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  1. Content type: Primary research

    Vitamin E δ-tocotrienol (VEDT), a vitamin E compound isolated from sources such as palm fruit and annatto beans, has been reported to have cancer chemopreventive and therapeutic effects.

    Authors: Rony A. Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Michael Kongnyuy, Surinder K. Batra, Domenico Coppola, Said M. Sebti and Mokenge P. Malafa

    Citation: Cancer Cell International 2019 19:189

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  2. Content type: Primary research

    Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths primarily due to chemoresistance. Somatic mutation of TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors ...

    Authors: Yize Zhang, Chae Young Han, Fu Gang Duan, Xing-Xing Fan, Xiao-Jun Yao, Robin J. Parks, Yi-Jun Tang, Mei-Fang Wang, Liang Liu, Benjamin K. Tsang and Elaine Lai-Han Leung

    Citation: Cancer Cell International 2019 19:188

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  3. Content type: Primary research

    MicroRNAs (miRNAs) play crucial roles in varieties of cancers, particularly in tumorigenesis, progression, and migration. Dysregulation of miR-28 was reported to occur in various types of human malignancies. I...

    Authors: Yan Lv, Huijun Yang, Xingkai Ma and Geping Wu

    Citation: Cancer Cell International 2019 19:187

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  4. Content type: Primary research

    Mounting evidences have demonstrated that HCC patients with or without cirrhosis possess different clinical characteristics, tumor development and prognosis. However, few studies directly investigated the unde...

    Authors: Bisha Ding, Weiyang Lou, Jingxing Liu, Ruohan Li, Jing Chen and Weimin Fan

    Citation: Cancer Cell International 2019 19:186

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  5. Content type: Primary research

    Renal cell carcinoma (RCC) is the most common kidney cancer and includes several molecular and histological subtypes with different clinical characteristics. The combination of DNA methylation and gene express...

    Authors: Wenbiao Chen, Jia Zhuang, Peizhong Peter Wang, Jingjing Jiang, Chenhong Lin, Ping Zeng, Yan Liang, Xujun Zhang, Yong Dai and Hongyan Diao

    Citation: Cancer Cell International 2019 19:185

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  6. Content type: Primary research

    Pleckstrin Homology Like Domain Family Member 2 (PHLDB2) is an important protein with a PH-domain for interaction with partners to regulate cell migration. However, the role of PHLDB2 in human cancer metastasi...

    Authors: Geng Chen, Tong Zhou, Tantan Ma, Tingting Cao and Zhenxiang Yu

    Citation: Cancer Cell International 2019 19:184

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  7. Content type: Primary research

    Evidence is increasingly indicating that circular RNAs (circRNAs) are closely involved in tumorigenesis and cancer progression. However, the function of circRNAs in gastric cancer (GC) are still unknown. Here,...

    Authors: Yong-jun Guan, Jian-ying Ma and Wei Song

    Citation: Cancer Cell International 2019 19:183

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  8. Content type: Primary research

    Metastasis is an important factor in the poor prognosis of breast cancer. As an important core clock protein, brain and muscle arnt-like 1 (BMAL1) is closely related to tumorigenesis. However, the molecular me...

    Authors: Jian Wang, Shujing Li, Xiahui Li, Bowen Li, Yanan Li, Kangkai Xia, Yuxi Yang, Sattout Aman, Miao Wang and Huijian Wu

    Citation: Cancer Cell International 2019 19:182

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  9. Content type: Primary research

    Emerging evidence has revealed miR-29 family as promising biomarkers for colorectal cancer (CRC), but their biomarker potential and molecular mechanisms remain poorly understood.

    Authors: Qiliang Peng, Zhengyang Feng, Yi Shen, Jiahao Zhu, Li Zou, Yuntian Shen and Yaqun Zhu

    Citation: Cancer Cell International 2019 19:181

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  10. Content type: Review

    Colorectal cancer (CRC) is the third most common cancer and one of the main causes of cancer death entire the world. Environmental, dietary, and lifestyle factors including red meat consumption, cigarette smok...

    Authors: Mohadese Honari, Rana Shafabakhsh, Russel J. Reiter, Hamed Mirzaei and Zatollah Asemi

    Citation: Cancer Cell International 2019 19:180

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  11. Content type: Primary research

    Multi-drug resistance is the major cause of chemotherapy failure in hepatocellular carcinoma (HCC). YAP, a critical effector of the Hippo pathway, has been shown to contribute to the progression, metastasis an...

