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  1. Endometrial cancer (EC) is one kind of women cancers. Bioinformatic technology could screen out relative genes which made targeted therapy becoming conventionalized.

    Authors: JinHui Liu, Mingming Feng, SiYue Li, Sipei Nie, Hui Wang, Shan Wu, Jiangnan Qiu, Jie Zhang and WenJun Cheng

    Citation: Cancer Cell International 2020 20:59

    Content type: Primary research

    Published on:

  2. Abnormally expressed circular RNAs (circRNAs) are implicated in the development and treatment of gastric cancer (GC). Previous study has reported that hsa_circ_0003159 is expressed in GC. However, the role and...

    Authors: Jingyu Wang, Weize Lv, Zhidong Lin, Xiao Wang, Juyuan Bu and Yonghui Su

    Citation: Cancer Cell International 2020 20:57

    Content type: Primary research

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  3. Accumulating evidence has demonstrated that microRNA-200s (miR-200a, miR-200b and miR-200c) could serve as promising molecular biomarkers for cancer prognosis. Nevertheless, the associations between miR-200s e...

    Authors: Qiliang Peng, Ming Cheng, Ting Li, Xiangying Chen, Yi Shen, Yaqun Zhu and Bo Xu

    Citation: Cancer Cell International 2020 20:56

    Content type: Primary research

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  4. The bromodomain and extra-terminal domain (BET) family of proteins, especially BRD4 play an important role in epigenetic regulation, and are essential for cell survival and also are promising anticancer target...

    Authors: Feng Jiao, Ting Han, Cuncun Yuan, Yiyi Liang, Jiujie Cui, Meng Zhuo and Liwei Wang

    Citation: Cancer Cell International 2020 20:55

    Content type: Primary research

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  5. Rhophilin Rho GTPase binding protein 1 antisense RNA 1 (RHPN1-AS1) is a newly discovered oncogene in several diseases, such as breast cancer, non-small cell lung cancer and uveal melanoma. Nevertheless, its mo...

    Authors: Wei Zheng, Hui Li, Hui Zhang, Chao Zhang, Zhonglin Zhu, Hong Liang and Yifeng Zhou

    Citation: Cancer Cell International 2020 20:54

    Content type: Primary research

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  6. Glioma is the most common and aggressive primary brain tumor with high mortality rate around the world. LncRNAs have been identified to play key roles in tumorigenesis in various cancers, including glioma. How...

    Authors: Lei Feng, Tao Lin, Haijiang Che and Xiaoming Wang

    Citation: Cancer Cell International 2020 20:53

    Content type: Primary research

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  7. Lung cancer is the leading cause of cancer related death worldwide. Over the past 15 years no major improvement of survival rates could be accomplished. The recently discovered histone methyltransferase KMT9 t...

    Authors: Hannah Maria Baumert, Eric Metzger, Matthias Fahrner, Julie George, Roman K. Thomas, Oliver Schilling and Roland Schüle

    Citation: Cancer Cell International 2020 20:52

    Content type: Primary research

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  8. The urgent problem in the treatment of breast cancer is the recurrence induced by breast cancer stem cells (CSCs). Understanding the role and molecular mechanism of specific molecules in breast cancer stem cel...

    Authors: Xiaohui Zhao, Chao Jiang, Rui Xu, Qingnan Liu, Guanglin Liu and Yan Zhang

    Citation: Cancer Cell International 2020 20:51

    Content type: Primary research

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  9. Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the dev...

    Authors: Zhiyuan Xiao, Zhigang Wei, Danling Deng, Zhe Zheng, Yali Zhao, Shenglu Jiang, Dan Zhang, Ling-Jie Zhang, Mingmei Fan, Siqi Chen, ShuYang Wang, Yanqing Ding, Yaping Ye and Hongli Jiao

    Citation: Cancer Cell International 2020 20:50

    Content type: Primary research

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  10. Osteosarcoma (OS) is a common primary malignant bone tumour. Growing evidence suggests that circular RNAs (circRNAs) are closely related to the development of tumours. However, the function of circRNAs in OS r...

