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  1. Squamous cell carcinoma of the oral cavity (SCCOC) is the dominant origin of cancer associated mortality. Previous findings by our study reported that acquisition of anoikis resistance has a significant role i...

    Authors: Kaushik Kumar Dey, Siddik Sarkar, Ipsita Pal, Subhasis Das, Goutam Dey, Rashmi Bharti, Payel Banik, Joygopal Roy, Sukumar Maity, Indranil kulavi and Mahitosh Mandal

    Citation: Cancer Cell International 2015 15:74

    Content type: Primary research

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    The Erratum to this article has been published in Cancer Cell International 2015 15:94

  2. A20 is a dual inhibitor of NF-κB activation and apoptosis in the tumor necrosis factor receptor 1 signaling pathway, and both are related to tumorigenesis. A20 is frequently inactivated by deletions and/or mut...

    Authors: Yi Xu, Junyan Hu, Xu Wang, Li Xuan, Jing Lai, Ling Xu, Shaohua Chen, Lijian Yang, Gengxin Luo, Kanger Zhu, Xiuli Wu and Yangqiu Li

    Citation: Cancer Cell International 2015 15:73

    Content type: Primary research

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  3. Interleukin (IL)-18 gene polymorphisms have been found to play multiple roles in various diseases. However, studies focused on its involvement in hepatocellular carcinoma (HCC) remains...

    Authors: Jingui Bao, Yu Lu, Yan Deng, Chengzhi Rong, Yanqiong Liu, Xiuli Huang, Liuying Song, Shan Li and Xue Qin

    Citation: Cancer Cell International 2015 15:72

    Content type: Primary Research

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  4. Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemothera...

    Authors: Khalid O Alfarouk, Christian-Martin Stock, Sophie Taylor, Megan Walsh, Abdel Khalig Muddathir, Daniel Verduzco, Adil H H Bashir, Osama Y Mohammed, Gamal O Elhassan, Salvador Harguindey, Stephan J Reshkin, Muntaser E Ibrahim and Cyril Rauch

    Citation: Cancer Cell International 2015 15:71

    Content type: Review

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  5. Glycogen synthase kinase-3β (GSK3β) expression and activity are upregulated in pancreatic cancer tissues. In our previous study, we found that stromal cell-derived factor-1/ chemokine receptor C-X-C motif chem...

    Authors: Xu Ying, Li Jing, Shijie Ma, Qianjun Li, Xiaoling Luo, Zhenguo Pan, Yanling Feng and Pan Feng

    Citation: Cancer Cell International 2015 15:70

    Content type: Primary research

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  6. Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first step in the synthesis of prostanoids, is associated with carcinogenesis, which is suspected to promote angiogenesis and tissue...

    Authors: Liyan Qu and Bing Liu

    Citation: Cancer Cell International 2015 15:69

    Content type: Review

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  7. Variants in the axis inhibition 2 (AXIN2) gene might alter the protein’s structure or function or create a multiprotein destruction complex in the Wnt signaling pathway and thus affect an individual’s susceptibil...

    Authors: Zhitong Wu, Yifan Sun, Shifu Tang, Chunming Liu, Shengbo Zhu, Lili Wei and Hong Xu

    Citation: Cancer Cell International 2015 15:68

    Content type: Primary research

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  8. Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a therapy target of cancer. We aimed to confirm the effect of dual PI3K/mTOR inhibitor NVP-BEZ235 on cell proliferatio...

    Authors: Chuntuan Li, Pengliang Xin, Huifang Xiao, Yan Zheng, Yuanling Huang and Xiongpeng Zhu

    Citation: Cancer Cell International 2015 15:65

    Content type: Primary research

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  9. The development of new approaches based on wide profiling methods in studying biological and medical systems is bringing large amounts of data on a daily basis.

    Authors: Nives Pećina-Šlaus and Marko Pećina

    Citation: Cancer Cell International 2015 15:64

    Content type: Review

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  10. Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays...

