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  1. Recent findings indicated that Derlin-1 has an important function in tumour progression. In this study, we aimed to determine whether Derlin-1 has an oncogene function as a cross-talk molecule with autophagy.

    Authors: Li Xu, Zan-Hong Wang, Dong Xu, Gang Lin, Dai-Rong Li, Tao Wan and Shu-Liang Guo

    Citation: Cancer Cell International 2014 14:50

    Content type: Primary research

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  2. 2-Methoxyestradiol is known to have antitumour and antiproliferative action in vitro and in vivo. However, when 2-methoxyestradiol is orally administered, it is rapidly oxidized by the enzyme 17β-hydroxysteriod ...

    Authors: Lisa Repsold, Etheresia Pretorius and Annie Margaretha Joubert

    Citation: Cancer Cell International 2014 14:48

    Content type: Primary research

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  3. Pin2/TRF1 binding protein X1 (PinX1) has been identified as an endogenous telomerase inhibitor and a major haploinsufficient tumor suppressor gene. Increasing evidence suggests that reduced expression of PinX1...

    Authors: Rong Shi, Zhen Zhao, Hui Zhou, Min Wei, Wen-Li Ma, Jue-Yu Zhou and Wan-Long Tan

    Citation: Cancer Cell International 2014 14:46

    Content type: Primary research

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  4. Tumors are not merely masses of neoplastic cells but complex tissues composed of cellular and noncellular elements. This review provides recent data on the main components of a dynamic system, such as carcinom...

    Authors: Gvantsa Kharaishvili, Dana Simkova, Katerina Bouchalova, Mariam Gachechiladze, Nato Narsia and Jan Bouchal

    Citation: Cancer Cell International 2014 14:41

    Content type: Review

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  5. The role of the microenvironment during the initiation and progression of carcinogenesis is thought to be of critical importance, both for the enhanced understanding of fundamental cancer biology as well as fo...

    Authors: Viviana Salvatore, Gabriella Teti, Silvia Bolzani, Stefano Focaroli, Sandra Durante, Maria Carla Mazzotti and Mirella Falconi

    Citation: Cancer Cell International 2014 14:40

    Content type: Primary research

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  6. Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2. Over-expression of COX-2 was considered to increase the proliferation and enhance the inva...

    Authors: Jie Gao, Hua-Feng Kang, Xiao-Bin Ma, Wei Tang, Di Liu, Yang Zhao, Shu-Qun Zhang, Hai-Tao Guan, Shuai Lin, Hong-Tao Ren, Xi-Jing Wang and Zhi-Jun Dai

    Citation: Cancer Cell International 2014 14:38

    Content type: Primary research

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  7. Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates the cellular adaptation to hypoxia. HIF-1α gene single nucleotide polymorphisms (SNPs) are implicated to be associated with cance...

    Authors: Yuqiao Zhou, Lin Lin, Yun Wang, Xin Jin, Xin Zhao, Dongjuan Liu, Ting Hu, Lu Jiang, Hongxia Dan, Xin Zeng, Jing Li, Jiayi Wang and Qianming Chen

    Citation: Cancer Cell International 2014 14:37

    Content type: Primary research

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  8. Cell-mediated immunity is often suppressed in patients with hematological malignancies. Recently, we found that low T cell receptor (TCR)-CD3 signaling was related to abnormal expression of the negative regula...

    Authors: Xu Wang, Yan Xu, Lichan Liang, Yi Xu, Chunyan Wang, Liang Wang, Shaohua Chen, Lijian Yang, Xiuli Wu, Bo Li, Gengxin Luo, Huo Tan, Wenyu Li and Yangqiu Li

    Citation: Cancer Cell International 2014 14:36

    Content type: Primary research

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  9. Glucocorticoids (GCs) are often included in the therapy of lymphoid malignancies because they kill several types of malignant lymphoid cells. GCs activate the glucocorticoid receptor (GR), to regulate a comple...

    Authors: Aaron L Miller, Chuandong Geng, Georgiy Golovko, Meenakshi Sharma, Jason R Schwartz, Jiabin Yan, Lawrence Sowers, William R Widger, Yuriy Fofanov, Wayne V Vedeckis and E Brad Thompson

    Citation: Cancer Cell International 2014 14:35

    Content type: Primary research

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  10. Prostate cancer is a gland tumor in the male reproductive system. It is a multifaceted and genomically complex disease. Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ER...

    Authors: Ammad Ahmad Farooqi, Ming-Feng Hou, Chien-Chi Chen, Chun-Lin Wang and Hsueh-Wei Chang

    Citation: Cancer Cell International 2014 14:34

    Content type: Review

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  11. PRO2000/ANCCA may be an important candidate gene which located within a region of chromosome 8q in hepatocellular carcinoma (HCC). However, its significance remains unclear. The aim of this study was to explor...