    Authors: Yu Qiu, Chao Pu, Yanchao Li and Baochuang Qi

    Citation: Cancer Cell International 2020 20:48

    Content type: Primary research

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  11. This study aimed to investigate the clinical characteristics of miR-450b-3p in the patients of gastric cancer (GC), and further explore whether miR-450b-3p could inhibit the proliferation of GC cells via regul...

    Authors: Juan Yao, Hao Zhang, Cheng Liu, Shuangshuang Chen, Rongyu Qian and Kun Zhao

    Citation: Cancer Cell International 2020 20:47

    Content type: Primary research

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  12. This study is to investigate the effects of zoledronic acid (ZA) on TSC2-null cell proliferation and on the tumor progression and recurrence in mouse models of lymphangioleiomyomatosis (LAM).

    Authors: Dandan Zhao, Jing Wu, Yinjuan Zhao, Wei Shao, Qi Cheng, Xiaoyan Shao, Xianwen Yuan, Juan Ye, Jianpu Gao, Meiling Jin, Chaojun Li, Xiaolin Chen, Yue Zhao and Bin Xue

    Citation: Cancer Cell International 2020 20:46

    Content type: Primary research

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  13. Aberrant expression of ubiquitin-specific peptide 22 (USP22) has been detected in various cancers. This study aimed to investigate the role of USP22 and the underlying mechanism in human gastric cancer.

    Authors: ChitChoon Lim, Jia-Cheng Xu, Tian-Yin Chen, Jia-Xin Xu, Wei-Feng Chen, Jian-Wei Hu, Quan-Lin Li and Yi-Qun Zhang

    Citation: Cancer Cell International 2020 20:45

    Content type: Primary research

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  14. The Ecotropic viral integration site 5 (Evi5) is recognized as a potential oncogene and a cell cycle regulator. Evi5 regulates the abundance of Emi1, an inhibitor of the anaphase-promoting complex/cyclosome, t...

    Authors: Cheng-Gang Mao, Xiao-Chun Zhou, Yi-Dao Jiang, Li-Jia Wan, Ze-Zhang Tao and Jun Guo

    Citation: Cancer Cell International 2020 20:44

    Content type: Primary research

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  15. Suppressor anaphase-promoting complex domain containing 2 (SAPCD2) is a novel gene playing important roles in the initiation, invasion, and metastasis of several malignancies. However, its role in colorectal c...

    Authors: Yage Luo, Lili Wang, Wenwen Ran, Guangqi Li, Yujing Xiao, Xiaonan Wang, Han Zhao and Xiaoming Xing

    Citation: Cancer Cell International 2020 20:43

    Content type: Primary research

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  16. Although major driver gene mutations have been identified, the complex molecular heterogeneity of colorectal cancer (CRC) remains unclear. Capicua (CIC) functions as a tumor suppressor in various types of canc...

    Authors: Jeon-Soo Lee, Eunjeong Kim, Jongeun Lee, Donghyo Kim, Hyeongjoo Kim, Chang-Jin Kim, Sanguk Kim, Dongjun Jeong and Yoontae Lee

    Citation: Cancer Cell International 2020 20:42

    Content type: Primary research

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  17. Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Due to the shortage of effective biomarkers for predicting survival and diagnosing PC, the underlying mechanism is still ...

    Authors: Wenjia Zhou, Lu Chen, Chao Li, Rui Huang, Mian Guo, Shangwei Ning, Jingjing Ji, Xiaorong Guo, Ge Lou, Xinqi Jia, Junjie Zhao, Feng Luo, Chunlong Li, Zhaowei Qu, Shan Yu and Sheng Tai

    Citation: Cancer Cell International 2020 20:41

    Content type: Review

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  18. Recently, the De Ritis (AST/ALT) ratio has been considered as a prognostic biomarker for various malignancies. We conducted this systematic review and meta-analysis to explore the prognostic value of preoperat...

    Authors: Xu Hu, Wei-Xiao Yang, Yan Wang, Yan-Xiang Shao, San-Chao Xiong and Xiang Li

    Citation: Cancer Cell International 2020 20:39

    Content type: Primary research

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  19. Aberrant expression of long non-coding RNAs (lncRNAs) is closely associated with development and prognosis of human cancers. LncRNA SNHG16 is reportedly involved in human cancer; however, its roles in multiple...

