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  1. Spheroid based culture methods are gaining prominence to elucidate the role of the microenvironment in liver carcinogenesis. Additionally, the phenomenon of epithelial-mesenchymal transition also plays an impo...

    Authors: Joseph M. Pomo, Robert M. Taylor and Rama R. Gullapalli

    Citation: Cancer Cell International 2016 16:44

    Content type: Primary research

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  2. With the continuing development of new anti-cancer drugs comes a need for preclinical experimental models capable of predicting the clinical activity of these novel agents in cancer patients. However existing ...

    Authors: Kyung-Min Kim, Jin-Kyoung Shim, Jong Hee Chang, Ji-Hyun Lee, Se-Hoon Kim, Junjeong Choi, Junseong Park, Eui-Hyun Kim, Sun Ho Kim, Yong-Min Huh, Su-Jae Lee, Jae-Ho Cheong and Seok-Gu Kang

    Citation: Cancer Cell International 2016 16:43

    Content type: Primary research

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  3. Deregulation of miRNA-210 is a common event in several types of cancer. However, increased expression levels in the cancer tissue have been associated with both poor and good prognosis of patients. Similarly, ...

    Authors: Katrin E. Tagscherer, Anne Fassl, Tabea Sinkovic, Jutta Richter, Sabrina Schecher, Stephan Macher-Goeppinger and Wilfried Roth

    Citation: Cancer Cell International 2016 16:42

    Content type: Primary research

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  4. Hepatocellular carcinoma (HCC) is an aggressive cancer with high mortality and morbidity worldwide. The limited clinically relevant model has impeded the development of effective HCC treatment strategy. Patien...

    Authors: Phyllis F. Y. Cheung, Chi Wai Yip, Linda W. C. Ng, Kwok Wai Lo, Chit Chow, Kui Fat Chan, Tan To Cheung and Siu Tim Cheung

    Citation: Cancer Cell International 2016 16:41

    Content type: Primary research

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  5. Marine algae consumption is linked to law cancer incidences in countries that traditionally consume marine products. Hence, Phytochemicals are considered as potential chemo-preventive and chemotherapeutic agen...

    Authors: Hossam Murad, Mohammad Hawat, Adnan Ekhtiar, Abdulmunim AlJapawe, Assef Abbas, Hussein Darwish, Oula Sbenati and Ahmed Ghannam

    Citation: Cancer Cell International 2016 16:39

    Content type: Primary research

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  6. Lyn, an import member of Src family kinases (SFKs), is supposed to be implicated in acute myeloid leukemia (AML) pathogenesis and development by participation in AML differentiation, yet the details still rema...

    Authors: Noriyoshi Iriyama, Bo Yuan, Yoshihiro Hatta, Norio Takagi and Masami Takei

    Citation: Cancer Cell International 2016 16:37

    Content type: Primary research

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  7. Temozolomide (TMZ) is a first-line drug for the treatment of glioblastoma. Long-term TMZ-treated tumour cells acquire TMZ resistance by profound reprogramming of the transcriptome, proteome, kinome, metabolism...

    Authors: Aleksei A. Stepanenko, Svitlana V. Andreieva, Kateryna V. Korets, Dmytro O. Mykytenko, Vladimir P. Baklaushev, Nataliya L. Huleyuk, Oksana A. Kovalova, Kateryna V. Kotsarenko, Vladimir P. Chekhonin, Yegor S. Vassetzky, Stanislav S. Avdieiev and Vladimir V. Dmitrenko

    Citation: Cancer Cell International 2016 16:36

    Content type: Primary research

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  8. Malignant Mesothelioma (MM) is a highly aggressive tumor with poor prognosis. Multimodal treatments and novel molecular targeted therapies against MM are in high demand in order treat this disease effectively....

    Authors: Mutsumi Hayashi, Hiroko Madokoro, Koji Yamada, Hiroko Nishida, Chikao Morimoto, Michiie Sakamoto and Taketo Yamada

    Citation: Cancer Cell International 2016 16:35

    Content type: Primary research

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  9. For Glioblastoma (GBM) patients, a number of anti-neoplastic strategies using specifically targeting drugs have been tested; however, the effects on survival have been limited. One explanation could be treatme...

