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  1. Abnormal expression of the eukaryotic initiation factor 3 (eIF3) subunits plays critical roles in tumorigenesis and progression, and also has potential prognostic value in cancers. However, the expression and ...

    Authors: Rui-Chao Chai, Ning Wang, Yu-Zhou Chang, Ke-Nan Zhang, Jing-Jun Li, Jun-Jie Niu, Fan Wu, Yu-Qing Liu and Yong-Zhi Wang

    Citation: Cancer Cell International 2019 19:155

    Content type: Primary research

    Published on:

  2. Lymphoma is one of the most common hematologic malignancy. Drug resistance is the main obstacle faced in lymphoma treatment. Cancer stem cells are considered as the source of tumor recurrence, metastasis and d...

    Authors: Li-Na Lv, Xiao-Chao Wang, Li-Ju Tao, Hong-Wen Li, Shu-You Li and Fei-Meng Zheng

    Citation: Cancer Cell International 2019 19:153

    Content type: Primary research

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  3. Recently, lncRNA-Testis developmental related gene 1 (TDRG1) was proved to be a key modulator in reproductive organ-related cancers. The biological role of TDRG1 in cervical cancer (CC) progression remains lar...

    Authors: Hui Jiang, Min liang, Yanqiong Jiang, Ting Zhang, Kexin Mo, Suwen Su, Aiping Wang, Yongyi Zhu, Guanqun Huang and Rujian Zhou

    Citation: Cancer Cell International 2019 19:152

    Content type: Primary research

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  4. One of the most important metabolic hallmarks of breast cancer cells is enhanced lipogenesis. Increasing evidences suggest that fatty acid synthase (FAS) plays an important role in human breast cancer. Previou...

    Authors: Wenyuan Huang, Yan Liang and Xiaofeng Ma

    Citation: Cancer Cell International 2019 19:151

    Content type: Primary research

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  5. NPL4 is an important cofactor of the valosin-containing protein (VCP)–NPL4–UFD1 complex. The VCP–NPL4–UFD1 has been considered as a ubiquitin proteasome system (UPS) regulator and response to protein degradati...

    Authors: Bao-Sai Lu, Yue-Wei Yin, Yan-Ping Zhang, Ping-Ying Guo, Wei Li and Kai-Long Liu

    Citation: Cancer Cell International 2019 19:149

    Content type: Primary research

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  6. It is becoming increasingly clear that cancers can rarely be ascribed to just one or a few genomic variations. Genes generally do not function alone, but in groups that function as “networks”. This study aimed...

    Authors: Min-Er Zhong, Yanyu Chen, Guannan Zhang, Lai Xu, Wei Ge and Bin Wu

    Citation: Cancer Cell International 2019 19:148

    Content type: Primary research

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  7. Accumulating evidence has highlighted the tumor suppressive roles of microRNA (miRNAs) in cervical cancer (CC). In the present study, we aim to delineate the functional relevance of microRNA-137 (miR-137) in i...

    Authors: Hui Miao, Nuan Wang, Lin-Xin Shi, Zheng Wang and Wen-Bo Song

    Citation: Cancer Cell International 2019 19:147

    Content type: Primary research

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  8. Programmed cell death ligand 1 (PD-L1) expression has been shown to associate with poor prognosis in a variety of solid tumors. However, the prognostic value of PD-L1 expression in cervical cancer is still con...

    Authors: Xiaobin Gu, Meilian Dong, Zheyan Liu, Yin Mi, Jing Yang, Zhigang Zhang, Ke Liu, Li Jiang, Yue Zhang, Shiliang Dong and Yonggang Shi

    Citation: Cancer Cell International 2019 19:146

    Content type: Primary research

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  9. Pancreatic cancer stem cells (CSCs), a special population of cells, renew themselves infinitely and resist to various treatment. Gramicidin A (GrA), an ionophore antibiotic derived from microorganism, can form...

