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  1. Hypoxic microenvironments play a significant role in the progression of colorectal cancer (CRC). Silencing information regulator 1 (SIRT1), a class III histone deacetylase, modulates the multiple biological be...

    Authors: Shentong Yu, Ru Zhou, Tong Yang, Shuang Liu, Zhuqing Cui, Qing Qiao and Jing Zhang
    Citation: Cancer Cell International 2019 19:116
    Content type: Primary research Published on:

  2. As an aggressive hematological malignancy, acute myeloid leukemia (AML) remains a dismal disease with poor prognosis. Long non-coding RNAs (lncRNAs) have been widely reported to be involved in tumorigenesis of...

    Authors: Si-Li Wang, Yun Huang, Rui Su and Yong-Yang Yu
    Citation: Cancer Cell International 2019 19:114
    Content type: Primary research Published on:

  3. Although contemporary chemotherapy has improved the cure rate of childhood acute lymphoblastic leukemia (ALL) to nearly 90%, relapsed/refractory ALL is still a leading cause of tumor-related death in children....

    Authors: Yiping Zhu, Rong Yang, Ju Gao, Yanle Zhang, Ge Zhang and Ling Gu
    Citation: Cancer Cell International 2019 19:113
    Content type: Primary research Published on:

  4. Prostate cancer (PCa), a major cause of cancer-related morbidity and mortality worldwide and mostly asymptomatic at earliest stages, is characterized by disruption of genetic and epigenetic balance. A better u...

    Authors: Tânia Soraia Vieira-Silva, Sara Monteiro-Reis, Daniela Barros-Silva, João Ramalho-Carvalho, Inês Graça, Isa Carneiro, Ana Teresa Martins, Jorge Oliveira, Luis Antunes, Sarah Hurtado-Bagès, Marcus Buschbeck, Rui Henrique and Carmen Jerónimo
    Citation: Cancer Cell International 2019 19:112
    Content type: Primary research Published on:

  5. Acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Therefore, subtype classification is important and indispensable in ALL diagnosis. In ...

    Authors: Yanran Sun, Qiaosheng Zhang, Guoshuang Feng, Zhen Chen, Chao Gao, Shuguang Liu, Ruidong Zhang, Han Zhang, Xueling Zheng, Wenyu Gong, Yadong Wang, Yong Wu, Jie Li and Huyong Zheng
    Citation: Cancer Cell International 2019 19:110
    Content type: Primary research Published on:

  6. The aim of this study is to explore the effect of microRNA-103a (miR-103a) on astrocytes activation and hippocampal neuron injury in epilepsy rats by targeting brain-derived neurotrophic factor (BDNF).

    Authors: Ping Zheng, He Bin and Wei Chen
    Citation: Cancer Cell International 2019 19:109
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:562

  7. MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown.

    Authors: Xin Huang, Fen Tang, Zeping Weng, Mengyao Zhou and Qing Zhang
    Citation: Cancer Cell International 2019 19:108
    Content type: Primary research Published on:

  8. Compelling lines of evidence indicate that DNA methylation of non-coding RNAs (ncRNAs) plays critical roles in various tumour progression. In addition, the differential methylation of ncRNAs can predict progno...

    Authors: Jie Zhang, Keqing Shi, Weiguo Huang, Wanqing Weng, Zhongjing Zhang, Yangyang Guo, Tuo Deng, Yukai Xiang, Xiaofeng Ni, Bicheng Chen and Mengtao Zhou
    Citation: Cancer Cell International 2019 19:107
    Content type: Primary research Published on:

  9. Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is over-expressed in multiple human cancers, and...

    Authors: Haifeng Deng, Hongbing Shi, Lujun Chen, You Zhou and Jingting Jiang
    Citation: Cancer Cell International 2019 19:106
    Content type: Primary research Published on:

  10. Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case–c...

    Authors: Tianbo Liu, Liangliang Jiang, Libo Yu, Tingting Ge, Jing Wang and Hongyu Gao
    Citation: Cancer Cell International 2019 19:105
    Content type: Primary research Published on:

  11. Increasing reports demonstrated that dysregulated expression of microRNAs (miRNAs) leads to the progression of various tumors. Previous studies revealed that miR-328-3p exhibited dysregulated expression in var...