    Authors: Jun Zeng, Rong Shi, Cui-xia Cai, Xin-rui Liu, Yan-bin Song, Min Wei and Wen-li Ma

    Citation: Cancer Cell International 2015 15:63

    Content type: Primary research

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  11. Although recent studies have shown the utility of miR-203 as a cancer-relevant biomarker, the validated clinical significance of miR-203 in HCC remains obscure. The aim of the present study was to evaluate the...

    Authors: Yongru Liu, Fanghui Ren, Minhua Rong, Yihuan Luo, Yiwu Dang and Gang Chen

    Citation: Cancer Cell International 2015 15:62

    Content type: Primary research

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  12. Increasing evidence indicates that dysregulation of microRNAs is involved in tumor progression and development. The aim of this study was to investigate the expression of microRNA-24 (miR-24) and its function ...

    Authors: Li Xu, Zhifeng Chen, Fei Xue, Wei Chen, Ruina Ma, Shiyin Cheng and Pengcheng Cui

    Citation: Cancer Cell International 2015 15:61

    Content type: Primary research

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  13. This study is to explore the pathological features of transplanted tumor established by CD133 positive TJ905 glioblastoma stem-like cells.

    Authors: Feng Jin, Ran Zhang, Song Feng, Chuan-Tao Yuan, Ren-Ya Zhang, Guang-Kui Han, Gen-Hua Li, Xi-Zhen Yu, Yang Liu, Ling-Sheng Kong, Shu-Ling Zhang and Lei Zhao

    Citation: Cancer Cell International 2015 15:60

    Content type: Primary research

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  14. This study sought to explore the exact mechanism of Matrine inhibited migration and invasion of human pancreatic cancer cells.

    Authors: Yongchao Ma, Fazhang Zou, Junping Xiong, Wei Wan, Li Yin, Xianjia Li, Zhanyu Bei, Lei Yuan, Song Meng, Jianguo Wang and Guohua Song

    Citation: Cancer Cell International 2015 15:59

    Content type: Primary research

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  15. Several theories aim to explain the malignant transformation of cells, including the mutation of tumor suppressors and proto-oncogenes. Deletion of Rb (a tumor suppressor), overexpression of mutated Ras (a proto-...

    Authors: Mario Orozco-Morales, Francisco Javier Sánchez-García, Irene Golán-Cancela, Norma Hernández-Pedro, Jose A. Costoya, Verónica Pérez de la Cruz, Sergio Moreno-Jiménez, Julio Sotelo and Benjamín Pineda

    Citation: Cancer Cell International 2015 15:57

    Content type: Primary research

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  16. Radiotherapy is an important therapeutic method for lung cancer. However, in clinical situations, cellular resistance to radiotherapy is a significant component of tumor treatment failure. Thus, clarification ...

    Authors: Chen Liao, Wei Xiao, Nuo Zhu, Zhiyuan Liu, Jiu Yang, Yanhu Wang and Mei Hong

    Citation: Cancer Cell International 2015 15:56

    Content type: Primary research

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  17. Recently, we have reported the induction of apoptosis by 2-amino-4-(3-nitrophenyl)-3-cyano-7-(dimethylamino)-4H-chromene (3-NC) in HepG2, T47D and HCT116 cells with low nano molar IC50 values. In this study, anti...

    Authors: Mohammad Hassan Naseri, Majid Mahdavi, Jamshid Davoodi, Saeed Hesami Tackallou, Mahdi Goudarzvand and Shima Hallaj Neishabouri

    Citation: Cancer Cell International 2015 15:55

    Content type: Primary research

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  18. Nasopharyngeal carcinoma (NPC) is commonly found in Asia, especially among the Chinese ethnic group. Chromosome rearrangements are common among NPC patients. Although the mechanism underlying the chromosome re...

    Authors: Siaw Shi Boon and Sai-Peng Sim

    Citation: Cancer Cell International 2015 15:54

    Content type: Primary research

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  19. The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsi...