    Authors: Mikkel Staberg, Signe Regner Michaelsen, Louise Stobbe Olsen, Mette Kjølhede Nedergaard, Mette Villingshøj, Marie-Thérése Stockhausen, Petra Hamerlik and Hans Skovgaard Poulsen

    Citation: Cancer Cell International 2016 16:34

    Content type: Primary Research

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  10. Persistent hypoxia stimulation, one of the most critical microenvironmental factors, accelerates the acquisition of epithelial–mesenchymal transition (EMT) phenotypes in lung cancer cells. Loss of phosphatase ...

    Authors: Takashi Kohnoh, Naozumi Hashimoto, Akira Ando, Koji Sakamoto, Shinichi Miyazaki, Daisuke Aoyama, Masaaki Kusunose, Motohiro Kimura, Norihito Omote, Kazuyoshi Imaizumi, Tsutomu Kawabe and Yoshinori Hasegawa

    Citation: Cancer Cell International 2016 16:33

    Content type: Primary research

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  11. Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant brain tumor that almost exclusively develops in young children. AT/RT belongs to the embryonal brain tumor group, comprising primitive tumors reca...

    Authors: Seung Ah Choi, Seung-Ki Kim, Ji Yeoun Lee, Kyu-Chang Wang, Chanhee Lee and Ji Hoon Phi

    Citation: Cancer Cell International 2016 16:32

    Content type: Primary research

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  12. Glioblastoma (GBM) is considered to be one of the most aggressive tumors of the central nervous system (CNS). Even with the use of modern treatment protocols, the prognosis remains reserved, with children with...

    Authors: Pamela Viani de Andrade, Augusto Faria Andrade, Rosane Gomes de Paula Queiroz, Carlos Alberto Scrideli, Luiz Gonzaga Tone and Elvis Terci Valera

    Citation: Cancer Cell International 2016 16:31

    Content type: Primary research

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  13. Cisplatin (DDP)-based chemotherapy is the mainstay of first-line therapy for lung cancer. However, their efficacy is often limited by the existence or development of chemoresistance. The aim of this study was ...

    Authors: Weili Li, Wenzhe Wang, Mingjian Ding, Xiaoliang Zheng, Shenglin Ma and Xiaoju Wang

    Citation: Cancer Cell International 2016 16:30

    Content type: Primary Research

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  14. Endometrial cancer (EC) is the most common form of malignant gynecological tumor. Treatment with cisplatin (CDDP) is the mainstay of EC chemotherapy. The apoptotic machinery is regarded as an important etiolog...

    Authors: Yongli Zhang, FeiZhou Jiang, Wei Bao, Huilin Zhang, XiaoYing He, Huihui Wang and Xiaoping Wan

    Citation: Cancer Cell International 2016 16:29

    Content type: Primary Research

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  15. Lung cancer bone metastasis causes poor prognosis. Basigin-2, a novel cancer-associated biomarker, is upregulated in lung cancer and has been linked with tumor progression. But little is known about the role o...

    Authors: Cheng-Gong Liao, Li Yao, Wei Xie, Lili Liu, Sheng-Da Wu, Ning Lu, Jian-Guo Huang, Ling-Min Kong and He-Long Zhang

    Citation: Cancer Cell International 2016 16:28

    Content type: Primary Research

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  16. Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct ind...

    Authors: Martina Broecker-Preuss, Nina Becher-Boveleth, Stefan Müller and Klaus Mann

    Citation: Cancer Cell International 2016 16:27

    Content type: Primary research

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  17. Obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). BBC has no targeted therapies, making the need for mechanistic insight urgent. Reducing adiposity in adu...

    Authors: Yuanyuan Qin, Sneha Sundaram, Luma Essaid, Xin Chen, Samantha M. Miller, Feng Yan, David B. Darr, Joseph A. Galanko, Stephanie A. Montgomery, Michael B. Major, Gary L. Johnson, Melissa A. Troester and Liza Makowski

    Citation: Cancer Cell International 2016 16:26

    Content type: Primary research

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  18. Epidermal growth factor receptor (EGFR) is an important oncogenic protein in multiple types of cancer. Endocytosis and degradation of epidermal growth factor receptor (EGFR) are two key steps for down-regulati...

