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  1. Content type: Primary research

    Long non-coding RNAs (lncRNAs) are promising therapeutic molecules of cancer. Here we aim to study the therapeutic effect and mechanism of a lncRNA, HOXA11-AS, in oral squamous cell carcinoma (OSCC).

    Authors: Baojun Li, Wei Wang, Susheng Miao, Guofu Li, Yuanjing Lv, Cheng Xiang and Rong Pei

    Citation: Cancer Cell International 2019 19:140

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  2. Content type: Primary research

    Hepatocellular carcinoma (HCC) remains a major challenge for public health worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models are urgently needed. To identify a robust progn...

    Authors: Gao-Min Liu, Hua-Dong Zeng, Cai-Yun Zhang and Ji-Wei Xu

    Citation: Cancer Cell International 2019 19:138

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  3. Content type: Primary research

    Endometrial cancer (EC) is one of the female malignant tumors. Endometrial cancer predominately affects post-menopausal women. Bioinformatics analysis has been widely applied to screen and analyze genes in lin...

    Authors: JinHui Liu, ShuLin Zhou, SiYue Li, Yi Jiang, YiCong Wan, XiaoLing Ma and WenJun Cheng

    Citation: Cancer Cell International 2019 19:136

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  4. Content type: Primary research

    Acute myeloid leukemia (AML) is a typically fatal malignancy and new drug and treatment need to be developed for a better survival outcome. Cold atmospheric plasma (CAP) is a novel technology, which has been w...

    Authors: Dehui Xu, Ning Ning, Yujing Xu, Bingchuan Wang, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen and Michael G. Kong

    Citation: Cancer Cell International 2019 19:135

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  5. Content type: Primary research

    Cancer stem cells (CSCs), drug-resistant cancer cell subsets, are known to be responsible for tumor metastasis and relapse. The JAK/STAT pathway, activated by SH2 domain, is known to regulate the tumor growth ...

    Authors: Xiao-Feng Xu, Feng Gao, Jian-Jiang Wang, Cong Long, Xing Chen, Lan Tao, Liu Yang, Li Ding and Yong Ji

    Citation: Cancer Cell International 2019 19:133

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  6. Content type: Primary research

    CHIP is an E3 ubiquitin ligase that plays contrast roles in diverse human malignancies, depending on its targets. To date, the mechanisms underlying the function of CHIP in gastric cancer remains unclear. Here...

    Authors: Hanjue Dai, Hao Chen, Jingjing Xu, Jun Zhou, Zhili Shan, Hengying Yang, Xiaojun Zhou and Feng Guo

    Citation: Cancer Cell International 2019 19:132

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  7. Content type: Review

    Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of ...

    Authors: Mohammad Hossein Pourhanifeh, Mehran Sharifi, Russel J. Reiter, Abdoulhossein Davoodabadi and Zatollah Asemi

    Citation: Cancer Cell International 2019 19:131

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  8. Content type: Primary research

    Bursopentin (BP5) is a multifunctional pentapeptide found in the chicken bursa of Fabricius. Recent study indicated that BP5 significantly stimulates expression of p53 protein in colon cancer HCT116 cells. How...

    Authors: Jing Li, Tian-xiang Li, Yao Ma, Yong Zhang, De-yuan Li and Hai-rong Xu

    Citation: Cancer Cell International 2019 19:130

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  9. Content type: Primary research

    Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies. However, whether PKM2 regulates the radiosensitivity of human...

    Authors: Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He and Xinping Cao

    Citation: Cancer Cell International 2019 19:129

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  10. Content type: Primary research

    Cumulative evidences demonstrated the aberrant overexpression of Small Nucleolar RNA Host Gene 12 (SNHG12) in diverse human cancer. However, the expression status and involvement of SNHG12 in renal cell carcin...

    Authors: Qiguang Chen, Wei Zhou, Shu-qi Du, Da-xin Gong, Jun Li, Jian-bin Bi, Zhen-hua Li, Zhe Zhang, Ze-liang Li, Xian-kui Liu and Chui-ze Kong

    Citation: Cancer Cell International 2019 19:128

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  11. Content type: Primary research

    It is recommended postoperative adjuvant chemotherapy for all rectal cancers undergoing neo-chemoradiotherapy regardless of the final yield pathology. However, the role of adjuvant chemotherapy in pathological...

    Authors: Xiang Hu, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai and Jun-Jie Peng

    Citation: Cancer Cell International 2019 19:127

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  12. Content type: Primary research

    Ubinuclein-2 (UBN2) is a nuclear protein that interacts with many transcription factors. The molecular role and mechanism of UBN2 in the development and progression of cancers, including colorectal cancer (CRC...

