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  1. Breast cancer stem cells (BCSCs) have a crucial role in breast carcinogenesis, development, and progression. The aim of the current study is to characterize the BCSCs through the genetic profiling of different...

    Authors: Abdel-Rahman N. Zekri, Abeer Bahnassy, Magda Mourad, Ibrahim Malash, Ola Ahmed and Mona S. Abdellateif
    Citation: Cancer Cell International 2022 22:423
  2. The endogenous tissue inhibitor of metalloproteinase-2 (TIMP-2), through its homeostatic action on certain metalloproteinases, plays a vital role in remodelling extracellular matrix (ECM) to facilitate cancer ...

    Authors: Ruth M. Escalona, Simon Chu, Elif Kadife, Jason K. Kelly, George Kannourakis, Jock K. Findlay and Nuzhat Ahmed
    Citation: Cancer Cell International 2022 22:422
  3. Hyaluronic acid (HA) promotes cancer metastasis; however, the currently approved treatments do not target HA. Metastatic renal carcinoma (mRCC) is an incurable disease. Sorafenib (SF) is a modestly effective a...

    Authors: Jiaojiao Wang, Andre R. Jordan, Huabin Zhu, Sarrah L. Hasanali, Eric Thomas, Soum D. Lokeshwar, Daley S. Morera, Sung Alexander, Joseph McDaniels, Anuj Sharma, Karina Aguilar, Semih Sarcan, Tianyi Zhu, Mark S. Soloway, Martha K. Terris, Muthusamy Thangaraju…
    Citation: Cancer Cell International 2022 22:421
  4. Melatonin is a neuro-hormone with conserved roles in evolution. Initially synthetized as an antioxidant molecule, it has gained prominence as a key molecule in the regulation of the circadian rhythm. Melatonin...

    Authors: Ainaz Mihanfar, Bahman Yousefi, Bita Azizzadeh and Maryam Majidinia
    Citation: Cancer Cell International 2022 22:420
  5. Cancer is a heterogeneous disease with multifaceted drug resistance mechanisms (e.g., tumour microenvironment [TME], tumour heterogeneity, and immune evasion). Natural products are interesting repository of bi...

    Authors: Mohammed Moustapha Anwar, Chris Albanese, Nadia M. Hamdy and Ahmed S. Sultan
    Citation: Cancer Cell International 2022 22:419
  6. Patients with intrahepatic cholangiocarcinoma (ICC) require chemotherapy due to late detection, rapid disease progression, and low surgical resection rate. Tumor cell lines are extremely important in cancer re...

    Authors: Xin Miao, Jinjing Hu, Changpeng Chai, Huan Tang, Zhenjie Zhao, Wei Luo, Wence Zhou and Hao Xu
    Citation: Cancer Cell International 2022 22:418
  7. Pancreatic cancer is one of the most aggressive malignancies without effective targeted therapies. MUC1 has emerged as a potential common target for cancer therapy because it is overexpressed in a variety of d...

    Authors: Guang Wu, Lan Li, Mengnan Liu, Chunyan Chen, Guangze Wang, Zewei Jiang, Yaqian Qin, Licai He, Hongzhi Li, Jiawei Cao and Haihua Gu
    Citation: Cancer Cell International 2022 22:417
  8. The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-function (GOF) activities that affect molecular pathways crucial for tumorigenesis and progression like some of the p53 mutants...

    Authors: Shinjinee Sengupta, Shaikh Maryam Ghufran, Aqsa Khan, Subhrajit Biswas and Susanta Roychoudhury
    Citation: Cancer Cell International 2022 22:416
  9. MicroRNAs (miRNAs), as an indispensable type of non-coding RNA (ncRNA), participate in diverse biological processes. However, the specific regulatory mechanism of certain miRNAs in pancreatic ductal adenocarci...