    Authors: Rui-Qi Wang, Jing Geng, Wei-Jin Sheng, Xiu-Jun Liu, Min Jiang and Yong-Su Zhen

    Citation: Cancer Cell International 2019 19:145

    Content type: Primary research

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  10. Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is an H3K27me3 demethylase, a permissive mark associated with active gene transcription. UTX has been linked to various human cancers. Colo...

    Authors: Xin Tang, Wenwei Cai, Jing Cheng, Ping Lu, Shaojun Ma, Chaoting Chen, Yi Chen, Yun Sun, Caofeng Wang, Ping Hu, Xiaomin Lv, G. Sun, Yu Wang and Jing Sheng

    Citation: Cancer Cell International 2019 19:144

    Content type: Primary research

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  11. Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid car...

    Authors: Xiaoli Zhang, Fei Li, Yeqing Cui, Shuang Liu and Haichen Sun

    Citation: Cancer Cell International 2019 19:143

    Content type: Primary research

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  12. Esophageal squamous cell carcinoma (ESCC) is one of leading malignant cancers of gastrointestinal tract worldwide. Until now, the involved mechanisms during the development of ESCC are largely unknown. This st...

    Authors: Wanli Yang, Xinhui Zhao, Yu Han, Lili Duan, Xin Lu, Xiaoqian Wang, Yujie Zhang, Wei Zhou, Jinqiang Liu, Hongwei Zhang, Qingchuan Zhao, Liu Hong and Daiming Fan

    Citation: Cancer Cell International 2019 19:142

    Content type: Primary research

    Published on:

  13. Whether PD-L1/PD-1 expression plays a significant role in the prognosis of NPC is still controversial. The present study mainly aimed to investigate the prognostic significance of PD-L1/PD-1 expression in pati...

    Authors: Zi-Lu Huang, Shan Liu, Guan-Nan Wang, Shuo-Han Zheng, Shi-Rong Ding, Ya-lan Tao, Chen Chen, Song-Ran Liu, Xin Yang, Hui Chang, Xiao-Hui Wang and Yun-Fei Xia

    Citation: Cancer Cell International 2019 19:141

    Content type: Primary research

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  14. Long non-coding RNAs (lncRNAs) are promising therapeutic molecules of cancer. Here we aim to study the therapeutic effect and mechanism of a lncRNA, HOXA11-AS, in oral squamous cell carcinoma (OSCC).

    Authors: Baojun Li, Wei Wang, Susheng Miao, Guofu Li, Yuanjing Lv, Cheng Xiang and Rong Pei

    Citation: Cancer Cell International 2019 19:140

    Content type: Primary research

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  15. Hepatocellular carcinoma (HCC) remains a major challenge for public health worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models are urgently needed. To identify a robust progn...

    Authors: Gao-Min Liu, Hua-Dong Zeng, Cai-Yun Zhang and Ji-Wei Xu

    Citation: Cancer Cell International 2019 19:138

    Content type: Primary research

    Published on:

  16. The aim of the present study was to clarify the correlations between SPARC expression in gastric cancer-associated fibroblasts (GCAFs) and the prognosis of patients with gastric cancer and to elucidate the rol...

    Authors: Yongchen Ma, Jing Zhu, Shanwen Chen, Ju Ma, Xiaoqian Zhang, Sixia Huang, Jianwen Hu, Taohua Yue, Junling Zhang, Pengyuan Wang, Xin Wang, Long Rong, Hongjie Guo, Guowei Chen and Yucun Liu

    Citation: Cancer Cell International 2019 19:137

    Content type: Primary research

    Published on:

  17. Endometrial cancer (EC) is one of the female malignant tumors. Endometrial cancer predominately affects post-menopausal women. Bioinformatics analysis has been widely applied to screen and analyze genes in lin...

    Authors: JinHui Liu, ShuLin Zhou, SiYue Li, Yi Jiang, YiCong Wan, XiaoLing Ma and WenJun Cheng

    Citation: Cancer Cell International 2019 19:136

    Content type: Primary research

    Published on:

  18. Acute myeloid leukemia (AML) is a typically fatal malignancy and new drug and treatment need to be developed for a better survival outcome. Cold atmospheric plasma (CAP) is a novel technology, which has been w...