    Authors: Jie Yang, Jie Huang, Luqiao Luo, Zhenzhu Chen, Ying Guo and Linlang Guo

    Citation: Cancer Cell International 2014 14:33

    Content type: Primary research

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  12. Although rituximab in the combination of CHOP chemotherapy has been widely used as the standard treatment for several kinds of B-cell non-Hodgkin lymphoma (B-NHL), a great number of B-NHL patients treated with...

    Authors: Xiaohui Zheng, Ning Ding, Yuqin Song, Lixia Feng and Jun Zhu

    Citation: Cancer Cell International 2014 14:32

    Content type: Primary research

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  13. Previously, we found that treatment of LM8 murine osteosarcoma cells with genistein, an isoflavone found in soy, increased the cellular level of β-catenin and decreased its invasive and motile potential. The p...

    Authors: Teruki Kidani, Atsushi Nakamura, Setsuya Kamei, Yoshiaki Norimatsu, Hiromasa Miura and Hiroshi Masuno

    Citation: Cancer Cell International 2014 14:31

    Content type: Primary research

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  14. Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prost...

    Authors: Chengsen Xue, Hilda A Pasolli, Irene Piscopo, Daniel J Gros, Christina Liu, Yamei Chen and Jen Wei Chiao

    Citation: Cancer Cell International 2014 14:30

    Content type: Primary research

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  15. ORAI1 channels play an important role for breast cancer progression and metastasis. Previous studies indicated the strong correlation between breast cancer and individual single nucleotide polymorphisms (SNPs) of...

    Authors: Wei-Chiao Chang, Yong-Yuan Fang, Hsueh-Wei Chang, Li-Yeh Chuang, Yu-Da Lin, Ming-Feng Hou and Cheng-Hong Yang

    Citation: Cancer Cell International 2014 14:29

    Content type: Primary research

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  16. Nkx2.8 (Nk2 homeobox 8) is a novel NK-2 gene family member that has been implicated in the progression of human cancer. Its role in the progression of HCC remains unknown. In this study, we investigated the ex...

    Authors: Lei Qu, Biao Deng, Yue Zeng and Zhongwei Cao

    Citation: Cancer Cell International 2014 14:28

    Content type: Primary research

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  17. Primary and secondary brain cancers are highly treatment resistant, and their marked angiogenesis attracts interest as a potential therapeutic target. Recent observations reveal that the microvascular endothel...

    Authors: Natsuko Nomura, Sandra Pastorino, Pengfei Jiang, Gage Lambert, John R Crawford, Marco Gymnopoulos, David Piccioni, Tiffany Juarez, Sandeep C Pingle, Milan Makale and Santosh Kesari

    Citation: Cancer Cell International 2014 14:26

    Content type: Primary research

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  18. Rituximab in the combination of CHOP chemotherapy has been widely used as the standard treatment for several kinds of B-cell non-Hodgkin lymphoma (B-NHL). Inactivation of phosphorylation of STAT3 plays an essenti...

    Authors: Yunfei Hu, Ning Ding, Xuan Jin, Lixia Feng, Lingyan Ping, Yuqin Song and Jun Zhu

    Citation: Cancer Cell International 2014 14:25

    Content type: Primary research

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  19. Nasopharyngeal carcinoma (NPC) is a common malignancy in China and Southeast Asia. Radiotherapy is the major treatment modality for patients with NPC, but does not always achieve fully satisfactory outcomes. S...

    Authors: Yanyang Liu, Zhixi Li, Lu Wu, Zi Wang, Xia Wang, Yang Yu, Qian Zhao and Feng Luo

    Citation: Cancer Cell International 2014 14:24

    Content type: Primary research

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  20. The enumeration and characterization of circulating tumor cells (CTCs) in the blood of cancer patients is useful for cancer prognostic and treatment monitoring purposes. The number of CTCs present in patient b...

    Authors: Jianbing Qin, Jodi R Alt, Bradford A Hunsley, Thomas L Williams and M Rohan Fernando

    Citation: Cancer Cell International 2014 14:23

    Content type: Primary research

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  21. Breast cancer is the most common malignancy in women throughout the world. Mitochondria play important roles in cellular energy production, free radical generation and apoptosis. Identification of mitochondria...

    Authors: Massoud Ghaffarpour, Reza Mahdian, Forouzandeh Fereidooni, Behnam Kamalidehghan, Nasrin Moazami and Massoud Houshmand

    Citation: Cancer Cell International 2014 14:21

    Content type: Primary research

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  22. In vivo, the transforming growth factor-beta1 (TGF-β1)-induced epithelial to mesenchymal transition (EMT) occurs in seconds during cancer cells intravasation and extravasation. Although it has been established th...

