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  1. Betulinic acid and betulin are triterpenes that have anticancer properties in various types of cancer. Unfortunately, the bioavailability and the bio-distribution of betulinic acid and its metabolic precursor,...

    Authors: Małgorzata Drąg-Zalesińska, Marcin Drąg, Marcin Poręba, Sylwia Borska, Julita Kulbacka and Jolanta Saczko

    Citation: Cancer Cell International 2017 17:4

    Content type: Primary Research

    Published on:

  2. Hypoxia is the condition where tumor cells have been deprived of oxygen and has been shown to have a role of tumor development in the hepatocellular carcinoma (HCC).

    Authors: Sung Hoon Choi and Jun Yong Park

    Citation: Cancer Cell International 2017 17:3

    Content type: Review

    Published on:

    The Erratum to this article has been published in Cancer Cell International 2017 17:69

  3. COX-2, an inducible enzyme, is associated with inflammatory diseases and carcinogenesis. Overexpression of COX-2 occurs in many human malignancies, including osteosarcoma. COX-2 positivity is form 67 to 92% in...

    Authors: Bing Liu, Shigui Yan, Liyan Qu and Jian Zhu

    Citation: Cancer Cell International 2017 17:1

    Content type: Primary research

    Published on:

  4. Autophagy can either be protective and confer survival to stressed cells, or it can contribute to cell death. The antimitotic drug 2-ethyl-3-O-sulpamoyl-estra-1,3,5(10),15-tetraen-17-ol (ESE-15-ol) is an in sili...

    Authors: Marcel Verwey, Elsie M. Nolte, Anna M. Joubert and Anne E. Theron

    Citation: Cancer Cell International 2016 16:91

    Content type: Primary research

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  5. Kallistatin is a serine proteinase inhibitor and heparin-binding protein. It is considered an endogenous angiogenic inhibitor. In addition, multiple studies demonstrated that kallistatin directly inhibits canc...

    Authors: Guoquan Wang, Xiao Wang, Xiaoping Huang, Huiyong Yang, Suqiu Pang, Xiaolan Xie, Shulan Zeng, Junsheng Lin and Yong Diao

    Citation: Cancer Cell International 2016 16:90

    Content type: Primary research

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  6. Long noncoding RNAs (lncRNAs) are related to different biological processes in non-small cell lung cancer (NSCLC). However, the possible molecular mechanisms underlying the effects of the long noncoding RNA HO...

    Authors: Yu Zhang, Rong-quan He, Yi-wu Dang, Xiu-ling Zhang, Xiao Wang, Su-ning Huang, Wen-ting Huang, Meng-tong Jiang, Xiao-ning Gan, You Xie, Ping Li, Dian-zhong Luo, Gang Chen and Ting-qing Gan

    Citation: Cancer Cell International 2016 16:89

    Content type: Hypothesis

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  7. Genomic instability is a hallmark of cancer cells, and this cellular phenomenon can emerge as a result of replicative stress. It is possible to take advantage of replicative stress, and enhance it in a targete...

    Authors: Zubeyde Erbayraktar, Begum Alural, Resat Serhat Erbayraktar and Erdogan Pekcan Erkan

    Citation: Cancer Cell International 2016 16:88

    Content type: Primary research

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  8. The aim of this hypothesis is to propose a new approach in targeted therapy of cancer: The simultaneous, dual targeting of two single molecules, Par-4 and G6PD, rather than inhibition of full-length signaling ...

    Authors: Ingeborg Elisabeth Cernaj

    Citation: Cancer Cell International 2016 16:87

    Content type: Hypothesis

    Published on:

  9. Human DNA polymerase β (polβ) is a small monomeric protein that is essential for short-patch base excision repair. It plays an important role in regulating the sensitivity of tumor cells to chemotherapy.

