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  1. Bladder cancer (BC) is the sixth most common worldwide urologic malignancy associated with elevated morbidity and mortality rates if not well treated. The muscle-invasive form of BC develops in about 25% of pa...

    Authors: Sameh M. Farouk, Asmaa F. Khafaga and Ahmed M. Abdellatif
    Citation: Cancer Cell International 2023 23:251
  2. Cancer Stem Cells (CSCs) are the main “seeds” for the initiation, growth, metastasis, and recurrence of tumors. According to many studies, several viral infections, including the human papillomaviruses, hepati...

    Authors: Amirhosein Faghihkhorasani, Alaleh Dalvand, Ehsan Derafsh, Farnaz Tavakoli, Nada Khairi Younis, Saman Yasamineh, Omid Gholizadeh and Pooria Shokri
    Citation: Cancer Cell International 2023 23:250
  3. Alternative pre-mRNA splicing is a critical mechanism that generates multiple mRNA from a single gene, thereby increasing the diversity of the proteome. Recent research has highlighted the significance of spec...

    Authors: Sunkyung Choi, Namjoon Cho, Eun-Mi Kim and Kee K. Kim
    Citation: Cancer Cell International 2023 23:249
  4. An immunosuppressive tumor microenvironment in ovarian cancer facilitates tumor progression and resistance to immunotherapy. The function of MYB Proto-Oncogene Like 2 (MYBL2) in the tumor microenvironment rema...

    Authors: Baoyue Pan, Ting Wan, Yun Zhou, Shuting Huang, Linjing Yuan, Yinan Jiang, Xiaojing Zheng, Pingping Liu, Huiling Xiang, Mingxiu Ju, Rongzhen Luo, Weihua Jia, ChunYan Lan, Jundong Li and Min Zheng
    Citation: Cancer Cell International 2023 23:248
  5. Prostate cancer (PCa) is a non-cutaneous malignancy in males with wide variation in incidence rates across the globe. It is the second most reported cause of cancer death. Its etiology may have been linked to ...

    Authors: Khurram Rehman, Zoya Iqbal, Deng Zhiqin, Hina Ayub, Naseem Saba, Muzammil Ahamd Khan, Liang Yujie and Li Duan
    Citation: Cancer Cell International 2023 23:247
  6. RAD51B plays a significant role in homologous recombination-mediated repair of DNA double-strand breaks. Many enhancer variants are involved in cancer development and progression. However, the significance of ...

    Authors: Liming Huang, Wenshen Xu, Danfang Yan, Xi Shi, Shu Zhang, Meiqin Chen and Lian Dai
    Citation: Cancer Cell International 2023 23:246
  7. GAS41, a member of the human YEATS domain family, plays a pivotal role in human cancer development. It serves as a highly promising epigenetic reader, facilitating precise regulation of cell growth and develop...

    Authors: Kangkang Ji, Li Li, Hui Liu, Yucheng Shen, Jian Jiang, Minglei Zhang, Hongwei Teng, Xun Yan, Yanhua Zhang, Yong Cai and Hai Zhou
    Citation: Cancer Cell International 2023 23:245
  8. Primary hepatocellular carcinoma (HCC) is a malignancy with high morbidity and mortality. KH domain-containing, RNA-binding signal transduction-associated protein 3 (KHDRBS3) is an RNA-binding protein that is ...

    Authors: Mingda Zhao, Yibing Zhang, Longfei Li, Xiaobin Liu, Wenping Zhou, Chunhui Wang and Yufu Tang
    Citation: Cancer Cell International 2023 23:244
  9. Drug resistance is a major obstacle causing chemotherapy failure, and enabling cancer progression. Exosome excreted by cancer cells is participated in cancer progression and chemoresistance, and can be used as...

    Authors: Xiao-Xue Qiao, Hui-Bo Shi and Li Xiao
    Citation: Cancer Cell International 2023 23:243
  10. Epigenetic modifications have long been recognized as an essential level in transcriptional regulation linking behavior and environmental conditions or stimuli with biological processes and disease development...

    Authors: Chengyin Liu, Han Tang, Nana Hu and Tianbao Li
    Citation: Cancer Cell International 2023 23:242
  11. MicroRNAs (miRNAs) are a group of small non-coding RNAs that affect gene expression. The role of miRNAs in different types of cancers has been published and it was shown that several miRNAs are inappropriately...

    Authors: Chunguang Wang, Meiling Bai, Zhiguang Sun, Nan Yao, Aiting Zhang, Shengyu Guo and Zatollah Asemi
    Citation: Cancer Cell International 2023 23:241
  12. Triple-negative breast cancer (TNBC) cells’ secretome can induce a pro-inflammatory phenotype in human adipose-derived mesenchymal stem cells (hADMSC). This can be prevented by the green tea polyphenol epigall...