    Authors: Ya-li Zhao, Shen-Rong Zhong, Shi-Hong Zhang, Jia-Xin Bi, Zhi-Yuan Xiao, Shu-Yang Wang, Hong-Li Jiao, Dan Zhang, Jun-Feng Qiu, Ling-Jie Zhang, Cheng-Mei Huang, Xiao-Ling Chen, Yan-Qing Ding, Ya-Ping Ye, Li Liang and Wen-ting Liao

    Citation: Cancer Cell International 2019 19:126

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  13. Content type: Primary research

    Breast cancer (BC) is the most frequent malignancy occurring in women worldwide. Emerging evidence indicates that small nucleolar RNAs (snoRNAs) play a role in tumor development. In the current study, we evalu...

    Authors: Yihan Sun, Endong Chen, Yuefeng Li, Danrong Ye, Yefeng Cai, Qingxuan Wang, Quan Li and Xiaohua Zhang

    Citation: Cancer Cell International 2019 19:125

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  14. Content type: Primary research

    Colon cancer is one of the three common malignant tumors, with lower 5 years survival rate. Akt is an important therapeutic target, while SC66 is a novel allosteric AKT inhibitor, which enhances the therapeuti...

    Authors: Yeying Liu, Yuan Huang, Jie Ding, Nannan Liu, Shuang Peng, Jiangang Wang, Feng Wang and Yingjie Zhang

    Citation: Cancer Cell International 2019 19:124

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  15. Content type: Primary research

    Increasing evidences supported the association between long non-coding RNA (lncRNA) and disease free survival in gastric cancer (GC) patients. The purpose of the current study was to construct and verify a non...

    Authors: Canchang Cheng, Qicai Wang, Minggu Zhu, Kelong Liu and Zhiqiao Zhang

    Citation: Cancer Cell International 2019 19:123

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  16. Content type: Primary research

    Acute myeloid leukemia (AML) pertains to a hematologic malignancy with heterogeneous therapeutic responses. Improvements in risk stratification in AML patients are warranted. MicroRNAs have been associated wit...

    Authors: Mingshan Niu, Yuan Feng, Ninghan Zhang, Tingting Shao, Huihui Zhang, Rong Wang, Yao Yao, Ruosi Yao, Qingyun Wu, Jiang Cao, Xuejiao Liu, Yubo Liu and Kailin Xu

    Citation: Cancer Cell International 2019 19:122

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  17. Content type: Primary research

    Further analysis of phase I trial of the KEYNOTE-001 has shown that previous radiotherapy improves the outcomes of patients with advanced non-small cell lung cancer (NSCLC) who received pembrolizumab treatment...

    Authors: Chao Liu, Qinyong Hu, Bin Xu, Xiaoyu Hu, Huichao Su, Qian Li, Xiaoling Zhang, Jinbo Yue and Jinming Yu

    Citation: Cancer Cell International 2019 19:121

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  18. Content type: Primary research

    We have characterized the human cell line arised from the Epstein–Barr virus (EBV) positive multiple myeloma aspirate subjected to the long-term cultivation. This cell line has acquired the ability to form fre...

    Authors: Evgeniya V. Dolgova, Daria D. Petrova, Anastasia S. Proskurina, Genrikh S. Ritter, Polina E. Kisaretova, Ekaterina A. Potter, Yaroslav R. Efremov, Sergey I. Bayborodin, Tatiana V. Karamysheva, Margarita V. Romanenko, Sergey V. Netesov, Oleg S. Taranov, Aleksandr A. Ostanin, Elena R. Chernykh and Sergey S. Bogachev

    Citation: Cancer Cell International 2019 19:120

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  19. Content type: Primary research

    Lung cancer is one of the most common and deadly tumors around the world. Targeted therapy for patients with certain mutations, especially by use of tyrosine kinase inhibitors (TKIs) targeting epidermal growth...

    Authors: Yong-An Song, Ting Ma, Xue-Yan Zhang, Xiang-Song Cheng, Ayobami-Matthew Olajuyin, Zhi-Fu Sun and Xiao-Ju Zhang

    Citation: Cancer Cell International 2019 19:117

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  20. Content type: Primary research

    Hypoxic microenvironments play a significant role in the progression of colorectal cancer (CRC). Silencing information regulator 1 (SIRT1), a class III histone deacetylase, modulates the multiple biological be...

    Authors: Shentong Yu, Ru Zhou, Tong Yang, Shuang Liu, Zhuqing Cui, Qing Qiao and Jing Zhang

    Citation: Cancer Cell International 2019 19:116

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  21. Content type: Primary research

    miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relat...

    Authors: Zhihui Wang, Zhiquan Zhu, Zhong Lin, Youli Luo, Zibin Liang, Caibin Zhang, Jianxu Chen and Peijian Peng

    Citation: Cancer Cell International 2019 19:115

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  22. Content type: Primary research

    As an aggressive hematological malignancy, acute myeloid leukemia (AML) remains a dismal disease with poor prognosis. Long non-coding RNAs (lncRNAs) have been widely reported to be involved in tumorigenesis of...

