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  1. The DNA methyltransferase 1 inhibitor, 5-Aza-2′-deoxycytidine (5-Aza-dC) is a potential treatment for breast cancer. However, not all breast tumors will respond similarly to treatment with 5-Aza-dC, and little...

    Authors: Stephanie M. Zimmers, Eva P. Browne, Kristin E. Williams, Rahul M. Jawale, Christopher N. Otis, Sallie S. Schneider and Kathleen F. Arcaro

    Citation: Cancer Cell International 2018 18:94

    Content type: Primary research

    Published on:

  2. Breast cancer (BC) is the most frequent malignancy among females worldwide. Despite several efforts and improvements in early diagnosis and treatment, there are still tumors characterized by an aggressive beha...

    Authors: Jessica Iorio, Icro Meattini, Simonetta Bianchi, Marco Bernini, Virginia Maragna, Luca Dominici, Donato Casella, Vania Vezzosi, Lorenzo Orzalesi, Jacopo Nori, Lorenzo Livi, Annarosa Arcangeli and Elena Lastraioli

    Citation: Cancer Cell International 2018 18:93

    Content type: Primary research

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  3. Glycolysis is an important metabolic oncogenic change also play a pivot role in the Warburg effect. Glycolysis related gene PKM2 expressed differently individually. Presently, we sought to investigate the effe...

    Authors: Na Cao, Meng Li, Jun Han, Yongren Wang and Xiaowei Wang

    Citation: Cancer Cell International 2018 18:92

    Content type: Primary research

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  4. Long non-coding RNAs play pivotal roles in the carcinogenesis of multiple types of cancers. This study is firstly to evaluate influence of rs4848320 and rs1110839 polymorphisms in long non-coding RNA AC016683....

    Authors: Juan Li, Hang Li, Xiaoting Lv, Zitai Yang, Min Gao, Yanhong Bi, Ziwei Zhang, Shengli Wang, Zhigang Cui, Baosen Zhou and Zhihua Yin

    Citation: Cancer Cell International 2018 18:91

    Content type: Primary research

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  5. Recent studies showed that benzimidazoleisoquinolinone derivatives exhibit anticancer activity against human cancer cell lines. The aim of this study is to evaluate the anti-tumor effects and mechanisms of ben...

    Authors: Ya-Jun Zhang, Zhi-Gang Xu, Shi-Qiang Li, Liu-Jun He, Yan Tang, Zhong-Zhu Chen and Dong-Lin Yang

    Citation: Cancer Cell International 2018 18:90

    Content type: Primary research

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  6. Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-...

    Authors: Peter Y. Yu, Gonzalo Lopez, Danielle Braggio, David Koller, Kate Lynn J. Bill, Bethany C. Prudner, Abbie Zewdu, James L. Chen, O. Hans Iwenofu, Dina Lev, Anne M. Strohecker, Joelle M. Fenger, Raphael E. Pollock and Denis C. Guttridge

    Citation: Cancer Cell International 2018 18:89

    Content type: Primary research

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  7. Lung cancer is a leading public health issue worldwide. Although therapeutic approaches have improved drastically in the last decades, the prognosis of lung cancer patients remains suboptimal. The canonical nu...

    Authors: Hualong Qin, Jun Zhou, Jingjing Xu, Li Cheng, Zaixiang Tang, Haitao Ma and Feng Guo

    Citation: Cancer Cell International 2018 18:88

    Content type: Primary research

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  8. Semaphorin 5A has been linked to tumor growth, invasion, and metastasis in pancreatic cancer. However, the role of semaphorin 5A in cervical cancer is not known. Our aim is to investigate the prognostic value ...

    Authors: Jian-Bing Xiao, Xin-Lei Li, Le Liu, Geng Wang, Song-Nan Hao, Hui-Juan Dong, Xue-Min Wang, Ya-Fang Zhang and Hui-Dong Liu

    Citation: Cancer Cell International 2018 18:87

    Content type: Primary research

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  9. Platinum-based drugs are used extensively in neoadjuvant chemotherapy for triple-negative breast cancer (TNBC), but their use can be limited by resistance. In this study, we established cisplatin (DDP) resista...

    Authors: Yuzhu Zhang, Jingjing Wu, Meina Ye, Bing Wang, Jiayu Sheng, Bailing Shi and Hongfeng Chen

    Citation: Cancer Cell International 2018 18:86

    Content type: Primary research

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  10. Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune t...

    Authors: Anton Deicher, Roland Andersson, Bobby Tingstedt, Gert Lindell, Monika Bauden and Daniel Ansari

    Citation: Cancer Cell International 2018 18:85

    Content type: Review

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  11. Endothelial-to-mesenchymal transition (EMT) and angiogenesis play important roles in colorectal cancer (CRC) development. Connective tissue growth factor (CTGF) has been reported to promote several kinds of ca...

