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  1. Content type: Primary research

    Lung cancer is a leading public health issue worldwide. Although therapeutic approaches have improved drastically in the last decades, the prognosis of lung cancer patients remains suboptimal. The canonical nu...

    Authors: Hualong Qin, Jun Zhou, Jingjing Xu, Li Cheng, Zaixiang Tang, Haitao Ma and Feng Guo

    Citation: Cancer Cell International 2018 18:88

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  2. Content type: Primary research

    Semaphorin 5A has been linked to tumor growth, invasion, and metastasis in pancreatic cancer. However, the role of semaphorin 5A in cervical cancer is not known. Our aim is to investigate the prognostic value ...

    Authors: Jian-Bing Xiao, Xin-Lei Li, Le Liu, Geng Wang, Song-Nan Hao, Hui-Juan Dong, Xue-Min Wang, Ya-Fang Zhang and Hui-Dong Liu

    Citation: Cancer Cell International 2018 18:87

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  3. Content type: Primary research

    Platinum-based drugs are used extensively in neoadjuvant chemotherapy for triple-negative breast cancer (TNBC), but their use can be limited by resistance. In this study, we established cisplatin (DDP) resista...

    Authors: Yuzhu Zhang, Jingjing Wu, Meina Ye, Bing Wang, Jiayu Sheng, Bailing Shi and Hongfeng Chen

    Citation: Cancer Cell International 2018 18:86

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  4. Content type: Review

    Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune t...

    Authors: Anton Deicher, Roland Andersson, Bobby Tingstedt, Gert Lindell, Monika Bauden and Daniel Ansari

    Citation: Cancer Cell International 2018 18:85

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  5. Content type: Primary research

    Endothelial-to-mesenchymal transition (EMT) and angiogenesis play important roles in colorectal cancer (CRC) development. Connective tissue growth factor (CTGF) has been reported to promote several kinds of ca...

    Authors: Weijian Lun, Xiongjian Wu, Qiliang Deng and Fachao Zhi

    Citation: Cancer Cell International 2018 18:83

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  6. Content type: Primary research

    Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cyt...

    Authors: Katie L. Uhl, Chad R. Schultz, Dirk Geerts and André S. Bachmann

    Citation: Cancer Cell International 2018 18:82

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  7. Content type: Primary research

    Protease-activated receptors (PARs) are a family of four G protein-coupled receptors expressed widely in many types of cells. PAR1, 2, and 4 have been shown to play an important role in many of the physiologic...

    Authors: Ping Jiang, Shu De Li, Zhi Gang Li, Yue Chun Zhu, Xiao Jia Yi and Si Man Li

    Citation: Cancer Cell International 2018 18:81

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  8. Content type: Primary research

    Formin-like 2 (FMNL2) is a member of Formin family which governs cytokinesis, cellular polarity and morphogenesis. Dysregulation of FMNL2 has been discovered in cancers and is closely related to cancers. Howev...

    Authors: Banghua Zhong, Kewei Wang, Hao Xu and Fanmin Kong

    Citation: Cancer Cell International 2018 18:79

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  9. Content type: Primary research

    Ovarian cancer is a heterogeneous disease with a high degree of genomic instability, pro-/antitumor immunity and inflammation, and remains the most lethal gynecologic cancer worldwide. APOBEC3B, a member of th...

    Authors: Yan Du, Xiang Tao, Jing Wu, Huandi Yu, Yinhua Yu and Hongbo Zhao

    Citation: Cancer Cell International 2018 18:78

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  10. Content type: Primary research

    Meningioma cancer stem cells (MCSCs) contribute to tumor aggressiveness and drug resistance. Successful therapies developed for inoperable, recurrent, or metastatic tumors must target these cells and restrict ...

    Authors: Hanin Alamir, Mona Alomari, Abdulla Ahmed A. Salwati, Mohamad Saka, Mohammed Bangash, Saleh Baeesa, Fahad Alghamdi, Angel Carracedo, Hans-Juergen Schulten, Adeel Chaudhary, Adel Abuzenadah and Deema Hussein

    Citation: Cancer Cell International 2018 18:77

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  11. Content type: Primary research

    SOX2 overlapping transcript (SOX2OT) has been reported to be an important lncRNA in various cancers. SOX2 is embedded in an intron of the SOX2OT gene. But the role of SOX2OT in esophageal squamous cell carcino...

