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  1. Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. There are two subtypes, fusion gene-positive RMS (FP-RMS) and fusion gene-negative RMS (FN-RMS), depending on the presence of a fusion g...

    Authors: Kazutaka Ouchi, Mitsuru Miyachi, Shigeki Yagyu, Ken Kikuchi, Yasumichi Kuwahara, Kunihiko Tsuchiya, Tomoko Iehara and Hajime Hosoi

    Citation: Cancer Cell International 2020 20:192

    Content type: Primary research

    Published on:

  2. Nicotinamide N-methyltransferase (NNMT) is highly expressed in several cancers and can regulate cell epigenetic status and various cell metabolism pathways, such as ATP synthesis and cellular stress response. ...

    Authors: Haitao Yu, Xi Zhou, Yanzhong Wang, Xucheng Huang, Jun Yang, Jin Zeng, Guoli Li, Xinyou Xie and Jun Zhang

    Citation: Cancer Cell International 2020 20:191

    Content type: Primary research

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  3. Cisplatin (DDP) is a major chemotherapeutic drug which was widely used for cervical cancer (CC) patients with advanced or recurrent although its limitation in the development of resistance. LncRNA nicotinamide...

    Authors: Yanjie Liu, Ruixia Guo, Yuhuan Qiao, Liping Han and Mingzhu Liu

    Citation: Cancer Cell International 2020 20:190

    Content type: Primary research

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  4. The stem cell factor SALL4 is reactivated in human cancers. SALL4 plays diverse roles in tumor growth, metastasis, and drug resistance, but its role in tumor metabolism has not been well characterized.

    Authors: Meng Shao, Jiayin Zhang, Jiahui Zhang, Hui Shi, Yu Zhang, Runbi Ji, Fei Mao, Hui Qian, Wenrong Xu and Xu Zhang

    Citation: Cancer Cell International 2020 20:188

    Content type: Primary research

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  5. Exosomes (EXs) are small extracellular vesicles, a size range of 40-100 nm in diameter, actively secreted by most eukaryotic cells into surrounding body fluids like blood, saliva, urine, bile, breast milk and ...

    Authors: Leyla Norouzi-Barough, Amir Asgari Khosro Shahi, Farnoosh Mohebzadeh, Ladan Masoumi, Mohammad Reza Haddadi and Sadegh Shirian

    Citation: Cancer Cell International 2020 20:187

    Content type: Review

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  6. Programmed death-ligand 1 (PD-L1) expression determines the eligibility for anti-PD-1 treatment in patients with advanced gastric cancer, but evidence indicates that PD-L1 staining is heterogeneous. Patients w...

    Authors: Min Ye, Dan Huang, Qiongyan Zhang, Weiwei Weng, Cong Tan, Guangqi Qin, Wenhua Jiang, Weiqi Sheng and Lei Wang

    Citation: Cancer Cell International 2020 20:186

    Content type: Primary research

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  7. Our previous clinical study has shown that Chinese herbal medicine (CHM) Fuzheng Kang-Ai (FZKA) decoction is effective in treating advanced lung cancer patients through prolonging the drug resistance to Gefiti...

    Authors: Sumei Wang, Zhiwei Peng, Wenjuan Li, Shunqin Long, Shujing Xiao and Wanyin Wu

    Citation: Cancer Cell International 2020 20:185

    Content type: Primary research

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  8. Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. Cell lines are widely used disease models for basic...

    Authors: Xiang Li, Dongping Tian, Yi Guo, Shiyue Qiu, Zexin Xu, Wen Deng and Min Su

    Citation: Cancer Cell International 2020 20:184

    Content type: Primary research

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  9. Endometrial cancer is the fourth most common cancer in women. The death rate for endometrial cancer has increased. Glycolysis of cellular respiration is a complex reaction and is the first step in most carbohy...

    Authors: JinHui Liu, SiYue Li, Gao Feng, HuangYang Meng, SiPei Nie, Rui Sun, Jing Yang and WenJun Cheng

    Citation: Cancer Cell International 2020 20:183

    Content type: Primary research

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  10. Ovarian cancer (OC) is a common female reproductive malignancy with a high mortality rate. Although LAMA4 was observed to be downregulated in OC cells, its mechanism in regulating OC metastasis is still unknow...

    Authors: Yang Liu, Yangchun Xu, Lei Ding, Lili Yu, Butian Zhang and Dan Wei

    Citation: Cancer Cell International 2020 20:181

    Content type: Primary research

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  11. MicroRNA 942-5p (miR-942-5p) has been reported to promote migration and invasion in non-small cell lung cancer (NSCLC), but the underlying mechanism is not completely understood. The interplay between long non...