    Authors: Tsung-Hsien Wu, Yu-Wei Chou, Pei-Hung Chiu, Ming-Jer Tang, Chun-Wen Hu and Ming-Long Yeh

    Citation: Cancer Cell International 2014 14:20

    Content type: Primary research

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  23. We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced...

    Authors: Geordon Avery-Cooper, Meghan Doerr, Richard WD Gilbert, Mahmoud Youssef, Amy Richard, Patricia Huether and Alicia M Viloria-Petit

    Citation: Cancer Cell International 2014 14:19

    Content type: Primary research

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  24. General transcription is required for the growth and survival of all living cells. However, tumor cells require extraordinary levels of transcription, including the transcription of ribosomal RNA genes by RNA ...

    Authors: Claudia Villicaña, Grisel Cruz and Mario Zurita

    Citation: Cancer Cell International 2014 14:18

    Content type: Review

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  25. The oncogene PTI-1 was originally isolated from a prostate cancer cell line by its capability to transform rat fibroblasts. The PTI-1 mRNA has a very eccentric structure as the 5′UTR is similar to prokaryotic 23S...

    Authors: Louise D Dahl, Thomas J Corydon, Liina Ränkel, Karen Margrethe Nielsen, Ernst-Martin Füchtbauer and Charlotte R Knudsen

    Citation: Cancer Cell International 2014 14:17

    Content type: Primary research

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  26. Liver X receptors (LXRs) are nuclear receptors that function as ligand-activated transcription factors regulating lipid metabolism and inflammation. Recent discoveries found LXRs could regulate tumor growth in...

    Authors: Wenjun Zhang, Hua Jiang, Jianlin Zhang, Yinfan Zhang, Antang Liu, Yaozhong Zhao, Xiaohai Zhu, Zihao Lin and Xiangbin Yuan

    Citation: Cancer Cell International 2014 14:16

    Content type: Primary research

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  27. Wnt5a is classified as a non-transforming Wnt family member and plays complicated roles in oncogenesis and cancer metastasis. However, Wnt5a signaling in osteosarcoma progression remains poorly defined. In thi...

    Authors: Ailiang Zhang, Shuanghua He, Xiaoliang Sun, Lianghua Ding, Xinnan Bao and Neng Wang

    Citation: Cancer Cell International 2014 14:15

    Content type: Primary research

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  28. Two novel triple negative breast cancer cell lines, NIPBC-1 and NIPBC-2 were successfully established from primary tumors of two young breast cancer patients aged 39 and 38 years respectively, diagnosed as inf...

    Authors: Santhi Latha Pandrangi, Sarangadhara Appala Raju Bagadi, Navin Kumar Sinha, Manoj Kumar, Rima Dada, Meena Lakhanpal, Abha Soni, Shreshtha Malvia, Sheeba Simon, Chintamani Chintamani, Ravindar Singh Mohil, Dinesh Bhatnagar and Sunita Saxena

    Citation: Cancer Cell International 2014 14:14

    Content type: Primary research

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  29. The resistance of cancerous cells to chemotherapy remains the main limitation for cancer treatment at present. Doxorubicin (DOX) is a potent antitumor drug that activates the ubiquitin-proteasome system, but u...

    Authors: Pablo César Ortiz-Lazareno, Alejandro Bravo-Cuellar, José Manuel Lerma-Díaz, Luis Felipe Jave-Suárez, Adriana Aguilar-Lemarroy, Jorge Ramiro Domínguez-Rodríguez, Oscar González-Ramella, Ruth De Célis, Paulina Gómez-Lomelí and Georgina Hernández-Flores

    Citation: Cancer Cell International 2014 14:13

    Content type: Primary research

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  30. Esophageal squamous incidence in many developed countries has increased dramatically over last decades, while the underlying mechanism of the biogenesis of ES was still unknown.

    Authors: Bo Ye, Chun-Yu Ji, Yi Zhao, Wang Li, Jian Feng and Xu Zhang

    Citation: Cancer Cell International 2014 14:12

    Content type: Primary research

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  31. Although advanced gastric cancer has many limitations and response rate is marginal in chemotherapy. Overexpression of human epidermal growth factor receptor 2(HER-2/neu) gene and its protein are associated with ...

    Authors: Hai Cui, Ying Cheng, Su-Zhou Piao, Yun-Jie Xu, Hong-Hua Sun, Xian Cui, Xiang-Zi Li, Song-Nan Zhang, Long-Zhen Piao, Yong-Min Jin, Zhen-hua Lin and Xiong-Hu Shen

    Citation: Cancer Cell International 2014 14:10

    Content type: Primary research

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  32. Immunosuppression in breast cancer has been reported in women and in the highly metastatic mouse mammary tumor model 4 T1. The immunosuppressive environment complicates the use of the humoral response against ...