    Authors: Jianhui Shi, Gang An, Ying Guan, Tianli Wei, Zhibin Peng, Min Liang and Yansong Wang
    Citation: Cancer Cell International 2019 19:104
    Content type: Primary research Published on:

  12. Cancer cells are characterized by aberrant activation of lipid biosynthesis, producing saturated fatty acids and monounsaturated fatty acids via stearoyl-CoA desaturases (SCD) for regulating metabolic and sign...

    Authors: Kelin She, Shenghua Fang, Wei Du, Xingxing Fan, Jiaxi He, Hui Pan, Liyan Huang, Ping He and Jun Huang
    Citation: Cancer Cell International 2019 19:103
    Content type: Primary research Published on:

  13. Most colorectal cancer (CRC) patients are diagnosed at an advanced or metastatic stage with poor prognosis. Ubiquitin-specific protease 6 N-terminal-like protein (USP6NL) with high expression in CRC tissues re...

    Authors: Kang Sun, Song-Bing He, Yi-Zhou Yao, Jian-Guo Qu, Rong Xie, Yu-Qiao Ma, Ming-Hui Zong and Ji-Xiang Chen
    Citation: Cancer Cell International 2019 19:102
    Content type: Primary research Published on:

  14. It is well known that human clear cell renal cell carcinoma (ccRCC) is a highly immunogenic and chemo-resistant tumor. Recently, emerging data suggest that the immune checkpoint blockade therapy is an importan...

    Authors: Lujun Chen, Dawei Zhu, Jun Feng, You Zhou, Qi Wang, Huijing Feng, Junping Zhang and Jingting Jiang
    Citation: Cancer Cell International 2019 19:101
    Content type: Primary research Published on:

  15. Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a subs...

    Authors: Yanfang Wang, Quanli Zhang, Zhaojia Gao, Shan Xin, Yanbo Zhao, Kai Zhang, Run Shi and Xuanwen Bao
    Citation: Cancer Cell International 2019 19:100
    Content type: Primary research Published on:

  16. Radiotherapy is becoming one major therapeutics for non-small cell lung cancer (NSCLC). Identifying novel radiosensitizers will greatly increase the efficacy of radiotherapy and benefit more patients. OTU deub...

    Authors: Zhiqiang Wu, Minghan Qiu, Yu Guo, Jinlin Zhao, Zhuang Liu, Hui Wang, Maobin Meng, Zhiyong Yuan and Zeyun Mi
    Citation: Cancer Cell International 2019 19:99
    Content type: Primary research Published on:

  17. Currently offered therapeutics to treat colon cancer (CoCa) are toxic when given at maximum tolerated dose to achieve optimal clinical response. Hence, less toxic therapeutic intervention is needed to treat Co...

    Authors: Ian T. Saunders, Hina Mir, Neeraj Kapur and Shailesh Singh
    Citation: Cancer Cell International 2019 19:98
    Content type: Primary research Published on:

  18. 5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment ...

    Authors: Weilong Yao, Shengtao Zhu, Peng Li and Shutian Zhang
    Citation: Cancer Cell International 2019 19:97
    Content type: Primary research Published on:

  19. The homeodomain transcription factor, PITX2 is associated with tumorigenesis of multiple cancers. In this research, we aimed to study the expression, function and mechanism of PITX2 in lung adenocarcinoma (LUAD).

    Authors: Jing Luo, Yu Yao, Saiguang Ji, Qi Sun, Yang Xu, Kaichao Liu, Qiang Diao, Yong Qiang and Yi Shen
    Citation: Cancer Cell International 2019 19:96
    Content type: Primary research Published on:

  20. After publication of the original article [1], the authors have notified us of 5 errors which are highlighted below. The authors apologize for any inconvenience.

    Authors: Ming-Hui Ma, Jia-Xiang An, Cheng Zhang, Jie Liu, Yu Liang, Chun-Dong Zhang, Zhen Zhang and Dong-Qiu Dai
    Citation: Cancer Cell International 2019 19:95
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2019 19:27

  21. In recent years, gastric cancer (GC) has become a major cause of mortality among various malignancies worldwide with high incidence rates. Long non-coding RNA (lncRNAs) may serve as oncogenes and tumor suppres...

