distinct metastatic potential are essential to study the mechanism of ccRCC metastasis. However, none of them originated from Chinese.

    Authors: Xiaojie Tan, Songqin He, Yifang Han, Yongwei Yu, Jianru Xiao, Danfeng Xu, Guoping Wang, Yan Du, Wenjun Chang, Jianhua Yin, Tong Su, Jianguo Hou and Guangwen Cao

    Citation: Cancer Cell International 2013 13:20

    Content type: Primary research

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  25. Malignant mesothelioma is an asbestos-related fatal disease with no effective cure. We studied whether a green tea polyphenol, epigallocathechin-3-gallate (EGCG), could induce cell death in five human mesothel...

    Authors: Motohiko Satoh, Yukitoshi Takemura, Hironobu Hamada, Yoshitaka Sekido and Shunichiro Kubota

    Citation: Cancer Cell International 2013 13:19

    Content type: Primary research

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  26. The loss of tumor suppressor gene expression is involved in the carcinogenesis of gastric cancer (GC). Klotho is a recently identified tumor suppressor gene that epigenetically inactivated in gastric cancer. Howe...

    Authors: Biao Xie, Jianping Zhou, Guoshun Shu, Dong-cai Liu, Jiapeng Zhou, Jinhui Chen and Lianwen Yuan

    Citation: Cancer Cell International 2013 13:18

    Content type: Primary research

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  27. A fribotic tumor microenvironment promotes progression of cancer. In this study, we utilize a reconstituted basement membrane mimics Matrigel based three-dimensional organotypic culture (rBM 3-D) to investigat...

    Authors: Hong T Nguyen, Yan Zhuang, Lichun Sun, Steven P Kantrow, Jay K Kolls, Zongbing You, Ying Zhuo and Bin Shan

    Citation: Cancer Cell International 2013 13:16

    Content type: Primary research

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  28. Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G...

    Authors: Ling Wang, Fubiao Kang, Jie Li, Jing Zhang and Baoen Shan

    Citation: Cancer Cell International 2013 13:14

    Content type: Primary research

    Published on:

  29. Natural products, including plants, microorganisms and marines, have been considered as valuable sources for anticancer drug discovery. Many Chinese herbs have been discovered to be potential sources of antitu...

    Authors: Shengjie Yang, Qi Zhao, Hongmei Xiang, Minjie Liu, Qiuyun Zhang, Wei Xue, Baoan Song and Song Yang

    Citation: Cancer Cell International 2013 13:12

    Content type: Primary research

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  30. Geldanamycin (GA) can be considered a relatively new component with a promising mode of action against human malignancies. It specifically targets heat shock protein 90 (Hsp90) and interferes with its function...

    Authors: Panagiotis K Karkoulis, Dimitrios J Stravopodis, Eumorphia G Konstantakou and Gerassimos E Voutsinas

    Citation: Cancer Cell International 2013 13:11

    Content type: Primary research

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  31. This study examined whether combining paclitaxel (taxol) with a novel epigenetic agent phenethyl isothiocyanate (PEITC) will yield a synergistic effect on inhibiting breast cancer cells. Two drug-resistant bre...

    Authors: Katherine Liu, Shundong Cang, Yuehua Ma and Jen Wei Chiao

    Citation: Cancer Cell International 2013 13:10

    Content type: Primary research

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  32. Senescence in the population of cells is often described as a program of restricted proliferative capacity, which is manifested by broad morphological and biochemical changes including a metabolic shift toward...

    Authors: Anna Litwiniec, Lidia Gackowska, Anna Helmin-Basa, Agnieszka Żuryń and Alina Grzanka

    Citation: Cancer Cell International 2013 13:9

    Content type: Primary research

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  33. Small cell lung cancer (SCLC) is a special kind of lung cancers, lymph or blood metastasis of SCLC usually occurs in early stage. Studies in breast and colon cancer showed over expression of SATB1 could promot...