    Authors: Si-Li Wang, Yun Huang, Rui Su and Yong-Yang Yu

    Citation: Cancer Cell International 2019 19:114

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  23. Content type: Primary research

    Although contemporary chemotherapy has improved the cure rate of childhood acute lymphoblastic leukemia (ALL) to nearly 90%, relapsed/refractory ALL is still a leading cause of tumor-related death in children....

    Authors: Yiping Zhu, Rong Yang, Ju Gao, Yanle Zhang, Ge Zhang and Ling Gu

    Citation: Cancer Cell International 2019 19:113

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  24. Content type: Primary research

    Prostate cancer (PCa), a major cause of cancer-related morbidity and mortality worldwide and mostly asymptomatic at earliest stages, is characterized by disruption of genetic and epigenetic balance. A better u...

    Authors: Tânia Soraia Vieira-Silva, Sara Monteiro-Reis, Daniela Barros-Silva, João Ramalho-Carvalho, Inês Graça, Isa Carneiro, Ana Teresa Martins, Jorge Oliveira, Luis Antunes, Sarah Hurtado-Bagès, Marcus Buschbeck, Rui Henrique and Carmen Jerónimo

    Citation: Cancer Cell International 2019 19:112

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  25. Content type: Primary research

    Acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Therefore, subtype classification is important and indispensable in ALL diagnosis. In ...

    Authors: Yanran Sun, Qiaosheng Zhang, Guoshuang Feng, Zhen Chen, Chao Gao, Shuguang Liu, Ruidong Zhang, Han Zhang, Xueling Zheng, Wenyu Gong, Yadong Wang, Yong Wu, Jie Li and Huyong Zheng

    Citation: Cancer Cell International 2019 19:110

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  26. Content type: Primary research

    The aim of this study is to explore the effect of microRNA-103a (miR-103a) on astrocytes activation and hippocampal neuron injury in epilepsy rats by targeting brain-derived neurotrophic factor (BDNF).

    Authors: Ping Zheng, He Bin and Wei Chen

    Citation: Cancer Cell International 2019 19:109

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  27. Content type: Primary research

    MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown.

    Authors: Xin Huang, Fen Tang, Zeping Weng, Mengyao Zhou and Qing Zhang

    Citation: Cancer Cell International 2019 19:108

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  28. Content type: Primary research

    Compelling lines of evidence indicate that DNA methylation of non-coding RNAs (ncRNAs) plays critical roles in various tumour progression. In addition, the differential methylation of ncRNAs can predict progno...

    Authors: Jie Zhang, Keqing Shi, Weiguo Huang, Wanqing Weng, Zhongjing Zhang, Yangyang Guo, Tuo Deng, Yukai Xiang, Xiaofeng Ni, Bicheng Chen and Mengtao Zhou

    Citation: Cancer Cell International 2019 19:107

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  29. Content type: Primary research

    Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is over-expressed in multiple human cancers, and...

    Authors: Haifeng Deng, Hongbing Shi, Lujun Chen, You Zhou and Jingting Jiang

    Citation: Cancer Cell International 2019 19:106

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  30. Content type: Primary research

    Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case–c...

    Authors: Tianbo Liu, Liangliang Jiang, Libo Yu, Tingting Ge, Jing Wang and Hongyu Gao

    Citation: Cancer Cell International 2019 19:105

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  31. Content type: Primary research

    Increasing reports demonstrated that dysregulated expression of microRNAs (miRNAs) leads to the progression of various tumors. Previous studies revealed that miR-328-3p exhibited dysregulated expression in var...

    Authors: Jianhui Shi, Gang An, Ying Guan, Tianli Wei, Zhibin Peng, Min Liang and Yansong Wang

    Citation: Cancer Cell International 2019 19:104

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  32. Content type: Primary research

    Cancer cells are characterized by aberrant activation of lipid biosynthesis, producing saturated fatty acids and monounsaturated fatty acids via stearoyl-CoA desaturases (SCD) for regulating metabolic and sign...

    Authors: Kelin She, Shenghua Fang, Wei Du, Xingxing Fan, Jiaxi He, Hui Pan, Liyan Huang, Ping He and Jun Huang

    Citation: Cancer Cell International 2019 19:103

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  33. Content type: Primary research

    Most colorectal cancer (CRC) patients are diagnosed at an advanced or metastatic stage with poor prognosis. Ubiquitin-specific protease 6 N-terminal-like protein (USP6NL) with high expression in CRC tissues re...