    Authors: Lin Tang, Jian-Bo Wen, Ping Wen, Xing Li, Min Gong and Qiang Li
    Citation: Cancer Cell International 2019 19:94
    Content type: Primary research Published on:

  22. Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of...

    Authors: Jia Cao, Xi Wang, Danni Wang, Rong Ma, Xiaohan Li, Huimin Feng, Jia Wang, Shihai Liu and Libin Wang
    Citation: Cancer Cell International 2019 19:93
    Content type: Primary research Published on:

  23. In the past decade, increasing research attention investigated the novel therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its main active constituent Bufalin have been s...

    Authors: Chien-shan Cheng, Jiaqiang Wang, Jie Chen, Kuei Ting Kuo, Jian Tang, Huifeng Gao, Lianyu Chen, Zhen Chen and Zhiqiang Meng
    Citation: Cancer Cell International 2019 19:92
    Content type: Review Published on:

  24. Breast cancer heterogeneity allows cells with different phenotypes to co-exist, contributing to treatment failure and development of drug resistance. In addition, abnormal signal transduction and dysfunctional...

    Authors: Eric Chekwube Aniogo, Blassan Plackal Adimuriyil George and Heidi Abrahamse
    Citation: Cancer Cell International 2019 19:91
    Content type: Review Published on:

  25. Long noncoding RNAs (lncRNAs) can act as microRNA (miRNA) sponges to regulate protein-coding gene expression; therefore, lncRNAs are considered a major part of the competitive endogenous RNA (ceRNA) network an...

    Authors: Junyu Long, Yi Bai, Xiaobo Yang, Jianzhen Lin, Xu Yang, Dongxu Wang, Li He, Yongchang Zheng and Haitao Zhao
    Citation: Cancer Cell International 2019 19:90
    Content type: Primary research Published on:

  26. Hepatocellular carcinoma (HCC) is one of the leading cause of cancer associated deaths worldwide. Independent studies have proposed altered DNA methylation pattern and aberrant microRNA (miRNA) levels leading ...

    Authors: Kashif Rafiq Zahid, Mingyang Su, Abdur Rehman Raza Khan, Shiming Han, Gou Deming and Umar Raza
    Citation: Cancer Cell International 2019 19:89
    Content type: Primary research Published on:

  27. The Editor-in-Chief has retracted this article [1] because Figure 6a and 6b show overlap with Figure 4b in [2]. An investigation by Zhengzhou University has confirmed that these figures overlap. The data repor...

    Authors: Yuanyuan Wang, Xiaonan Chen, Qianqian Sun, Wenqiao Zang, Min Li, Ziming Dong and Guoqiang Zhao
    Citation: Cancer Cell International 2019 19:88
    Content type: Retraction Note Published on:

    The original article was published in Cancer Cell International 2016 16:85

  28. To determine the association between circadian pathway genetic variants and the risk of prostate cancer progression.

    Authors: Chia-Cheng Yu, Lih-Chyang Chen, Chih-Yung Chiou, Yu-Jia Chang, Victor C. Lin, Chao-Yuan Huang, I-Ling Lin, Ta-Yuan Chang, Te-Ling Lu, Cheng-Hsueh Lee, Shu-Pin Huang and Bo-Ying Bao
    Citation: Cancer Cell International 2019 19:87
    Content type: Primary research Published on:

  29. Ovarian cancer is known as one of the most common cancers in the world among women. ST6GALNAC1 is highly expressed in cancer stem cells (CSCs), which correlates to high tumor-initiating, self-renewal and diffe...

    Authors: Wen-Yan Wang, Yun-Xia Cao, Xiao Zhou, Bing Wei, Lei Zhan and Shi-Ying Sun
    Citation: Cancer Cell International 2019 19:86
    Content type: Primary research Published on:

  30. DA-9401 was prepared as a mixture of Chinese medicinal herb extracts from roots of Morinda officinalis How (Rubiaceae), outer scales of Allium cepa L. (Liliceae) and seeds of Cuscuta chinensis Lamark (Convolvulac...

