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  1. In this report the phytochemical profile of Nitraria. Retusa (N. Retusa) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated.

    Authors: Jihed Boubaker, Wissem Bhouri, Mohamed Ben Sghaier, Ines Bouhlel, Ines Skandrani, Kamel Ghedira and Leila Chekir-Ghedira

    Citation: Cancer Cell International 2011 11:37

    Content type: Primary research

    Published on:

  2. Hepatocellular carcinoma (HCC) accounts for majority of liver cancers and is the leading cause of cancer related death in Asia. Like any other cancer, HCC develops when there is a mutation to the cellular mach...

    Authors: SNCVL Pushpavalli, M Janaki Ramaiah, Ch Srinivas, Debasmita Mukhopadhya, JL Aditya, Ravindra M Kumbhare, Utpal Bhadra and Manika Pal Bhadra

    Citation: Cancer Cell International 2011 11:36

    Content type: Primary research

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  3. The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT)...

    Authors: Jessica T Li, Ka Bian, Alan L Zhang, Dong H Kim, William W Ashley, Rahul Nath, Ian McCutcheon, Bingliang Fang and Ferid Murad

    Citation: Cancer Cell International 2011 11:35

    Content type: Primary research

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  4. Rhabdoid tumors (RTs) are aggressive pediatric malignancies with poor prognosis. N-(4-hydroxy phenyl) retinamide (4-HPR or fenretinide) is a potential chemotherapeutic for RTs with activity correlated to its a...

    Authors: Melissa E Smith, Bhaskar C Das and Ganjam V Kalpana

    Citation: Cancer Cell International 2011 11:34

    Content type: Primary research

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  5. Multiple innate and adaptive immune effector cells and molecules partake in the recognition and destruction of cancer cells to protect against growing tumors, a concept that is known as cancer immunosurveillan...

    Authors: Heba A Alshaker and Khalid Z Matalka

    Citation: Cancer Cell International 2011 11:33

    Content type: Review

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  6. Cell fusion induced by polyethylene glycol (PEG) is an efficient but poorly controlled procedure for obtaining somatic cell hybrids used in gene mapping, monoclonal antibody production, and tumour immunotherap...

    Authors: Filippo Pedrazzoli, Iraklis Chrysantzas, Luca Dezzani, Vittorio Rosti, Massimo Vincitorio and Giammaria Sitar

    Citation: Cancer Cell International 2011 11:32

    Content type: Primary research

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  7. The objective of this study was to investigate whether the levels of glucose or certain amino acids could regulate the expression of a cell cycle repressor protein p27(Kip1), thereby dictating the risk of canc...

    Authors: Isao Eto

    Citation: Cancer Cell International 2011 11:31

    Content type: Primary research

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  8. The synergic action of KHCO3 and D-ribose is tested on A72 and HTB-126 cell lines proliferation using K:D-Rib solution. Altered Na+/K+ ATPase expression and activity were shown in patients with cancer. Studies in...

    Authors: Simonetta Croci, Luca Bruni, Simona Bussolati, Marianna Castaldo and Maurizio Dondi

    Citation: Cancer Cell International 2011 11:30

    Content type: Primary research

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  9. The inhibition of Br east Ca ncer 1 (BRCA1) expression sensitizes breast and ovarian cancer cells to platinum chemotherapy. However, therapeutically relevant agents that target BRCA1 expression have not been iden...

    Authors: Johanne I Weberpals, Anna M O'Brien, Nima Niknejad, Kyla D Garbuio, Katherine V Clark-Knowles and Jim Dimitroulakos

    Citation: Cancer Cell International 2011 11:29

    Content type: Primary research

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  10. Molecular classification of human breast cancers has identified at least 5 distinct tumor subtypes; luminal A, luminal B, Her2-enriched, basal-like and claudin-low. The claudin-low subtype was identified in 20...

    Authors: Craig I Campbell, Devan E Thompson, Megan D Siwicky and Roger A Moorehead

    Citation: Cancer Cell International 2011 11:28

    Content type: Primary research

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  11. In this study, we pilot tested an in vitro assay of cancer killing activity (CKA) in circulating leukocytes of 22 cancer cases and 25 healthy controls.

    Authors: Michael J Blanks, John R Stehle Jr, Wei Du, Jonathan M Adams, Mark C Willingham, Glenn O Allen, Jennifer J Hu, James Lovato, Istvan Molnar and Zheng Cui

    Citation: Cancer Cell International 2011 11:26

    Content type: Primary research

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  12. Many potassium ion (K+) channels function as oncogenes to sustain growth of solid tumors, but their role in cancer progression is not well understood. Emerging evidence suggests that the early progenitor cancer c...