    Authors: Yuanyuan Wu, Xuedan Chen, Yan Liang, Juan Li, Kun Zhang, Limeng Dai, Xingying Guan, Kai Wang and Yun Bai

    Citation: Cancer Cell International 2018 18:76

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  12. Content type: Primary research

    Bile acids have been implicated in the development of digestive tract malignancy by epidemiological, clinical and animal studies. The growth and transformation signaling by most of the bile acids is thought to...

    Authors: Yu-Chung Wu, Chang-Fang Chiu, Chung-Tzu Hsueh and Chung-Tsen Hsueh

    Citation: Cancer Cell International 2018 18:75

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  13. Content type: Primary Research

    Dysregulated expression of long non-coding RNAs (lncRNAs) has been reported in the pathogenesis and progression of multiple cancers, including hepatocellular carcinoma (HCC). LncRNA CTD-2547G23.4 is a novel ln...

    Authors: Dong-yue Wen, Peng Lin, Hai-wei Liang, Xia Yang, Hai-yuan Li, Yun He, Hong Yang and Gang Chen

    Citation: Cancer Cell International 2018 18:74

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  14. Content type: Correction

    Upon publication of the original article [1] it was highlighted by the authors that a grant awarded to support the research work of the study was missed in the Funding Acknowledgements of their manuscript. It ...

    Authors: Du-Chu Chen, You-De Liang, Liang Peng, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, Yasmeen Saeed, Bin Yu, Jingying Huang, Yuxin Gao, Jiaqi Liu, Yi-Zhou Jiang, Min Liu and Demeng Chen

    Citation: Cancer Cell International 2018 18:73

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    The original article was published in Cancer Cell International 2017 17:103

  15. Content type: Primary Research

    Castrate resistant prostate cancer (CRPC) is often driven by constitutively active forms of the androgen receptor such as the V7 splice variant (AR-V7) and commonly becomes resistant to established hormonal th...

    Authors: Sergio Regufe da Mota, Sarah Bailey, Rosemary A. Strivens, Annette L. Hayden, Leon R. Douglas, Patrick J. Duriez, M. Teresa Borrello, Hanae Benelkebir, A. Ganesan, Graham Packham and Simon J. Crabb

    Citation: Cancer Cell International 2018 18:71

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  16. Content type: Primary Research

    Intrinsic chemoresistance of glioblastoma (GBM) is frequently owed to activation of the PI3K and MEK/ERK pathways. These signaling cascades are tightly interconnected however the quantitative contribution of b...

    Authors: Bodo Haas, Veronika Klinger, Christina Keksel, Verena Bonigut, Daniela Kiefer, Julia Caspers, Julia Walther, Maria Wos-Maganga, Sandra Weickhardt, Gabriele Röhn, Marco Timmer, Roland Frötschl and Niels Eckstein

    Citation: Cancer Cell International 2018 18:69

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  17. Content type: Primary research

    To explore the genetic effect of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 (CYP2E1) gene on the risk of squamous cell carcinoma (SCC), a meta-analysis was performed.

    Authors: Hai Zhang, Haiyan Li and Huanxin Yu

    Citation: Cancer Cell International 2018 18:67

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  18. Content type: Primary research

    MicroRNAs deregulation are common in human tumor progression. miR-1236-3p has been reported to function as tumor suppressor microRNA in various malignancies. The aim of this study was to demonstrate the downre...

    Authors: Jia-Xiang An, Ming-Hui Ma, Chun-Dong Zhang, Shuai Shao, Nuo-Ming Zhou and Dong-Qiu Dai

    Citation: Cancer Cell International 2018 18:66

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  19. Content type: Primary research

    Ovarian cancer is the most lethal gynaecological malignancy. Chemotherapy is the main stay of treatment for metastatic disease, with modest response rates but significant side effects. Therefore, there is a ne...

    Authors: Karen K. L. Chan, Michelle K. Y. Siu, Yu-xin Jiang, Jing-jing Wang, Thomas H. Y. Leung and Hextan Y. S. Ngan

    Citation: Cancer Cell International 2018 18:65

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  20. Content type: Primary research

    Abnormal microRNA expression is closely related to cancer occurrence and development. miR-365a-3p plays an oncogenic role in skin cancer, but its role in lung cancer remains unclear. In this study, we aimed to...

