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  1. Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tu...

    Authors: Gábor Petővári, Zoltán Hujber, Ildikó Krencz, Titanilla Dankó, Noémi Nagy, Fanni Tóth, Regina Raffay, Katalin Mészáros, Hajnalka Rajnai, Enikő Vetlényi, Krisztina Takács-Vellai, András Jeney and Anna Sebestyén
    Citation: Cancer Cell International 2018 18:211
  2. It has been demonstrated that bufadienolides exert potent anti-cancer activity in various tumor types. However, the mechanisms that underlie their anti-cancer properties remain unclear. Yes-associated protein,...

    Authors: Li-Juan Deng, Ming Qi, Qun-Long Peng, Min-Feng Chen, Qi Qi, Jia-Yan Zhang, Nan Yao, Mao-Hua Huang, Xiao-Bo Li, Yin-Hui Peng, Jun-Shan Liu, Deng-Rui Fu, Jia-Xu Chen, Wen-Cai Ye and Dong-Mei Zhang
    Citation: Cancer Cell International 2018 18:209
  3. TRIP13 is highly expressed in several cancers and is closely connected with cancer progression. However, its roles on the growth and metastasis of hepatocellular carcinoma (HCC), and the underlying mechanism a...

    Authors: Jianning Yao, Xuexiu Zhang, Jiaheng Li, Dongyao Zhao, Bing Gao, Haining Zhou, Shilin Gao and Lianfeng Zhang
    Citation: Cancer Cell International 2018 18:208
  4. To investigate the potential prognostic role of pre-treatment prognostic nutritional index (PNI) in urinary cancers.

    Authors: Feng Qi, Xiang Zhou, Yi Wang, Yamin Wang, Yichun Wang, Qijie Zhang, Rong Cong, Jie Yang and Ninghong Song
    Citation: Cancer Cell International 2018 18:207
  5. Chromophobe renal cell carcinoma (ChRCC) is the second common subtype of non-clear cell renal cell carcinoma (nccRCC), which accounting for 4–5% of renal cell carcinoma (RCC). However, there is no effective bi...

    Authors: Xiaomao Yin, Jianfeng Wang and Jin Zhang
    Citation: Cancer Cell International 2018 18:206
  6. The origin of cancer cells is the most fundamental yet unresolved problem in cancer research. Cancer cells are thought to be transformed from the normal cells. However, recent studies reveal that the primary c...

    Authors: Qing-lin Dong and Xiang-ying Xing
    Citation: Cancer Cell International 2018 18:205
  7. Homeobox C6 (HOXC6) plays a part in malignant progression of some tumors. However, the expression of HOXC6 and its clinical significance remains unclear in cervical carcinoma (CC). The purpose of this study is...

    Authors: Feng Zhang, Chen-Chen Ren, Ling Liu, Yan-Nan Chen, Li Yang and Xiao-An Zhang
    Citation: Cancer Cell International 2018 18:204
  8. Colorectal cancer (CRC) is one of the most lethal malignancies. Tripartite Motif Containing 14 (TRIM14) is a member of TRIM family proteins, which are involved in the pathogenesis of various cancers. This stud...

    Authors: Zhonghai Jin, Hongguang Li, Xiaofei Hong, Guangrong Ying, Xiaofeng Lu, Lilei Zhuang and Shenbao Wu
    Citation: Cancer Cell International 2018 18:202
  9. There is increasing evidence that inflammation-based biomarkers are associated with tumor microenvironment which plays important roles in cancer progression. A high lymphocyte-to-monocyte ratio (LMR), has been...

    Authors: Yiming Mao, Donglai Chen, Shanzhou Duan, Yuhuan Zhao, Changjiang Wu, Feng Zhu, Chang Chen and Yongbing Chen
    Citation: Cancer Cell International 2018 18:201
  10. Apoptosis and autophagy are known to play important roles in cancer development. It has been reported that HVJ-E induces apoptosis in cancer cells, thereby inhibiting the development of tumors. To define the m...

    Authors: Tao Wang, Ning Yu, Miao Qian, Jie Feng, Shuyang Cao, Jun Yin and Quan Zhang
    Citation: Cancer Cell International 2018 18:200
  11. To get insight into the molecular mechanisms underlying the anti-tumor activity of S-adenosyl-l-methionine (AdoMet), we analyzed AdoMet-induced modulation of microRNAs (miRNAs) expression profile in MCF-7 breast ...