    Authors: Dehui Xu, Ning Ning, Yujing Xu, Bingchuan Wang, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen and Michael G. Kong

    Citation: Cancer Cell International 2019 19:135

    Content type: Primary research

    Published on:

  19. Cancer stem cells (CSCs), drug-resistant cancer cell subsets, are known to be responsible for tumor metastasis and relapse. The JAK/STAT pathway, activated by SH2 domain, is known to regulate the tumor growth ...

    Authors: Xiao-Feng Xu, Feng Gao, Jian-Jiang Wang, Cong Long, Xing Chen, Lan Tao, Liu Yang, Li Ding and Yong Ji

    Citation: Cancer Cell International 2019 19:133

    Content type: Primary research

    Published on:

  20. CHIP is an E3 ubiquitin ligase that plays contrast roles in diverse human malignancies, depending on its targets. To date, the mechanisms underlying the function of CHIP in gastric cancer remains unclear. Here...

    Authors: Hanjue Dai, Hao Chen, Jingjing Xu, Jun Zhou, Zhili Shan, Hengying Yang, Xiaojun Zhou and Feng Guo

    Citation: Cancer Cell International 2019 19:132

    Content type: Primary research

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  21. Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of ...

    Authors: Mohammad Hossein Pourhanifeh, Mehran Sharifi, Russel J. Reiter, Abdoulhossein Davoodabadi and Zatollah Asemi

    Citation: Cancer Cell International 2019 19:131

    Content type: Review

    Published on:

  22. Bursopentin (BP5) is a multifunctional pentapeptide found in the chicken bursa of Fabricius. Recent study indicated that BP5 significantly stimulates expression of p53 protein in colon cancer HCT116 cells. How...

    Authors: Jing Li, Tian-xiang Li, Yao Ma, Yong Zhang, De-yuan Li and Hai-rong Xu

    Citation: Cancer Cell International 2019 19:130

    Content type: Primary research

    Published on:

  23. Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies. However, whether PKM2 regulates the radiosensitivity of human...

    Authors: Yanzhu Lin, Hui Zhai, Yi Ouyang, Zhiyuan Lu, Chengbiao Chu, Qianting He and Xinping Cao

    Citation: Cancer Cell International 2019 19:129

    Content type: Primary research

    Published on:

  24. Cumulative evidences demonstrated the aberrant overexpression of Small Nucleolar RNA Host Gene 12 (SNHG12) in diverse human cancer. However, the expression status and involvement of SNHG12 in renal cell carcin...

    Authors: Qiguang Chen, Wei Zhou, Shu-qi Du, Da-xin Gong, Jun Li, Jian-bin Bi, Zhen-hua Li, Zhe Zhang, Ze-liang Li, Xian-kui Liu and Chui-ze Kong

    Citation: Cancer Cell International 2019 19:128

    Content type: Primary research

    Published on:

  25. It is recommended postoperative adjuvant chemotherapy for all rectal cancers undergoing neo-chemoradiotherapy regardless of the final yield pathology. However, the role of adjuvant chemotherapy in pathological...

    Authors: Xiang Hu, Ya-Qi Li, Xiao-ji Ma, Long Zhang, San-Jun Cai and Jun-Jie Peng

    Citation: Cancer Cell International 2019 19:127

    Content type: Primary research

    Published on:

  26. Ubinuclein-2 (UBN2) is a nuclear protein that interacts with many transcription factors. The molecular role and mechanism of UBN2 in the development and progression of cancers, including colorectal cancer (CRC...

    Authors: Ya-li Zhao, Shen-Rong Zhong, Shi-Hong Zhang, Jia-Xin Bi, Zhi-Yuan Xiao, Shu-Yang Wang, Hong-Li Jiao, Dan Zhang, Jun-Feng Qiu, Ling-Jie Zhang, Cheng-Mei Huang, Xiao-Ling Chen, Yan-Qing Ding, Ya-Ping Ye, Li Liang and Wen-ting Liao

    Citation: Cancer Cell International 2019 19:126

    Content type: Primary research

    Published on:

  27. Breast cancer (BC) is the most frequent malignancy occurring in women worldwide. Emerging evidence indicates that small nucleolar RNAs (snoRNAs) play a role in tumor development. In the current study, we evalu...

