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  1. Prostate cancer (PCa) is the second leading cause of cancer death in men in 2018. Thus, the evaluation of prognosis is crucial for clinical treatment decision of human PCa patients. We aim to establishing an e...

    Authors: Yongzhi Wang and Zhonghua Yang

    Citation: Cancer Cell International 2020 20:159

    Content type: Primary research

    Published on:

  2. The mortality rate of clear cell renal cell carcinoma (ccRCC) remains high. The aim of this study was to identify novel prognostic biomarkers by using m6A RNA methylation regulators capable of improving the risk-...

    Authors: Jing Chen, Kun Yu, Guansheng Zhong and Wei Shen

    Citation: Cancer Cell International 2020 20:157

    Content type: Primary research

    Published on:

  3. Multiple myeloma (MM) is a prevalent hematological malignancy. Long noncoding RNAs are correlated with the development of MM. In this project, the function of lncRNA opa interacting protein 5-antisense 1 (OIP5...

    Authors: Yong Wang, Haibao Wang, Jianwei Ruan, Wenbiao Zheng, Zeyu Yang and Weiwei Pan

    Citation: Cancer Cell International 2020 20:155

    Content type: Primary research

    Published on:

  4. Fucoidan is a kind of the polysaccharide, which comes from brown algae and comprises of sulfated fucose residues. It has shown a large range of biological activities in basic researches, including many element...

    Authors: Yuan Lin, Xingsi Qi, Hengjian Liu, Kuijin Xue, Shan Xu and Zibin Tian

    Citation: Cancer Cell International 2020 20:154

    Content type: Review

    Published on:

  5. Previous literature has revealed long non-coding RNAs (lncRNAs) are crucial regulators for cell functions and gene expression. LncRNA fetal-lethal non-coding developmental regulatory RNA (FENDRR) was reported ...

    Authors: Yunheng Zhu, Xiaohua Zhang, Lifeng Wang, Xiuxiang Zhu, Ziyin Xia, Ling Xu and Jun Xu

    Citation: Cancer Cell International 2020 20:152

    Content type: Primary research

    Published on:

  6. Circular RNAs (circRNAs) play an essential role in the regulation of gene expression. However, the underlying mechanisms remain unknown. This study aimed to evaluate the role of hsa_circ_0068307 in bladder can...

    Authors: Qi Chen, Qiuping Yin, Yemeng Mao, Zheyu Zhang, Siqi Wu, Zhang Cheng, Xinan Chen, Hanren Xu, Shengming Jin, Haowen Jiang and Chen Yang

    Citation: Cancer Cell International 2020 20:151

    Content type: Primary research

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  7. Arginine is a semi essential amino acid that is used in protein biosynthesis. It can be obtained from daily food intake or synthesized in the body through the urea cycle using l-citrulline as a substrate. Arginin...

    Authors: Houssam Al-Koussa, Nour El Mais, Hiba Maalouf, Ralph Abi-Habib and Mirvat El-Sibai

    Citation: Cancer Cell International 2020 20:150

    Content type: Review

    Published on:

  8. Accumulating evidence suggests androgen receptor splice variant 7 (AR-V7) may be associated with the prognosis of castration-resistant prostate cancer (CRPC) received novel hormonal therapy while its character...

    Authors: Zhize Wang, Haixiang Shen, Zhen Liang, Yeqing Mao, Chaojun Wang and Liping Xie

    Citation: Cancer Cell International 2020 20:149

    Content type: Review

    Published on:

  9. Osteosarcoma (OS) is one of the most aggressive malignancies with mortality rate worldwide. Accumulating evidence has revealed that long noncoding RNAs (lncRNAs) exert important functions in regulation of canc...

    Authors: Zhiqian Gu, Shaokun Wu, Jingnan Wang and Shoujun Zhao

    Citation: Cancer Cell International 2020 20:147

    Content type: Primary research

    Published on:

  10. We used bioinformatic tools to dichotomize 157 non-M3 AML patients from the TCGA dataset based on the presence or absence of TP53 mutations, and screened out a key gene related to TP53 mutation for future analysi...