    Authors: Bojing Chi, Yao Zheng, Fuming Xie, Wen Fu, Xianxing Wang, Jianyou Gu, Jiali Yang, Jingyang Yin, Lei Cai, Peng Tang, Jianbo Li, Shixiang Guo and Huaizhi Wang
    Citation: Cancer Cell International 2022 22:415
  10. Mass spectrometry imaging (MSI) enables obtaining multidimensional results simultaneously in a single run, including regiospecificity and m/z values corresponding with specific proteins, peptides, lipids, etc. Th...

    Authors: Dagmara Pietkiewicz, Szymon Plewa, Mikołaj Zaborowski, Timothy J. Garrett, Eliza Matuszewska, Zenon J. Kokot and Jan Matysiak
    Citation: Cancer Cell International 2022 22:414
  11. As a member of the miR-1 family, miR-206 is located between IL-17 and PKHD1 genes in human. This miRNA has been shown to be involved in the pathogenic processes in a variety of human disorders including cancers, ...

    Authors: Sheyda Khalilian, Seyedeh Zahra Hosseini Imani and Soudeh Ghafouri-Fard
    Citation: Cancer Cell International 2022 22:412
  12. Glioblastoma (GBM) is the most malignant, aggressive and recurrent primary brain tumor. Cell senescence can cause irreversible cessation of cell division in normally proliferating cells. According to studies, ...

    Authors: Chenyang Tan, Yan Wei, Xuan Ding, Chao Han, Zhongzheng Sun and Chengwei Wang
    Citation: Cancer Cell International 2022 22:411
  13. Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural ...

    Authors: Stefania Garzoli, Pedro Alarcón-Zapata, Gulnaz Seitimova, Barbara Alarcón-Zapata, Miquel Martorell, Farukh Sharopov, Patrick Valere Tsouh Fokou, Darline Dize, Lauve Rachel Tchokouaha Yamthe, Francisco Les, Guillermo Cásedas, Víctor López, Marcello Iriti, Javad Sharifi Rad, Eda Sönmez Gürer, Daniela Calina…
    Citation: Cancer Cell International 2022 22:407
  14. In-situ tumor ablation provides the immune system with the appropriate antigens to induce anti-tumor immunity. Here, we present an innovative technique for generating anti-tumor immunity by delivering exogenou...

    Authors: Hila Confino, Frederick M. Dirbas, Matan Goldshtein, Shay Yarkoni, Rinat Kalaora, Meital Hatan, Shani Puyesky, Yakir Levi, Lidor Malka, Matt Johnson, Selena Chaisson, Jedidiah M. Monson, Amir Avniel, Steve Lisi, David Greenberg and Ido Wolf
    Citation: Cancer Cell International 2022 22:405
  15. Cancer-associated fibroblasts (CAFs) coordinate the malignancy of cancer cells via secretory materials. Reprogrammed lipid metabolism and signaling play critical roles in cancer biology. Oleic acid (OA) serves...

    Authors: Sung-Hyun Hwang, Yeseul Yang, Jae-Ha Jung and Yongbaek Kim
    Citation: Cancer Cell International 2022 22:404
  16. Metabolic reprogramming is an important issue in tumor biology. A recently-identified actor in this regard is the molecular chaperone TRAP1, that is considered an oncogene in several cancers for its high expre...

    Authors: Danilo Swann Matassa, Daniela Criscuolo, Rosario Avolio, Ilenia Agliarulo, Daniela Sarnataro, Consiglia Pacelli, Rosella Scrima, Alessandra Colamatteo, Giuseppe Matarese, Nazzareno Capitanio, Matteo Landriscina and Franca Esposito
    Citation: Cancer Cell International 2022 22:402
  17. Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade therapy has become a game-changing therapeutic approach revolutionizing the treatment setting of human malignancies, such as renal cell carc...