    Authors: Xi Yang, Hongming Huang, Xinfeng Wang, Haiyan Liu, Hong Liu and Zenghua Lin

    Citation: Cancer Cell International 2020 20:38

    Content type: Primary research

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  20. The presence of tumor-associated stroma and tumor-infiltrated immune cells have been largely reported across glioblastomas. Tumor purity, defined as the proportion of tumor cells in the tumor, was associated w...

    Authors: Yi Xiong, Zujian Xiong, Hang Cao, Chang Li, Siyi Wanggou and Xuejun Li

    Citation: Cancer Cell International 2020 20:37

    Content type: Primary research

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  21. Melanoma is one of the most aggressive tumors with the remarkable characteristic of resistance to traditional chemotherapy and radiotherapy. Although targeted therapy and immunotherapy benefit advanced melanom...

    Authors: Keke Li, Shuang Zhao, Jing Long, Juan Su, Lisha Wu, Juan Tao, Jianda Zhou, JiangLin Zhang, Xiang Chen and Cong Peng

    Citation: Cancer Cell International 2020 20:36

    Content type: Primary research

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  22. Radiation resistance is the main cause of recurrence after radiotherapy, and increased autophagy after radiotherapy is related to radiotherapy resistance. This study aims to investigate the reversal effect of ...

    Authors: Cong Wang, Yinli Yang, Lining Sun, Jing Wang, Zhansheng Jiang, Yanwei Li, Dongying Liu, Haiyan Sun and Zhanyu Pan

    Citation: Cancer Cell International 2020 20:35

    Content type: Primary research

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  23. Interleukin-24 (IL-24) is a therapeutic gene for melanoma, which can induce melanoma cell apoptosis. Mesenchymal stem cells (MSCs) show promise as a carrier to delivery anti-cancer factors to tumor tissues. Induc...

    Authors: Zheng Wu, Wei Liu, Zujia Wang, Baitao Zeng, Guangnan Peng, Hongyan Niu, Linlin Chen, Cong Liu, Qian Hu, Yuxuan Zhang, Mengmeng Pan, Lingqian Wu, Mujun Liu, Xionghao Liu and Desheng Liang

    Citation: Cancer Cell International 2020 20:33

    Content type: Primary research

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  24. Melanoma is notoriously resistant to current treatments, and less than 25% of metastatic melanoma cases respond to existing therapies. Growing evidence has shown that microRNAs (miRNAs) play a vital role in th...

    Authors: Chao Yang, Zeqiang Yan, Fen Hu, Wei Wei, Zhihua Sun and Wei Xu

    Citation: Cancer Cell International 2020 20:32

    Content type: Primary research

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  25. Circular RNAs (circRNAs) have received considerable attention in human cancer research. However, many circRNAs remain to be detected. In our study, we determined novel circRNAs and investigated their effects o...

    Authors: Hong-cheng Lu, Jia-qi Yao, Xiao Yang, Jie Han, Jing-zi Wang, Kun Xu, Rui Zhou, Hao Yu, Qiang Lv and Min Gu

    Citation: Cancer Cell International 2020 20:31

    Content type: Primary research

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  26. Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing one of the most frequent causes of cancer-related death worldwide. About 8–15% of CRCs harbor a mutation in BRAF gene, a pro...

    Authors: Giuseppe Nicolò Fanelli, Carlo Alberto Dal Pozzo, Ilaria Depetris, Marta Schirripa, Stefano Brignola, Paola Biason, Mariangela Balistreri, Luca Dal Santo, Sara Lonardi, Giada Munari, Fotios Loupakis and Matteo Fassan

    Citation: Cancer Cell International 2020 20:30

    Content type: Review

    Published on:

  27. Glioma is one of the most widely diagnosed malignancies worldwide. It has been reported that long noncoding RNAs (lncRNAs) are participators in the tumorgenesis of cancers. Nevertheless, the role and function ...