    Authors: Brandon M Schickling, Nukhet Aykin-Burns, Kimberly K Leslie, Douglas R Spitz and Victoria P Korovkina

    Citation: Cancer Cell International 2011 11:25

    Content type: Primary research

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  13. In adults, bone is the preferential target site for metastases from primary cancers of prostate, breast, lungs and thyroid. The tendency of these cancers to metastasize to bone is determined by the anatomical ...

    Authors: Liviu Feller, Beverley Kramer and Johan Lemmer

    Citation: Cancer Cell International 2011 11:24

    Content type: Review

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  14. Brain-derived neurotrophic factor (BDNF) has established physiological roles in the development and function of the vertebrate nervous system. BDNF has also been implicated in several human malignancies, inclu...

    Authors: Neill Patani, Wen G Jiang and Kefah Mokbel

    Citation: Cancer Cell International 2011 11:23

    Content type: Primary research

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  15. Previously we have shown that oncogenic Ha-Ras stimulated in vivo metastasis through RalGEF-Ral signaling. RalA and RalB are highly homologous small G proteins belonging to Ras superfamily. They can be activated ...

    Authors: Vera A Rybko, Anna V Knizhnik, Andrei V Komelkov, Vasily N Aushev, Lyubov S Trukhanova and Elena M Tchevkina

    Citation: Cancer Cell International 2011 11:22

    Content type: Primary research

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  16. Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tis...

    Authors: Christa Nagler, Cornelia Hardt, Kurt S Zänker and Thomas Dittmar

    Citation: Cancer Cell International 2011 11:21

    Content type: Primary research

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  17. Genomic alterations are common features of cancer cells, and some of these changes are proven to be neoplastic-specific. Such alterations may serve as valuable tools for diagnosis and classification of tumors,...

    Authors: Eva Falck, Carola Hedberg, Karin Klinga-Levan and Afrouz Behboudi

    Citation: Cancer Cell International 2011 11:20

    Content type: Primary research

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  18. Secondary therapy-related acute lymphoblastic leukemia might emerge following chemotherapy and/or radiotherapy for primary malignancies. Therefore, other alternatives should be pursued to treat leukemia.

    Authors: Angelica R Bonilla-Porras, Marlene Jimenez-Del-Rio and Carlos Velez-Pardo

    Citation: Cancer Cell International 2011 11:19

    Content type: Primary research

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  19. Glioblastoma (GBM) develops resistance to the advances in chemotherapy leading to poor prognosis and life quality. Consequently, new treatment modalities are needed. Our aims were to investigate the effects of...

    Authors: Mine Erguven, Ayhan Bilir, Nuray Yazihan, Ezgi Ermis, Akin Sabanci, Esin Aktas, Yavuz Aras and Vehbi Alpman

    Citation: Cancer Cell International 2011 11:18

    Content type: Primary research

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  20. Aimed to facilitate candidate biomarkers selection and improve network-based multi-target therapy, we perform comparative proteomics research on muscle-invasive bladder transitional cell carcinoma. Laser captu...

    Authors: Hai Tao Niu, Zhen Dong, Gang Jiang, Ting Xu, Yan Qun Liu, Yan Wei Cao, Jun Zhao and Xin Sheng Wang

    Citation: Cancer Cell International 2011 11:17

    Content type: Primary research

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  21. Natural killer (NK) cells are an important resource of the innate immune system directly involved in the spontaneous recognition and lysis of virus-infected and tumor cells. An exquisite balance of inhibitory ...

    Authors: Susana del Toro-Arreola, Naela Arreygue-Garcia, Adriana Aguilar-Lemarroy, Angel Cid-Arregui, Miriam Jimenez-Perez, Jesse Haramati, Patricio Barros-Nuñez, Oscar Gonzalez-Ramella, Alicia del Toro-Arreola, Pablo Ortiz-Lazareno, Georgina Hernandez-Flores, Alejandro Bravo-Cuellar, Adrian Daneri-Navarro and Luis F Jave-Suarez

    Citation: Cancer Cell International 2011 11:15

    Content type: Primary research

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  22. MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cance...

    Authors: Jessica Carlsson, Sabina Davidsson, Gisela Helenius, Mats Karlsson, Zelmina Lubovac, Ove Andrén, Björn Olsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2011 11:14

    Content type: Primary research

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  23. Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two m...

    Authors: Anna Patrikidou, Panagiotis J Vlachostergios, Ioannis A Voutsadakis, Eleana Hatzidaki, Rosalia-Maria Valeri, Chariklia Destouni, Effie Apostolou, Danai Daliani and Christos N Papandreou

    Citation: Cancer Cell International 2011 11:13

    Content type: Primary research

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  24. Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring ole...