    Authors: Ke Peng, Qian Dai, Jing Wei, Genbao Shao, Aiqin Sun, Wannian Yang and Qiong Lin

    Citation: Cancer Cell International 2016 16:25

    Content type: Primary research

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  19. Understanding the cause of therapeutic resistance and identifying new biomarkers in breast cancer to predict therapeutic responses will help optimise patient care. Calcium (Ca2+)-signalling is important in a vari...

    Authors: Elena Pera, Elke Kaemmerer, Michael J. G. Milevskiy, Kunsala T. D. S. Yapa, Jake S. O’Donnell, Melissa A. Brown, Fiona Simpson, Amelia A. Peters, Sarah J. Roberts-Thomson and Gregory R. Monteith

    Citation: Cancer Cell International 2016 16:24

    Content type: Primary research

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  20. Breast cancer is a heterogeneous disorder for which the underlying genetic basis remains unclear. We developed a method for identifying adenomatous polyposis coli (APC) mutations and we evaluated the possible ass...

    Authors: Ya-Sian Chang, Chien-Yu Lin, Shu-Fen Yang, Cheng-Mao Ho and Jan-Gowth Chang

    Citation: Cancer Cell International 2016 16:23

    Content type: Primary research

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  21. Prostate stem cell antigen (PSCA) expression has been shown to correlate with prostatic carcinogenesis and prostate cancer (PCa) progression. The underlying mechanisms for these processes are currently unknown...

    Authors: Ran Kang, Shankun Zhao, Luhao Liu, Futian Li, Ermao Li, Lianmin Luo, Lihua Xu, ShawPong Wan and Zhigang Zhao

    Citation: Cancer Cell International 2016 16:20

    Content type: Primary research

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  22. Cancer stem cells contribute to tumor initiation, heterogeneity, and recurrence, and are critical targets in cancer therapy. Sprouty4 (Spry4) is a potent inhibitor of signal transduction pathways elicited by r...

    Authors: Hongyu Jing, Lucy Liaw, Robert Friesel, Calvin Vary, Shucheng Hua and Xuehui Yang

    Citation: Cancer Cell International 2016 16:19

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2017 17:53

  23. The thieno[2,3-b]pyridines were discovered by virtual high throughput screening as potential inhibitors of phospholipase C (PLC) isoforms and showed potent growth inhibitory effects in National Cancer Institute’s...

    Authors: Jóhannes Reynisson, Jagdish K. Jaiswal, David Barker, Stacey A. N. D’mello, William A. Denny, Bruce C. Baguley and Euphemia Y. Leung

    Citation: Cancer Cell International 2016 16:18

    Content type: Primary research

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  24. The transcription factor CCAAT/enhancer binding protein α (C/EBPα) and microRNA (miRNA) let-7a-1 act as tumor suppressors in many types of cancers including lung cancer. In the present study, we aim to investi...

    Authors: Yani Lin, Jian Zhao, Xiaoyan Hu, Lina Wang, Liming Liang and Weiwen Chen

    Citation: Cancer Cell International 2016 16:17

    Content type: Primary research

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  25. We aimed to discover the potential microRNA (miRNA) targets and to explore the underlying molecular mechanisms of clear cell renal cell carcinoma (ccRCC).

    Authors: Yongsheng Chen, Lichen Teng, Wenhua Liu, Yan Cao, Dexin Ding, Wentao Wang, Hui Chen, Changfu Li and Ruihua An

    Citation: Cancer Cell International 2016 16:16

    Content type: Primary research

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  26. Sushi Domain Containing 2 (SUSD2) has been identified as a regulator of colon and breast cancer. Increasing evidence suggests that SUSD2 plays a key role in tumorigenesis. However, the SUSD2 expression status ...

    Authors: Xin-rui Liu, Cui-xia Cai, Li-min Luo, Wen-Ling Zheng, Rong Shi, Jun Zeng, You-qin Xu, Min Wei and Wen-li Ma

    Citation: Cancer Cell International 2016 16:15

    Content type: Primary research

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  27. Methotrexate is an important chemotherapeutic drug widely known as an inhibitor of dihydrofolate reductase (DHFR) which inhibits the reduction of folic acid. DHFR-mediated effects are apparently responsible fo...

    Authors: Martin Sramek, Jakub Neradil, Jaroslav Sterba and Renata Veselska

    Citation: Cancer Cell International 2016 16:14

    Content type: Primary research

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  28. Prostate cancer (PCa) remains to be a diagnostic challenge due to its variable presentation and the lack of reliable diagnosis tool. MicroRNAs (miRNAs) regulate gene in extensive range of pathophysiologic proc...