    Authors: Yuan Zhou, Yubo Wang, Wuhua Zhou, Tianchi Chen, Qinchuan Wu, Vikram Kumar Chutturghoon, Bingyi Lin, Lei Geng, Zhe Yang, Lin Zhou and Shusen Zheng

    Citation: Cancer Cell International 2019 19:179

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  12. Content type: Primary research

    MicroRNA-29c (miR-29c) is abnormally expressed in several cancers and serves as an important predictor of tumor prognosis. Herein, we investigate the effects of abnormal miR-29c expression and analyze its clin...

    Authors: Li-juan Tang, Guo-kang Sun, Ting-juan Zhang, De-hong Wu, Jing-dong Zhou, Bei-bei Ma, Zi-jun Xu, Xiang-mei Wen, Qin Chen, Dong-ming Yao, Jun Qian, Ji-chun Ma and Jiang Lin

    Citation: Cancer Cell International 2019 19:177

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  13. Content type: Primary research

    Considering the effect of smoking on tumor immunity, we attempted to investigate the impact of smoking history on the prognostic value of circulating naïve and memory CD4+ and CD8+ T cells in advanced non-smal...

    Authors: Chao Liu, Bin Xu, Qian Li, Aijie Li, Lan Li, Jinbo Yue, Qinyong Hu and Jinming Yu

    Citation: Cancer Cell International 2019 19:176

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  14. Content type: Primary research

    Accumulated evidences have demonstrated that long non-coding RNAs (lncRNAs) are correlated with prognosis of patients with hepatocellular carcinoma. The current study aimed to develop and validate a prognostic...

    Authors: Zhiqiao Zhang, Yanling Ouyang, Yiyan Huang, Peng Wang, Jing Li, Tingshan He and Qingbo Liu

    Citation: Cancer Cell International 2019 19:174

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  15. Content type: Review

    Colorectal cancer (CRC) is one type of tumor with the highest frequency and mortality worldwide. Although current treatments increase patient survival, it is important to detect CRC in early stages; however, m...

    Authors: Elsa N. Garza Treviño, Paulina Delgado González, Carlos I. Valencia Salgado and Alejandra Martinez Garza

    Citation: Cancer Cell International 2019 19:173

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  16. Content type: Primary research

    Triple negative breast cancer (TNBC) is a specific subtype of breast cancer with a poor prognosis due to its aggressive biological behaviour and lack of therapeutic targets. We aimed to explore some novel gene...

    Authors: Xuemei Lv, Miao He, Yanyun Zhao, Liwen Zhang, Wenjing Zhu, Longyang Jiang, Yuanyuan Yan, Yue Fan, Hongliang Zhao, Shuqi Zhou, Heyao Ma, Yezhi Sun, Xiang Li, Hong Xu and Minjie Wei

    Citation: Cancer Cell International 2019 19:172

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  17. Content type: Primary research

    Caveolin-1 (Cav-1) plays an important role in the development of various human cancers. We investigated the relationship between Cav-1 expression and non-small cell lung cancer (NSCLC) progression in the conte...

    Authors: Yeong-Jin Kim, Ju-Hwi Kim, Ok Kim, Eun-Jung Ahn, Se-Jeong Oh, Md Rashedunnabi Akanda, In-Jae Oh, Shin Jung, Kyung-Keun Kim, Jae-Hyuk Lee, Hyung-Seok Kim, Hangun Kim, Kyung-Hwa Lee and Kyung-Sub Moon

    Citation: Cancer Cell International 2019 19:171

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  18. Content type: Primary research

    The Warburg effect demonstrates the importance of glycolysis in the development of primary and metastatic cancers. We aimed to explore the role of monocarboxylate transporter 1 (MCT1) and MCT4, two essential t...

    Authors: Chen Guo, Tao Huang, Qing-Hai Wang, Hong Li, Aashish Khanal, En-Hao Kang, Wei Zhang, Hai-Tao Niu, Zhen Dong and Yan-Wei Cao

    Citation: Cancer Cell International 2019 19:170

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  19. Content type: Review

    Mounting evidence has shown that long noncoding RNAs (lncRNAs) can play a substantial role in gallbladder cancer (GBC) development as tumor promotors or suppressors, and their abnormal expression is relevant t...