    Authors: Weijian Lun, Xiongjian Wu, Qiliang Deng and Fachao Zhi

    Citation: Cancer Cell International 2018 18:83

    Content type: Primary research

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  12. Neuroblastoma (NB) is an early childhood malignancy that arises from the developing sympathetic nervous system. Harmine is a tricyclic β-carboline alkaloid isolated from the harmal plant that exhibits both cyt...

    Authors: Katie L. Uhl, Chad R. Schultz, Dirk Geerts and André S. Bachmann

    Citation: Cancer Cell International 2018 18:82

    Content type: Primary research

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  13. Protease-activated receptors (PARs) are a family of four G protein-coupled receptors expressed widely in many types of cells. PAR1, 2, and 4 have been shown to play an important role in many of the physiologic...

    Authors: Ping Jiang, Shu De Li, Zhi Gang Li, Yue Chun Zhu, Xiao Jia Yi and Si Man Li

    Citation: Cancer Cell International 2018 18:81

    Content type: Primary research

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  14. Formin-like 2 (FMNL2) is a member of Formin family which governs cytokinesis, cellular polarity and morphogenesis. Dysregulation of FMNL2 has been discovered in cancers and is closely related to cancers. Howev...

    Authors: Banghua Zhong, Kewei Wang, Hao Xu and Fanmin Kong

    Citation: Cancer Cell International 2018 18:79

    Content type: Primary research

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  15. Ovarian cancer is a heterogeneous disease with a high degree of genomic instability, pro-/antitumor immunity and inflammation, and remains the most lethal gynecologic cancer worldwide. APOBEC3B, a member of th...

    Authors: Yan Du, Xiang Tao, Jing Wu, Huandi Yu, Yinhua Yu and Hongbo Zhao

    Citation: Cancer Cell International 2018 18:78

    Content type: Primary research

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  16. Meningioma cancer stem cells (MCSCs) contribute to tumor aggressiveness and drug resistance. Successful therapies developed for inoperable, recurrent, or metastatic tumors must target these cells and restrict ...

    Authors: Hanin Alamir, Mona Alomari, Abdulla Ahmed A. Salwati, Mohamad Saka, Mohammed Bangash, Saleh Baeesa, Fahad Alghamdi, Angel Carracedo, Hans-Juergen Schulten, Adeel Chaudhary, Adel Abuzenadah and Deema Hussein

    Citation: Cancer Cell International 2018 18:77

    Content type: Primary research

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  17. SOX2 overlapping transcript (SOX2OT) has been reported to be an important lncRNA in various cancers. SOX2 is embedded in an intron of the SOX2OT gene. But the role of SOX2OT in esophageal squamous cell carcino...

    Authors: Yuanyuan Wu, Xuedan Chen, Yan Liang, Juan Li, Kun Zhang, Limeng Dai, Xingying Guan, Kai Wang and Yun Bai

    Citation: Cancer Cell International 2018 18:76

    Content type: Primary research

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  18. Bile acids have been implicated in the development of digestive tract malignancy by epidemiological, clinical and animal studies. The growth and transformation signaling by most of the bile acids is thought to...

    Authors: Yu-Chung Wu, Chang-Fang Chiu, Chung-Tzu Hsueh and Chung-Tsen Hsueh

    Citation: Cancer Cell International 2018 18:75

    Content type: Primary research

    Published on:

  19. Dysregulated expression of long non-coding RNAs (lncRNAs) has been reported in the pathogenesis and progression of multiple cancers, including hepatocellular carcinoma (HCC). LncRNA CTD-2547G23.4 is a novel ln...

    Authors: Dong-yue Wen, Peng Lin, Hai-wei Liang, Xia Yang, Hai-yuan Li, Yun He, Hong Yang and Gang Chen

    Citation: Cancer Cell International 2018 18:74

    Content type: Primary Research

    Published on:

  20. Upon publication of the original article [1] it was highlighted by the authors that a grant awarded to support the research work of the study was missed in the Funding Acknowledgements of their manuscript. It ...

    Authors: Du-Chu Chen, You-De Liang, Liang Peng, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, Yasmeen Saeed, Bin Yu, Jingying Huang, Yuxin Gao, Jiaqi Liu, Yi-Zhou Jiang, Min Liu and Demeng Chen

    Citation: Cancer Cell International 2018 18:73

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2017 17:103

  21. Castrate resistant prostate cancer (CRPC) is often driven by constitutively active forms of the androgen receptor such as the V7 splice variant (AR-V7) and commonly becomes resistant to established hormonal th...