    Authors: Jiaqi Wang, Huamao Ye, Dandan Zhang, Yijun Hu, Xiya Yu, Long Wang, Changjing Zuo, Yongwei Yu, Guixia Xu and Shanrong Liu

    Citation: Cancer Cell International 2016 16:12

    Content type: Primary Research

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  29. Previous reports showed that the Steroidal Glycoalkaloid Solamargine inhibited proliferation of non-melanoma skin cancer cells. However, Solamargine was not tested systematically on different types of melanoma...

    Authors: Sana S. Al Sinani, Elsadig A. Eltayeb, Brenda L. Coomber and Sirin A. Adham

    Citation: Cancer Cell International 2016 16:11

    Content type: Primary research

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  30. The use of the dietary polyphenols as chemosensitizing agents to enhance the efficacy of conventional cytostatic drugs has recently gained the attention of scientists and clinicians as a plausible approach fo...

    Authors: Anna Klimaszewska-Wisniewska, Marta Halas-Wisniewska, Tadeusz Tadrowski, Maciej Gagat, Dariusz Grzanka and Alina Grzanka

    Citation: Cancer Cell International 2016 16:10

    Content type: Primary research

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  31. The most common genetic changes identified in human NSCLC are Kras mutations (10–30 %) and p53 mutation or loss (50–70 %). Moreover, NSCLC with mutations in Kras and p53 poorly respond to current therapies, so...

    Authors: Huanan Wang, Lei Wang, Yingjie Zhang, Ji Wang, Yibin Deng and Degui Lin

    Citation: Cancer Cell International 2016 16:9

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2016 16:38

  32. Most women with primary breast cancers that express estrogen receptor alpha (ER or ESR1) are treated with endocrine therapies including the anti-estrogen tamoxifen, but resistance to these anti-endocrine ther...

    Authors: Lily M. Fitzgerald, Eva P. Browne, Kevin D. Christie, Elizabeth C. Punska, Leo O. Simmons, Kristin E. Williams, Brian T. Pentecost, Rahul M. Jawale, Christopher N. Otis and Kathleen F. Arcaro

    Citation: Cancer Cell International 2016 16:8

    Content type: Primary research

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  33. Through research carried out in the last 25 years about the breast cancer etiology, it has been possible to estimate that less than 10 % of patients who are diagnosed with the condition are carriers of some ge...

    Authors: Marco Allán Pérez-Solis, Guadalupe Maya-Nuñez, Patricia Casas-González, Aleida Olivares and Arturo Aguilar-Rojas

    Citation: Cancer Cell International 2016 16:7

    Content type: Review

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  34. This last decade, a lot of emphasis has been placed on developing new cancer cell culture models, closer to in vivo condition, in order to test new drugs and therapies. In the case of colorectal cancer, the us...

    Authors: Sébastien Relier, Laura Yazdani, Oualid Ayad, Armelle Choquet, Jean-François Bourgaux, Michel Prudhomme, Julie Pannequin, Françoise Macari and Alexandre David

    Citation: Cancer Cell International 2016 16:6

    Content type: Primary research

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  35. Despite the fact that melatonin treatment shows some promise in gastric cancer, the molecular mechanisms of gastric cancer cells in response to melatonin remains to be determined.

    Authors: Wenjie Deng, Yujie Zhang, Luo Gu, Jie Cui, Biao Duan, Yueyuan Wang and Jun Du

    Citation: Cancer Cell International 2016 16:5

    Content type: Primary research

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  36. Alterations in cellular metabolism are considered as hallmarks of cancers, however, to recognize these alterations and understand their mechanisms appropriate techniques are required. Our hypothesis was to det...

    Authors: A. Jeney, Z. Hujber, N. Szoboszlai, A. Fullár, J. Oláh, É. Pap, Á. Márk, Cs. Kriston, J. Kralovánszky, I. Kovalszky, K. Vékey and A. Sebestyén

    Citation: Cancer Cell International 2016 16:4

    Content type: Primary research

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  37. Breast cancer is the most prevalent malignancies among the women that have a high mortality. Previous studies demonstrated that hypericin, a bioactive component of Hypericum perforatum have a cytotoxic effect on ...

