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  1. Colorectal cancers develop through several pathways, including the adenoma–carcinoma sequence and colitis-associated carcinogenesis. An altered intestinal microflora has been reported to be associated with the...

    Authors: Takuya Iwama, Mikihiro Fujiya, Hiroaki Konishi, Hiroki Tanaka, Yuki Murakami, Takehito Kunogi, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Shin Kashima, Kentaro Moriichi, Hiroki Tanabe and Toshikatsu Okumura

    Citation: Cancer Cell International 2021 21:21

    Content type: Primary research

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  2. Angiogenic placental growth factor (PlGF) plays a role in hypoxia-induced angiogenesis. Here, we aimed to investigate the biological roles of PlGF in cell proliferation and glycolysis of lung adenocarcinoma (L...

    Authors: Wei Zhang, Yanwei Zhang, Wensheng Zhou, Fangfei Qian, Minjuan Hu, Ya Chen, Jun Lu, Yuqing Lou and Baohui Han

    Citation: Cancer Cell International 2021 21:18

    Content type: Primary research

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  3. Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of ...

    Authors: Yin Leng, Zhixian Chen, Hui Ding, Xiaoxu Zhao, Li Qin and Yunlong Pan

    Citation: Cancer Cell International 2021 21:17

    Content type: Primary research

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  4. A growing body of evidence has demonstrated the vital roles of circular RNAs (circRNAs) in cancer progression and drug resistance. We intended to explore the roles and mechanisms of circ_ZFR in the paclitaxel ...

    Authors: Junmin Li, Rongmei Fan and Hui Xiao

    Citation: Cancer Cell International 2021 21:15

    Content type: Primary research

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  5. Although immune checkpoint blockade has emerged as a novel promising strategy for triple-negative breast cancer (TNBC), many patients fail response or acquire resistance to current agents. Consequently, our fo...

    Authors: Zheng Li, Yaming Li, Xiaolong Wang and Qifeng Yang

    Citation: Cancer Cell International 2021 21:13

    Content type: Primary research

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  6. XPF (xeroderma pigmentosum complementation group F) is a key factor contributing to DNA damage excision of nucleotide excision repair pathway. The relationship between XPF expression and the risk and prognosis...

    Authors: Huixin Hu, Jingjing Jing, Xiaodong Lu, Yuan Yuan and Chengzhong Xing

    Citation: Cancer Cell International 2021 21:12

    Content type: Primary research

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  7. LncRNA was known to be closely associated with the progression of human tumors. The role of lncRNA LIFR-AS1 in the pathogenesis and progression of gastric tumor is still unclear. The aim of this study was to i...

    Authors: Haiyan Pan, Yuanlin Ding, Yugang Jiang, Xingjie Wang, Jiawei Rao, Xingshan Zhang, Haibing Yu, Qinghua Hou and Tao Li

    Citation: Cancer Cell International 2021 21:7

    Content type: Primary research

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  8. Vestibular schwannoma (VS) is a kind of benign tumor deriving from the acoustic nerve sheath. Substantial long non-coding RNAs (lncRNAs) were illustrated to have crucial roles in multiple cancers. However, few...

    Authors: Ruiqing Long, Zhuohui Liu, Jinghui Li, Yuan Zhang and Hualin Yu

    Citation: Cancer Cell International 2021 21:5

    Content type: Primary research

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  9. Leptin Receptor (LEPR) has been suggested to have several roles in cancer metastasis. However, the role of LEPR and its underlying mechanisms in lymphatic metastasis of hepatocarcinoma have not yet been studied.

    Authors: He Huang, Jun Zhang, Fei Ling, Yuhong Huang, Min Yang, Yao Zhang, Yuanyi Wei, Qingqing Zhang, Honghai Wang, Lin Song, Ying Wu, Jiayu Yang and Jianwu Tang

    Citation: Cancer Cell International 2021 21:4

    Content type: Primary research

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  10. Soft tissue sarcomas (STS) has a high rate of early metastasis. In this study, we aimed to uncover the potential metastasis mechanisms and related signaling pathways in STS with differentially expressed genes ...

