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  1. Intrahepatic cholangiocarcinoma (ICC) is a fatal primary liver cancer, and its long-term survival rate remains poor. RNA-binding proteins (RBPs) play an important role in critical cellular processes, failure o...

    Authors: Wenbo Zou, Zizheng Wang, Xiuping Zhang, Shuai Xu, Fei Wang, Lincheng Li, Zhaoda Deng, Jing Wang, Ke Pan, Xinlan Ge, Chonghui Li, Rong Liu and Minggen Hu

    Citation: Cancer Cell International 2021 21:657

    Content type: Primary research

    Published on:

  2. Accumulating evidence has demonstrated the close relation of SOX1 with tumorigenesis and tumor progression. Upregulation of SOX1 was recently shown to suppress growth of human cancers. However, the expression ...

    Authors: Da Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Bing Wang and Yongjun Chen

    Citation: Cancer Cell International 2021 21:656

    Content type: Primary Research

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  3. SWI/SNF, a well-known ATP-dependent chromatin-remodeling complex, plays an essential role in several biological processes. SNF5, the core subunit of the SWI/SNF remodeling complex, inactivated in 95% of malign...

    Authors: Hua Ding, Yaqin Huang, Jiazhong Shi, Liwei Wang, Sha Liu, Baixiong Zhao, Yuting Liu, Jin Yang and Zhiwen Chen

    Citation: Cancer Cell International 2021 21:655

    Content type: Primary Research

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  4. Tumor migration and invasion is a complex and diverse process that involves the epithelial–mesenchymal transition (EMT) of tumor cells and degradation of the extracellular matrix by matrix metalloproteases (MM...

    Authors: Mengying Teng, Chunyan Hu, Bingmo Yang, Wei Xiao, Qian Zhou, Yuan Li and Zhong Li

    Citation: Cancer Cell International 2021 21:654

    Content type: Primary Research

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  5. MYB is often overexpressed in malignant tumors and plays a carcinogenic role in the initiation and development of cancer. Deletion of the MYB regulatory C-terminal domain may be a driving mutation leading to t...

    Authors: Dingyu Hu, Wenjun Shao, Li Liu, Yanyan Wang, Shunling Yuan, Zhaoping Liu, Jing Liu and Ji Zhang

    Citation: Cancer Cell International 2021 21:653

    Content type: Review

    Published on:

  6. Aging and senescence can alter immune cell fitness and influence the efficacy of lung cancer treatments, especially immunotherapy. However, the correlations between cellular senescence and tumor microenvironme...

    Authors: Weihao Lin, Xin Wang, Zhenyi Xu, Zhen Wang, Tiejun Liu, Zheng Cao, Xiaoli Feng, Yibo Gao and Jie He

    Citation: Cancer Cell International 2021 21:652

    Content type: Primary Research

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  7. Circular RNAs (circRNAs) act pivotal roles in the progression of multiple malignancies. However, the underlying mechanisms by which hsa_circ_0007031 (circTUBGCP3) contributes to lung adenocarcinoma (LAC) remai...

    Authors: Yang Yang, Xin Fan, Yunfei Nie, Donglei Liu, Dengyan Zhu, Kai Wu, Yuan Zhang, Wenhua Li, Xiangyu Tian, Huaqi Wang and Yuxia Fan

    Citation: Cancer Cell International 2021 21:651

    Content type: Primary Research

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  8. Previous studies indicated CRNDE to have a pivotal part within tumorigenesis. Notwithstanding, precise details on CRNDE activities within NPC are still uncertain. The investigation described in this article se...

    Authors: Sichen Ge, Chengyi Jiang, Min Li, Zhongqiang Cheng and Xiaojia Feng

    Citation: Cancer Cell International 2021 21:650

    Content type: Primary Research

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  9. The ESR1 gene suffers methylation changes in many types of cancers, including breast cancer (BC), the most frequently diagnosed cancer in women that is also present in men. Methylation at promoter A of ESR1 is th...

    Authors: Laura Itzel Quintas-Granados, Hernán Cortés, Manuel González-Del Carmen, Gerardo Leyva-Gómez, Lilia Patricia Bustamante-Montes, Miguel Rodríguez-Morales, Edgar Yebran Villegas-Vazquez, Israel López-Reyes, Sofía Lizeth Alcaraz-Estrada, Jorge Sandoval-Basilio, Ernesto Soto-Reyes, Javad Sharifi-Rad, Gabriela Figueroa-González and Octavio Daniel Reyes-Hernández

    Citation: Cancer Cell International 2021 21:649

    Content type: Primary Research

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  10. Osteosarcoma (OS) patients with lung metastasis have poor prognoses, and effective therapeutic strategies for delaying or inhibiting the spread of lung metastasis from the primary OS site are lacking. Hence, i...