    Authors: Mohammadsaleh Jahangir, Omid Yazdani, Mohammad Saeed Kahrizi, Sara Soltanzadeh, Hamidreza Javididashtbayaz, Azam Mivefroshan, Saba Ilkhani and Romina Esbati
    Citation: Cancer Cell International 2022 22:401
  18. Papillary thyroid cancer (PTC) is the most frequent thyroid tumor. The tissue inhibitor of metalloproteinase-3 (TIMP3) gene encodes a matrix metalloproteinases inhibitor that exerts a tumor suppressor role in ...

    Authors: M. Mazzoni, K. Todoerti, L. Agnelli, E. Minna, S. Pagliardini, T. Di Marco, M. G. Borrello, A. Neri and A. Greco
    Citation: Cancer Cell International 2022 22:400
  19. Incidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the development of resistance against currently available treatment strategies has contributed to the cancer-associated mortality....

    Authors: Sameen Zafar, Khushbukhat Khan, Amna Hafeez, Muhammad Irfan, Muhammad Armaghan, Anees ur Rahman, Eda Sönmez Gürer, Javad Sharifi-Rad, Monica Butnariu, Iulia-Cristina Bagiu and Radu Vasile Bagiu
    Citation: Cancer Cell International 2022 22:399
  20. Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized macrophages. Besides binding to hyaluronan, LYVE-1 can mediate adhesion of leuk...

    Authors: Anna Sophia Jauch, Sebastian A. Wohlfeil, Céline Weller, Bianca Dietsch, Verena Häfele, Ana Stojanovic, Maximilian Kittel, Hendrik Nolte, Adelheid Cerwenka, Michael Neumaier, Kai Schledzewski, Carsten Sticht, Philipp-Sebastian Reiners-Koch, Sergij Goerdt and Cyrill Géraud
    Citation: Cancer Cell International 2022 22:398
  21. Simplistic two-dimensional (2D) in vitro assays have long been the standard for studying the metastatic abilities of cancer cells. However, tri-dimensional (3D) organotypic models provide a more complex enviro...

    Authors: Sabrina J. Ritch, Abu Shadat M. Noman, Alicia A. Goyeneche and Carlos M. Telleria
    Citation: Cancer Cell International 2022 22:397
  22. Papillary thyroid cancer (PTC) is the most common endocrine malignancy with a fast-growing incidence in recent decades. HOTAIR as a long non-coding RNA has been shown to be highly expressed in papillary thyroid c...

    Authors: Feng-Chih Kuo, Yu-Ting Wang, Chia-Hsin Liu, Yao-Feng Li, Chieh-Hua Lu, Sheng-Chiang Su, Jhih-Syuan Liu, Peng-Fei Li, Chia-Luen Huang, Li-Ju Ho, Chien-Ming Lin and Chien-Hsing Lee
    Citation: Cancer Cell International 2022 22:396
  23. Dystroglycan (DG) is a glycoprotein composed of two subunits that remain non-covalently bound at the plasma membrane: α-DG, which is extracellular and heavily O-mannosyl glycosylated, and β-DG, an integral transm...

    Authors: Cristina Quereda, Àngels Pastor and José Martín-Nieto
    Citation: Cancer Cell International 2022 22:395
  24. The dysregulation of CD5L has been reported in hepatocellular carcinoma (HCC). However, its functions in HCC were controversial. In this study, we aimed to identify CD5L-associated pathways and markers and exp...

    Authors: Xiuzhi Zhang, Xiaoli Liu, Keke Zhu, Xue Zhang, Ningning Li, Tao Sun, Shasha Fan, Liping Dai and Jinzhong Zhang
    Citation: Cancer Cell International 2022 22:393
  25. The tumor microenvironment is one of the most important factors determining the efficacy of cancer immunotherapy. In particular, variability in efficacy has been linked to whether tumors are hot or cold, with ...