    Authors: Runzhi Huang, Zhiwei Zeng, Penghui Yan, Huabin Yin, Xiaolong Zhu, Peng Hu, Juanwei Zhuang, Jiaju Li, Siqi Li, Dianwen Song, Tong Meng and Zongqiang Huang

    Citation: Cancer Cell International 2021 21:3

    Content type: Primary research

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  11. Osteosarcoma (OS) is a malignant tumor characterized by the direct production of bone or osteoid tissues by proliferating tumor cells. Suppressor of variegation 3–9 homolog 2 (SUV39H2) is implicated in the occ...

    Authors: Yingying Miao, Guifeng Liu and Lin Liu

    Citation: Cancer Cell International 2021 21:2

    Content type: Primary research

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  12. Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes ...

    Authors: Yimin Cheng, Liting Yang, Guangyao Shi, Peng Chen, Liang Li, Hangrong Fang and Chao Chen

    Citation: Cancer Cell International 2021 21:1

    Content type: Primary research

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  13. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-020-01712-y.

    Authors: Qunbang Chen, Jian Gao, Yingjia Zhao and Ruizhe Hou

    Citation: Cancer Cell International 2020 20:600

    Content type: Retraction Note

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    The original article was published in Cancer Cell International 2020 20:411

  14. Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of tumors for which the overall survival rate worldwide is around 60%. The tumor microenvironment, including cancer-associated fibroblasts...

    Authors: Mustafa Magan, Emilia Wiechec and Karin Roberg

    Citation: Cancer Cell International 2020 20:599

    Content type: Primary research

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  15. Glioblastoma (GB) cells have the ability to migrate and infiltrate the normal parenchyma, leading to the formation of recurrent tumors often adjacent to the surgical extraction site. We recently showed that Phone...

    Authors: Natália Barreto, Marcus Caballero, Amanda Pires Bonfanti, Felipe Cezar Pinheiro de Mato, Jaqueline Munhoz, Thomaz A. A. da Rocha‐e‐Silva, Rafael Sutti, João Luiz Vitorino-Araujo, Liana Verinaud and Catarina Rapôso

    Citation: Cancer Cell International 2020 20:576

    Content type: Primary research

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  16. Growing evidence suggests that suppressor of tumorigenicity 7 antisense RNA 1 (ST7-AS1) is an oncogenic long noncoding RNA (lncRNA). However, little is known on its clinical significance, biological functions,...

    Authors: Rong-Hang Hu, Zi-Teng Zhang, Hai-Xiang Wei, Lu Ning, Jiang-Shan Ai, Wen-Hui Li, Heng Zhang and Shao-Qiang Wang

    Citation: Cancer Cell International 2020 20:568

    Content type: Primary research

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  17. miRNAs have been reported to be involved in multiple biological processes of gliomas. Here, we aimed to analyze miR-4310 and its correlation genes involved in the progression of human glioma.

    Authors: Zhiyong Wu, Jie Luo, Tengyue Huang, Renhui Yi, Shengfeng Ding, Cheng Xie, An’qi Xu, Yu Zeng, Xizhao Wang, Ye Song, Xiaofeng Shi and Hao Long

    Citation: Cancer Cell International 2020 20:567

    Content type: Primary research

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  18. Exosomes, emerging mediators of intercellular communication, are reported to transfer certain non-coding RNAs, such as microRNAs (miRNAs), which play a crucial role in cancer progression. The objective of this...

    Authors: Mingjun Li, Qianqian Wang, Xiaofei Zhang, Ningning Yan and Xingya Li

    Citation: Cancer Cell International 2020 20:574

    Content type: Primary research

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  19. Ovarian cancer greatly threatens the general health of women worldwide. Implementation of predictive prognostic biomarkers aids in ovarian cancer management.