    Authors: Siyu Gu, Jie Zi, Qi Han, Chunhua Song and Zheng Ge

    Citation: Cancer Cell International 2020 20:146

    Content type: Primary research

    Published on:

  11. Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function ...

    Authors: Lijuan Zhu, Aihua Wang, Mei Gao, Xiaoyan Duan and Zehua Li

    Citation: Cancer Cell International 2020 20:145

    Content type: Primary research

    Published on:

  12. Non-small cell lung cancer (NSCLC) is the most deadly cancer worldwide. LncRNA KCNQ1OT1 has been reported to be involved in the progression of various tumors, including NSCLC. However, the precise mechanism of...

    Authors: Yan Wang, Lei Zhang, Jiasheng Yang and Ruilin Sun

    Citation: Cancer Cell International 2020 20:144

    Content type: Primary research

    Published on:

  13. Genetic biomarkers of lung cancer (LC) susceptibility may provide a basis for treatment and prevention. This study analyzed an association between SNPs (single nucleotide polymorphisms) in the complementary re...

    Authors: Shimin Yang, Fanglin Yu, Mingyan Lin, Linyi Sun, Junjie Wei, Cheng Lai, Lin Cai, Zhijian Hu and Fei He

    Citation: Cancer Cell International 2020 20:143

    Content type: Primary research

    Published on:

  14. The eukaryotic translation initiation factor 5A1 (eIF5A1) and its homolog eIF5A2 are the only two human proteins containing the unique post-translational modification–hypusination, which is essential for the f...

    Authors: Gao-Qi Wu, Yan-Ming Xu and Andy T. Y. Lau

    Citation: Cancer Cell International 2020 20:142

    Content type: Review

    Published on:

  15. Without targets, triple negative breast cancer (TNBC) has the worst prognosis in all subtypes of breast cancer (BC). Recently, eukaryotic translation initiation factor 3 m (eIF3m) has been declared to be invol...

    Authors: Wei Han, Cong Zhang, Chun-tao Shi, Xiao-jiao Gao, Ming-hui Zhou, Qi-xiang Shao, Xiao-jun Shen, Cheng-jiang Wu, Fang Cao, Yong-wei Hu, Jian-liang Yuan, Hou-zhong Ding, Qing-hua Wang and Hao-nan Wang

    Citation: Cancer Cell International 2020 20:141

    Content type: Primary research

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  16. The primary tumor, regional lymph nodes and distant metastasis (TNM) stage is an independent risk factor for 1-year hepatocellular carcinoma (HCC) recurrence but has insufficient predictive efficiency. We atte...

    Authors: Haohan Liu, Yongcong Yan, Ruibing Chen, Mengdi Zhu, Jianhong Lin, Chuanchao He, Bingchao Shi, Kai Wen, Kai Mao and Zhiyu Xiao

    Citation: Cancer Cell International 2020 20:140

    Content type: Primary research

    Published on:

  17. Canine prostate cancer represents a unique model for human prostate cancer. In vitro systems offer various possibilities but Xenograft in vivo imaging allows studying complex tasks as tumor progression and dru...

    Authors: Wen Liu, Sina Sender, Weibo Kong, Julia Beck, Anett Sekora, Kirsten Bornemann-Kolatzki, Ekkehart Schuetz, Christian Junghanss, Bertram Brenig, Ingo Nolte and Hugo Murua Escobar

    Citation: Cancer Cell International 2020 20:139

    Content type: Primary research

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  18. Nasopharyngeal carcinoma (NPC) is a subtype of head and neck cancer with dismal prognosis and high relapse rate. The role of long non-coding RNAs (lncRNAs) in NPC has become a research hotspot in recent years....