    Authors: Haoran Kong, Wenhui Yu, Zhuning Chen, Haonan Li, Guiwen Ye, Jiacong Hong, Zhongyu Xie, Keng Chen, Yanfeng Wu and Huiyong Shen

    Citation: Cancer Cell International 2021 21:648

    Content type: Primary Research

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  11. Eribulin has shown antitumour activity in some soft tissue sarcomas (STSs), but it has only been approved for advanced liposarcoma (LPS).

    Authors: Javier Escudero, Victoria Heredia-Soto, Yinyin Wang, Patricia Ruiz, Yingying Hu, Alejandro Gallego, Jose Juan Pozo-Kreilinger, Virginia Martinez-Marin, Alberto Berjon, Eduardo Ortiz-Cruz, Daniel Bernabeu, Jaime Feliu, Jing Tang, Andres Redondo and Marta Mendiola

    Citation: Cancer Cell International 2021 21:646

    Content type: Primary Research

    Published on:

  12. Glioma is a common type of malignant brain tumor with a high mortality and relapse rate. The endosomal sorting complex required for transport (ESCRT) has been reported to be involved in tumorigenesis. However,...

    Authors: Xiaolong Zhu, Hui Yang, Mengying Zhang, Xingwei Wu, Lan Jiang, Xiaocen Liu and Kun Lv

    Citation: Cancer Cell International 2021 21:645

    Content type: Primary research

    Published on:

  13. The lncRNA H19 is believed to act as an oncogene in various types of tumors and is considered to be a therapeutic target and diagnostic marker. However, the role of the lncRNA H19 in regulating the radiosensit...

    Authors: Xueshan Zhao, Xiaodong Jin, Qiuning Zhang, Ruifeng Liu, Hongtao Luo, Zhen Yang, Yichao Geng, Shuangwu Feng, Chengcheng Li, Lina Wang, Xiaohu Wang and Qiang Li

    Citation: Cancer Cell International 2021 21:644

    Content type: Primary research

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  14. Human papillomavirus (HPV) E6/E7 mRNA in situ hybridization (HPV E6/E7 RNAscope) appears to be a sensitive and specific technique in detecting transcriptionally active HPV. We aimed to examine the diagnostic u...

    Authors: Rong-Zhen Luo, Shu-Lin Chen, Mei Li, Yue Li, Xia Yang and Li-Li Liu

    Citation: Cancer Cell International 2021 21:643

    Content type: Primary Research

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  15. Heterogeneous nuclear ribonucleoprotein K (HnRNPK) is a nucleic acid-binding protein that regulates diverse biological events. Pathologically, HnRNPK proteins are frequently overexpressed and clinically correl...

    Authors: Huan-Lei Wu, Sen-Mao Li, Yao-chen Huang, Qi-Dong Xia, Peng Zhou, Xian-Miao Li, Xiao Yu, Shao-Gang Wang, Zhang-Qun Ye and Jia Hu

    Citation: Cancer Cell International 2021 21:641

    Content type: Primary Research

    Published on:

  16. Osteosarcoma (OS) metastasis is the most common cause of cancer-related mortality, however, no sufficient clinical biomarkers have been identified. In this study, we identified five genes to help predict metas...

    Authors: Fu-peng Ding, Jia-yi Tian, Jing Wu, Dong-feng Han and Ding Zhao

    Citation: Cancer Cell International 2021 21:640

    Content type: Primary research

    Published on:

  17. Cervical cancer (CC) is the leading cause of cancer-related death in women. A limited number of studies have investigated whether immune-prognostic features can be used to predict the prognosis of CC. This stu...

    Authors: Ya-Nan Pi, Jun-Nan Guo, Ge Lou and Bin-Bin Cui

    Citation: Cancer Cell International 2021 21:639

    Content type: Primary Research

    Published on:

  18. The emergence of chemoresistance to 5-fluorouracil (5-FU)-based chemotherapy is the main cause of treatment failure in advanced and metastatic colorectal cancer (CRC) patients. Long noncoding RNAs (lncRNAs) ha...