    Authors: Narjara Gonzalez Suarez, Yuniel Fernandez-Marrero, Mathieu P. A. Hébert, Marie-Eve Roy, Luc H. Boudreau and Borhane Annabi
    Citation: Cancer Cell International 2023 23:240
  13. Hepatocellular carcinoma (HCC) is the most predominant primary liver cancer, causing many illnesses and deaths worldwide. The insidious clinical presentation, difficulty in early diagnosis, and the highly mali...

    Authors: Kaige Deng, Jiali Xing, Gang Xu, Bao Jin, Xueshuai Wan, Yongchang Zheng, Shunda Du and Xinting Sang
    Citation: Cancer Cell International 2023 23:239
  14. Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological chara...

    Authors: Peyman Tabnak, Aysa Hasanzade Bashkandi, Mohammad Ebrahimnezhad and Mahdieh Soleimani
    Citation: Cancer Cell International 2023 23:238
  15. Lysine Demethylase 2A (KDM2A) plays a crucial role in cancer cell growth, differentiation, metastasis, and the maintenance of cancer stemness. Our previous study found that cancer-secreted IL-6 can upregulate ...

    Authors: Jia-Shing Chen, Yu-Ning Teng, Cheng-Yi Chen and Jing-Yi Chen
    Citation: Cancer Cell International 2023 23:237
  16. Breast cancer (BC) is the most common malignancy with very high incidence and relatively high mortality in women. The PIK3CA gene plays a pivotal role in the pathogenicity of breast cancer. Despite this, the m...

    Authors: Rahul Kumar, Rakesh Kumar, Harsh Goel, Sonu Kumar, Somorjit Singh Ningombam, Imran Haider, Usha Agrawal, Svs Deo, Ajay Gogia, Atul Batra, Ashok Sharma, Sandeep Mathur, Amar Ranjan, Anita Chopra, Showket Hussain and Pranay Tanwar
    Citation: Cancer Cell International 2023 23:236
  17. Drug resistance is a main factor affecting the chemotherapy efficacy of gastric cancer (GC), in which meiosis plays an important role. Therefore, it is urgent to explore the effect of meiosis related genes on ...

    Authors: Xiaosi Hu, Shuai Zhou, Haohao Li, Zehui Wu, Ye Wang, Lei Meng, Zhangming Chen, Zhijian Wei, Qing Pang and Aman Xu
    Citation: Cancer Cell International 2023 23:234
  18. Surgery and chemo-radiotherapy are used as the common first-line treatment options in many cancers. However, tumor relapse is observed in many cancer patients following such first-line treatments. Therefore, t...

    Authors: Negin Taghehchian, Amirhosein Maharati, Iman Akhlaghipour, Amir Sadra Zangouei and Meysam Moghbeli
    Citation: Cancer Cell International 2023 23:233
  19. Ovarian cancer (OV) is the most lethal gynecological malignancies worldwide. The coagulation cascade could induce tumor cell infiltration and contribute to OV progression. However, coagulation-related gene (CR...

    Authors: Jiani Yang, Chao Wang, Yue Zhang, Shanshan Cheng, Meixuan Wu, Sijia Gu, Shilin Xu, Yongsong Wu, Jindan Sheng, Dominic Chih-Cheng Voon and Yu Wang
    Citation: Cancer Cell International 2023 23:232
  20. RAD51 overexpression has been reported to serve as a marker of poor prognosis in several cancer types. This study aimed to survey the role of RAD51 in oral squamous cell carcinoma and whether RAD51 could be a ...

    Authors: Yu-Fen Tsai, Leong-Perng Chan, Yuk-Kwan Chen, Chang-Wei Su, Ching-Wei Hsu, Yen-Yun Wang and Shyng-Shiou F. Yuan
    Citation: Cancer Cell International 2023 23:231
  21. Mutations in the KEAP1-NFE2L2 signaling pathway were linked to increased tumorigenesis and aggressiveness. Interestingly, not all hotspot mutations on NFE2L2 were damaging; some even were activating. However, ...

    Authors: Kewei Wang, Zixi Li, Ying Xuan, Yong Zhao, Chao Deng, Meidan Wang, Chenjun Xie, Fenglai Yuan, Qingfeng Pang, Wenjun Mao, Dongyan Cai, Zhangfeng Zhong and Jie Mei
    Citation: Cancer Cell International 2023 23:229
  22. Melanoma is the deadliest type of skin cancer and despite improvements in treatment outcomes, melanoma claimed 57,043 lives in 2020. In most malignancies, p53 mutation rates are above 50% and provide prognosti...