    Authors: Keshab Kumar Karna, Bo Ram Choi, Jae Hyung You, Yu Seob Shin, Kiran Kumar Soni, Wan Shou Cui, Sung Won Lee, Chul Young Kim, Hye Kyung Kim and Jong Kwan Park
    Citation: Cancer Cell International 2019 19:85
    Content type: Primary research Published on:

  31. GTF2I-RARA is a newly identified RARA fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive o...

    Authors: Wenzhe Yan, Ji Li, Yang Zhang, Yafei Yin, Zhao Cheng, Jiayi Wang, Guoyu Hu, Sufang Liu, Yewei Wang, Yunxiao Xu, Hongling Peng and Guangsen Zhang
    Citation: Cancer Cell International 2019 19:84
    Content type: Primary research Published on:

  32. In addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an...

    Authors: Serena Salehzadeh, Francesca Guerrini, Umberto Pizzano, Susanna Grassi, Elena Ciabatti, Lorenzo Iovino, Gabriele Buda, Francesco Caracciolo, Edoardo Benedetti, Enrico Orciuolo, Matteo Pelosini, Giovanni Consani, Giovanni Carulli, Maria Rita Metelli, Francesca Martini, Francesco Mazziotta…
    Citation: Cancer Cell International 2019 19:83
    Content type: Primary research Published on:

  33. lncRNAs have been proved to play crucial parts in various human cytopathology and cell physiology, including tumorigenesis. Down-regulated lncRNAs SNHG6 have shown great cell proliferation inhibitory effects i...

    Authors: Xin Zhu, Guangling Yang, Jisheng Xu and Chuanlin Zhang
    Citation: Cancer Cell International 2019 19:82
    Content type: Primary research Published on:

  34. Gastric cancer, as a multifactorial disorders, shows cytological and architectural heterogeneity compared to other gastrointestinal cancers, making it therapeutically challenging. Cisplatin is generally used i...

    Authors: Yan Xia, Xingkai Liu, Luping Zhang, Jinzhu Zhang, Chaoying Li, Nan Zhang, Hong Xu and Yan Li
    Citation: Cancer Cell International 2019 19:81
    Content type: Primary research Published on:

  35. Invasion and metastasis are determinant events in the prognosis of Colorectal cancer (CRC), a common neoplasm worldwide. An important factor for metastasis is the acquired capacity of the cell to proliferate a...

    Authors: Jossimar Coronel-Hernández, Eduardo López-Urrutia, Carlos Contreras-Romero, Izamary Delgado-Waldo, Gabriela Figueroa-González, Alma D. Campos-Parra, Rebeca Salgado-García, Antonio Martínez-Gutierrez, Miguel Rodríguez-Morales, Nadia Jacobo-Herrera, Luis Ignacio Terrazas, Abraham Silva-Carmona, César López-Camarillo and Carlos Pérez-Plasencia
    Citation: Cancer Cell International 2019 19:80
    Content type: Primary research Published on:

  36. The mammalian homologs of Lin-28, Lin28 (also called Lin28A) and Lin28B, are promising cancer biomarkers. This meta-analysis was performed to evaluate the prognostic values of Lin28A and Lin28B in multiple hum...

    Authors: Jiayi Zhang, Aiming Xu, Chenkui Miao, Jie Yang, Min Gu and Ninghong Song
    Citation: Cancer Cell International 2019 19:79
    Content type: Primary research Published on:

  37. Zinc finger E-box binding homeobox 1 (ZEB1) is a molecule involved in the progression of epithelial-to-mesenchymal transition (EMT) in various kinds of cancers. Here, we aimed to determine whether the expressi...

    Authors: Ziping Wu, Lei Zhang, Shuguang Xu, Yanping Lin, Wenjin Yin, Jinglu Lu, Rui Sha, Xiaonan Sheng, Liheng Zhou and Jinsong Lu
    Citation: Cancer Cell International 2019 19:78
    Content type: Primary research Published on:

  38. The nucleation-promoting factor cortactin is expressed and promotes tumor progression and metastasis in various cancers. However, little is known about the biological role of cortactin in the progression of pa...