    Authors: Zeyad D Nassar, Abdalrahim FA Aisha, Mohamed BK Ahamed, Zhari Ismail, Khalid M Abu-Salah, Salman A Alrokayan and Amin Malik Shah Abdul Majid

    Citation: Cancer Cell International 2011 11:12

    Content type: Primary research

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  25. Breast cancer is one of the most prevalent cancers in the world and more than one million women are diagnosed leading to 410,000 deaths every year. In our previous studies new chalcone-imidazolone conjugates w...

    Authors: M Janaki Ramaiah, SNCVL Pushpavalli, G Rama Krishna, Pranjal Sarma, Debasmita Mukhopadhyay, Ahmed Kamal, Utpal Bhadra and Manika Pal Bhadra

    Citation: Cancer Cell International 2011 11:11

    Content type: Primary research

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  26. Authors: Sandra-Nadia Ngwabyt Bikeye, Carole Colin, Yannick Marie, Raphaël Vampouille, Philippe Ravassard, Audrey Rousseau, Blandine Boisselier, Ahmed Idbaih, Charles Félix Calvo, Pascal Leuraud, Myriam Lassalle, Soufiane El Hallani, Jean-Yves Delattre and Marc Sanson

    Citation: Cancer Cell International 2011 11:10

    Content type: Erratum

    Published on:

    The original article was published in Cancer Cell International 2010 10:1

  27. There are currently three postulated genomic subtypes of the childhood tumour neuroblastoma (NB); Type 1, Type 2A, and Type 2B. The most aggressive forms of NB are characterized by amplification of the oncogene M...

    Authors: Frida Abel, Daniel Dalevi, Maria Nethander, Rebecka Jörnsten, Katleen De Preter, Joëlle Vermeulen, Raymond Stallings, Per Kogner, John Maris and Staffan Nilsson

    Citation: Cancer Cell International 2011 11:9

    Content type: Primary research

    Published on:

  28. Bladder cancer is the commonest type of malignant tumors as a result of schistosomaisis which is a major healthy problem in many subtropical developing countries. The aim of this study is to comparatively eluc...

    Authors: Nadia S Metwally, Sanaa A Ali, Azza M Mohamed, Hussein M Khaled and Samia A Ahmed

    Citation: Cancer Cell International 2011 11:8

    Content type: Primary research

    Published on:

  29. The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channel...

    Authors: Viren Asher, Averil Warren, Robert Shaw, Heidi Sowter, Anish Bali and Raheela Khan

    Citation: Cancer Cell International 2011 11:6

    Content type: Primary research

    Published on:

  30. Less than 30% of malignant gliomas respond to adjuvant chemotherapy. Here, we have asked whether variations in the constitutive expression of early-growth response factor 1 (EGR-1) predicted acute cytotoxicity...

    Authors: Antonella Calogero, Antonio Porcellini, Vincenza Lombari, Cinzia Fabbiano, Antonietta Arcella, Massimo Miscusi, Donatella Ponti and Giuseppe Ragona

    Citation: Cancer Cell International 2011 11:5

    Content type: Primary research

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  31. Increasing evidences show that beyond its role in coagulation, endothelial protein C receptor (EPCR) interferes with carcinogenesis. Pro-carcinogenic effects of EPCR were linked with a raised generation of act...

    Authors: Mario Menschikowski, Albert Hagelgans, Oliver Tiebel, Ludwig Klinsmann, Graeme Eisenhofer and Gabriele Siegert

    Citation: Cancer Cell International 2011 11:4

    Content type: Primary research

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  32. The development of multi-drug resistant (MDR) cancer is a significant challenge in the clinical treatment of recurrent disease. Hypoxia is an environmental selection pressure that contributes to the developmen...

    Authors: Lara Milane, Zhenfeng Duan and Mansoor Amiji

    Citation: Cancer Cell International 2011 11:3

    Content type: Primary research

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  33. Studies have shown that metallothionein 3 (MT-3) is not expressed in normal urothelium or in the UROtsa cell line, but is expressed in urothelial cancer and in tumors generated from the UROtsa cells that have ...

    Authors: Seema Somji, Scott H Garrett, Conrad Toni, Xu Dong Zhou, Yun Zheng, Amornpan Ajjimaporn, Mary Ann Sens and Donald A Sens

    Citation: Cancer Cell International 2011 11:2

    Content type: Primary research

    Published on:

  34. Physiologic wound repair and tissue regeneration are associated with distinct cellular behaviors triggered by tissue damage. Normally quiescent stem cells proliferate to regenerate damaged tissue, while relati...