    Authors: Kira Groen, Luiza Steffens Reinhardt, Jean-Christophe Bourdon and Kelly A. Avery-Kiejda
    Citation: Cancer Cell International 2023 23:228
  23. Glioma is the most common and lethal type of brain tumor, and it is characterized by unfavorable prognosis and high recurrence rates. The reprogramming of energy metabolism and an immunosuppressive tumor micro...

    Authors: Shupeng Li, Ziwei Li, Xinyu Wang, Junzhe Zhong, Daohan Yu, Hao Chen, Wenbin Ma, Lingling Liu, Minghuang Ye, Ruofei Shen, Chuanlu Jiang, Xiangqi Meng and Jinquan Cai
    Citation: Cancer Cell International 2023 23:227
  24. N6-methyladenosine(m6A), is the most abundant post-transcriptional modification of mRNA in biology. When the first nucleotide after the m7G cap is adenosine, it is methylated at the N6 position to form N6,2-O-...

    Authors: Yuting Wu, Xi Pu, Sihui Wu, Yiran Zhang, Shengqiao Fu, Haowen Tang, Xu Wang and Min Xu
    Citation: Cancer Cell International 2023 23:226
  25. Post-translational modifications (PTMs) of proteins contribute to the occurrence and development of tumors. Previous studies have suggested that canonical PTMs such as ubiquitination, glycosylation, and phosph...

    Authors: Yihong Liu, Jingwei Liu, Na Peng, Shuangshuang Hai, Shen Zhang, Haibo Zhao and Weixin Liu
    Citation: Cancer Cell International 2023 23:225
  26. Hyper progressive disease (HPD) describes the phenomenon that patients can’t benefit from immunotherapy but cause rapid tumor progression. HPD is a particular phenomenon in immunotherapy but lacks prediction m...

    Authors: Yaping Long, Wenyu Yang, Yibing Bai, Haitao Tao, Fan Zhang, Lijie Wang, Bo Yang, Di Huang, Xiao Han and Yi Hu
    Citation: Cancer Cell International 2023 23:224
  27. High-grade serous ovarian cancer (HGSOC) is a challenging malignancy characterized by complex interactions between tumor cells and the surrounding microenvironment. Understanding the immune landscape of HGSOC,...

    Authors: Qihui Wu, Xiaoyun He, Jiaxin Liu, Chunlin Ou, Yimin Li and Xiaodan Fu
    Citation: Cancer Cell International 2023 23:223
  28. According to the latest epidemiological investigation, lung adenocarcinoma (LUAD) is one of the most fatal cancer among both men and women. Despite continuous advancements in treatment approaches in recent yea...

    Authors: Pengdou Zheng, Zhenyu Mao, Miao Luo, Ling Zhou, Lingling Wang, Huiguo Liu, Wei Liu and Shuang Wei
    Citation: Cancer Cell International 2023 23:222
  29. Bladder cancer (BCa) is one of the most common malignancies worldwide. However, the lack of accurate and effective targeted drugs has become a major problem in current clinical treatment of BCa. Studies have d...

    Authors: Fan Zou, Wu Chen, Tianbao Song, Ji Xing, Yunlong Zhang, Kang Chen, Weimin Hu, Linzhi Li, Jinzhuo Ning, Chenglong Li, Weimin Yu and Fan Cheng
    Citation: Cancer Cell International 2023 23:221
  30. Myosin heavy chain 9 (MYH9) plays an important role in a number of diseases. Nevertheless, the function of MYH9 in glioma is unclear. The present research aimed to investigate the role of MYH9 in glioma and de...

    Authors: Zigui Chen, Xin Yan, Changfeng Miao, Longyang Liu, Su Liu, Ying Xia, Weiyi Fang, Dandan Zheng and Qisheng Luo
    Citation: Cancer Cell International 2023 23:220
  31. Recently, natural killer (NK) cells emerged as a treatment option for various solid tumors. However, the immunosuppressive tumor immune microenvironment (TIME) can reduce the cytotoxic ability of NK cells in p...

    Authors: Hyun-Ah Kim, Hyunsoo Kim, Min-Kyung Nam, Jong Kook Park, Moo-Yeal Lee, Seok Chung, Kyung-Mi Lee and Hyo-Jeong Kuh
    Citation: Cancer Cell International 2023 23:219
  32. Disulfidptosis is independent of apoptosis, ferroptosis, and cuproptosis and is associated with cancer progression, treatment response, and prognosis. However, the predictive potential of disulfidptosis-associ...

    Authors: Weijie Xue, Kang Qiu, Bingzi Dong, Dong Guo, Junhua Fu, Chengzhan Zhu and Zhaojian Niu
    Citation: Cancer Cell International 2023 23:218
  33. The aim of this study was to determine the underlying potential mechanisms and function of DIO3OS, a lincRNA in osteosarcoma and clarify that DIO3OS can be used as a potential diagnostic biomarker and immunoth...