    Authors: Jiahong Tan, Kangjia Tao, Xu Zheng, Dan Liu, Ding Ma and Qinglei Gao

    Citation: Cancer Cell International 2020 20:598

    Content type: Primary research

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  20. Glioblastoma (GBM) is the most lethal brain tumor characterized by high morbidity and limited treatment options. Tumor malignancy is usually associated with the epigenetic marks, which coordinate gene expressi...

    Authors: Aliaksandr A. Yarmishyn, Yi-Ping Yang, Kai-Hsi Lu, Yi-Chen Chen, Yueh Chien, Shih-Jie Chou, Ping-Hsing Tsai, Hsin-I. Ma, Chian-Shiu Chien, Ming-Teh Chen and Mong-Lien Wang

    Citation: Cancer Cell International 2020 20:597

    Content type: Primary research

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  21. Glutathione Peroxidase 8 (GPX8) as a member of the glutathione peroxidase (GPx) family plays an important role in anti-oxidation. Besides, dysregulation of GPX8 has been found in gastric cancer, but its detail...

    Authors: Hong Chen, Lu Xu, Zhi-li Shan, Shu Chen and Hao Hu

    Citation: Cancer Cell International 2020 20:596

    Content type: Primary research

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  22. In terms of biological behavior, gene regulation, or signaling pathways, there is a certain similarity between tumorigenesis and embryonic development of humans. Three germ layer structure exhibits the distinc...

    Authors: Xingjie Gao, Xiaoteng Cui, Xinxin Zhang, Chunyan Zhao, Nan Zhang, Yan Zhao, Yuanyuan Ren, Chao Su, Lin Ge, Shaoyuan Wu and Jie Yang

    Citation: Cancer Cell International 2020 20:595

    Content type: Primary research

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  23. Recent studies suggest that long noncoding RNAs (lncRNAs) play an important role in tumorigenesis. As a newly identified lncRNA, the role of XIST in colorectal cancer (CRC) has not been established. Here, we s...

    Authors: Nan Wang, Jia-Xing He, Guo-Zhan Jia, Ke Wang, Shuai Zhou, Tao Wu and Xian-Li He

    Citation: Cancer Cell International 2020 20:553

    Content type: Primary research

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  24. Activating transcription factor 2 (ATF2), a member of the activator protein 1 (AP-1) transcription factor family, has been shown to be involved in the pathobiology of numerous cancers. However, the biological ...

    Authors: Jian Liu, Kai Li, Rui Wang, Sisi Chen, Jie Wu, Xiang Li, Qian Ning, Ganghua Yang and Yamei Pang

    Citation: Cancer Cell International 2020 20:594

    Content type: Primary research

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  25. Circular RNAs (circRNAs) can regulate gene expression in different malignancies. However, the biological functions of circRNA polo-like kinase-1 (circPLK1) in the tumorigenesis of breast cancer (BC) and its po...

    Authors: Guanhong Lin, Shenyu Wang, Xinyu Zhang and Dan Wang

    Citation: Cancer Cell International 2020 20:593

    Content type: Primary research

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  26. The ability to treat glioblastoma (GBM) using the chemotherapeutic agent temozolomide (TMZ) has been hampered by the development of therapeutic resistance. In this study, we assessed the ability of the isoquin...

    Authors: Huiling Qu, Xiaofu Song, Zhuyin Song, Xin Jiang, Xin Gao, Lijuan Bai, Jiao Wu, Li Na and Zhicheng Yao

    Citation: Cancer Cell International 2020 20:592

    Content type: Primary research

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  27. A host of researches have demonstrated the regulation of long non-coding RNAs (lncRNAs) in the progression of pancreatic cancers (PC). In this study, our main task was to analyze the function of MAF bZIP trans...

    Authors: Liqing Ye, Weijian Feng, Hanqin Weng, Chongde Yuan, Jia Liu and Zaiguo Wang

    Citation: Cancer Cell International 2020 20:591

    Content type: Primary research

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  28. Although advanced non-squamous non-small cell lung cancer (NSCLC) patients have significantly better survival outcomes after pemetrexed based treatment, a subset of patients still show intrinsic resistance and...