    Authors: Sergio Regufe da Mota, Sarah Bailey, Rosemary A. Strivens, Annette L. Hayden, Leon R. Douglas, Patrick J. Duriez, M. Teresa Borrello, Hanae Benelkebir, A. Ganesan, Graham Packham and Simon J. Crabb

    Citation: Cancer Cell International 2018 18:71

    Content type: Primary Research

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  22. Intrinsic chemoresistance of glioblastoma (GBM) is frequently owed to activation of the PI3K and MEK/ERK pathways. These signaling cascades are tightly interconnected however the quantitative contribution of b...

    Authors: Bodo Haas, Veronika Klinger, Christina Keksel, Verena Bonigut, Daniela Kiefer, Julia Caspers, Julia Walther, Maria Wos-Maganga, Sandra Weickhardt, Gabriele Röhn, Marco Timmer, Roland Frötschl and Niels Eckstein

    Citation: Cancer Cell International 2018 18:69

    Content type: Primary Research

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  23. To explore the genetic effect of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 (CYP2E1) gene on the risk of squamous cell carcinoma (SCC), a meta-analysis was performed.

    Authors: Hai Zhang, Haiyan Li and Huanxin Yu

    Citation: Cancer Cell International 2018 18:67

    Content type: Primary research

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  24. MicroRNAs deregulation are common in human tumor progression. miR-1236-3p has been reported to function as tumor suppressor microRNA in various malignancies. The aim of this study was to demonstrate the downre...

    Authors: Jia-Xiang An, Ming-Hui Ma, Chun-Dong Zhang, Shuai Shao, Nuo-Ming Zhou and Dong-Qiu Dai

    Citation: Cancer Cell International 2018 18:66

    Content type: Primary research

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  25. Ovarian cancer is the most lethal gynaecological malignancy. Chemotherapy is the main stay of treatment for metastatic disease, with modest response rates but significant side effects. Therefore, there is a ne...

    Authors: Karen K. L. Chan, Michelle K. Y. Siu, Yu-xin Jiang, Jing-jing Wang, Thomas H. Y. Leung and Hextan Y. S. Ngan

    Citation: Cancer Cell International 2018 18:65

    Content type: Primary research

    Published on:

  26. Abnormal microRNA expression is closely related to cancer occurrence and development. miR-365a-3p plays an oncogenic role in skin cancer, but its role in lung cancer remains unclear. In this study, we aimed to...

    Authors: Yuhuan Wang, Shuhua Zhang, Hejing Bao, Shukun Mu, Baishen Zhang, Hao Ma and Shudong Ma

    Citation: Cancer Cell International 2018 18:64

    Content type: Primary research

    Published on:

  27. A growing field of evidence suggests the involvement of oncogenic receptor tyrosine kinases (RTKs) in cell transformation. Deregulated activity of RTKs in tumors can determine disease progression and therapeut...

    Authors: Sanja Aveic, Marcella Pantile, Pierfrancesco Polo, Viktoryia Sidarovich, Marilena De Mariano, Alessandro Quattrone, Luca Longo and Gian Paolo Tonini

    Citation: Cancer Cell International 2018 18:63

    Content type: Primary Research

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  28. Despite recent advances, multiple myeloma (MM) remains incurable. However, the appearance of allogeneic stem cell transplantation (allo-SCT) through graft-versus-myeloma effect provides a potential way to cure...

    Authors: Xuejiao Yin, Liang Tang, Fengjuan Fan, Qinyue Jiang, Chunyan Sun and Yu Hu

    Citation: Cancer Cell International 2018 18:62

    Content type: Primary Research

    Published on:

  29. Recently, long non-coding RNA (lncRNA) MIAT has been demonstrated as an oncogenic gene in several types of cancer. However, the role and mechanism of MIAT in colorectal cancer (CRC) have not been investigated.

    Authors: Zhaoxia Liu, Hai Wang, Hongwei Cai, Ye Hong, Yan Li, Dongming Su and Zhining Fan

    Citation: Cancer Cell International 2018 18:59

    Content type: Primary Research

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  30. Immunotoxins are typical therapeutic drugs that can target cancer cells. They exploit the affinity of specific monoclonal antibodies or ligands to cancer cells to deliver a conjugated protein toxin to target s...

    Authors: Miaonan Sun, Liankun Sun, Dejun Sun, Chunmei Zhang and Mei Li

    Citation: Cancer Cell International 2018 18:58

    Content type: Primary Research

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  31. Metastatic dissemination of solid tumors is often initiated by reactivation of an embryonic development program, epithelial-to-mesenchymal-transition (EMT). EMT has been associated with acquiring invasiveness ...