    Authors: William W Harless

    Citation: Cancer Cell International 2011 11:1

    Content type: Hypothesis

    Published on:

  35. CCAAT/enhancer binding protein-delta (C/EBP-delta) is a member of the highly conserved C/EBP family of basic region leucine zipper transcription factors. C/EBP family members regulate cell growth and different...

    Authors: Xueyan Yu, Junling Si, Yingjie Zhang and James W DeWille

    Citation: Cancer Cell International 2010 10:48

    Content type: Primary research

    Published on:

  36. Progerin is a truncated form of lamin A. It is identified in patients with Hutchinson-Gilford progeria syndrome (HGPS), a disease characterized by accelerated aging. The contribution of progerin toward aging h...

    Authors: Yong Tang, Yakun Chen, Hongmei Jiang and Daotai Nie

    Citation: Cancer Cell International 2010 10:47

    Content type: Primary research

    Published on:

  37. Glutathione peroxidase 3 (GPX3) is one of the key enzymes in the cellular defense against oxidative stress and the hepatocyte growth factor receptor, (MET) has been suggested to be influenced by the GPX3 gene exp...

    Authors: Eva Falck, Sandra Karlsson, Jessica Carlsson,, Gisela Helenius, Mats Karlsson and Karin Klinga-Levan

    Citation: Cancer Cell International 2010 10:46

    Content type: Primary research

    Published on:

  38. Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize th...

    Authors: Thangarajan Rajkumar, Neelakantan Vijayalakshmi, Gopisetty Gopal, Kesavan Sabitha, Sundersingh Shirley, Uthandaraman M Raja and Seshadri A Ramakrishnan

    Citation: Cancer Cell International 2010 10:45

    Content type: Primary research

    Published on:

  39. Epithelial cell adhesion molecule (EpCAM) is frequently and highly expressed on human carcinomas. The emerging role of EpCAM as a signalling receptor and activator of the wnt pathway, and its expression on tum...

    Authors: Markus Münz, Alexander Murr, Majk Kvesic, Doris Rau, Susanne Mangold, Stefan Pflanz, John Lumsden, Jörg Volkland, Jan Fagerberg, Gert Riethmüller, Dominik Rüttinger, Peter Kufer, Patrick A Baeuerle and Tobias Raum

    Citation: Cancer Cell International 2010 10:44

    Content type: Primary research

    Published on:

  40. The main morphological features of primitive cells, such as stem and progenitor cells, are that these cells consists only one nucleus. The main purpose of this study was to determine the differentiation capaci...

    Authors: Muhammad Dain Yazid, Shahrul Hisham Zainal Ariffin, Sahidan Senafi, Mohamad Abdul Razak and Rohaya Megat Abdul Wahab

    Citation: Cancer Cell International 2010 10:42

    Content type: Primary research

    Published on:

  41. Ephrin A1 (EFNA1) is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. In malignancy, the precise role of EFNA1 and its ...

    Authors: Spencer Alford, Adam Watson-Hurthig, Nadia Scott, Amanda Carette, Heather Lorimer, Jessa Bazowski and Perry L Howard

    Citation: Cancer Cell International 2010 10:41

    Content type: Primary research

    Published on:

  42. Alpha-tocopherol ether-linked acetic acid (α-TEA), an analog of vitamin E (RRR-alpha-tocopherol), is a potent and selective apoptosis-inducing agent for human cancer cells in vivo and in vitro. α-TEA induces apop...

    Authors: Jing Li, Weiping Yu, Richa Tiwary, Sook-Kyung Park, Ailian Xiong, Bob G Sanders and Kimberly Kline

    Citation: Cancer Cell International 2010 10:40

    Content type: Primary research

    Published on:

  43. The purpose of the present study is to investigate the direct biological effects of the epidermal growth factor receptor (EGFR) inhibitor C225 on the radiosensitivity of human lung squamous cancer cell-H520. H...

    Authors: Yingdong Zhang, Junjie Wang, Feng Liu, Zhenyu You, Ruijie Yang and Yong Zhao

    Citation: Cancer Cell International 2010 10:39

    Content type: Primary research

    Published on:

  44. Survivin is a member of the inhibitor-of-apoptosis (IAP) family which is widely expressed by many different cancers. Overexpression of survivin is associated with drug resistance in cancer cells, and reduced p...

    Authors: Chun Hei Antonio Cheung, Xueying Sun, Jagat R Kanwar, Ji-Zhong Bai, LiTing Cheng and Geoffrey W Krissansen

    Citation: Cancer Cell International 2010 10:36

    Content type: Primary research

    Published on:

    The Erratum to this article has been published in Cancer Cell International 2010 10:43

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