    Authors: Chang-Yi Xiao, Bing-Bing Fu, Zhi-Ying Li, Gohar Mushtaq, Mohammad Amjad Kamal, Jia-Hua Li, Gui-Cheng Tang and Shuo-Shuang Xiao

    Citation: Cancer Cell International 2015 15:53

    Content type: Primary research

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  20. Aberrant expression of heparanase (Hpa) is associated with apoor prognosis in ovarian and cervical cancer patients. Inhibitors of Hpa can prevent the growth and metastasis of malignant tumor cells, and suramin...

    Authors: HuaPing Li, HuaLi Li, HongJie Qu, MingZhu Zhao, Bo Yuan, MingHua Cao and JinQuan Cui

    Citation: Cancer Cell International 2015 15:52

    Content type: Primary research

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  21. The WASP (Wiskott-Aldrich syndrome protein) and WAVE (WASP Verpolin homologous) family of proteins are structurally related and responsible for regulation of actin polymerization through their interaction with...

    Authors: Muhammad Moazzam, Lin Ye, Ping-Hui Sun, Howard Kynaston and Wen G Jiang

    Citation: Cancer Cell International 2015 15:51

    Content type: Primary research

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  22. Despite the clinical response of conventional anticancer therapy, including chemotherapeutic treatments, radiation therapy and corticosteroids, tumorigenic B-cell lymphomas show an incomplete response to clini...

    Authors: Nunzia Migliaccio, Camillo Palmieri, Immacolata Ruggiero, Giuseppe Fiume, Nicola M Martucci, Iris Scala, Ileana Quinto, Giuseppe Scala, Annalisa Lamberti and Paolo Arcari

    Citation: Cancer Cell International 2015 15:50

    Content type: Primary research

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  23. MicroRNA is a type of endogenous non-coding RNA implicated in various cellular processes, and has been intensely investigated in the field of cancer research for many years. Here, we investigated the functions...

    Authors: Wei Zhang, Ye-qing Mao, Hua Wang, Wen-juan Yin, Shao-xing Zhu and Wei-cheng Wang

    Citation: Cancer Cell International 2015 15:49

    Content type: Primary research

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  24. Lung adenocarcinoma (LAC), the primary histological type of non-small cell lung cancer (NSCLC), has displayed an increasing incidence and mortality worldwide. However, therapeutic approaches were limited. Dysr...

    Authors: Juan Li, Ping Li, Wei Zhao, Rui Yang, Shanshan Chen, Yong Bai, Shaozhi Dun, Xiaonan Chen, Yuwen Du, Yuanyuan Wang, Wenqiao Zang, Guoqiang Zhao and Guojun Zhang

    Citation: Cancer Cell International 2015 15:48

    Content type: Primary research

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  25. Most of the knowledge about the mechanisms of multidrug resistance in lung cancer has been achieved through the use of cell lines isolated from tumours cultivated either in suspensions of isolated cells or in ...

    Authors: Raúl Barrera-Rodríguez and Jorge Morales Fuentes

    Citation: Cancer Cell International 2015 15:47

    Content type: Primary research

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  26. Natural products with diverse bioactivities are becoming an important source of novel agents with medicinal potential. Cancer is a devastating disease that causes the death of millions of people each year. Thu...

    Authors: Mohamed Salah I Abaza, Khaled Y Orabi, Ebtehal Al-Quattan and Raja’a J Al-Attiyah

    Citation: Cancer Cell International 2015 15:46

    Content type: Primary research

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  27. B7-homologue 3 (B7-H3), a recently identified immunoregulatory protein, has been shown to be overexpressed in human hepatocellular carcinoma (HCC). However, whether the dynamic expression pattern of B7-H3 cont...