    Authors: Mariana Díaz-Zaragoza, Ricardo Hernández and Pedro Ostoa-Saloma

    Citation: Cancer Cell International 2014 14:9

    Content type: Primary research

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  33. A recombinant antitumor/antiviral protein (Novaferon, Nova) is a new type of interferon, which is produced by artificial design technology combining DNA-shuffling and High Throughput Screening (HTS).

    Authors: Meng Li, Chunming Rao, Dening Pei, Lan Wang, Yonghong Li, Kai Gao, Minrong Wang and Junzhi Wang

    Citation: Cancer Cell International 2014 14:8

    Content type: Primary research

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  34. The telomere binding proteins play an important role in telomere function, which contribute greatly to the radio resistant in human cancers. This research is designed to investigate the relationship among the ...

    Authors: Zheng Li, Xiaoxi Yang, Nengxing Xia, Lei Yang, Haijun Yu, Fuxiang Zhou, Conghua X and Yunfeng Zhou

    Citation: Cancer Cell International 2014 14:7

    Content type: Primary research

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  35. Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other ...

    Authors: Carly C Barron, Jessy Moore, Theodoros Tsakiridis, Gary Pickering and Evangelia Tsiani

    Citation: Cancer Cell International 2014 14:6

    Content type: Primary research

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  36. Rituximab plus CHOP (R-CHOP) significantly improved the outcome of diffuse large B cell lymphoma (DLBCL), a common sub-type of non-Hodgkin lymphoma. But 40% – 50% of DLBCL patients cannot be cured by this regi...

    Authors: Zhiying Fu, Jun Zhu, Wen Zheng, Weiping Liu, Zhitao Ying, Yan Xie, Xiaopei Wang, Ningjing Lin, Meifeng Tu, Lingyan Ping, Lijuan Deng, Chen Zhang, Ning Ding and Yuqin Song

    Citation: Cancer Cell International 2014 14:5

    Content type: Primary research

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  37. Sorafenib was the first Food and Drug Administration approved anti-angiogenic therapy for renal cell carcinoma (RCC). Currently, there are no validated predictive biomarkers for sorafenib. Our purpose was to d...

    Authors: Saadia A Aziz, Joshua A Sznol, Laurence Albiges, Christopher Zito, Lucia B Jilaveanu, Robert L Camp, Bernard Escudier and Harriet M Kluger

    Citation: Cancer Cell International 2014 14:4

    Content type: Primary research

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  38. Several reports have revealed that cancer stem cells (CSCs) exist in many types of solid tumors. Some studies have demonstrated that side population (SP) cells isolated from diverse cancer lines harbor cancer ...

    Authors: Wenjuan Qi, Chao Zhao, Lijun Zhao, Ning Liu, Xiaoping Li, Weidong Yu and Lihui Wei

    Citation: Cancer Cell International 2014 14:3

    Content type: Primary research

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  39. CDK11p58 is one of the large families of p34cdc2-related kinases whose functions are linked with cell cycle progression, tumorigenesis and apoptotic signaling. Our previous investigation demonstrated that CDK11p5...

    Authors: Yayun Chi, Lisha Wang, Xiuying Xiao, Ping Wei, Yiqin Wang and Xiaoyan Zhou

    Citation: Cancer Cell International 2014 14:9000

    Content type: Primary research

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  40. The anticancer effects of ceramide have been reported in many types of cancers but less in lung cancer. In this study, we used C2-ceramide to further investigate its possible anticancer effects and mechanisms on ...

    Authors: I-Ling Lin, Han-Lin Chou, Jin-Ching Lee, Feng-Wei Chen, Yao Fong, Wei-Chiao Chang, Hurng Wern Huang, Chang-Yi Wu, Wen-Tsan Chang, Hui-Min David Wang and Chien-Chih Chiu

    Citation: Cancer Cell International 2014 14:1

    Content type: Primary research

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  41. Over the last few years, studies have suggested that oxidative stress plays a role in the regulation of hematopoietic cell homeostasis. In particular, the effects of hydrogen peroxide (H2O2) range from hematopoie...

    Authors: Amanda Nogueira-Pedro, Thalyta Aparecida Munhoz Cesário, Carolina Carvalho Dias, Clarice Silvia Taemi Origassa, Lilian Piñero Marcolin Eça, Edgar Julian Paredes-Gamero and Alice Teixeira Ferreira

    Citation: Cancer Cell International 2013 13:123

    Content type: Primary research

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