    Authors: Jinghong Yuan, Jingyu Jia, Tianlong Wu, Zhi Du, Qi Chen, Jian Zhang, Zhiwen Wu, Zhao Yuan, Xiaokun Zhao, Jiahao Liu, Jia Guo and Xigao Cheng
    Citation: Cancer Cell International 2023 23:215
  34. Immunoblockade therapy based on the PD-1 checkpoint has greatly improved the survival rate of patients with skin cutaneous melanoma (SKCM). However, existing anti-PD-1 therapeutic efficacy prediction markers o...

    Authors: Shaolong Leng, Gang Nie, Changhong Yi, Yunsheng Xu, Lvya Zhang and Linyu Zhu
    Citation: Cancer Cell International 2023 23:214
  35. Luteolin is an active ingredient in various traditional Chinese medicines for the treatment of multiple tumors. However, the mechanisms of its inhibitory effect on osteosarcoma proliferation and metastasis rem...

    Authors: Renxuan Huang, Mingxian Xu, Weitang Guo, Mingzhe Cheng, Rui Dong, Jian Tu, Shao Xu and Changye Zou
    Citation: Cancer Cell International 2023 23:213
  36. Research studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS) components. Angiotensin II is involved in tumor growth and angiogenesis in diff...

    Authors: Tai-Jan Chiu, Chang-Han Chen, Yi-Ju Chen, Yinshen Wee, Ching-Shuen Wang and Sheng‑Dean Luo
    Citation: Cancer Cell International 2023 23:212
  37. Pancreatic cancer is one of the leading causes of cancer death in Western societies. Its late diagnosis and resistance to chemotherapies result in a high mortality rate; thus, the development of more effective...

    Authors: Mariola Gimła, Agnieszka Pyrczak-Felczykowska, Marcelina Malinowska, Aleksandra Hać, Magdalena Narajczyk, Irena Bylińska, Tristan A. Reekie and Anna Herman-Antosiewicz
    Citation: Cancer Cell International 2023 23:210
  38. Lung cancer is a leading cause of cancer-related deaths, and the most common type is lung adenocarcinoma (LUAD). LUAD is frequently diagnosed in people who never smoked, patients are always diagnosed at advanc...

    Authors: Xu Lin, Ye-han Liu, Huan-qi Zhang, Lin-wen Wu, Qi Li, Jun Deng, Qingyi Zhang, Yuhong Yang, Chong Zhang, Yang-ling Li and Jian Hu
    Citation: Cancer Cell International 2023 23:208
  39. Lung cancer has the highest mortality rate in the world, and mounting evidence suggests that cancer stem cells (CSCs) are associated with poor prognosis, recurrence, and metastasis of lung cancer. It is urgent...

    Authors: Chia-Hao Tung, Jia-En Wu, Meng-Fan Huang, Wen-Lung Wang, Yi-Ying Wu, Yao-Tsung Tsai, Xiu-Rui Hsu, Sheng-Hsiang Lin, Yuh-Ling Chen and Tse-Ming Hong
    Citation: Cancer Cell International 2023 23:207
  40. Lymphangiogenesis has been reported to play crucial roles in the metastasis of thyroid cancer (THCA), but despite the significant research on lymphangiogenesis in THCA, the precise regulatory mechanism remains...

    Authors: Liyun Yang, Runyu Zhao, Peipei Qiao, Jiaxin Cui, Xiaoping Chen, Jinping Fan, An Hu and Shuixian Huang
    Citation: Cancer Cell International 2023 23:206
  41. Hepatocellular Carcinoma (HCC) possesses the high mortality in cancers worldwide. Nevertheless, the concrete mechanism underlying HCC proliferation remains obscure. In this study, we show that high expression ...

    Authors: Yabing Hu, Yongchu Huang, Xiaohang Xie, Longshan Li, Yong Zhang and Xiaochao Zhang
    Citation: Cancer Cell International 2023 23:205
  42. Triple negative breast cancer (TNBC) represents a significant clinical challenge. Chemotherapy remains the mainstay for a large part of TNBC patients, whereas drug resistance and tumor recurrence frequently oc...

    Authors: Hui Lyu, Fei Shen, Sanbao Ruan, Congcong Tan, Jundong Zhou, Ann D. Thor and Bolin Liu
    Citation: Cancer Cell International 2023 23:204
  43. Outcomes for patients with relapsed acute lymphoblastic leukemia (ALL) are poor and there is a need for novel therapies to improve outcomes. Targeted inhibition of WEE1 with small-molecule inhibitor adavoserti...

    Authors: Hayden L. Bell, Helen J. Blair, Mankaran Singh, Anthony V. Moorman, Olaf Heidenreich, Frederik W. van Delft, John Lunec and Julie A. E. Irving
    Citation: Cancer Cell International 2023 23:202

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