    Authors: Yuan Zhong, Xiaochao Wu, Quanpeng Li, Xianxiu Ge, Fei Wang, Peiyao Wu, Xueting Deng and Lin Miao

    Citation: Cancer Cell International 2019 19:169

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  20. Content type: Primary research

    DKK1 has been reported to act as a tumor suppressor in breast cancer. However, the mechanism of DKK1 inhibits breast cancer migration and invasion was still unclear.

    Authors: Jie Niu, Xiao-Meng Li, Xiao Wang, Chao Liang, Yi-Dan Zhang, Hai-Ying Li, Fan-Ye Liu, Hua Sun, Song-Qiang Xie and Dong Fang

    Citation: Cancer Cell International 2019 19:168

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  21. Content type: Primary research

    Studies have shown that miR-146a-5p was differentially expressed in diverse cancers, but the associations between miR-146a-5p expression and prognosis across multiple types of cancer as well its potential targ...

    Authors: Mei-wei Li, Li Gao, Yi-wu Dang, Ping Li, Zu-yun Li, Gang Chen and Dian-zhong Luo

    Citation: Cancer Cell International 2019 19:167

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  22. Content type: Primary research

    New therapeutic drug for breast cancer (BRCA), especially triple negative BRCA (TNBC), is urgently needed. Even though 2-(4-morpholinoanilino)-6-cyclohexylaminopurine (reversine) is an aurora kinase inhibitor,...

    Authors: Di Huang, Yu Huang, Zisheng Huang, Jiefeng Weng, Shuai Zhang and Weili Gu

    Citation: Cancer Cell International 2019 19:166

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  23. Content type: Primary research

    Enhanced glycolysis in tumors, known as the Warburg effect, provides the metabolic basis of enhanced cancer cell proliferation and metastasis. The Warburg pathway enzyme 6-phosphofructo-2-kinase/fructose-2,6-b...

    Authors: Ling Yao, Lei Wang, Zhi-Gang Cao, Xin Hu and Zhi-Ming Shao

    Citation: Cancer Cell International 2019 19:165

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  24. Content type: Primary research

    Abnormal expression of microRNAs (miRNAs) is related to human carcinogenesis. Although previous studies have shown that miR-503 expression in gastric cancer (GC) is downregulated, however, the underlying molec...

    Authors: Wenjing Li, Jun Li, Hong Mu, Meiqi Guo and Haixia Deng

    Citation: Cancer Cell International 2019 19:164

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  25. Content type: Primary research

    The IQ-motif-containing GTPase-activating protein (IQGAP) family comprises three members, IQGAP1, IQGAP2 and IQGAP3. IQGAP3 is the latest addition to the family. This study mainly investigated the novel marker...

    Authors: Huihua Cao, Qing Wang, Zhenyan Gao, Xiang Xu, Qicheng Lu and Yugang Wu

    Citation: Cancer Cell International 2019 19:163

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  26. Content type: Primary research

    AT-rich interactive domain-containing protein 1A (ARID1A) is a subunit of the mammary SWI/SNF chromatin remodeling complex and a tumor suppressor protein. The loss of ARID1A been observed in several types of h...

    Authors: Zhou-hua Jiang, Tao Peng, Hai-long Qian, Cai-de Lu, Feng Qiu and Su-zhan Zhang

    Citation: Cancer Cell International 2019 19:162

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  27. Content type: Primary research

    The interaction between human epididymis protein 4 (HE4) and annexin A2 (Annexin A2) has been found in ovarian cancer. However, it is dimness whether the interaction exists in other malignant tumors.

    Authors: Jing Wang, Lu Deng, Huiyu Zhuang, Juanjuan Liu, Dawo Liu, Xiao Li, Shan Jin, Liancheng Zhu, Huimin Wang and Bei Lin

    Citation: Cancer Cell International 2019 19:161

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  28. Content type: Primary research

    Our previous studies revealed that Jagged 2 (JAG2) is involved in the regulation of migration and invasion of colon cancer cells without affecting cell proliferation. This study further explored the specific m...