    Authors: Yihan Sun, Endong Chen, Yuefeng Li, Danrong Ye, Yefeng Cai, Qingxuan Wang, Quan Li and Xiaohua Zhang

    Citation: Cancer Cell International 2019 19:125

    Content type: Primary research

    Published on:

  28. Colon cancer is one of the three common malignant tumors, with lower 5 years survival rate. Akt is an important therapeutic target, while SC66 is a novel allosteric AKT inhibitor, which enhances the therapeuti...

    Authors: Yeying Liu, Yuan Huang, Jie Ding, Nannan Liu, Shuang Peng, Jiangang Wang, Feng Wang and Yingjie Zhang

    Citation: Cancer Cell International 2019 19:124

    Content type: Primary research

    Published on:

  29. Increasing evidences supported the association between long non-coding RNA (lncRNA) and disease free survival in gastric cancer (GC) patients. The purpose of the current study was to construct and verify a non...

    Authors: Canchang Cheng, Qicai Wang, Minggu Zhu, Kelong Liu and Zhiqiao Zhang

    Citation: Cancer Cell International 2019 19:123

    Content type: Primary research

    Published on:

  30. Acute myeloid leukemia (AML) pertains to a hematologic malignancy with heterogeneous therapeutic responses. Improvements in risk stratification in AML patients are warranted. MicroRNAs have been associated wit...

    Authors: Mingshan Niu, Yuan Feng, Ninghan Zhang, Tingting Shao, Huihui Zhang, Rong Wang, Yao Yao, Ruosi Yao, Qingyun Wu, Jiang Cao, Xuejiao Liu, Yubo Liu and Kailin Xu

    Citation: Cancer Cell International 2019 19:122

    Content type: Primary research

    Published on:

  31. Further analysis of phase I trial of the KEYNOTE-001 has shown that previous radiotherapy improves the outcomes of patients with advanced non-small cell lung cancer (NSCLC) who received pembrolizumab treatment...

    Authors: Chao Liu, Qinyong Hu, Bin Xu, Xiaoyu Hu, Huichao Su, Qian Li, Xiaoling Zhang, Jinbo Yue and Jinming Yu

    Citation: Cancer Cell International 2019 19:121

    Content type: Primary research

    Published on:

  32. We have characterized the human cell line arised from the Epstein–Barr virus (EBV) positive multiple myeloma aspirate subjected to the long-term cultivation. This cell line has acquired the ability to form fre...

    Authors: Evgeniya V. Dolgova, Daria D. Petrova, Anastasia S. Proskurina, Genrikh S. Ritter, Polina E. Kisaretova, Ekaterina A. Potter, Yaroslav R. Efremov, Sergey I. Bayborodin, Tatiana V. Karamysheva, Margarita V. Romanenko, Sergey V. Netesov, Oleg S. Taranov, Aleksandr A. Ostanin, Elena R. Chernykh and Sergey S. Bogachev

    Citation: Cancer Cell International 2019 19:120

    Content type: Primary research

    Published on:

  33. Lung cancer is one of the most common and deadly tumors around the world. Targeted therapy for patients with certain mutations, especially by use of tyrosine kinase inhibitors (TKIs) targeting epidermal growth...

    Authors: Yong-An Song, Ting Ma, Xue-Yan Zhang, Xiang-Song Cheng, Ayobami-Matthew Olajuyin, Zhi-Fu Sun and Xiao-Ju Zhang

    Citation: Cancer Cell International 2019 19:117

    Content type: Primary research

    Published on:

  34. Hypoxic microenvironments play a significant role in the progression of colorectal cancer (CRC). Silencing information regulator 1 (SIRT1), a class III histone deacetylase, modulates the multiple biological be...