    Authors: Yuhuan Wang, Shuhua Zhang, Hejing Bao, Shukun Mu, Baishen Zhang, Hao Ma and Shudong Ma

    Citation: Cancer Cell International 2018 18:64

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  21. Content type: Primary Research

    A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in cell transformation. Deregulated activity of RTKs in tumors can determine disease progression and therapeut...

    Authors: Sanja Aveic, Marcella Pantile, Pierfrancesco Polo, Viktoryia Sidarovich, Marilena De Mariano, Alessandro Quattrone, Luca Longo and Gian Paolo Tonini

    Citation: Cancer Cell International 2018 18:63

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  22. Content type: Primary Research

    Despite recent advances, multiple myeloma (MM) remains incurable. However, the appearance of allogeneic stem cell transplantation (allo-SCT) through graft-versus-myeloma effect provides a potential way to cure...

    Authors: Xuejiao Yin, Liang Tang, Fengjuan Fan, Qinyue Jiang, Chunyan Sun and Yu Hu

    Citation: Cancer Cell International 2018 18:62

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  23. Content type: Primary Research

    Recently, long non-coding RNA (lncRNA) MIAT has been demonstrated as an oncogenic gene in several types of cancer. However, the role and mechanism of MIAT in colorectal cancer (CRC) have not been investigated.

    Authors: Zhaoxia Liu, Hai Wang, Hongwei Cai, Ye Hong, Yan Li, Dongming Su and Zhining Fan

    Citation: Cancer Cell International 2018 18:59

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  24. Content type: Primary Research

    Immunotoxins are typical therapeutic drugs that can target cancer cells. They exploit the affinity of specific monoclonal antibodies or ligands to cancer cells to deliver a conjugated protein toxin to target s...

    Authors: Miaonan Sun, Liankun Sun, Dejun Sun, Chunmei Zhang and Mei Li

    Citation: Cancer Cell International 2018 18:58

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  25. Content type: Primary Research

    Metastatic dissemination of solid tumors is often initiated by reactivation of an embryonic development program, epithelial-to-mesenchymal-transition (EMT). EMT has been associated with acquiring invasiveness ...

    Authors: Mamta Singla, Ajay Kumar, Amanjit Bal, Subhendu Sarkar and Shalmoli Bhattacharyya

    Citation: Cancer Cell International 2018 18:57

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  26. Content type: Primary Research

    Renal cell carcinoma accounts for 2–3% of all cancers and metastasis increased the malignancy of renal cancer. However, the role of methylation in metastasis of renal cancer is poorly understood.

    Authors: Jianbo Zheng, Yanhui Mei, Ping Xiang, Guangsheng Zhai, Ning Zhao, Chuanbing Xu, Min Liu, Zhengsheng Pan, Kai Tang and Dongsheng Jia

    Citation: Cancer Cell International 2018 18:56

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  27. Content type: Correction

    After publication of the original article (1) it was noted that the author details and affiliations of this manuscript contained minor errors in the institution addresses.

    Authors: Yue Li, You Li, Yao Chen, Qian Xie, Ningning Dong, Yanjun Gao, Huan Deng, Chunhua Lu and Suihai Wang

    Citation: Cancer Cell International 2018 18:55

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    The original article was published in Cancer Cell International 2017 17:102

  28. Content type: Primary research

    Paired box gene 8 (PAX8) is expressed in and indispensable to thyroid development. MiR-144-3p is found dys-regulated in cancers, and it can block the expression of target gens. This study sought to understand ...

    Authors: Chang Liu, Chang Su, Yanchun Chen and Guang Li

    Citation: Cancer Cell International 2018 18:54

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  29. Content type: Primary Research

    Signal transducer and activator of transcription 3 (STAT3) is persistently activated in a wide variety of epithelial cancers. Aberrant activity of STAT3 correlates with tumor growth, invasion and metastasis, w...

    Authors: Chao Zhou, Jie Ma, Mengyuan Su, Dan Shao, Jianan Zhao, Tongjian Zhao, Zhuoyao Song, Yan Meng and Ping Jiao

    Citation: Cancer Cell International 2018 18:53

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  30. Content type: Primary Research

    Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical roles in diverse biological processes, including tumori...