    Authors: Wan He, Jun Tang, Wenwen Li, Yong Li, Yi Mei, Lisheng He, Keli Zhong and Ruilian Xu

    Citation: Cancer Cell International 2019 19:160

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  29. Content type: Primary research

    Mutationally activated Ras proteins are closely linked to a wide variety of human cancers. Hence, there has been an intensive search for anti-Ras therapies for cancer treatment. The sole Ras gene, which encode...

    Authors: Jiaojiao Ji, Jiang Yuan, Xiaoyu Guo, Ruifang Ji, Qinghua Quan, Mei Ding, Xia Li and Yonggang Liu

    Citation: Cancer Cell International 2019 19:159

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  30. Content type: Review

    As a pivotal regulator, cyclin D3 gives play to a crucial value in conversion from the G1 stage to the S stage of cell cycle, which is implicated in tumor progression, especially proliferation and migration. ...

    Authors: Bo Wang, Zijian Wang, Lizhi Han, Song Gong, Yanxue Wang, Zhiwen He, Yong Feng and Zhaohui Yang

    Citation: Cancer Cell International 2019 19:158

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  31. Content type: Review

    Fibromodulin (FMOD) is known as one of very important extracellular matrix small leucine-rich proteoglycans. This small leucine-rich proteoglycan has critical roles in the extracellular matrix organization and...

    Authors: Mohammad Hossein Pourhanifeh, Rezvan Mohammadi, Somaye Noruzi, Seyede Atefe Hosseini, Sahar Fanoudi, Yousef Mohamadi, Milad Hashemzehi, Zatollah Asemi, Hamid Reza Mirzaei, Reza Salarinia and Hamed Mirzaei

    Citation: Cancer Cell International 2019 19:157

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  32. Content type: Primary research

    Emerging evidence demonstrates that long non-coding RNA (lncRNA) is an important regulator in tumorigenesis and development. Tubulin Alpha 4B (TUBA4B), a novel lncRNA, was recently proposed as a tumor suppress...

    Authors: Jianbo Guo, Yan Li, He Duan and Lu Yuan

    Citation: Cancer Cell International 2019 19:156

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  33. Content type: Primary research

    Abnormal expression of the eukaryotic initiation factor 3 (eIF3) subunits plays critical roles in tumorigenesis and progression, and also has potential prognostic value in cancers. However, the expression and ...

    Authors: Rui-Chao Chai, Ning Wang, Yu-Zhou Chang, Ke-Nan Zhang, Jing-Jun Li, Jun-Jie Niu, Fan Wu, Yu-Qing Liu and Yong-Zhi Wang

    Citation: Cancer Cell International 2019 19:155

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  34. Content type: Primary research

    Lymphoma is one of the most common hematologic malignancy. Drug resistance is the main obstacle faced in lymphoma treatment. Cancer stem cells are considered as the source of tumor recurrence, metastasis and d...

    Authors: Li-Na Lv, Xiao-Chao Wang, Li-Ju Tao, Hong-Wen Li, Shu-You Li and Fei-Meng Zheng

    Citation: Cancer Cell International 2019 19:153

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  35. Content type: Primary research

    Recently, lncRNA-Testis developmental related gene 1 (TDRG1) was proved to be a key modulator in reproductive organ-related cancers. The biological role of TDRG1 in cervical cancer (CC) progression remains lar...

    Authors: Hui Jiang, Min liang, Yanqiong Jiang, Ting Zhang, Kexin Mo, Suwen Su, Aiping Wang, Yongyi Zhu, Guanqun Huang and Rujian Zhou

    Citation: Cancer Cell International 2019 19:152

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  36. Content type: Primary research

    One of the most important metabolic hallmarks of breast cancer cells is enhanced lipogenesis. Increasing evidences suggest that fatty acid synthase (FAS) plays an important role in human breast cancer. Previou...

    Authors: Wenyuan Huang, Yan Liang and Xiaofeng Ma

    Citation: Cancer Cell International 2019 19:151

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  37. Content type: Primary research

    NPL4 is an important cofactor of the valosin-containing protein (VCP)–NPL4–UFD1 complex. The VCP–NPL4–UFD1 has been considered as a ubiquitin proteasome system (UPS) regulator and response to protein degradati...