    Authors: Qun Wang, Jing Wu, Hui Huang, Yan Jiang, Ying Huang, Hongyan Fang, Gang Zheng, Xiaochun Zhou, Yujuan Wu, Changjiang Lei and Desheng Hu

    Citation: Cancer Cell International 2020 20:180

    Content type: Primary research

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  12. Obesity confers increased risk for various types of cancer. PD-L1 is a key molecule in tumor immune evasion by inducing T cell exhaustion. The relationship between obesity and PD-L1 is still ambiguous. This st...

    Authors: Zhi Li, Cai Zhang, Jing-Xia Du, Jia Zhao, Meng-Ting Shi, Man-Wen Jin and Hui Liu

    Citation: Cancer Cell International 2020 20:179

    Content type: Primary research

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  13. The purpose of this study is to perform bioinformatics analysis of autophagy-related genes in gastric cancer, and to construct a multi-gene joint signature for predicting the prognosis of gastric cancer.

    Authors: Jieping Qiu, Mengyu Sun, Yaoqun Wang and Bo Chen

    Citation: Cancer Cell International 2020 20:178

    Content type: Primary research

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  14. Bladder cancer is one of the most prevalent malignancies worldwide. However, traditional indicators have limited predictive effects on the clinical outcomes of bladder cancer. The aim of this study was to deve...

    Authors: Chen Zhang, Xin Gou, Weiyang He, Huaan Yang and Hubin Yin

    Citation: Cancer Cell International 2020 20:177

    Content type: Primary research

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  15. Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically challenging for ...

    Authors: Lu Zhang, Qiang Wang, Lijie Wang, Longxiang Xie, Yang An, Guosen Zhang, Wan Zhu, Yongqiang Li, Zhihui Liu, Xiaochen Zhang, Panpan Tang, Xiaozheng Huo and Xiangqian Guo

    Citation: Cancer Cell International 2020 20:176

    Content type: Primary research

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  16. Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer that lacks expression of estrogen receptor (ER) and progesterone receptor (PR) and the human epidermal growth factor recepto...

    Authors: Ruishan Zhang, Xiang Li, Zhuangkai Liu, Yuying Wang, Hao Zhang and Hong Xu

    Citation: Cancer Cell International 2020 20:175

    Content type: Primary research

    Published on:

  17. Ovarian cancer is the third most common gynecological cancer in the world but the leading cause of death among gynecological malignancies. Epithelial splicing regulatory protein-1 (ESRP1), a key negative splic...

    Authors: Guanming Deng, Xiaofang Zhou, Le Chen, Ying Yao, Junjun Li, Yun Zhang, Chenhui Luo, Lijuan Sun and Jie Tang

    Citation: Cancer Cell International 2020 20:174

    Content type: Primary research

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  18. Circular RNAs, as hopeful diagnosis markers and therapeutic molecules, have been studied, probed and applied into several diseases, such as cardiovascular diseases, systemic lupus erythematosus, leukemia, pulm...

    Authors: Zhuo-Zheng Liang, Cheng Guo, Man-Man Zou, Ping Meng and Tian-Tuo Zhang

    Citation: Cancer Cell International 2020 20:173

    Content type: Review

    Published on:

  19. Human polypyrimidine tract binding protein 3 (PTBP3), which belongs to the PTB family, demonstrate a significant tumorigenic capability in a variety of malignancies. However, the correlation between PTBP3 expr...

    Authors: Qiong Wu, Bo Zhang, Ben Li, Xiang Cao, Xinming Chen and Qun Xue

    Citation: Cancer Cell International 2020 20:172

    Content type: Primary research

    Published on:

  20. Circular RNAs (circRNAs) are a special kind of non-coding RNAs that are implicated in cancer malignant behavior, including glycolysis. However, their contributions to gastric cancer (GC) cell glycolysis are st...

    Authors: Jia Liu, Haiying Liu, Qingshan Zeng, Pei Xu, Mingxing Liu and Ning Yang

    Citation: Cancer Cell International 2020 20:171

    Content type: Primary research

    Published on:

  21. Drug resistance and chemotherapy-induced peripheral neuropathy continue to be significant problems in the successful treatment of acute lymphoblastic leukemia (ALL). 5,7-Dibromo-N-alkylisatins, a class of potent ...

    Authors: Bryce Keenan, Rocio K. Finol-Urdaneta, Ashleigh Hope, John B. Bremner, Maria Kavallaris, Daniel Lucena-Agell, María Ángela Oliva, Jose Fernando Díaz and Kara L. Vine

    Citation: Cancer Cell International 2020 20:170

    Content type: Primary research

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  22. Nestin has been revealed to promote tumorigenesis, progression, metastasis, and angiogenesis of breast cancer. Although the prognostic and clinicopathological impact of nestin expression on breast cancer patie...