    Authors: Concetta Paola Ilisso, Donatella Delle Cave, Laura Mosca, Martina Pagano, Alessandra Coppola, Luigi Mele, Michele Caraglia, Giovanna Cacciapuoti and Marina Porcelli
    Citation: Cancer Cell International 2018 18:197
  12. RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity. Dysregulation of A-to-I editing has been ...

    Authors: Ying Zhang, Kuanyu Wang, Zheng Zhao, Si Sun, Kenan Zhang, Ruoyu Huang, Fan Zeng and Huimin Hu
    Citation: Cancer Cell International 2018 18:196
  13. MicroRNAs play crucial roles in tumorigenesis and tumor progression. miR-770 has been reported to be downregulated in several cancers and affects cancer cell proliferation, apoptosis, metastasis and drug resis...

    Authors: Jun-feng Zhang, Jian-shui Zhang, Zhao-hua Zhao, Peng-bo Yang, Sheng-feng Ji, Nan Li, Qin-dong Shi, Jing Tan, Xi Xu, Cang-bao Xu and Ling-yu Zhao
    Citation: Cancer Cell International 2018 18:195
  14. As one of the most common malignant tumors in humans, lung cancer has experienced a gradual increase in morbidity and mortality. This study examined prognosis-related methylation-driven genes specific to lung ...

    Authors: Chundi Gao, Jing Zhuang, Huayao Li, Cun Liu, Chao Zhou, Lijuan Liu and Changgang Sun
    Citation: Cancer Cell International 2018 18:194
  15. Anoikis resistance has been demonstrated to facilitate distant metastases of cancers. MicroRNA-133b (miR-133b) is found to be down-regulated in various tumors, including esophageal squamous cell carcinoma (ESC...

    Authors: Jin-Feng Zhu, Yi Liu, He Huang, Li Shan, Zhi-Gang Han, Jun-Yuan Liu, Ying-Long Li, Xiang Dong and Wei Zeng
    Citation: Cancer Cell International 2018 18:193
  16. The response of soft tissue sarcomas to cytotoxic chemotherapy is inconsistent. Biomarkers of chemoresistance or chemosensitivity are needed in order to identify appropriate patients for treatment. Given that ...

    Authors: Yike Bing, Zacharie Wund, Tina Abratte, Lucia Borlle, Susie Kang, Teresa Southard and Kelly R. Hume
    Citation: Cancer Cell International 2018 18:192
  17. Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune respons...

    Authors: Bangshun He, Tao Xu, Bei Pan, Yuqin Pan, Xuhong Wang, Jingwu Dong, Huiling Sun, Xueni Xu, Xiangxiang Liu and Shukui Wang
    Citation: Cancer Cell International 2018 18:191
  18. Rhabdoid tumors (RTs) are aggressive tumors that occur most frequently in children under 2 years old, which often invade kidney (KRTs) and Center Nervous System, named Atypical teratoid/rhabdoid tumors (AT/RTs...

    Authors: Yanming Ren, Chuanyuan Tao, Xiliang Wang and Yan Ju
    Citation: Cancer Cell International 2018 18:190
  19. 2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical applicatio...

    Authors: Mandie Botes, Tamarin Jurgens, Zohreh Riahi, Michelle Visagie, Rustelle Janse van Vuuren, Anna Margaretha Joubert and Iman van den Bout
    Citation: Cancer Cell International 2018 18:188
  20. Accumulating evidence have indicated that regulatory T cells (Tregs) play an essential role in T cell-mediated immune response and development of multiple myeloma (MM). CD4+FoxP3+ T cells are composed of three ph...

    Authors: Ji-nuo Wang, Xin-xin Cao, Ai-lin Zhao, Hao Cai, Xuan Wang and Jian Li
    Citation: Cancer Cell International 2018 18:187
  21. MiRNAs was recognized as vital regulators involved in cancer development. Radioresistance remains a major obstacle for effective treatment of cancers. The mechanisms on the miRNA-mediated radioresistance of ca...