    Authors: Seyed Abbas Mirmalek, Mohammad Amin Azizi, Ehsan Jangholi, Soheila Yadollah-Damavandi, Mohammad Amin Javidi, Yekta Parsa, Tina Parsa, Seyed Alireza Salimi-Tabatabaee, Hossein Ghasemzadeh kolagar and Reza Alizadeh-Navaei

    Citation: Cancer Cell International 2016 16:3

    Content type: Primary Research

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  38. Mutation rates are consistently varied in cancer genome and play an important role in tumorigenesis, however, little has been known about their function potential and impact on the distribution of functional m...

    Authors: Chuance Du, Xiaoyuan Wu and Jia Li

    Citation: Cancer Cell International 2016 16:2

    Content type: Primary Research

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    The Retraction Note to this article has been published in Cancer Cell International 2017 17:67

  39. Development of alternative cancer-specific drugs would be of paramount importance to overcome toxicity toward normal tissues and tumor resistance. Here, we investigated the potential anti-tumoral effect of pee...

    Authors: Ichrak Riahi-Chebbi, Meriam Haoues, Makram Essafi, Ons Zakraoui, Sami Fattouch, Habib Karoui and Khadija Essafi-Benkhadir

    Citation: Cancer Cell International 2016 16:1

    Content type: Primary research

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  40. The resulting clinical impact of the combined use of G-CSF with chemotherapy as a chemosensitizing strategy for treatment of acute myeloid leukemia (AML) patients is still controversial. In this study, the eff...

    Authors: Meritxell Nomdedeu, María Carmen Lara-Castillo, Amaia Etxabe, Josep María Cornet-Masana, Marta Pratcorona, Marina Díaz-Beyá, Xavier Calvo, María Rozman, Dolors Costa, Jordi Esteve and Ruth M. Risueño

    Citation: Cancer Cell International 2015 15:122

    Content type: Primary research

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  41. Cisplatin causes male infertility but the exact mechanism have not been clarified, yet. MOTILIPERM has been implicated in alleviation of infertility in Sprague–Dawley rats caused by cisplatin. We evaluated re...

    Authors: Kiran Kumar Soni, Li Tao Zhang, Jae Hyung You, Sung Won Lee, Chul Young Kim, Wan Shou Cui, Han Jung Chae, Hye Kyung Kim and Jong Kwan Park

    Citation: Cancer Cell International 2015 15:121

    Content type: Primary research

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  42. DIXDC1 (Dishevelled-Axin domain containing 1) is a positive regulator of the Wnt pathway. In the field of cancer research, the role of DIXDC1 is unclear. Our previous in vitro study showed that DIXDC1 enhances...

    Authors: Lei Wang, Cong Tan, Fan Qiao, Weige Wang, Xiangnan Jiang, Peng Lian, Bin Chang and Weiqi Sheng

    Citation: Cancer Cell International 2015 15:120

    Content type: Primary research

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  43. Alizarin and purpurin are di- and trihydroxyanthraquinones derived from Rubia tinctorum L. Previous pharmacological studies have demonstrated that they exhibit certain degree of selective inhibitory effects towar...

    Authors: Eszter Lajkó, Péter Bányai, Zsófia Zámbó, László Kursinszki, Éva Szőke and László Kőhidai

    Citation: Cancer Cell International 2015 15:119

    Content type: Primary research

    Published on:

  44. In this study, we aim to evaluate the balance of interleukin (IL)-33 and its soluble receptor sST2 in patients with aplastic anemia (AA).

    Authors: Ming Sun, Hai-feng Ma, Ye-yun Che and Xin Cui

    Citation: Cancer Cell International 2015 15:118

    Content type: Primary research

    Published on:

  45. Advances in surgical and medical treatments for ovarian cancer have improved prognoses. Platinum drugs in particular are pivotal for the medical treatment of ovarian cancer. However, previous studies have reve...

    Authors: Shinya Matsuzaki, Kiyoshi Yoshino, Yutaka Ueda, Satoko Matsuzaki, Mamoru Kakuda, Akiko Okazawa, Tomomi Egawa-Takata, Eiji Kobayashi and Tadashi Kimura

    Citation: Cancer Cell International 2015 15:117

    Content type: Review

    Published on:

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