    Authors: Fu-biao Kang, Ling Wang, Heng-chuan Jia, Dong Li, Hai-jun Li, Yin-ge Zhang and Dian-xing Sun

    Citation: Cancer Cell International 2015 15:45

    Content type: Primary research

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  28. Wilms’ tumor (WT) is one of the most common malignant neoplasms of the urinary tract in children. Anaplastic histology (unfavorable histology) accounts for about 10% of whole WTs, and it is the single most imp...

    Authors: Jun Lu, Yan-Fang Tao, Zhi-Heng Li, Lan Cao, Shao-Yan Hu, Na-Na Wang, Xiao-Juan Du, Li-Chao Sun, Wen-Li Zhao, Pei-Fang Xiao, Fang Fang, Li-xiao Xu, Yan-Hong Li, Gang Li, He Zhao, Jian Ni…

    Citation: Cancer Cell International 2015 15:44

    Content type: Primary research

    Published on:

  29. The primary purpose of this study was to investigate the correlation between single nucleotide polymorphisms (SNPs) of ATP binding cassette superfamily G member 2 (ABCG2) and outcome of tyrosine kinase inhibition...

    Authors: Xueqin Chen, Dadong Chen, Shaoyu Yang, Ruobing Ma, Yuelong Pan, Xin Li and Shenglin Ma

    Citation: Cancer Cell International 2015 15:43

    Content type: Primary research

    Published on:

  30. Mesenchymal stem cells (MSCs) in tumors have emerged as progenitors involved in stroma formation and metastasis of cancers, partially owing to their abilities to differentially express paracrine factors relate...

    Authors: Dongmei Chen, Shudan Liu, Huiming Ma, Xueyun Liang, Haibin Ma, Xiurui Yan, Bao Yang, Jun Wei and Xiaoming Liu

    Citation: Cancer Cell International 2015 15:42

    Content type: Primary research

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  31. MicroRNAs (miRNAs) are a group of small non-coding RNA molecules that potentially play a critical role in tumorigenesis. Increasing evidences indicate that miR-378-5p is dysregulated in numerous human cancers ...

    Authors: Zhenlei Wang, Bin Ma, Xiaopin Ji, Yang Deng, Tao Zhang, Xiaojian Zhang, Haoji Gao, Hanxing Sun, Haoxuan Wu, Xianze Chen and Ren Zhao

    Citation: Cancer Cell International 2015 15:40

    Content type: Primary research

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  32. Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in respons...

    Authors: Umar Wazir, Mona MAW Orakzai, Zubair S Khanzada, Wen G Jiang, Anup K Sharma, Abdul Kasem and Kefah Mokbel

    Citation: Cancer Cell International 2015 15:39

    Content type: Review

    Published on:

  33. In recent years, there has been a tremendous and growing interest among researchers to investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes. miRNAs are a family of small ...

    Authors: Kaladhar B Reddy

    Citation: Cancer Cell International 2015 15:38

    Content type: Review

    Published on:

  34. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease and still continues to have the worst prognosis of all gastrointestinal malignancies. Reports have demonstrated that secretory leukocyte proteas...

    Authors: Wei Zhang, Jian-Long Yao, Shan-Chao Dong, Feng-Qiang Hou and He-Ping Shi

    Citation: Cancer Cell International 2015 15:37

    Content type: Primary research

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  35. Previous studies proved that interferon gamma (IFN-γ) gene polymorphisms were associated with the risk of hepatitis B virus (HBV) infection. However, the association between IFN-γ polymorphisms and HBV-related li...

    Authors: Yifan Sun, Yu Lu, Li Xie, Yan Deng, Shan Li and Xue Qin

    Citation: Cancer Cell International 2015 15:35

    Content type: Primary research

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  36. Apigenin is a nontoxic dietary flavonoid, and it may have chemopreventive and therapeutic potential as an anti-inflammatory, antioxidant, and anti-cancer agent. However, its role in bladder cancer remains poor...