    Authors: Bo Huang, Hongli Zhou, Xiaodong Wang and Zhiliang Liu

    Citation: Cancer Cell International 2013 13:8

    Content type: Primary research

    Published on:

  34. MicroRNAs (miRNAs) are small, non-coding RNAs (20–24 nucleotides) that post-transcriptionally modulate gene expression by negatively regulating the stability or translational efficiency of their target mRNAs. ...

    Authors: Jia Li, Xiangjie Kong, Junfeng Zhang, Qifeng Luo, Xiaoyu Li and Lin Fang

    Citation: Cancer Cell International 2013 13:7

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2013 13:17

  35. To evaluate the impacts of the negative lymph nodes (NLNs) count on the prognostic prediction of the ratio of positive and removed lymph nodes (RPL) in cervical cancer patients after radical hysterectomy and p...

    Authors: Ying Chen, Lei Zhang, Jing Tian, Xiubao Ren and Quan Hao

    Citation: Cancer Cell International 2013 13:6

    Content type: Primary research

    Published on:

  36. Metastatic brain tumours are a common end stage of breast cancer progression, with significant associated morbidity and high mortality. Walker 256 is a rat breast carcinoma cell line syngeneic to Wistar rats a...

    Authors: Kate M Lewis, Elizabeth Harford-Wright, Robert Vink and Mounir N Ghabriel

    Citation: Cancer Cell International 2013 13:5

    Content type: Primary research

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  37. TWIST1 plays a key role in EMT-mediated tumor invasion and metastasis. Since bone metastasis is a hallmark of advanced prostate cancer and is detected in at least 85% of patients who die of this disease, it is...

    Authors: Turid Eide, Håkon Ramberg, Carlotta Glackin, Donald Tindall and Kristin Austlid Taskén

    Citation: Cancer Cell International 2013 13:4

    Content type: Primary research

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  38. Hepatocellular carcinoma (HCC) exhibits strong intrinsic and acquired drug resistance which is the main obstacle to chemotherapy. Overexpression of ATP binding cassette (ABC) proteins correlates with activatio...

    Authors: Shibo Lin, Katrin Hoffmann, Zhi Xiao, Nan Jin, Uwe Galli, Elvira Mohr, Markus W Büchler and Peter Schemmer

    Citation: Cancer Cell International 2013 13:3

    Content type: Primary research

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  39. Mirk/Dyrk1B contributes to G0 arrest by destabilization of cyclin D1 and stabilization of p27kip1 to maintain the viability of quiescent human cancer cells, and it could be negatively regulated by mitogenic-ac...

    Authors: Jingchun Gao, Yi Zhao, Yunyi Lv, Yamin Chen, Bing Wei, Jianxin Tian, Zhihai Yang, Fandou Kong, Jian Pang, Jiwei Liu and Hong Shi

    Citation: Cancer Cell International 2013 13:2

    Content type: Primary research

    Published on:

  40. Cellular FLICE-Inhibitory Protein (long form, c-FLIPL) is a critical negative regulator of death receptor-mediated apoptosis. Overexpression of c-FLIPL has been reported in many cancer cell lines and is associate...

    Authors: Qilin Wang, Wendong Sun, Xuexi Hao, Tianliang Li, Ling Su and Xiangguo Liu

    Citation: Cancer Cell International 2012 12:54

    Content type: Primary research

    Published on:

  41. Cyclooxygenase-2(COX-2) promotes carcinogenesis, tumor proliferation, angiogenesis, prevention of apoptosis, and immunosuppression. Meanwhile, COX-2 over-expression has been associated with tumor behavior and ...

    Authors: Zhi-Jun Dai, Xiao-Bin Ma, Hua-Feng Kang, Jie Gao, Wei-Li Min, Hai-Tao Guan, Yan Diao, Wang-Feng Lu and Xi-Jing Wang

    Citation: Cancer Cell International 2012 12:53

    Content type: Primary research

    Published on:

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