    Authors: Yuanyuan Wang, Xiaonan Chen, Qianqian Sun, Wenqiao Zang, Min Li, Ziming Dong and Guoqiang Zhao

    Citation: Cancer Cell International 2016 16:85

    Content type: primary research

    Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2019 19:88

  10. Citation: Cancer Cell International 2016 16:83

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2013 13:469

  11. Neuroblastoma is a tumor arising in the peripheral sympathetic nervous system and is the most common cancer in childhood. Since most of the cellular and molecular mechanisms underlying neuroblastoma onset and ...

    Authors: Diana Corallo, Simona Candiani, Michela Ori, Sanja Aveic and Gian Paolo Tonini

    Citation: Cancer Cell International 2016 16:82

    Content type: Review

    Published on:

  12. Many long non coding RNAs have been identified as key modulators in cancer development. A lncRNA, DBCCR1-003, derived from the locus of tumor suppressor gene DBCCR1 (deleted in bladder cancer chromosome region...

    Authors: Defeng Qi, Jinhui Li, Biao Que, Jialin Su, Mengxi Li, Chaofeng Zhang, Mei Yang, Guoren Zhou and Weidong Ji

    Citation: Cancer Cell International 2016 16:81

    Content type: Primary research

    Published on:

  13. The molecular mechanisms underlying the development and progression of gastric carcinoma remain poorly understood. The main objective of this study was to investigate the expression level of targeting protein ...

    Authors: Cuijie Shao, Changsheng Duan, Jiani Wang, Shunlian Luan, Yong Gao, Dan Jin, Deqiang Wang, Yuming Li and Lihua Xu

    Citation: Cancer Cell International 2016 16:79

    Content type: Primary Research

    Published on:

  14. Mounting evidence suggests the fallopian tube as the origin for ovarian high grade serous carcinoma (HGSC). We attempted to identify the tubal cytological features that allow us to distinguish malignant from b...

    Authors: Hao Chen, Robert Klein, Stacy Arnold, Setsuko Chambers and Wenxin Zheng

    Citation: Cancer Cell International 2016 16:78

    Content type: Primary research

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  15. Molecular profiling of colorectal cancer (CRC) based on global gene expression has revealed multiple dysregulated signalling pathways associated with drug resistance and poor prognosis. However, the role of BM...

    Authors: Radhakrishnan Vishnubalaji, Shijun Yue, Musaad Alfayez, Moustapha Kassem, Fei-Fei Liu, Abdullah Aldahmash and Nehad M. Alajez

    Citation: Cancer Cell International 2016 16:77

    Content type: Primary research

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  16. To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function.

    Authors: Jian-jun Li, Jie Luo, Jing-ning Lu, Xiao-na Liang, Yi-huan Luo, Yong-ru Liu, Jie Yang, Hua Ding, Gui-hui Qin, Li-hua Yang, Yi-wu Dang, Hong Yang and Gang Chen

    Citation: Cancer Cell International 2016 16:76

    Content type: Primary research

    Published on:

    The Correction to this article has been published in Cancer Cell International 2020 20:60

  17. A trend of stage-by-stage increase in tumorsphere (TS) formation from glioma samples has been reported. Despite this trend, not all surgical specimens give rise to TSs, even World Health Organization (WHO) gra...

    Authors: Kyoung Su Sung, Jin-Kyoung Shim, Ji-Hyun Lee, Se Hoon Kim, Sohee Park, Tae-Hoon Roh, Ju Hyung Moon, Eui-Hyun Kim, Sun Ho Kim, Su Jae Lee, Yong Min Huh, Seok-Gu Kang and Jong Hee Chang

    Citation: Cancer Cell International 2016 16:75

    Content type: Primary research

    Published on:

  18. Ovarian cancer is a common type of gynecological malignancies, and is the fifth leading cause of cancer-related death in women in the United States. MiR-429 and KIAA0101 have been found to be involved in sever...