    Authors: Takayuki Horii, Yuki Orikawa, Yuta Ohira, Runa Eta, Nobuyoshi Kobayashi, Takanori Sato, Takeshi Watanabe and Takao Tanaka
    Citation: Cancer Cell International 2022 22:392
  26. Cervical cancer is the second most common cancer in women and causes more than 250,000 deaths worldwide. Among these, the incidence of cervical adenocarcinomas is increasing. Cervical adenocarcinoma is not onl...

    Authors: Kazumasa Sekihara, Hidetomo Himuro, Nao Saito, Yukihide Ota, Taku Kouro, Yohsuke Kusano, Shinichi Minohara, Ryoichi Hirayama, Hiroyuki Katoh, Tetsuro Sasada and Daisuke Hoshino
    Citation: Cancer Cell International 2022 22:391
  27. Long non-coding RNA (lncRNA) LINC00460 is an onco-lncRNA in a variety of cancers, including pancreatic cancer (PC). This study is aimed to investigate the regulatory mechanisms of LINC00460 in PC.

    Authors: Jun Yao, Ruoyu Gao, Minghan Luo, Defeng Li, Liliangzi Guo, Zichao Yu, Feng Xiong, Cheng Wei, Benhua Wu, Zhenglei Xu, Dingguo Zhang, Jianyao Wang and Lisheng Wang
    Citation: Cancer Cell International 2022 22:390
  28. The invasive nature of GBM combined with the diversity of brain microenvironments creates the potential for a topographic heterogeneity in GBM radioresponse. Investigating the mechanisms responsible for a micr...

    Authors: Charlotte Degorre, Ian C. Sutton, Stacey L. Lehman, Uma T. Shankavaram, Kevin Camphausen and Philip J. Tofilon
    Citation: Cancer Cell International 2022 22:389
  29. Anaplastic thyroid carcinoma (ATC) is the most aggressive subtype of thyroid cancer. In this study, we used a three-dimensional in vitro system to evaluate the effect of a dual MEK/Aurora kinase inhibitor, BI-...

    Authors: Hilda Samimi, Rezvan Tavakoli, Parviz Fallah, Alireza Naderi Sohi, Maryam Amini Shirkouhi, Mahmood Naderi and Vahid Haghpanah
    Citation: Cancer Cell International 2022 22:388
  30. Glioblastomas (GBs) are characterised as one of the most aggressive primary central nervous system tumours (CNSTs). Single-cell sequencing analysis identified the presence of a highly heterogeneous population ...

    Authors: Deema Hussein, Reem Alsereihi, Abdulla Ahmed A. Salwati, Rinad Algehani, Alazouf Alhowity, Ahmed M. Al-Hejin, Hans-Juergen Schulten, Saleh Baeesa, Mohammed Bangash, Fahad Alghamdi, Richard Cross, Torki Al Zughaibi, Mohamad Saka, Adeel Chaudhary and Adel Abuzenadah
    Citation: Cancer Cell International 2022 22:387
  31. Therapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of...

    Authors: Parteek Prasher, Mousmee Sharma, Sachin Kumar Singh, Monica Gulati, Dinesh Kumar Chellappan, Flavia Zacconi, Gabriele De Rubis, Gaurav Gupta, Javad Sharifi-Rad, William C. Cho and Kamal Dua
    Citation: Cancer Cell International 2022 22:386
  32. N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of the m6A methyltransferase METTL3 in cholangiocarc...

    Authors: Jingli Cai, Zheng Cui, Jingyi Zhou, Bosen Zhang, Ruiqi Lu, Youcheng Ding and Hai Hu
    Citation: Cancer Cell International 2022 22:385
  33. Pancreatic cancer is a rare but fatal disease. Patients present advanced disease due to the lack of or typical symptoms when the tumor is still localized. A high-quality image processing system has been in pra...

    Authors: Fan Xu, Min Huang, Yun Bai, Xueshi Yin, Jingzhe Yan, Fangfang Liu, Jie Chen and Xiechuan Weng
    Citation: Cancer Cell International 2022 22:383
  34. It is well-established that biochemical recurrence is detrimental to prostate cancer (PCa). In the present study, we explored the mechanisms underlying PCa progression.