    Authors: Katharina Stock, Rebekka Borrink, Jan-Henrik Mikesch, Anna Hansmeier, Jan Rehkämper, Marcel Trautmann, Eva Wardelmann, Wolfgang Hartmann, Jan Sperveslage and Konrad Steinestel
    Citation: Cancer Cell International 2019 19:77
    Content type: Primary research Published on:

  39. It is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such ...

    Authors: Shanli Li, Feng Xue, Yi Zheng, Pengtao Yang, Shuai Lin, Yujiao Deng, Peng Xu, Linghui Zhou, Qian Hao, Zhen Zhai, Ying Wu, Zhijun Dai and Shu Chen
    Citation: Cancer Cell International 2019 19:76
    Content type: Primary research Published on:

  40. The role of TMED3 involved in cancers has been seldom described, let alone in breast cancer. To explore the clinicopathological significance of TMED3 expression and the biological roles involved in breast canc...

    Authors: Jing Pei, Jing Zhang, Xiaowei Yang, Zhengsheng Wu, Chenyun Sun, Zhaorui Wang and Benzhong Wang
    Citation: Cancer Cell International 2019 19:75
    Content type: Primary research Published on:

  41. Gastric cardia adenocarcinoma (GCA) is an aggressive subtype of gastric cancer with a high metastatic rate. However, the metastatic biomarker of GCA has not been established.

    Authors: Jing Wei, Lincui Wang, Jun Zhu, Aiqin Sun, Guanzhen Yu, Miao Chen, Pan Huang, Hanqing Liu, Genbao Shao, Wannian Yang and Qiong Lin
    Citation: Cancer Cell International 2019 19:74
    Content type: Primary research Published on:

  42. Pediatric cancer survival rates overall have been improving, but neuroblastoma (NBL) and acute lymphoblastic leukemia (ALL), two of the more prevalent pediatric cancers, remain particularly challenging. One is...

    Authors: Andrea Diviney, Boris I. Chobrutskiy, Saif Zaman and George Blanck
    Citation: Cancer Cell International 2019 19:73
    Content type: Primary research Published on:

  43. Breast cancer anti-estrogen resistance 4 (BCAR4) is closely associated with colorectal cancer (CRC) initiation and propagation. However, the mechanisms underlying BCAR4 function in colon cancer remains largely...

    Authors: Shurui Ouyang, Xin Zhou, Zhengquan Chen, Maijian Wang, Xinbin Zheng and Ming Xie
    Citation: Cancer Cell International 2019 19:72
    Content type: Primary research Published on:

  44. Oxaliplatin-based chemotherapy is widely used to treat hepatocellular carcinoma (HCC). Recent studies suggested that therapeutic resistance of tumors was affected by tumor microenvironment (TME). As a major co...

    Authors: Xiu-Tao Fu, Kang Song, Jian Zhou, Ying-Hong Shi, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Zhen-Bin Ding and Jia Fan
    Citation: Cancer Cell International 2019 19:71
    Content type: Primary research Published on:

  45. Pretreatment inflammatory factors, including neutrophil, lymphocyte, platelet and monocyte counts as well as the ratios between them such as neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR) a...

    Authors: Hao Peng and Xiaogang Luo
    Citation: Cancer Cell International 2019 19:70
    Content type: Primary research Published on:

  47. Monoclonal antibodies targeting programmed death-1 receptor (PD-1) and its ligand (PD-L1) have been developed to treat cancers including lung cancer. In this study, we aimed to investigate whether lycopene cou...

    Authors: Xiufeng Jiang, Hui Wu, Wei Zhao, Xiao Ding, Qian You, Feng Zhu, Meifang Qian and Ping Yu
    Citation: Cancer Cell International 2019 19:68
    Content type: Primary research Published on:

  48. Low molecular weight protein tyrosine phosphatase (LMW-PTP) is overexpressed in different cancer types and its expression is related to more aggressive disease, reduced survival rate and drug resistance. Morin...

    Authors: Nagaja Capitani, Giulia Lori, Paolo Paoli, Laura Patrussi, Arianna Troilo, Cosima T. Baldari, Giovanni Raugei and Mario Milco D’Elios
    Citation: Cancer Cell International 2019 19:67
    Content type: Primary research Published on:

  49. The ovarian cancer microenvironment is responsible for cancer cell growth and disease relapse. Bone marrow mesenchymal stem cells (BM-MSCs) play important roles in ovarian cancer, however, the mechanism of BM-...

    Authors: Jinghui Hu, Wei Zhao, Yujie Huang, Zhe Wang, Tingting Jiang and Li Wang
    Citation: Cancer Cell International 2019 19:66
    Content type: Primary research Published on:
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Cancer Cell International

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