    Authors: Jingui Wang, Xiaoqian Zhang, Junling Zhang, Shangwen Chen, Jing Zhu and Xin Wang

    Citation: Cancer Cell International 2021 21:638

    Content type: Primary Research

    Published on:

  19. Esophageal carcinogenesis is a multifactorial process in which genetic and environmental factors interact to activate intracellular signals, leading to the uncontrolled survival and growth of esophageal squamo...

    Authors: Jia Zhao, Guangyu Jin, Xudong Liu, Kai Wu, Yang Yang, Zhanfeng He, Donglei Liu, Chunyang Zhang, Dengyan Zhu, Jia Jiao, Xiangnan Li and Song Zhao

    Citation: Cancer Cell International 2021 21:637

    Content type: Primary Research

    Published on:

  20. Circular RNAs (circRNAs), which are endogenous non-coding RNAs, are associated with various biological processes including development, homeostatic maintenance, and pathological responses. Accumulating evidenc...

    Authors: Yu Huang, Wenhao Ge, Yuan Ding, Lufei Zhang, Jiarong Zhou, Yang Kong, Bijun Cui, Bingqiang Gao, Xiaohui Qian and Weilin Wang

    Citation: Cancer Cell International 2021 21:636

    Content type: Primary Research

    Published on:

  21. The tumor microenvironment (TME) is critical in the progression and metastasis of skin cutaneous melanoma (SKCM). Differences in tumor-infiltrating immune cells (TICs) and their gene expression have been linke...

    Authors: Peipei Yang, Wanrong Chen, Hua Xu, Junhan Yang, Jinghang Jiang, Yunhui Jiang and Ganglin Xu

    Citation: Cancer Cell International 2021 21:635

    Content type: Primary Research

    Published on:

  22. Rhabdomyosarcoma (RMS) is a malignant soft-tissue tumour. In recent years, the tumour microenvironment (TME) has been reported to be associated with the development of tumours. However, the relationship betwee...

    Authors: Tian Xia, Lian Meng, Zhijuan Zhao, Yujun Li, Hao Wen, Hao Sun, Tiantian Zhang, Jingxian Wei, Feng Li and Chunxia Liu

    Citation: Cancer Cell International 2021 21:634

    Content type: Primary Research

    Published on:

  23. Current treatment options for glioma are limited, and the prognosis of patients with glioma is poor as the available drugs show low therapeutic efficacy. Furthermore, the molecular mechanisms associated with g...

    Authors: Lun Li, Yi Yang, Zhenshuang Wang, Chengran Xu, Jinhai Huang and Guangyu Li

    Citation: Cancer Cell International 2021 21:633

    Content type: Primary Research

    Published on:

  24. The precancerous disease of breast cancer is an inevitable stage in the tumorigenesis and development of breast neoplasms. Quercetin (Que) has shown great potential in breast cancer treatment by inhibiting cel...

    Authors: Dan Qiu, Xianxin Yan, Xinqin Xiao, Guijuan Zhang, Yanqiu Wang, Jingyu Cao, Ruirui Ma, Shouyi Hong and Min Ma

    Citation: Cancer Cell International 2021 21:632

    Content type: Primary Research

    Published on:

  25. A number of studies have indicated that Ubiquitin-conjugating enzyme E2T (UBE2T), as an oncogene, promotes progression and metastasis of lung cancer, including lung adenocarcinoma (LUAD), but it is completely ...

    Authors: Yongbing Chen, Haihua Hong, Qingqing Wang, Junqiang Li, Wenfeng Zhang, Tingting Chen and Pu Li

    Citation: Cancer Cell International 2021 21:631

    Content type: Primary Research

    Published on:

  26. Osteosarcoma is a primary malignant tumor that mainly affects children and young adults. Transmembrane emp24 trafficking protein 3 (TMED3) may be involved in the regulation of malignant cancer behaviors. Howev...

    Authors: Wei Xu, Yifan Li, Xiaojian Ye, Yunhan Ji, Yu Chen, Xiangyang Zhang and Zhikun Li

    Citation: Cancer Cell International 2021 21:630

    Content type: Primary Research

    Published on:

  27. MicroRNA (miRNA) that translocate from the nucleus to mitochondria are referred to as mitochondrial microRNA (mitomiR). Albeit mitomiRs have been shown to modulate gene expression, their functional impact with...

    Authors: Praveen Sharma, Vibhuti Sharma, Tarunveer Singh Ahluwalia, Nilambra Dogra, Santosh Kumar and Sandeep Singh

    Citation: Cancer Cell International 2021 21:629

    Content type: Primary Research

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  28. Non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancers, which is the most common malignant tumor worldwide. Polypeptide extract from scorpion venom (PESV) has been reported to inhibit NS...