    Authors: Cheng Yang, Lei Chen, Qingsong Niu, Qintao Ge, Jiong Zhang, Junyue Tao, Jun Zhou and Chaozhao Liang
    Citation: Cancer Cell International 2022 22:382
  35. MicroRNAs (miRNAs or miRs) are a class of noncoding single-stranded RNAs that can regulate gene expression by binding to the untranslated sequences at the 3 ' end of messenger RNAs. The microRNA-34 family is d...

    Authors: Xuechun Bai, Lianwen Zheng, Ying Xu, Yan Liang and Dandan Li
    Citation: Cancer Cell International 2022 22:381
  36. Pancreatic ductal adenocarcinoma (PDAC), as a highly lethal malignancy with high mortality, lacks of effective treatment. Canonical therapeutic targets in PDAC demand further verification among which HER2 rece...

    Authors: Tiebo Mao, Xiaofei Zhang, Haiyan Xu, Xiao Zhang, Weiyu Ge, Shumin Li, Jingyu Ma, Ming Yue, Shengbai Xue, Jiujie Cui and Liwei Wang
    Citation: Cancer Cell International 2022 22:380
  37. After cardiovascular diseases, cancer is the second main cause of death globally. Mushrooms have been demonstrated to contain amalgamation with properties capable of inhibiting carcinogenesis and microbial gro...

    Authors: John M. Macharia, Lu Zhang, Ruth W. Mwangi, Nora Rozmann, Zsolt Kaposztas, Tímea Varjas, Miklós Sugár, Huda Alfatafta, Márton Pintér and Raposa L. Bence
    Citation: Cancer Cell International 2022 22:379
  38. Membrane vesicles having a diameter of 30–150 nm are known as exosomes. Several cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs), microRNAs, or DNA. CircRNAs are endogenous R...

    Authors: Bashdar Mahmud Hussen, Snur Rasool Abdullah, Goran Sedeeq Hama Faraj, Mohammed Fatih Rasul, Abbas Salihi, Soudeh Ghafouri-Fard, Mohammad Taheri and Majid Mokhtari
    Citation: Cancer Cell International 2022 22:378
  39. Medulloblastoma (MB) is the most common pediatric malignant brain tumor. Despite current therapies, the morbidity and recurrent risk remains significant. Neuropilin-1 receptor (NRP1) has been implicated in the...

    Authors: Manon Douyère, Caifeng Gong, Mylène Richard, Nadia Pellegrini-Moïse, Joël Daouk, Julien Pierson, Pascal Chastagner and Cédric Boura
    Citation: Cancer Cell International 2022 22:377
  40. Colon cancer is often driven by mutations of the adenomatous polyposis coli (APC) gene, an essential tumor suppressor gene of the Wnt β-catenin signaling pathway. APC and its cytoplasmic interactions have been...

    Authors: Nayra M. Al-Thani, Stephanie Schaefer-Ramadan, Jovana Aleksic, Yasmin A. Mohamoud and Joel A. Malek
    Citation: Cancer Cell International 2022 22:376
  41. During the development of cervical cancer, HPV infection causes a series of changes in transcription factors and microRNAs. But their relationships with pathogenic processes are not clear.

    Authors: Juan Zhou, Yongpeng Li, Ke Xu, Yan Rong, Siting Huang, Hailun Wu, Xianlin Yi and Chanzhen Liu
    Citation: Cancer Cell International 2022 22:375
  42. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types and chemotherapeutic drug resistance is a stumbling block in improving the overall survival of PDAC patients. The nature of specif...

    Authors: Bangbo Zhao, Cheng Qin, Zeru Li, Yuanyang Wang, Tianhao Li, Hongtao Cao, Xiaoying Yang, Tianyu Li and Weibin Wang
    Citation: Cancer Cell International 2022 22:374

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