    Authors: Kang Sun, Song-Bing He, Yi-Zhou Yao, Jian-Guo Qu, Rong Xie, Yu-Qiao Ma, Ming-Hui Zong and Ji-Xiang Chen

    Citation: Cancer Cell International 2019 19:102

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  34. Content type: Primary research

    It is well known that human clear cell renal cell carcinoma (ccRCC) is a highly immunogenic and chemo-resistant tumor. Recently, emerging data suggest that the immune checkpoint blockade therapy is an importan...

    Authors: Lujun Chen, Dawei Zhu, Jun Feng, You Zhou, Qi Wang, Huijing Feng, Junping Zhang and Jingting Jiang

    Citation: Cancer Cell International 2019 19:101

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  35. Content type: Primary research

    Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a subs...

    Authors: Yanfang Wang, Quanli Zhang, Zhaojia Gao, Shan Xin, Yanbo Zhao, Kai Zhang, Run Shi and Xuanwen Bao

    Citation: Cancer Cell International 2019 19:100

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  36. Content type: Primary research

    Radiotherapy is becoming one major therapeutics for non-small cell lung cancer (NSCLC). Identifying novel radiosensitizers will greatly increase the efficacy of radiotherapy and benefit more patients. OTU deub...

    Authors: Zhiqiang Wu, Minghan Qiu, Yu Guo, Jinlin Zhao, Zhuang Liu, Hui Wang, Maobin Meng, Zhiyong Yuan and Zeyun Mi

    Citation: Cancer Cell International 2019 19:99

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  37. Content type: Primary research

    Currently offered therapeutics to treat colon cancer (CoCa) are toxic when given at maximum tolerated dose to achieve optimal clinical response. Hence, less toxic therapeutic intervention is needed to treat Co...

    Authors: Ian T. Saunders, Hina Mir, Neeraj Kapur and Shailesh Singh

    Citation: Cancer Cell International 2019 19:98

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  38. Content type: Primary research

    5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment ...

    Authors: Weilong Yao, Shengtao Zhu, Peng Li and Shutian Zhang

    Citation: Cancer Cell International 2019 19:97

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  39. Content type: Primary research

    The homeodomain transcription factor, PITX2 is associated with tumorigenesis of multiple cancers. In this research, we aimed to study the expression, function and mechanism of PITX2 in lung adenocarcinoma (LUAD).

    Authors: Jing Luo, Yu Yao, Saiguang Ji, Qi Sun, Yang Xu, Kaichao Liu, Qiang Diao, Yong Qiang and Yi Shen

    Citation: Cancer Cell International 2019 19:96

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  40. Content type: Correction

    After publication of the original article [1], the authors have notified us of 5 errors which are highlighted below. The authors apologize for any inconvenience.

    Authors: Ming-Hui Ma, Jia-Xiang An, Cheng Zhang, Jie Liu, Yu Liang, Chun-Dong Zhang, Zhen Zhang and Dong-Qiu Dai

    Citation: Cancer Cell International 2019 19:95

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    The original article was published in Cancer Cell International 2019 19:27

  41. Content type: Primary research

    In recent years, gastric cancer (GC) has become a major cause of mortality among various malignancies worldwide with high incidence rates. Long non-coding RNA (lncRNAs) may serve as oncogenes and tumor suppres...

    Authors: Lin Tang, Jian-Bo Wen, Ping Wen, Xing Li, Min Gong and Qiang Li

    Citation: Cancer Cell International 2019 19:94

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  42. Content type: Primary research

    Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of...

    Authors: Jia Cao, Xi Wang, Danni Wang, Rong Ma, Xiaohan Li, Huimin Feng, Jia Wang, Shihai Liu and Libin Wang

    Citation: Cancer Cell International 2019 19:93

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  43. Content type: Review

    In the past decade, increasing research attention investigated the novel therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its main active constituent Bufalin have been s...

    Authors: Chien-shan Cheng, Jiaqiang Wang, Jie Chen, Kuei Ting Kuo, Jian Tang, Huifeng Gao, Lianyu Chen, Zhen Chen and Zhiqiang Meng

    Citation: Cancer Cell International 2019 19:92

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  44. Content type: Review

    Breast cancer heterogeneity allows cells with different phenotypes to co-exist, contributing to treatment failure and development of drug resistance. In addition, abnormal signal transduction and dysfunctional...

    Authors: Eric Chekwube Aniogo, Blassan Plackal Adimuriyil George and Heidi Abrahamse

    Citation: Cancer Cell International 2019 19:91

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  45. Content type: Primary research

    Long noncoding RNAs (lncRNAs) can act as microRNA (miRNA) sponges to regulate protein-coding gene expression; therefore, lncRNAs are considered a major part of the competitive endogenous RNA (ceRNA) network an...

    Authors: Junyu Long, Yi Bai, Xiaobo Yang, Jianzhen Lin, Xu Yang, Dongxu Wang, Li He, Yongchang Zheng and Haitao Zhao

    Citation: Cancer Cell International 2019 19:90

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