    Authors: Hong Zhang, Haojian Zhang, Jiye Zhu, Huan Liu and Qin Zhou

    Citation: Cancer Cell International 2021 21:628

    Content type: Primary Research

    Published on:

  29. Cancer cachexia is a wasting disorder characterized by significant weight loss, and is attributed to skeletal muscle weakness. In the process of cancer development, microRNAs act as oncogenes or tumor suppress...

    Authors: Kairu Xie, Hairong Xiong, Wen Xiao, Zhiyong Xiong, Wenjun Hu, Jiaxin Ye, Ning Xu, Jian Shi, Changfei Yuan, Zhixian Chen, Daojia Miao, Xiaoping Zhang and Hongmei Yang

    Citation: Cancer Cell International 2021 21:627

    Content type: Primary Research

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  30. Controversial findings have been reported in the impact of speckle-type POZ protein (SPOP) on clinicopathological features and prognosis in diverse cancers. We conducted this meta-analysis to confirm whether S...

    Authors: Yan He, Jun Chen, Xingchen Peng, Yanli Xia and Yonglin Su

    Citation: Cancer Cell International 2021 21:626

    Content type: Review

    Published on:

  31. This article aimed to explore the prognostic and immunological roles of AXL gene in clear cell renal cell carcinoma (ccRCC) for overall survival (OS) and to identify the LncRNA/RBP/AXL mRNA networks.

    Authors: Yi Wang, Ye Tian, Shouyong Liu, Zengjun Wang and Qianwei Xing

    Citation: Cancer Cell International 2021 21:625

    Content type: Primary Research

    Published on:

  32. Long non-coding RNAs (lncRNAs) have been verified to play fatal role in regulating the progression of lung adenocarcinoma (LUAD). Although lncRNAs play important role in regulating the autophagy of tumor cells...

    Authors: Zhuochen Zhao, Junhu Wan, Manman Guo, Zhengwu Yang, Zhuofang Li, Yangxia Wang and Liang Ming

    Citation: Cancer Cell International 2021 21:624

    Content type: Primary Research

    Published on:

  33. Acquired glucocorticoid (GC) resistance remains the main obstacle in acute lymphoblastic leukemia (ALL) therapy. The aim of the present study was to establish a novel GC-resistant B-ALL cell line and investiga...

    Authors: Yuanyuan Li, Chuan Zuo and Ling Gu

    Citation: Cancer Cell International 2021 21:623

    Content type: Primary Research

    Published on:

  34. Morphine, a µ-opioid receptor (MOR) agonist, has been shown to be related to the activity of cancer cells, and a higher morphine dosage reduces the survival time of patients with lung cancer. However, the effe...

    Authors: Xingyun Liu, Jia Yang, Chengwei Yang, Xiang Huang, Mingming Han, Fang Kang and Juan Li

    Citation: Cancer Cell International 2021 21:622

    Content type: Primary Research

    Published on:

  35. The aim of this study was to construct a model based on the prognostic features associated with epithelial–mesenchymal transition (EMT) to explore the various mechanisms and therapeutic strategies available fo...

    Authors: Dafeng Xu, Yu Wang, Jincai Wu, Shixun Lin, Yonghai Chen and Jinfang Zheng

    Citation: Cancer Cell International 2021 21:621

    Content type: Primary Research

    Published on:

  36. Pancreatic cancer has been a threateningly lethal malignant tumor worldwide. Despite the promising survival improvement in other cancer types attributing to the fast development of molecular precise medicine, ...

    Authors: Rong Wei, Guoye Qi, Zixin Zeng, Ningning Shen, Ziyue Wang, Honghong Shen, Lifang Gao, Chen Song, Wenxia Ma and Chen Wang

    Citation: Cancer Cell International 2021 21:620

    Content type: Primary Research

    Published on:

  37. Neuroblastoma (NB) is a common solid malignancy in children that is associated with a poor prognosis. Although the novel small molecular compound Dimethylaminomicheliolide (DMAMCL) has been shown to induce cel...

    Authors: Simeng Zhang, Zhongyan Hua, Gen Ba, Ning Xu, Jianing Miao, Guifeng Zhao, Wei Gong, Zhihui Liu, Carol J. Thiele and Zhijie Li

    Citation: Cancer Cell International 2021 21:619

    Content type: Primary Research

    Published on:

  38. Papillary thyroid carcinoma (PTC) is a common endocrine tumor. Increasing evidence has shown that microRNA dysfunction is involved in the occurrence and development of cancer. The expression of MicroRNA-30b-5p...