    Authors: Hongchao Yao, Like Yang, Linli Tian, Yan Guo and Yushan Li

    Citation: Cancer Cell International 2020 20:138

    Content type: Primary research

    Published on:

  19. The purpose of this study was to explore the regulatory mechanism of the long non-coding RNA (lncRNA) LINC00461 underlying the breast cancer invasion and migration via the miR-144-3p/KPNA2 axis.

    Authors: Qiang Zhang, Xiaoyan Jin, Wenbiao Shi, Xin Chen, Wenyang Pang, Xiaodong Yu and Linjun Yang

    Citation: Cancer Cell International 2020 20:137

    Content type: Primary research

    Published on:

  20. The crucial role of long non-coding RNAs (lncRNAs) has been certified in human cancers. The lncRNAs with abnormal expressions could act as tumor inhibitors or oncogenes in the advancement of tumors. LBX2-AS1 w...

    Authors: Gang Xu, Yan Zhang, Na Li, Yanling Wu, Jinbiao Zhang, Rui Xu and Hui Ming

    Citation: Cancer Cell International 2020 20:136

    Content type: Primary research

    Published on:

  21. The primary bone tumor is usually observed in adolescence age group which has been shown to be part of nearly 20% of the sarcomas known today. Giant cell tumor of bone (GCTB) can be benign as well as malignant...

    Authors: Abdul Rouf War, Kai Dang, Shanfen Jiang, Zhongwei Xiao, Zhiping Miao, Tuanmin Yang, Yu Li and Airong Qian

    Citation: Cancer Cell International 2020 20:135

    Content type: Review

    Published on:

  22. Recent studies have emphasized determining the ability of microRNAs (miRNAs) as crucial regulators in the occurrence and development of pancreatic cancer (PC), which continues to be one of the deadliest malign...

    Authors: Jingyang Zhou, Haihong Wang, Jinhui Che, Lu Xu, Weizhong Yang, Yunjiu Li and Wuyuan Zhou

    Citation: Cancer Cell International 2020 20:134

    Content type: Primary research

    Published on:

  23. Spinal osteosarcoma (OS) is a rare and aggressive malignancy. Long noncoding RNA (lncRNA) BSN-AS2 has been shown to be an oncogenic gene in several cancers. However, the role and function of BSN-AS2 in spinal ...

    Authors: Xianwei Zhou, Jitian Li, Junyan Teng, Yufeng Liu, Di Zhang, Linyun Liu and Wenming Zhang

    Citation: Cancer Cell International 2020 20:133

    Content type: Primary research

    Published on:

  24. Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal malignancies. Long non-coding RNAs (lncRNAs) are being found to play crucial roles in ATC progression. Herein, we focused on the role...

    Authors: Xiangrong Tan, Peng Wang, Jianlin Lou and Jiazheng Zhao

    Citation: Cancer Cell International 2020 20:132

    Content type: Primary research

    Published on:

  25. Compared with conventional cancer treatments, the main advantage of oncolytic virotherapy is its tumor-selective replication followed by the destruction of malignant cells without damaging healthy cells. Accor...

    Authors: Mohsen Keshavarz, Ailar Sabbaghi, Seyed Mohammad Miri, Abolhasan Rezaeyan, Yaser Arjeini and Amir Ghaemi

    Citation: Cancer Cell International 2020 20:131

    Content type: Review

    Published on:

  26. Cholangiocarcinoma (CCA) is an invasive malignancy arising from biliary epithelial cells; it is the most common primary tumour of the bile tract and has a poor prognosis. The aim of this study was to screen pr...

    Authors: Zijian Da, Long Gao, Gang Su, Jia Yao, Wenkang Fu, Jinduo Zhang, Xu Zhang, Zhaoji Pei, Ping Yue, Bing Bai, Yanyan Lin, Wenbo Meng and Xun Li

    Citation: Cancer Cell International 2020 20:130

    Content type: Primary research

    Published on:

  27. Recent evidence of clinical trials highlights that the combination of two noncompetitive anti-EGFR antibodies can benefit patients with several cancers. Previous studies propose that a lattice complex assemble...