    Authors: Xinyi Zhang, Changsheng Xing, Wenting Guan, Lang Chen, Kai Guo, Anze Yu and Kai Xie

    Citation: Cancer Cell International 2020 20:169

    Content type: Primary research

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  23. Cyclooxygenase-2 (COX-2), an inflammation-associated enzyme, has been implicated in tumorigenesis and progression of glioblastoma (GBM). The poor survival of GBM was mainly associated with the presence of glio...

    Authors: Paola Palumbo, Francesca Lombardi, Francesca Rosaria Augello, Ilaria Giusti, Vincenza Dolo, Pietro Leocata, Maria Grazia Cifone and Benedetta Cinque

    Citation: Cancer Cell International 2020 20:167

    Content type: Primary research

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  24. Renal cell carcinoma (RCC) is one of the most common aggressive malignant tumors in urogenital system, and the clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal carcinoma. Immune rela...

    Authors: Yuanbin Jiang, Xin Gou, Zongjie Wei, Jianyu Tan, Haitao Yu, Xiang Zhou and Xinyuan Li

    Citation: Cancer Cell International 2020 20:166

    Content type: Primary research

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  25. Increased long noncoding RNA (lncRNA) expression is characteristic to hepatocellular carcinoma (HCC) and several other neoplasms. The present study aimed to identify the mechanism underlying modulation of HCC ...

    Authors: Ningfu Peng, Jingrong He, Jindu Li, Hao Huang, Weiqiao Huang, Yingyang Liao and Shaoliang Zhu

    Citation: Cancer Cell International 2020 20:165

    Content type: Primary research

    Published on:

  26. The objective of the present study is to comprehensively evaluate the impact of the rs1800975 A/G polymorphism within the human xeroderma pigmentosum group A (XPA) gene on susceptibility to overall cancer by perf...

    Authors: Maoxi Yuan, Chunmei Yu and Kuiying Yu

    Citation: Cancer Cell International 2020 20:164

    Content type: Primary research

    Published on:

  27. Paclitaxel is a first-line chemotherapy drug for pancreatic, ovarian, endometrial cancers and other malignancies. However, its efficacy is often compromised by decreased cell sensitivity or the development of ...

    Authors: Fengbiao Guo, Jinping Li, Yaozhi Qi, Jianqing Hou, Haibin Chen and Shi-Wen Jiang

    Citation: Cancer Cell International 2020 20:163

    Content type: Primary research

    Published on:

  28. Colorectal neoplasia differentially expressed (CRNDE) is a long non-coding RNA which has been proved upregulated in various cancers. Meanwhile, CRNDE has been demonstrated to be involved in multiple biological...

    Authors: Ya Lu, Huanhuan Sha, Xun Sun, Yuan Zhang, Yang Wu, Junying Zhang, Hui Zhang, Jianzhong Wu and Jifeng Feng

    Citation: Cancer Cell International 2020 20:162

    Content type: Review

    Published on:

  29. Circular RNAs (circRNAs) play a vital role in the development of various cancers. Circ_100565 was found to be a highly expressed circRNA in non-small cell lung cancer (NSCLC) tissues screened by microarray pro...

    Authors: Li Li, Haitao Wei, Haifeng Zhang, Feng Xu and Guowei Che

    Citation: Cancer Cell International 2020 20:160

    Content type: Primary research

    Published on:

  30. Prostate cancer (PCa) is the second leading cause of cancer death in men in 2018. Thus, the evaluation of prognosis is crucial for clinical treatment decision of human PCa patients. We aim to establishing an e...

    Authors: Yongzhi Wang and Zhonghua Yang

    Citation: Cancer Cell International 2020 20:159

    Content type: Primary research

    Published on:

  31. The mortality rate of clear cell renal cell carcinoma (ccRCC) remains high. The aim of this study was to identify novel prognostic biomarkers by using m6A RNA methylation regulators capable of improving the risk-...

    Authors: Jing Chen, Kun Yu, Guansheng Zhong and Wei Shen

    Citation: Cancer Cell International 2020 20:157

    Content type: Primary research

    Published on:

  32. Multiple myeloma (MM) is a prevalent hematological malignancy. Long noncoding RNAs are correlated with the development of MM. In this project, the function of lncRNA opa interacting protein 5-antisense 1 (OIP5...

    Authors: Yong Wang, Haibao Wang, Jianwei Ruan, Wenbiao Zheng, Zeyu Yang and Weiwei Pan

    Citation: Cancer Cell International 2020 20:155

    Content type: Primary research

    Published on:

  33. Fucoidan is a kind of the polysaccharide, which comes from brown algae and comprises of sulfated fucose residues. It has shown a large range of biological activities in basic researches, including many element...