    Authors: Bo Jia, Zhi Dong, Di Wu, Jun Zhao, Meina Wu, Tongtong An, Yuyan Wang, Minglei Zhuo, Jianjie Li, Yang Wang, Jie Zhang, Xinghui Zhao, Sheng Li, Junfeng Li, Menglei Ma, Chen Chen…

    Citation: Cancer Cell International 2020 20:590

    Content type: Primary research

    Published on:

  29. In past few years, long non-coding RNAs (lncRNAs) have been reported to play regulatory roles during cancer progression. LncRNA SNHG10 has been explored in several sorts of cancers. However, its detailed role ...

    Authors: Lide Jin, Shengquan Huang, Congjin Guan and Shun Chang

    Citation: Cancer Cell International 2020 20:589

    Content type: Primary research

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  30. It is increasingly evidenced that long non-coding RNAs (lncRNAs) play an important role in various diseases. LncRNA LINC01194 acts as an oncogene in several cancer types. Nevertheless, the role of LINC01194 in...

    Authors: Fanmei Meng, Yijing Zhou, Baohua Dong, Aiqin Dong and Jingtao Zhang

    Citation: Cancer Cell International 2020 20:588

    Content type: Primary research

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  31. Ferroptosis is the process of cell death triggered by lipid peroxides, and inhibition of glutathione (GSH) synthesis leads to ferroptosis. Liver cancer progression is closely linked to ferroptosis suppression....

    Authors: Yueyue Yang, Jiafei Lin, Susu Guo, Xiangfei Xue, Yikun Wang, Shiyu Qiu, Jiangtao Cui, Lifang Ma, Xiao Zhang and Jiayi Wang

    Citation: Cancer Cell International 2020 20:587

    Content type: Primary research

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  32. M2-polarized tumor-associated macrophages (M2-TAMs) have been shown to correlate with the progression of various cancers, including intrahepatic cholangiocarcinoma (ICC). However, the interactions and mechanis...

    Authors: Hui Yuan, Zelong Lin, Yingjun Liu, Yuchuan Jiang, Ke Liu, Mengxian Tu, Nan Yao, Chen Qu and Jian Hong

    Citation: Cancer Cell International 2020 20:586

    Content type: Primary research

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  33. RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associat...

    Authors: Shanshan Xie, Wenwen Chen, Kanghua Chen, Yongxia Chang, Feng Yang, Aifu Lin, Qiang Shu, Tianhua Zhou and Xiaoyi Yan

    Citation: Cancer Cell International 2020 20:585

    Content type: Review

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  34. VHL mutation is the most common mutation in clear cell renal cell carcinoma (ccRCC). Here, we developed and validated an immune-related signature to predict the prognosis of ccRCC with VHL mutations.

    Authors: Jin Zhang, Aiting Yan, Wei Cao, Honglei Shi, Kai Cao and Xiaowu Liu

    Citation: Cancer Cell International 2020 20:584

    Content type: Primary research

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  35. PD-L1 inhibitors is widely applied in lung adenocarcinoma patients. Tumor cells with high PD-L1 expression could trigger immune evasion. Cancer stem cells (CSCs) can evade from immunesurveillance due to their ...

    Authors: Chenyue Zhang, Hui Wang, Xia Wang, Chenglong Zhao and Haiyong Wang

    Citation: Cancer Cell International 2020 20:583

    Content type: Primary research

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  36. Plasmacytoid dendritic cells (pDCs) are present in various primary and metastatic human neoplasms; however, their clinical significance in intrahepatic cholangiocarcinoma is not clear.

    Authors: Zhi-Qiang Hu, Zheng-Jun Zhou, Chu-Bin Luo, Hao-Yang Xin, Jia Li, Song-Yang Yu and Shao-Lai Zhou

    Citation: Cancer Cell International 2020 20:582

    Content type: Primary research

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  37. Long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) exhibits an oncogenic role in multiple cancers, including gastric cancer (GC). But, the functions of NEAT1 in modulating radio-sensitivity of G...