    Authors: Hong Chen, Bairong Xia, Tianbo Liu, Mei Lin and Ge Lou

    Citation: Cancer Cell International 2016 16:74

    Content type: Primary research

    Published on:

  19. Osteosarcoma is the most common malignancy of bone. Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of aggressive phenotype. ANRIL has been shown to be a long nonc...

    Authors: Xiaokang Wei, Chuanshun Wang, Chunhui Ma, Wei Sun, Haoqing Li and Zhendong Cai

    Citation: Cancer Cell International 2016 16:73

    Content type: Primary research

    Published on:

    The Retraction Note to this article has been published in Cancer Cell International 2017 17:60

  20. Membrane depolarization is associated with breast cancer. Depolarization-activated voltage-gated ion channels are directly implicated in the initiation, proliferation, and metastasis of breast cancer.

    Authors: Seher Berzingi, Mackenzie Newman and Han-Gang Yu

    Citation: Cancer Cell International 2016 16:72

    Content type: Primary research

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  21. The transmembrane receptor family Roundabout (Robo) was described to have an essential role in the developing nervous system. Recent studies demonstrated that Robo3 shows an altered expression in rheumatoid ar...

    Authors: Anke Ruedel, Mandy Schott, Thomas Schubert and Anja Katrin Bosserhoff

    Citation: Cancer Cell International 2016 16:71

    Content type: Primary research

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  22. The glycolysis inhibitor 2-deoxy-d-glucose (2-DG) is a safe, potentially useful anti-tumour drug, but its efficacy is normally low when used alone. Recent studies indicated that 2-DG stimulates the PI3K/Akt and M...

    Authors: Elena de Blas, María Cristina Estañ, María del Carmen Gómez de Frutos, Javier Ramos, María del Carmen Boyano-Adánez and Patricio Aller

    Citation: Cancer Cell International 2016 16:70

    Content type: Primary research

    Published on:

  23. The acquisition of inappropriate migratory feature is crucial for tumor metastasis. Rho-family GTPases including RhoA are molecular switches that play critical roles in regulating cell movement. We investigate...

    Authors: Ruo Chen, Shi-Jie Wang, Yang Zhang, Rong Hou, Jian-Li Jiang and Hong-Yong Cui

    Citation: Cancer Cell International 2016 16:69

    Content type: Primary research

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  24. Recent studies indicated that histone deacetylase inhibitors (HDACi), a class of anticancer agents, are in addition to their ability of apoptosis induction also capable of provoking autophagy. Promoted by the ...

    Authors: Leopold F. Fröhlich, Maria Mrakovcic, Claudia Smole and Kurt Zatloukal

    Citation: Cancer Cell International 2016 16:68

    Content type: Primary research

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  25. To investigate the role of total cellular microRNA (miRNA) in regulating epithelial-to-mesenchymal transition (EMT) during human endometrial endometrioid adenocarcinoma (EEC).

    Authors: Ping Liu, Chao Wang, Chengbin Ma, Qiongwei Wu, Wenying Zhang and Guoying Lao

    Citation: Cancer Cell International 2016 16:67

    Content type: Primary research

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  26. Lung cancer causes the most cancer deaths worldwide, thus there is a urgent need to develop new treatment options. Concurrent chemoradiotherapy has become a common strategy for the treatment of non-resectable ...

    Authors: Patrick Dorn, Colin Charles Tièche, Ren-Wang Peng, Laurène Froment, Ralph Alexander Schmid and Thomas Michael Marti

    Citation: Cancer Cell International 2016 16:66

    Content type: Primary research

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  27. Pancreatic cancer is currently one of the leading causes of cancer deaths without any effective therapies. Mir-145 has been found to be tumor-suppressive in various types of cancers. The aim of this study is t...