    Authors: Huixia Li, Tianhao Li, Dehai Huang and Peng Zhang

    Citation: Cancer Cell International 2020 20:29

    Content type: Primary research

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  28. Ubiquitin-specific protease 7 (USP7) is a de-ubiquitin enzyme that plays an essential role in multiple cancers and becomes a target for treatment. However, the role of USP7 and its therapeutic value for HCC re...

    Authors: Wei Zhang, Jingxin Zhang, Chenzhou Xu, Shiqing Zhang, Saiyan Bian, Feng Jiang, Wenkai Ni, Lishuai Qu, Cuihua Lu, Runzhou Ni, Yihui Fan, Mingbing Xiao and Jinxia Liu

    Citation: Cancer Cell International 2020 20:28

    Content type: Primary research

    Published on:

  29. Clear cell renal cell carcinoma (ccRCC) comprises the majority of kidney cancer death worldwide, whose incidence and mortality are not promising. Identifying ideal biomarkers to construct a more accurate progn...

    Authors: Zedan Zhang, Enyu Lin, Hongkai Zhuang, Lu Xie, Xiaoqiang Feng, Jiumin Liu and Yuming Yu

    Citation: Cancer Cell International 2020 20:27

    Content type: Primary research

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  30. Therapeutic approaches for cancer rely on careful consideration of finding the optimal way of delivering the pro-drug for cellular-based cancer treatment. Cell lines and cell cultures have been used in these s...

    Authors: Jehad Zweiri and Stephen E. Christmas

    Citation: Cancer Cell International 2020 20:26

    Content type: Primary research

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  31. Circular RNAs (circRNAs) which are shown as a class of RNAs exhibit the importance in the regulation of gene expression and the development of biological process. However, the expression profile and molecular ...

    Authors: Zhen Zhang, Honglei Wu, Zhaosheng Chen, Guangchun Li and Bin Liu

    Citation: Cancer Cell International 2020 20:25

    Content type: Primary research

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  32. Increasing evidences have underlined the importance of long non-coding RNAs (lncRNAs) in human malignancies. LINC00958 has been found involved in some cancers. However, the underlying mechanical performance of...

    Authors: Longhai Yang, Lili Li, Zizi Zhou, Yi Liu, Jinyuan Sun, Xiaoming Zhang, Huiyu Pan and Song Liu

    Citation: Cancer Cell International 2020 20:24

    Content type: Primary research

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  33. Retinoblastoma (RB) is acknowledged to be the commonest intraocular malignancy in infants and children and the outcome of RB patients is unfavorable due to limited early diagnosis and effective therapy. SMAD f...

    Authors: Hui Wang and Xiang Ji

    Citation: Cancer Cell International 2020 20:23

    Content type: Primary research

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  34. Immune-related genes (IRGs) were linked to the prognosis of head and neck squamous cell carcinoma (HNSCC). This study aimed to identify the effects of an immune-related gene signature (IRGS) that can predict t...

    Authors: Yangyang She, Xiangbo Kong, Yaping Ge, Ping Yin, Zhiyong Liu, Jieyu Chen, Feng Gao and Silian Fang

    Citation: Cancer Cell International 2020 20:22

    Content type: Primary research

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  35. After publication of our article [1] it was highlighted by the authors that the type of this article was primary research, instead of review.

    Authors: Shengnan Zhang, Mengjuan Li, Fangfang Yuan, Lin Chen, Ruihua Mi, Xudong Wei, Yongping Song and Qingsong Yin

    Citation: Cancer Cell International 2020 20:21

    Content type: Correction

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    The original article was published in Cancer Cell International 2019 19:272

  36. The erythropoietin-producing hepatocellular (Eph) receptor A5 (EphA5) has been found to be overexpressed in some malignant tumors and is associated with disease prognosis. However, the role of EphA5 in esophag...

    Authors: Rui Zhang, Jing Liu, Wei Zhang, Lei Hua, Li-Ting Qian and Shao-Bing Zhou

    Citation: Cancer Cell International 2020 20:20

    Content type: Primary research

    Published on:

  37. Preeclampsia (PE) is a prevalent pregnancy disorder that has been one of the leading causes of maternal and perinatal mortality worldwide. Circular RNAs (circRNAs) have recently considered as important regulat...