    Authors: Dianshuai Huang, Tianqi Lu, Xingyu Du, Xi Xi, Xin Zhang, Xitian Zhang, Haoran Zhang and Fei Sun

    Citation: Cancer Cell International 2020 20:129

    Content type: Primary research

    Published on:

  28. Cisplatin is a platinum-based first-line drug for treating ovarian cancer. However, chemotherapy tolerance has limited the efficacy of cisplatin for ovarian cancer patients. Research has demonstrated that cisp...

    Authors: Xiao-Yu Yan, Xian-Zhi Qu, Long Xu, Si-Hang Yu, Rui Tian, Xin-Ru Zhong, Lian-Kun Sun and Jing Su

    Citation: Cancer Cell International 2020 20:128

    Content type: Review

    Published on:

  29. Thymidine kinase 1 (TK1) is a pyrimidine salvage pathway enzyme that is up-regulated in malignant tissues and elevated in the serum of cancer patients. While TK1 has been well established as a tumor biomarker,...

    Authors: Edwin J. Velazquez, Taylor D. Brindley, Gajendra Shrestha, Eliza E. Bitter, Jordan D. Cress, Michelle H. Townsend, Bradford K. Berges, Richard A. Robison, K. Scott Weber and Kim L. O’Neill

    Citation: Cancer Cell International 2020 20:127

    Content type: Primary research

    Published on:

  30. Colorectal carcinoma is one of the most deadly cancers that requests effective and safe chemotherapy. Evaluation of natural product-based anticancer drugs as adjuvant treatment with fewer side effects is large...

    Authors: Omar Al-Obeed, Adila Salih El-Obeid, Sabine Matou-Nasri, Mansoor-Ali Vaali-Mohammed, Yazeid AlHaidan, Mohammed Elwatidy, Hamad Al Dosary, Zeyad Alehaideb, Khayal Alkhayal, Adil Haseeb, James McKerrow, Rehan Ahmad and Maha-Hamadien Abdulla

    Citation: Cancer Cell International 2020 20:126

    Content type: Primary research

    Published on:

  31. Kinesin superfamily proteins (KIFs) can transport membranous organelles and protein complexes in an ATP-dependent manner. Kinesin family member 15 (KIF15) is overexpressed in various cancers. However, the func...

    Authors: Lixian Ding, Bin Li, Xiaotong Yu, Zhongsheng Li, Xinglong Li, Shuwei Dang, Qiang Lv, Jiufeng Wei, Haixia Sun, Hongsheng Chen, Ming Liu and Guodong Li

    Citation: Cancer Cell International 2020 20:125

    Content type: Primary research

    Published on:

  32. LNK adaptor protein is a crucial regulator of normal hematopoiesis, which down-regulates activated tyrosine kinases at the cell surface resulting in an antitumor effect. To date, little studies have examined a...

    Authors: Jianxin Lv, Wei Yu, Yanan Zhang, Xinhua Cao, Lifei Han, Haolin Hu and Chenfei Wang

    Citation: Cancer Cell International 2020 20:124

    Content type: Primary research

    Published on:

  33. Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our st...

    Authors: Tian-Fu Li, Hui-Juan Zeng, Zhen Shan, Run-Yi Ye, Tuck-Yun Cheang, Yun-Jian Zhang, Si-Hong Lu, Qi Zhang, Nan Shao and Ying Lin

    Citation: Cancer Cell International 2020 20:123

    Content type: Primary research

    Published on:

  34. Tenascin-C (TNC) is an extracellular matrix protein that is widely expressed in the stromal fibroblasts of various cancers. However, the roles of TNC in colorectal cancer (CRC) cells remain unclear.

    Authors: Zhaoting Yang, Chengye Zhang, Ying Feng, Mingji Quan, Yan Cui and Yanhua Xuan

    Citation: Cancer Cell International 2020 20:122

    Content type: Primary research

    Published on:

  35. As one of the many breast cancer subtypes, human epidermal growth factor receptor 2 (Her2)-positive breast cancer has higher invasiveness and poor prognosis, although the advent of anti-Her2 drugs has brought ...