    Authors: Hao Wang, Cheng Hang, Xi-Long Ou, Jin-Shan Nie, Yi-Tao Ding, Shi-Gui Xue, Hua Gao and Jian-Xin Zhu

    Citation: Cancer Cell International 2016 16:65

    Content type: Primary research

    Published on:

  28. Chemoresistance hinders curative cancer chemotherapy in osteosarcoma (OS), resulting in only an approximately 20 % survival rate in patients with metastatic disease at diagnosis. Identifying the mechanisms res...

    Authors: Youguang Pu, Qiyi Yi, Fangfang Zhao, Haiyan Wang, Wenjing Cai and Shanbao Cai

    Citation: Cancer Cell International 2016 16:64

    Content type: Primary research

    Published on:

  29. Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Many microRNAs (miRNAs), small non-coding RNAs, are involved in regulating cancer cell proliferation, metastasis, migrat...

    Authors: Yue-Bin Zeng, Xing-Hua Liang, Guang-Xian Zhang, Nan Jiang, Tong Zhang, Jian-Ying Huang, Lei Zhang and Xian-Cheng Zeng

    Citation: Cancer Cell International 2016 16:63

    Content type: Primary research

    Published on:

  30. A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in the transformation of malignant cells. Constitutive and abnormal activation of RTKs may occur in tumors eit...

    Authors: Sanja Aveic and Gian Paolo Tonini

    Citation: Cancer Cell International 2016 16:62

    Content type: Review

    Published on:

  31. Peptidylarginine deiminase (PAD) post-translationally converts arginine residues to citrulline residues. Recent studies have suggested that PADI2 (PAD isoform 2), a member of the PAD family, is involved in the...

    Authors: Huifeng Wang, Bing Xu, Xiaoqian Zhang, Yabing Zheng, Yan Zhao and Xiaotian Chang

    Citation: Cancer Cell International 2016 16:61

    Content type: Primary research

    Published on:

  32. Enhancer of Zeste Drosophila Homologue 2 (EZH2) is a key regulator of transcription as a member of polycomb repressive complex 2 (PRC2) which exerts repression of downstream genes and is correlated to invasivenes...

    Authors: Maria Ramaglia, Velia D’Angelo, Adriana Iannotta, Daniela Di Pinto, Elvira Pota, Maria Carmen Affinita, Vittoria Donofrio, Maria Elena Errico, Angela Lombardi, Cristiana Indolfi, Fiorina Casale and Michele Caraglia

    Citation: Cancer Cell International 2016 16:59

    Content type: Primary research

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  33. Glioblastoma stem cells (GSC) have been extensively recognized as a plausible cause of glioblastoma resistance to therapy and recurrence resulting in high glioblastoma mortality. Abnormalities in the DNA repai...

    Authors: Saša Kenig, Valentina Faoro, Evgenia Bourkoula, Neža Podergajs, Tamara Ius, Marco Vindigni, Miran Skrap, Tamara Lah, Daniela Cesselli, Paola Storici and Alessandro Vindigni

    Citation: Cancer Cell International 2016 16:58

    Content type: Primary research

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  34. Oridonin (ORI) can inhibit proliferation and migration in various types of cancer cell lines. However, the exact mechanism remains unclear. We investigated the migration inhibitory effect of ORI on human pancr...

    Authors: Qian-Qian Liu, Ke Chen, Qiao Ye, Xiao-Hua Jiang and Yun-Wei Sun

    Citation: Cancer Cell International 2016 16:57

    Content type: Primary research

    Published on:

  35. The introduction of effective novel biomarkers of invasion and metastasis is integral for the advancement of breast cancer management. The present study focused on the identification and evaluation of calretic...

    Authors: Mohammadreza Zamanian, Lama Abdel Qader Hamadneh, Abhi Veerakumarasivam, Sabariah Abdul Rahman, Shamarina Shohaimi and Rozita Rosli

    Citation: Cancer Cell International 2016 16:56

    Content type: Primary research

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  36. This retrospective study aimed to investigate the prognostic significance of pretreatment lymphocyte-to-monocyte ratio (LMR) in locally advanced cervical cancer and its effect on overall survival.