    Authors: Shentong Yu, Ru Zhou, Tong Yang, Shuang Liu, Zhuqing Cui, Qing Qiao and Jing Zhang

    Citation: Cancer Cell International 2019 19:116

    Content type: Primary research

    Published on:

  35. miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relat...

    Authors: Zhihui Wang, Zhiquan Zhu, Zhong Lin, Youli Luo, Zibin Liang, Caibin Zhang, Jianxu Chen and Peijian Peng

    Citation: Cancer Cell International 2019 19:115

    Content type: Primary research

    Published on:

  36. As an aggressive hematological malignancy, acute myeloid leukemia (AML) remains a dismal disease with poor prognosis. Long non-coding RNAs (lncRNAs) have been widely reported to be involved in tumorigenesis of...

    Authors: Si-Li Wang, Yun Huang, Rui Su and Yong-Yang Yu

    Citation: Cancer Cell International 2019 19:114

    Content type: Primary research

    Published on:

  37. Although contemporary chemotherapy has improved the cure rate of childhood acute lymphoblastic leukemia (ALL) to nearly 90%, relapsed/refractory ALL is still a leading cause of tumor-related death in children....

    Authors: Yiping Zhu, Rong Yang, Ju Gao, Yanle Zhang, Ge Zhang and Ling Gu

    Citation: Cancer Cell International 2019 19:113

    Content type: Primary research

    Published on:

  38. Prostate cancer (PCa), a major cause of cancer-related morbidity and mortality worldwide and mostly asymptomatic at earliest stages, is characterized by disruption of genetic and epigenetic balance. A better u...

    Authors: Tânia Soraia Vieira-Silva, Sara Monteiro-Reis, Daniela Barros-Silva, João Ramalho-Carvalho, Inês Graça, Isa Carneiro, Ana Teresa Martins, Jorge Oliveira, Luis Antunes, Sarah Hurtado-Bagès, Marcus Buschbeck, Rui Henrique and Carmen Jerónimo

    Citation: Cancer Cell International 2019 19:112

    Content type: Primary research

    Published on:

  39. Acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Therefore, subtype classification is important and indispensable in ALL diagnosis. In ...

    Authors: Yanran Sun, Qiaosheng Zhang, Guoshuang Feng, Zhen Chen, Chao Gao, Shuguang Liu, Ruidong Zhang, Han Zhang, Xueling Zheng, Wenyu Gong, Yadong Wang, Yong Wu, Jie Li and Huyong Zheng

    Citation: Cancer Cell International 2019 19:110

    Content type: Primary research

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  40. The aim of this study is to explore the effect of microRNA-103a (miR-103a) on astrocytes activation and hippocampal neuron injury in epilepsy rats by targeting brain-derived neurotrophic factor (BDNF).

    Authors: Ping Zheng, He Bin and Wei Chen

    Citation: Cancer Cell International 2019 19:109

    Content type: Primary research

    Published on:

  41. MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown.

    Authors: Xin Huang, Fen Tang, Zeping Weng, Mengyao Zhou and Qing Zhang

    Citation: Cancer Cell International 2019 19:108

    Content type: Primary research

    Published on:

  42. Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is over-expressed in multiple human cancers, and...

    Authors: Haifeng Deng, Hongbing Shi, Lujun Chen, You Zhou and Jingting Jiang

    Citation: Cancer Cell International 2019 19:106

    Content type: Primary research

    Published on:

  43. Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case–c...

    Authors: Tianbo Liu, Liangliang Jiang, Libo Yu, Tingting Ge, Jing Wang and Hongyu Gao

    Citation: Cancer Cell International 2019 19:105

    Content type: Primary research

    Published on:

  44. Increasing reports demonstrated that dysregulated expression of microRNAs (miRNAs) leads to the progression of various tumors. Previous studies revealed that miR-328-3p exhibited dysregulated expression in var...

    Authors: Jianhui Shi, Gang An, Ying Guan, Tianli Wei, Zhibin Peng, Min Liang and Yansong Wang

    Citation: Cancer Cell International 2019 19:104

    Content type: Primary research

    Published on:

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