    Authors: JinHui Liu, ChunYu Li, Yi Jiang, YiCong Wan, ShuLin Zhou and WenJun Cheng

    Citation: Cancer Cell International 2018 18:51

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  31. Content type: Primary Research

    Gastric cancer presents a major health burden worldwide. Therefore, many molecular targeting agents have been evaluated for treatment of gastric cancer. Gefitinib has shown anticancer activity against gastric ...

    Authors: Jia Huafeng, Zhang Deqing, Ding Yong, Zhang Yulian and Hu Ailing

    Citation: Cancer Cell International 2018 18:50

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  32. Content type: Primary research

    Osteosarcoma (OS) is a rare, malignant bone tumor that primarily affects adolescents and has a high degree of malignancy and high incidence of recurrence and metastasis. Our study aimed to explore the role of ...

    Authors: Riliang Cao, Jianli Shao, Yabin Hu, Liang Wang, Zhizhong Li, Guodong Sun and Xiaoliang Gao

    Citation: Cancer Cell International 2018 18:49

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  33. Content type: Primary Research

    Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRPs family that modulates the Wnt signal transduction pathway. Recent studies have showed down-regulation of SFRP1 expression in colorectal canc...

    Authors: Zhongchuan Wang, Rujia Li, Yongshan He and Shiyong Huang

    Citation: Cancer Cell International 2018 18:48

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  34. Content type: Primary Research

    Long noncoding RNAs (lncRNAs) have been reported to have potential diagnostic and prognostic values for numerous cancers. However, the plasma expression of lncRNA BLACAT1 and its clinical value in patients wit...

    Authors: Denghui Liao, Gang Lv, Ting Wang, Jie Min, Yadong Wang and Shengchun Liu

    Citation: Cancer Cell International 2018 18:47

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  35. Content type: Primary Research

    Abnormally high expression of the mammalian de novo lipogenesis (DNL) pathway in various cancer cells promotes cell over-proliferation and resistance to apoptosis. Inhibition of key enzymes in the DNL pathway,...

    Authors: Phuriwat Khiewkamrop, Pattamaphron Phunsomboon, Lysiane Richert, Dumrongsak Pekthong and Piyarat Srisawang

    Citation: Cancer Cell International 2018 18:46

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  36. Content type: Primary Research

    Abnormal expression of long non-coding RNA (lncRNAs) often facilitates unrestricted growth of cancer cells. Long intergenic non-protein coding RNA 1510, an enhancer lncRNA (LINC01510), a lncRNA enhancer is upr...

    Authors: Chaoqun Cen, Jian Li, Jingjing Liu, Mingshi Yang, Tianyi Zhang, Yu Zuo, Changwei Lin and Xiaorong Li

    Citation: Cancer Cell International 2018 18:45

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  37. Content type: Primary Research

    Despite new progress of chemotherapy in multiple myeloma (MM) clinical treatment, MM is still a refractory disease and new technology is needed to improve the outcomes and prolong the survival. Cold atmospheri...

    Authors: Dehui Xu, Yujing Xu, Ning Ning, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen and Michael G. Kong

    Citation: Cancer Cell International 2018 18:42

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  38. Content type: Primary Research

    The abnormal expression of non-coding RNAs (ncRNAs), such as microRNAs and long ncRNAs, often contribute to the development of cancers. miR-200c functions as a tumour suppressor that impacts the growth of blad...

    Authors: Ran Xu, Xuan Zhu, Fangzhi Chen, Changkun Huang, Kai Ai, Hongtao Wu, Lei Zhang and Xiaokun Zhao

    Citation: Cancer Cell International 2018 18:41

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  39. Content type: Primary Research

    Low expression of E2F3a and caspase 8 associated protein 2 (CASP8AP2) are associated with poor prognosis of childhood acute lymphoblastic leukemia (ALL).

    Authors: Fei-Fei Liu, Kai-Ling Wang, Li-Ping Deng, Xiao Liu, Min-yuan Wu, Tian-You Wang, Lei Cui and Zhi-Gang Li

    Citation: Cancer Cell International 2018 18:40

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  40. Content type: Primary Research

    MicroRNA-21 (miR-21) was previously reported being dysregulated in many kinds of cancer including esophageal squamous cell carcinoma (ESCC). In the present study, we aimed to investigate the role of miR-21 in ...

    Authors: Fang Li, Jia-Hua Lv, Long Liang, Jun-chao Wang, Chu-Rong Li, Lei Sun and Tao Li

    Citation: Cancer Cell International 2018 18:39

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