    Authors: Bao-Sai Lu, Yue-Wei Yin, Yan-Ping Zhang, Ping-Ying Guo, Wei Li and Kai-Long Liu

    Citation: Cancer Cell International 2019 19:149

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  38. Content type: Primary research

    It is becoming increasingly clear that cancers can rarely be ascribed to just one or a few genomic variations. Genes generally do not function alone, but in groups that function as “networks”. This study aimed...

    Authors: Min-Er Zhong, Yanyu Chen, Guannan Zhang, Lai Xu, Wei Ge and Bin Wu

    Citation: Cancer Cell International 2019 19:148

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  39. Content type: Primary research

    Accumulating evidence has highlighted the tumor suppressive roles of microRNA (miRNAs) in cervical cancer (CC). In the present study, we aim to delineate the functional relevance of microRNA-137 (miR-137) in i...

    Authors: Hui Miao, Nuan Wang, Lin-Xin Shi, Zheng Wang and Wen-Bo Song

    Citation: Cancer Cell International 2019 19:147

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  40. Content type: Primary research

    Programmed cell death ligand 1 (PD-L1) expression has been shown to associate with poor prognosis in a variety of solid tumors. However, the prognostic value of PD-L1 expression in cervical cancer is still con...

    Authors: Xiaobin Gu, Meilian Dong, Zheyan Liu, Yin Mi, Jing Yang, Zhigang Zhang, Ke Liu, Li Jiang, Yue Zhang, Shiliang Dong and Yonggang Shi

    Citation: Cancer Cell International 2019 19:146

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  41. Content type: Primary research

    Pancreatic cancer stem cells (CSCs), a special population of cells, renew themselves infinitely and resist to various treatment. Gramicidin A (GrA), an ionophore antibiotic derived from microorganism, can form...

    Authors: Rui-Qi Wang, Jing Geng, Wei-Jin Sheng, Xiu-Jun Liu, Min Jiang and Yong-Su Zhen

    Citation: Cancer Cell International 2019 19:145

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  42. Content type: Primary research

    Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is an H3K27me3 demethylase, a permissive mark associated with active gene transcription. UTX has been linked to various human cancers. Colo...

    Authors: Xin Tang, Wenwei Cai, Jing Cheng, Ping Lu, Shaojun Ma, Chaoting Chen, Yi Chen, Yun Sun, Caofeng Wang, Ping Hu, Xiaomin Lv, G. Sun, Yu Wang and Jing Sheng

    Citation: Cancer Cell International 2019 19:144

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  43. Content type: Primary research

    Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid car...

    Authors: Xiaoli Zhang, Fei Li, Yeqing Cui, Shuang Liu and Haichen Sun

    Citation: Cancer Cell International 2019 19:143

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  44. Content type: Primary research

    Esophageal squamous cell carcinoma (ESCC) is one of leading malignant cancers of gastrointestinal tract worldwide. Until now, the involved mechanisms during the development of ESCC are largely unknown. This st...

    Authors: Wanli Yang, Xinhui Zhao, Yu Han, Lili Duan, Xin Lu, Xiaoqian Wang, Yujie Zhang, Wei Zhou, Jinqiang Liu, Hongwei Zhang, Qingchuan Zhao, Liu Hong and Daiming Fan

    Citation: Cancer Cell International 2019 19:142

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  45. Content type: Primary research

    Whether PD-L1/PD-1 expression plays a significant role in the prognosis of NPC is still controversial. The present study mainly aimed to investigate the prognostic significance of PD-L1/PD-1 expression in pati...

    Authors: Zi-Lu Huang, Shan Liu, Guan-Nan Wang, Shuo-Han Zheng, Shi-Rong Ding, Ya-lan Tao, Chen Chen, Song-Ran Liu, Xin Yang, Hui Chang, Xiao-Hui Wang and Yun-Fei Xia

    Citation: Cancer Cell International 2019 19:141

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  46. Content type: Primary research

    The aim of the present study was to clarify the correlations between SPARC expression in gastric cancer-associated fibroblasts (GCAFs) and the prognosis of patients with gastric cancer and to elucidate the rol...

    Authors: Yongchen Ma, Jing Zhu, Shanwen Chen, Ju Ma, Xiaoqian Zhang, Sixia Huang, Jianwen Hu, Taohua Yue, Junling Zhang, Pengyuan Wang, Xin Wang, Long Rong, Hongjie Guo, Guowei Chen and Yucun Liu

    Citation: Cancer Cell International 2019 19:137

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