    Authors: Ye Wang, Congjun Wang, Zhao Fu, Siwen Zhang and Junqiang Chen

    Citation: Cancer Cell International 2021 21:618

    Content type: Primary Research

    Published on:

  39. UCA1 is frequently upregulated in a variety of cancers, including CRC, and it can play an oncogenic role by various mechanisms. However, how UCA1 is regulated in cancer is largely unknown. In this study, we ai...

    Authors: Rong-Zhang He, Jing Jiang, Xinglin Hu, Ming Lei, Jia Li, Weihao Luo, Lili Duan, Zheng Hu, Yin-Yuan Mo, Di-Xian Luo and Wan-Xin Peng

    Citation: Cancer Cell International 2021 21:616

    Content type: Primary research

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  40. There is mounting evidence that demonstrated the association of aberrant NEDD4L expression with diverse human cancers. However, the expression pattern and clinical implication of NEDD4L in acute myeloid leukemia ...

    Authors: Ming-qiang Chu, Liu-chao Zhang, Qian Yuan, Ting-juan Zhang and Jing-dong Zhou

    Citation: Cancer Cell International 2021 21:615

    Content type: Primary Research

    Published on:

  41. Most previous studies compared the risk for non-melanoma skin cancer (NMSC) in biologic-treated common inflammatory diseases with the general population. Whether the increased NMSC risk is caused by the diseas...

    Authors: Ruolin Liu, Qianyi Wan, Rui Zhao, Haitao Xiao, Ying Cen and Xuewen Xu

    Citation: Cancer Cell International 2021 21:614

    Content type: Review

    Published on:

  42. Bladder cancer (BLCA) is the most common genitourinary tumor but lacks specific diagnostic biomarkers. Recent years have witnessed significant advances in the use and approval of immune checkpoint blockade (IC...

    Authors: YiHeng Du, Jin Cao, Xiang Jiang, XiaoWei Cai, Bo Wang, Yi Wang, XiZhi Wang and BoXin Xue

    Citation: Cancer Cell International 2021 21:613

    Content type: Primary research

    Published on:

  43. Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers....

    Authors: Shabnam Sharmin, Md. Mizanur Rahaman, Miquel Martorell, Jorge Sastre-Serra, Javad Sharifi-Rad, Monica Butnariu, Iulia Cristina Bagiu, Radu Vasile Bagiu and Mohammad Torequl Islam

    Citation: Cancer Cell International 2021 21:612

    Content type: Review

    Published on:

  44. The underlying circular RNAs (circRNAs)-related competitive endogenous RNA (ceRNA) mechanisms of pathogenesis and prognosis in non-small cell lung cancer (NSCLC) remain unclear.

    Authors: Jia Yang, Ran Hao, Yunlong Zhang, Haibin Deng, Wenjing Teng and Zhongqi Wang

    Citation: Cancer Cell International 2021 21:611

    Content type: Primary research

    Published on:

  45. The accumulation of single nucleotide variants (SNVs) and the emergence of neoantigens can affect tumour proliferation and the immune microenvironment. However, the SNV-related immune microenvironment characte...

    Authors: Yu-Jie Xu, Min-Ke He, Shuang Liu, Li-Chang Huang, Xiao-Yun Bu, Anna Kan and Ming Shi

    Citation: Cancer Cell International 2021 21:610

    Content type: Primary Research

    Published on:

  46. N6-methyladenosine (m6A) is the most abundant RNA modification of mammalian mRNAs and plays a vital role in many diseases, especially tumours. In recent years, m6A has become the topic of intense discussion in...

    Authors: Jialu Guo, Jianfeng Zheng, Huizhi Zhang and Jinyi Tong

    Citation: Cancer Cell International 2021 21:609

    Content type: Review

    Published on:

  47. Uveal melanoma (UM), the most prevalent intraocular tumor in adults, is a highly metastatic and drug resistant lesion. Recent studies have demonstrated cytotoxic and anti-metastatic effects of the antiprogesti...

    Authors: Prisca Bustamante Alvarez, Alexander Laskaris, Alicia A. Goyeneche, Yunxi Chen, Carlos M. Telleria and Julia V. Burnier

    Citation: Cancer Cell International 2021 21:607

    Content type: Primary research

    Published on:

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