    Authors: Chunbao Zang, Fangfang Zhao, Lei Hua and Youguang Pu
    Citation: Cancer Cell International 2018 18:186
  22. Lung cancer is the leading cause of cancer deaths in the world. The major histopathological subtype of lung cancer is non-small cell lung cancer (NSCLC). Platinum-based therapy is the standard of care for pati...

    Authors: Heather E. Kapperman, Alicia A. Goyeneche and Carlos M. Telleria
    Citation: Cancer Cell International 2018 18:185
  23. miRNA clusters are widely expressed across species, accumulating evidence has illustrated that miRNA cluster functioned more efficiently than single miRNA in cancer oncogenesis. It is likely that miRNA cluster...

    Authors: Zhikui Gao, Peng Zhang, Ming Xie, Han Gao, Lihong Yin and Ran Liu
    Citation: Cancer Cell International 2018 18:184
  24. Cervical cancer (CC) is one of the most common cancers among females worldwide. Spindle and kinetochore-associated complex subunit 3 (SKA3), located on chromosome 13q, was identified as a novel gene involved i...

    Authors: Rong Hu, Ming-qing Wang, Wen-bo Niu, Yan-jing Wang, Yang-yang Liu, Ling-yu Liu, Ming Wang, Juan Zhong, Hai-yan You, Xiao-hui Wu, Ning Deng, Lu Lu and Lian-bo Wei
    Citation: Cancer Cell International 2018 18:183
  25. Nuclear transcription factor kappa B (NF-κB) subunits exhibit crucial roles in tumorigenesis and chemo-sensitivity. Recent studies suggest that RelB, the key subunit of the alternative NF-κB pathway, plays a c...

    Authors: Xiaojun Zhou, Zhili Shan, Hengying Yang, Jingjing Xu, Wenjing Li and Feng Guo
    Citation: Cancer Cell International 2018 18:181
  26. With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women’s health. The main goal of this study is to identify the potential outcome of WPS on human brea...

    Authors: Khaled W. Sadek, Mahmoud Y. Haik, Anas A. Ashour, Tahira Baloch, Tahar Aboulkassim, Amber Yasmeen, Semir Vranic, Asad Zeidan and Ala-Eddin Al Moustafa
    Citation: Cancer Cell International 2018 18:180
  27. Some progresses have been made in research of long non-coding RNA (hereunder referred to as LncRNA) related to breast cancer. Lots of data about LncRNA transcription concerning breast cancer have been obtained...

    Authors: Xu Bin, Yang Hongjian, Zhang Xiping, Chen Bo, Yang Shifeng and Tang Binbin
    Citation: Cancer Cell International 2018 18:179
  28. Deregulated Hippo signaling has been uncovered to be intricately involved in tumorigenesis. Transcriptional factor TEADs serve as key mediators of Hippo signaling and have been increasingly appreciated as puta...

    Authors: Wei Zhang, Jin Li, Yaping Wu, Han Ge, Yue Song, Dongmiao Wang, Hua Yuan, Hongbing Jiang, Yanling Wang and Jie Cheng
    Citation: Cancer Cell International 2018 18:178
  29. Sorafenib is the standard targeted drug used to treat hepatocellular carcinoma (HCC), but the therapeutic response between individuals varies markedly. Recently, cytokine-based immunotherapy has been a topic o...

    Authors: Xiaoyan Ding, Wei Sun and Jinglong Chen
    Citation: Cancer Cell International 2018 18:176

    The Retraction Note to this article has been published in Cancer Cell International 2019 19:358

  30. Gao-Min Liu and Yao-Ming Zhang recently published a review entitled «Targeting FBPase is an emerging novel approach for cancer therapy» (Liu and Zhang in Cancer Cell Int 18:36, 2018). In this paper, the authors h...

    Authors: Philippe Icard, Ludovic Fournel, Antoine Coquerel, Joseph Gligorov, Marco Alifano and Hubert Lincet
    Citation: Cancer Cell International 2018 18:175
  31. Pancreatic cancer is characterized by its unsatisfying early detection rate, rapid disease progression and poor prognosis. Further studies on molecular mechanism and novel predictive biomarkers for pancreatic ...