    Authors: Bing Zhou, Xia Zhang, Ting Li, Rongping Xie, Jianbin Zhou, Yu Luo and Chunfen Yang

    Citation: Cancer Cell International 2020 20:19

    Content type: Primary research

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  38. There are different treatments for breast cancer and melanoma that mostly have some side effects. One of the therapeutic strategies is the use of natural components. Phenol components are a class of antioxidan...

    Authors: Khatereh Khorsandi, Zahra Kianmehr, Zohreh hosseinmardi and Reza Hosseinzadeh

    Citation: Cancer Cell International 2020 20:18

    Content type: Primary research

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  39. Microtubule-associated proteins 7(MAP7) was reported to be engaged into the function of neuronal function. The function of MAP7 in human cervical cancer (CC) was unknown. We aimed to uncover the function and m...

    Authors: Li Zhang, Xudong Liu, Lina Song, Hui Zhai and Chaohua Chang

    Citation: Cancer Cell International 2020 20:17

    Content type: Primary research

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  40. To evaluate the prognostic value of pretreatment lymphocyte counts with respect to clinical outcomes in patients with solid tumors.

    Authors: Jiawen Zhao, Weijia Huang, Yongxian Wu, Yihuan Luo, Bo Wu, Jiwen Cheng, Junqiang Chen, Deyun Liu and Chengyang Li

    Citation: Cancer Cell International 2020 20:15

    Content type: Primary research

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  41. Increasing evidence has suggested that microRNAs (miRNAs) act as key post-transcriptional regulators in tumor progression. Previous studies have confirmed that miR-17-5p functions as an oncogene in multiple ca...

    Authors: Jian-Xing Wang, Xin-Ju Jia, Yan Liu, Jin-Hui Dong, Xiu-Min Ren, Ou Xu, Sheng-Hui Liu and Chun-Guang Shan

    Citation: Cancer Cell International 2020 20:14

    Content type: Primary research

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  42. microRNA Let-7 serves as a tumor suppressor by targeting various oncogenic pathways in cancer cells. However, the underlying mechanism of its involvement in breast cancer remains largely unknown. With our rese...

    Authors: Hongbin Wang, Yanlv Ren, Cheng Qian, Jiaxin Liu, Ge Li and Zhigao Li

    Citation: Cancer Cell International 2020 20:13

    Content type: Primary research

    Published on:

  43. Melanoma is the most aggressive type of skin cancer with high mortality rate and poor prognosis. lncRNA MEG3, a tumor suppressor, is closely related to the development of various cancers. However, the role of ...

    Authors: Liangcai Wu, Lifei Zhu, Yanchang Li, Zhixin Zheng, Xi Lin and Chaoying Yang

    Citation: Cancer Cell International 2020 20:12

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:158

  44. Rapid progression contributes to treatment failure in anaplastic thyroid carcinoma (ATC) patients. In a preliminary study, we demonstrated that some hematopoietic factors may be involved in the progression of ...

    Authors: Zhao-Ming Zhong, Xue Chen, Xiao Qi, Xue-Min Wang, Chun-Yan Li, Ru-Jia Qin, Shi-Qi Wang, Jin Liang, Mu-Sheng Zeng and Chuan-Zheng Sun

    Citation: Cancer Cell International 2020 20:11

    Content type: Primary research

    Published on:

  45. Accumulating evidence has associated aberrant long non-coding RNAs (lncRNAs) with various human cancers. This study aimed to explore the role of LINC00908 in prostate cancer (PCa) and its possible underlying m...

    Authors: Li Fan, Hai Li and Yun Zhang

    Citation: Cancer Cell International 2020 20:10

    Content type: Primary research

    Published on:

  46. Accumulating evidence indicates that the long noncoding RNA taurine upregulated gene 1(TUG1) plays a critical role in cancer progression and metastasis. However, the overall biological role and clinical signif...

    Authors: Qun Dai, Jingyi Deng, Jinrong Zhou, Zhuhong Wang, Xiao-feng Yuan, Shunwen Pan and Hong-bin Zhang

    Citation: Cancer Cell International 2020 20:8

    Content type: Primary research

    Published on:

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