    Authors: Ying Jiang, Shan Jin, Shisheng Tan, Yingbo Xue and Xue Cao

    Citation: Cancer Cell International 2020 20:581

    Content type: Primary research

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  38. Despite an enormous research effort, patients diagnosed with advanced colorectal cancer (CRC) still have low prognosis after surgical resection and chemotherapy. The major obstacle for CRC treatment is chemore...

    Authors: Xianjun Sun, Wenhou Hou, Xin Liu, Jie Chai, Hongliang Guo and Jinming Yu

    Citation: Cancer Cell International 2020 20:580

    Content type: Primary research

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  39. Cancer stem cells (CSCs) have been recognized as an important drug target, however, the underlying mechanisms have not been fully understood. SKP1 is a traditional drug target for cancer therapy, while, whethe...

    Authors: Cong Tian, Tingyuan Lang, Jiangfeng Qiu, Kun Han, Lei Zhou, Daliu Min, Zhiqi Zhang and Dachuan Qi

    Citation: Cancer Cell International 2020 20:579

    Content type: Primary research

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  40. Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early mut...

    Authors: Ronja S. Adam, Sanne M. van Neerven, Cayetano Pleguezuelos-Manzano, Salvatore Simmini, Nicolas Léveillé, Nina E. de Groot, Andrew N. Holding, Florian Markowetz and Louis Vermeulen

    Citation: Cancer Cell International 2020 20:578

    Content type: Primary research

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  41. Radiation resistance is a major obstacle to the prognosis of cervical cancer (CC) patients. Many studies have confirmed that long non-coding RNAs (lncRNAs) are involved in the regulation of radiosensitivity of...

    Authors: Chen Wang, Shiqing Shao, Li Deng, Shelian Wang and Yongyan Zhang

    Citation: Cancer Cell International 2020 20:554

    Content type: Primary research

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  42. Autophagy plays an essential role in metastasis of malignancies. Although our studies showed that Aurora-B facilitate pulmonary metastasis in OS, the mechanism of Aurora-B kinase on autophagy and metastasis in...

    Authors: Xin Wu, Jia-ming Liu, Hong-hai Song, Qi-kun Yang, Hui Ying, Wei-lai Tong, Yang Zhou and Zhi-li Liu

    Citation: Cancer Cell International 2020 20:575

    Content type: Primary research

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  43. Gliomas are one of the most common primary tumors of the central nervous system, and have an unfavorable prognosis. SLC39A1 is a zinc ion transport protein which inhibits the progression of prostate cancer. By...

    Authors: Peng Wang, Jingjing Zhang, Shuai He, Boan Xiao and Xiaobin Peng

    Citation: Cancer Cell International 2020 20:573

    Content type: Primary research

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  44. Prostate cancer (PC) is common male cancer with high mortality worldwide. Emerging evidence demonstrated that long noncoding RNAs (lncRNAs) play critical roles in various type of cancers including PC by servin...

    Authors: Yunxia Zhang and Yang Li

    Citation: Cancer Cell International 2020 20:571

    Content type: Primary research

    Published on:

  45. Colorectal adenocarcinoma (CRA) is one of the leading causes of cancer-related deaths in the world. Long non-coding RNAs (lncRNAs) have been implicated to be effective regulators in the disease course of human...

    Authors: Yang Liu, Qinshan Li, Dongxin Tang, Mengxing Li, Peng Zhao, Wenxiu Yang, Liping Shu, Jishi Wang, Zhixu He, Yanju Li and Feiqing Wang

    Citation: Cancer Cell International 2020 20:566

    Content type: Primary research

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  46. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Qiao Zhang, Zhe Yang, Yueli Ni, Honggang Bai, Qiaoqiao Han, Zihan Yi, Xiaojia Yi, Yannick Luther Agbana, Yingmin Kuang and Yuechun Zhu

    Citation: Cancer Cell International 2020 20:565

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2020 20:483

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