    Authors: Defeng Sun, Haoyi Jin, Jun Zhang and Xiaodong Tan
    Citation: Cancer Cell International 2018 18:174
  32. Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis. Unfortunately, the mechanisms underlying these pr...

    Authors: Yujie Feng, Xiao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao, Fangzhen Shen, Kai Ma, Chuandong Sun, Chengzhan Zhu and Bingyuan Zhang
    Citation: Cancer Cell International 2018 18:173
  33. Galectin-3 as a β-galactoside-binding protein, has been found to be involved in tumor cell growth, anti-apoptosis, adhesion, angiogenesis, invasion, and distant metastases, indicating that it may play a pivota...

    Authors: Yi Wang, Shiwei Liu, Ye Tian, Yamin Wang, Qijie Zhang, Xiang Zhou, Xianghu Meng and Ninghong Song
    Citation: Cancer Cell International 2018 18:172
  34. Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions...

    Authors: Xin-Xing Wang, Guang-Cheng Guo, Xue-Ke Qian, Dong-Wei Dou, Zhe Zhang, Xiao-Dong Xu, Xin Duan and Xin-Hong Pei
    Citation: Cancer Cell International 2018 18:171
  35. Cancer metastasis is the major reason for cancer related deaths, and the mechanism of cancer metastasis still unclear. RPLP1, a member of a group of proteins known as ribosomal proteins, is associated with tum...

    Authors: Zhixian He, Qian Xu, Xi Wang, Jun Wang, Xiangming Mu, Yunhui Cai, Yangyang Qian, Weiwei Shao and Zhimin Shao
    Citation: Cancer Cell International 2018 18:170
  36. Gene knockout technologies involving programmable nucleases have been used to create knockouts in several applications. Gene editing using Zinc-finger nucleases (ZFNs), Transcription activator like effectors (...

    Authors: Sumitra Shankar, Ahalya Sreekumar, Deepti Prasad, Ani V. Das and M. Radhakrishna Pillai
    Citation: Cancer Cell International 2018 18:169
  37. Drug resistance prevents the effective treatment of cancers. DNA methylation has been found to participate in the development of cancer drug resistance.

    Authors: Dabing Huang, Yong Wang, Yifu He, Gang Wang, Wei Wang, Xinghua Han, Yubei Sun, Lin Lin, Benjie Shan, Guodong Shen, Min Cheng, Geng Bian, Xiang Fang, Shilian Hu and Yueyin Pan
    Citation: Cancer Cell International 2018 18:168
  38. Inflammation is a major player in breast cancer (BC) progression. Allograft-inflammatory factor-1 (AIF1) is a crucial mediator in the inflammatory response. AIF1 reportedly plays a role in BC, but the mechanis...

    Authors: Ferial Amira Slim, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Simon Jacob, Caroline Diorio and Francine Durocher
    Citation: Cancer Cell International 2018 18:167
  39. Mitochondrial fragmentation drastically regulates the viability of pancreatic cancer through a poorly understood mechanism. The present study used erlotinib to activate mitochondrial fragmentation and then inv...

    Authors: Jun Wan, Jie Cui, Lei Wang, Kunpeng Wu, Xiaoping Hong, Yulin Zou, Shuang Zhao and Hong Ke
    Citation: Cancer Cell International 2018 18:165

    The Retraction Note to this article has been published in Cancer Cell International 2019 19:286

  40. Primary or acquired resistance to cetuximab often occurs during targeted therapy in metastatic colorectal cancer (mCRC) patients. In many cancers, the key role of the long noncoding RNA (lncRNA) urothelial car...

    Authors: Ying-nan Yang, Rui Zhang, Jing-wen Du, Heng-heng Yuan, Yan-jing Li, Xiao-li Wei, Xiao-xue Du, Shu-lin Jiang and Yu Han
    Citation: Cancer Cell International 2018 18:164
  41. Follistatin (FST), an activin-binding protein, inhibits activin action by interfering with activin binding to its receptor. The prognostic value of FST has been studied in various cancers. However, these studi...

    Authors: Pengyu Zhang, Yingxin Ruan, Jun Xiao, Fangfang Chen and Xuejun Zhang
    Citation: Cancer Cell International 2018 18:162

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