    Authors: Mamta Singla, Ajay Kumar, Amanjit Bal, Subhendu Sarkar and Shalmoli Bhattacharyya

    Citation: Cancer Cell International 2018 18:57

    Content type: Primary Research

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  32. Renal cell carcinoma accounts for 2–3% of all cancers and metastasis increased the malignancy of renal cancer. However, the role of methylation in metastasis of renal cancer is poorly understood.

    Authors: Jianbo Zheng, Yanhui Mei, Ping Xiang, Guangsheng Zhai, Ning Zhao, Chuanbing Xu, Min Liu, Zhengsheng Pan, Kai Tang and Dongsheng Jia

    Citation: Cancer Cell International 2018 18:56

    Content type: Primary Research

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  33. After publication of the original article (1) it was noted that the author details and affiliations of this manuscript contained minor errors in the institution addresses.

    Authors: Yue Li, You Li, Yao Chen, Qian Xie, Ningning Dong, Yanjun Gao, Huan Deng, Chunhua Lu and Suihai Wang

    Citation: Cancer Cell International 2018 18:55

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2017 17:102

  34. Paired box gene 8 (PAX8) is expressed in and indispensable to thyroid development. MiR-144-3p is found dys-regulated in cancers, and it can block the expression of target gens. This study sought to understand ...

    Authors: Chang Liu, Chang Su, Yanchun Chen and Guang Li

    Citation: Cancer Cell International 2018 18:54

    Content type: Primary research

    Published on:

  35. Signal transducer and activator of transcription 3 (STAT3) is persistently activated in a wide variety of epithelial cancers. Aberrant activity of STAT3 correlates with tumor growth, invasion and metastasis, w...

    Authors: Chao Zhou, Jie Ma, Mengyuan Su, Dan Shao, Jianan Zhao, Tongjian Zhao, Zhuoyao Song, Yan Meng and Ping Jiao

    Citation: Cancer Cell International 2018 18:53

    Content type: Primary Research

    Published on:

  36. Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical roles in diverse biological processes, including tumori...

    Authors: JinHui Liu, ChunYu Li, Yi Jiang, YiCong Wan, ShuLin Zhou and WenJun Cheng

    Citation: Cancer Cell International 2018 18:51

    Content type: Primary Research

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  37. Gastric cancer presents a major health burden worldwide. Therefore, many molecular targeting agents have been evaluated for treatment of gastric cancer. Gefitinib has shown anticancer activity against gastric ...

    Authors: Jia Huafeng, Zhang Deqing, Ding Yong, Zhang Yulian and Hu Ailing

    Citation: Cancer Cell International 2018 18:50

    Content type: Primary Research

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  38. Osteosarcoma (OS) is a rare, malignant bone tumor that primarily affects adolescents and has a high degree of malignancy and high incidence of recurrence and metastasis. Our study aimed to explore the role of ...

    Authors: Riliang Cao, Jianli Shao, Yabin Hu, Liang Wang, Zhizhong Li, Guodong Sun and Xiaoliang Gao

    Citation: Cancer Cell International 2018 18:49

    Content type: Primary research

    Published on:

  39. Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRPs family that modulates the Wnt signal transduction pathway. Recent studies have showed down-regulation of SFRP1 expression in colorectal canc...

    Authors: Zhongchuan Wang, Rujia Li, Yongshan He and Shiyong Huang

    Citation: Cancer Cell International 2018 18:48

    Content type: Primary Research

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  40. Long noncoding RNAs (lncRNAs) have been reported to have potential diagnostic and prognostic values for numerous cancers. However, the plasma expression of lncRNA BLACAT1 and its clinical value in patients wit...

    Authors: Denghui Liao, Gang Lv, Ting Wang, Jie Min, Yadong Wang and Shengchun Liu

    Citation: Cancer Cell International 2018 18:47

    Content type: Primary Research

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  41. Abnormally high expression of the mammalian de novo lipogenesis (DNL) pathway in various cancer cells promotes cell over-proliferation and resistance to apoptosis. Inhibition of key enzymes in the DNL pathway,...

    Authors: Phuriwat Khiewkamrop, Pattamaphron Phunsomboon, Lysiane Richert, Dumrongsak Pekthong and Piyarat Srisawang

    Citation: Cancer Cell International 2018 18:46

    Content type: Primary Research

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  42. Abnormal expression of long non-coding RNA (lncRNAs) often facilitates unrestricted growth of cancer cells. Long intergenic non-protein coding RNA 1510, an enhancer lncRNA (LINC01510), a lncRNA enhancer is upr...

    Authors: Chaoqun Cen, Jian Li, Jingjing Liu, Mingshi Yang, Tianyi Zhang, Yu Zuo, Changwei Lin and Xiaorong Li

    Citation: Cancer Cell International 2018 18:45

    Content type: Primary Research

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