    Authors: Si-wei Li, Wenxin Yuan, Bo Zhao, Zhuo-kai He, Xiang Guo, Wei-xiong Xia and Li-hua Xu

    Citation: Cancer Cell International 2016 16:54

    Content type: Primary research

    Published on:

  37. Poly(ADP-ribose) polymerase (PARP) inhibitors have entered the clinics for their promising anticancer effect as adjuvant in chemo- and radiotherapy and as single agent on BRCA-mutated tumours. Poly(ADP-ribose)...

    Authors: Aurélia Noll, Giuditta Illuzzi, Jean-Christophe Amé, Françoise Dantzer and Valérie Schreiber

    Citation: Cancer Cell International 2016 16:53

    Content type: Primary research

    Published on:

  38. The conventional radical resection of proximal gastric cancer is even more risky when performed laparoscopically, though this technique is widely used in gastrointestinal surgery and is accepted as the superio...

    Authors: Liansheng Zheng, Ce Zhang, Da Wang, Qi Xue, Xiaoping Liu, Ke-Jian Zhou, Hao Liu and Guoxin Li

    Citation: Cancer Cell International 2016 16:52

    Content type: Primary research

    Published on:

  39. Euglena tuba, a microalga, is known for its excellent antioxidant and iron-chelation activities; however its anticancer efficacies have not been reported yet. This study investigates t...

    Authors: Sourav Panja, Nikhil Baban Ghate and Nripendranath Mandal

    Citation: Cancer Cell International 2016 16:51

    Content type: Primary research

    Published on:

  40. Human chorionic gonadotropin (hCG) can play a crucial role in angiogenesis. In the present study, we focused on hCG to gain insight into its potential effects on vasculogenic mimicry (VM) in ovarian cancer cells.

    Authors: Min Su, Xiangxiang Xu, Weiwei Wei, Sainan Gao, Xiaoying Wang, Caoyi Chen and Yuquan Zhang

    Citation: Cancer Cell International 2016 16:50

    Content type: Primary research

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  41. Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique prot...

    Authors: Himani Garg, Prerna Suri, Jagdish C. Gupta, G. P. Talwar and Shweta Dubey

    Citation: Cancer Cell International 2016 16:49

    Content type: Review

    Published on:

  42. Epithelial to mesenchymal transition (EMT) has been shown to be a crucial enhancing mechanism in the process of cancer metastasis, as it increases cancer cell capabilities to migrate, invade and survive in cir...

    Authors: Chuanpit Ninsontia, Preeyaporn Plaimee Phiboonchaiyanan and Pithi Chanvorachote

    Citation: Cancer Cell International 2016 16:48

    Content type: Primary research

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  43. Glioblastoma (GBM) is the most common primary brain tumor presenting self-renewing cancer stem cells. The role of these cells on the development of the tumors has been proposed to recapitulate programs from em...

    Authors: Maria Cecília Oliveira-Nunes, Suzana Assad Kahn, Ana Luiza de Oliveira Barbeitas, Tania Cristina Leite de Sampaio e Spohr, Luiz Gustavo Feijó Dubois, Grasiella Maria Ventura Matioszek, William Querido, Loraine Campanati, José Marques de Brito Neto, Flavia Regina Souza Lima, Vivaldo Moura-Neto and Katia Carneiro

    Citation: Cancer Cell International 2016 16:46

    Content type: Primary Research

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  44. Since cytotoxic T cell (CTL) response is the major cellular type in attacking tumor cells, most immunotherapy targets to manipulate the CTL response. Immunotherapies targeting melanoma-specific antigens (MAGEs...

    Authors: Wang Junwei, Zhan Xiumin, Ye Jing, Yang Shoujing and Li Zengshan

    Citation: Cancer Cell International 2016 16:45

    Content type: Primary research

    Published on:

    The Erratum to this article has been published in Cancer Cell International 2017 17:10

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