    Authors: Ming-Der Shi, Cheng-Kai Shiao, Yi-Chieh Lee and Yuan-Wei Shih

    Citation: Cancer Cell International 2015 15:33

    Content type: Primary research

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  37. Extracellular double-stranded DNA participates in various processes in an organism. Here we report the suppressive effects of fragmented human double-stranded DNA along or in combination with cyclophosphamide ...

    Authors: Ekaterina A Alyamkina, Valeriy P Nikolin, Nelly A Popova, Alexandra M Minkevich, Artem V Kozel, Evgenia V Dolgova, Yaroslav R Efremov, Sergey I Bayborodin, Oleg M Andrushkevich, Oleg S Taranov, Vladimir V Omigov, Vladimir A Rogachev, Anastasia S Proskurina, Evgeniy I Vereschagin, Elena V Kiseleva, Maria V Zhukova…

    Citation: Cancer Cell International 2015 15:32

    Content type: Primary research

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  38. Osteosarcoma is the most frequent bone cancer in children and young adults. The outcome of patients with advanced disease is dismal. Exploitation of tumor-immune cell interactions may provide novel therapeutic...

    Authors: Jens HW Pahl, Susy J Santos, Marieke L Kuijjer, Gerharda H Boerman, Laurens GL Sand, Karoly Szuhai, Annemarie Cleton-Jansen, R Maarten Egeler, Judith VMG Boveé, Marco W Schilham and Arjan C Lankester

    Citation: Cancer Cell International 2015 15:31

    Content type: Primary research

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  39. Granulocyte colony-stimulating factor (G-CSF) promotes proliferation, survival, and differentiation of myeloid-linage leukemic cells, as well as normal hematopoietic cells. Terminal granulocytic differentiatio...

    Authors: Yoshihito Uchino, Noriyoshi Iriyama, Yoshihiro Hatta and Masami Takei

    Citation: Cancer Cell International 2015 15:30

    Content type: Primary research

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  40. Plectin is one of the cytolinker proteins that play a crucial role in maintaining the integrity of cellular architecture. It is a component of desmosome complexes connecting cytoskeletal proteins and trans-mem...

    Authors: Chiung-Chi Cheng, Yen-Chang Clark Lai, Yih-Shyong Lai, Yung-Hsiang Hsu, Wei-Ting Chao, Kee-Chin Sia, Yu-Hui Tseng and Yi-Hsiang Liu

    Citation: Cancer Cell International 2015 15:29

    Content type: Primary research

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  41. The Editor-in- Chief would like to thank all the reviewers who contributed to the journal in 2014.

    Authors: Denys Wheatley

    Citation: Cancer Cell International 2015 15:28

    Content type: Reviewer acknowledgement

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  42. PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine kinase, is tightly controlled in normal tissues but elevated in many tumors, and fu...

    Authors: Xiaoyan Dou, Jing Wei, Aiqin Sun, Genbao Shao, Chandra Childress, Wannian Yang and Qiong Lin

    Citation: Cancer Cell International 2015 15:27

    Content type: Primary research

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  43. Duguelin is a rotenoid extracted from plants and has potent antitumor effects in vitro and in vivo. However, the mechanism underlying the antitumor effect remains unclear. Our preliminary study showed that Deg...

    Authors: Huae Xu, Xiaolin Li, Wenqiu Ding, Xiaoning Zeng, Hui Kong, Hong Wang and Weiping Xie

    Citation: Cancer Cell International 2015 15:25

    Content type: Primary research

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  44. Emerging evidence indicates that dysregulated long intervening non-coding RNA (lincRNA) HOTAIR correlates highly with tumor invasion and metastasis but a link between the high expression of HOTAIR and the meta...

    Authors: Jing Wang, Dengyu Chen, Xiangfeng He, Yuxia Zhang, Fangfang Shi, Di Wu, Junsong Chen, Ying Zhang, Fengsu Zhao and Jun Dou

    Citation: Cancer Cell International 2015 15:24

    Content type: Primary research

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