    Authors: Chundi Gao, Jing Zhuang, Huayao Li, Cun Liu, Chao Zhou, Lijuan Liu, Fubin Feng, Changgang Sun and Jibiao Wu

    Citation: Cancer Cell International 2020 20:121

    Content type: Primary research

    Published on:

  36. Splicing factor SRSF3 is an oncogene and overexpressed in various kinds of cancers, however, the function and mechanism involved in colorectal cancer (CRC) remained unclear. The aim of this study was to explor...

    Authors: Ji-Lin Wang, Chun-Rong Guo, Tian-Tian Sun, Wen-Yu Su, Qiang Hu, Fang-Fang Guo, Lun-Xi Liang, Jie Xu, Hua Xiong and Jing-Yuan Fang

    Citation: Cancer Cell International 2020 20:120

    Content type: Primary research

    Published on:

  37. Circular RNAs (circRNAs) are identified to play an important role in many human cancers, such as glioblastoma. However, the potential mechanisms underlying the relationship between circRNAs and glioblastoma pa...

    Authors: Fei Zhu, Cheng Cheng, Hong qin, Hongsheng Wang and Hailong Yu

    Citation: Cancer Cell International 2020 20:118

    Content type: Primary research

    Published on:

  38. The carcinogenesis and progression of cervical cancer is a complex process in which numerous microRNAs are involved. The purpose of this study is to investigate the role of miR-125a-5p in progression of cervic...

    Authors: Qinxue Cao, Ning Wang, Lu Ren, Jun Tian, Shaoqin Yang and Hailing Cheng

    Citation: Cancer Cell International 2020 20:117

    Content type: Primary research

    Published on:

  39. The significance of long non-coding RNAs (lncRNAs) in mediating oxidative stress of cancers has been implicated recently. This study proposed a potential therapeutic target lncRNA growth arrest-specific transc...

    Authors: Wei Xu, Zeqiang Yan, Fen Hu, Wei Wei, Chao Yang and Zhihua Sun

    Citation: Cancer Cell International 2020 20:116

    Content type: Primary research

    Published on:

  40. Emerging studies have explored the prognostic value of MIR31HG in cancers, but its role remains elusive. Herein, we aimed to summarize the prognostic potential of MIR31HG in this study.

    Authors: Chao Tu, Xiaolei Ren, Jieyu He, Shuangqing Li, Lin Qi, Zhixi Duan, Wanchun Wang and Zhihong Li

    Citation: Cancer Cell International 2020 20:115

    Content type: Primary research

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  41. Acute myeloid leukemia (AML) is a heterogeneous hematological disease. Our purpose of the research was to investigate the regulatory influence of long non-coding RNA (lncRNA) nuclear enriched abundant transcri...

    Authors: Song Feng, Na Liu, Xiaoguang Chen, Yufeng Liu and Jindou An

    Citation: Cancer Cell International 2020 20:112

    Content type: Primary research

    Published on:

  42. Glioblastoma (GBM) is a subclass of brain malignancy with unsatisfactory prognosis. MicroRNAs (miRNAs) are a group of non-coding RNAs (ncRNAs) that exert key function on tumorigenesis and tumor development.

    Authors: Xinli Zhao, Fazheng Shen, Jiwei Ma, Shupeng Zhao, Lei Meng, Xiangyang Wang, Shufeng Liang, Jianing Liang, Chaoshuai Hu and Xinzhong Zhang

    Citation: Cancer Cell International 2020 20:111

    Content type: Primary research

    Published on:

  43. A number of studies have demonstrated the critical role of long non-coding RNA gastric cancer high expressed transcript 1 (GHET1) in many cancers. This meta-analysis provides an evidence-based evaluation of th...

    Authors: Dingding Wang, Hong Zhang, Xiaolian Fang, Xue Zhang and Honggang Liu

    Citation: Cancer Cell International 2020 20:109

    Content type: Review

    Published on:

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