    Authors: Yuan Lin, Xingsi Qi, Hengjian Liu, Kuijin Xue, Shan Xu and Zibin Tian

    Citation: Cancer Cell International 2020 20:154

    Content type: Review

    Published on:

  34. Previous literature has revealed long non-coding RNAs (lncRNAs) are crucial regulators for cell functions and gene expression. LncRNA fetal-lethal non-coding developmental regulatory RNA (FENDRR) was reported ...

    Authors: Yunheng Zhu, Xiaohua Zhang, Lifeng Wang, Xiuxiang Zhu, Ziyin Xia, Ling Xu and Jun Xu

    Citation: Cancer Cell International 2020 20:152

    Content type: Primary research

    Published on:

  35. Circular RNAs (circRNAs) play an essential role in the regulation of gene expression. However, the underlying mechanisms remain unknown. This study aimed to evaluate the role of hsa_circ_0068307 in bladder can...

    Authors: Qi Chen, Qiuping Yin, Yemeng Mao, Zheyu Zhang, Siqi Wu, Zhang Cheng, Xinan Chen, Hanren Xu, Shengming Jin, Haowen Jiang and Chen Yang

    Citation: Cancer Cell International 2020 20:151

    Content type: Primary research

    Published on:

  36. Arginine is a semi essential amino acid that is used in protein biosynthesis. It can be obtained from daily food intake or synthesized in the body through the urea cycle using l-citrulline as a substrate. Arginin...

    Authors: Houssam Al-Koussa, Nour El Mais, Hiba Maalouf, Ralph Abi-Habib and Mirvat El-Sibai

    Citation: Cancer Cell International 2020 20:150

    Content type: Review

    Published on:

  37. Accumulating evidence suggests androgen receptor splice variant 7 (AR-V7) may be associated with the prognosis of castration-resistant prostate cancer (CRPC) received novel hormonal therapy while its character...

    Authors: Zhize Wang, Haixiang Shen, Zhen Liang, Yeqing Mao, Chaojun Wang and Liping Xie

    Citation: Cancer Cell International 2020 20:149

    Content type: Review

    Published on:

  38. Osteosarcoma (OS) is one of the most aggressive malignancies with mortality rate worldwide. Accumulating evidence has revealed that long noncoding RNAs (lncRNAs) exert important functions in regulation of canc...

    Authors: Zhiqian Gu, Shaokun Wu, Jingnan Wang and Shoujun Zhao

    Citation: Cancer Cell International 2020 20:147

    Content type: Primary research

    Published on:

  39. We used bioinformatic tools to dichotomize 157 non-M3 AML patients from the TCGA dataset based on the presence or absence of TP53 mutations, and screened out a key gene related to TP53 mutation for future analysi...

    Authors: Siyu Gu, Jie Zi, Qi Han, Chunhua Song and Zheng Ge

    Citation: Cancer Cell International 2020 20:146

    Content type: Primary research

    Published on:

  40. Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function ...

    Authors: Lijuan Zhu, Aihua Wang, Mei Gao, Xiaoyan Duan and Zehua Li

    Citation: Cancer Cell International 2020 20:145

    Content type: Primary research

    Published on:

  41. Non-small cell lung cancer (NSCLC) is the most deadly cancer worldwide. LncRNA KCNQ1OT1 has been reported to be involved in the progression of various tumors, including NSCLC. However, the precise mechanism of...

    Authors: Yan Wang, Lei Zhang, Jiasheng Yang and Ruilin Sun

    Citation: Cancer Cell International 2020 20:144

    Content type: Primary research

    Published on:

  42. Genetic biomarkers of lung cancer (LC) susceptibility may provide a basis for treatment and prevention. This study analyzed an association between SNPs (single nucleotide polymorphisms) in the complementary re...

    Authors: Shimin Yang, Fanglin Yu, Mingyan Lin, Linyi Sun, Junjie Wei, Cheng Lai, Lin Cai, Zhijian Hu and Fei He

    Citation: Cancer Cell International 2020 20:143

    Content type: Primary research

    Published on:

  43. Without targets, triple negative breast cancer (TNBC) has the worst prognosis in all subtypes of breast cancer (BC). Recently, eukaryotic translation initiation factor 3 m (eIF3m) has been declared to be invol...

    Authors: Wei Han, Cong Zhang, Chun-tao Shi, Xiao-jiao Gao, Ming-hui Zhou, Qi-xiang Shao, Xiao-jun Shen, Cheng-jiang Wu, Fang Cao, Yong-wei Hu, Jian-liang Yuan, Hou-zhong Ding, Qing-hua Wang and Hao-nan Wang

    Citation: Cancer Cell International 2020 20:141

    Content type: Primary research

    Published on:

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