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  1. Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer. Although there are different treatment options, these strategies are not efficient in terms of restricting the tumor cell’s pr...

    Authors: Zahra Farzaneh, Massoud Vosough, Tarun Agarwal and Maryam Farzaneh
    Citation: Cancer Cell International 2021 21:208
    Content type: Review Published on:

  2. Cervical cancer is a type of the most common gynecology tumor in women of the whole world. Accumulating data have shown that icariin (ICA), a natural compound, has anti-cancer activity in different cancers, in...

    Authors: Chunyang Li, Shuangqing Yang, Huaqing Ma, Mengjia Ruan, Luyan Fang and Jing Cheng
    Citation: Cancer Cell International 2021 21:206
    Content type: Primary research Published on:

  3. Preoperative tumor markers, inflammation, and nutritional status are considered important predictors of prognosis and tumor response in locally advanced rectal cancer (LARC) patients. This study aims to explor...

    Authors: Siyi Lu, Zhenzhen Liu, Bingyan Wang, Fei Li, Yan Meng, Junwei Wang, Yuxia Wang, Hao Wang, Xin Zhou and Wei Fu
    Citation: Cancer Cell International 2021 21:205
    Content type: Primary research Published on:

  4. Relapse and metastasis in colorectal cancer (CRC) are often attributed to cancer stem-like cells (CSCs), as small sub-population of tumor cells with ability of drug resistance. Accordingly, development of appr...

    Authors: Elmira Gheytanchi, Marzieh Naseri, Feridoun Karimi-Busheri, Fatemeh Atyabi, Ensie Sadat Mirsharif, Mahmood Bozorgmehr, Roya Ghods and Zahra Madjd
    Citation: Cancer Cell International 2021 21:204
    Content type: Primary research Published on:

  5. Long non-coding RNA is considered to be essential to modulate the development and progression of human malignant cancers. And long non-coding RNA can act as crucial modulators by sponging the corresponding mic...

    Authors: Qingyun Pan, Ying Huang, Yirui Wang, Deke Li and Changjiang Lei
    Citation: Cancer Cell International 2021 21:203
    Content type: Primary research Published on:

  6. Microarray profiles of hepatocellular carcinoma (HCC) identified that long intergenic noncoding RNA 00221 (LINC00221) was upregulated. Herein, we aimed to identify the functional significance and underlying me...

    Authors: Lin Yang, Hailong Si, Meng Ma, Yu Fang, Yina Jiang, Jintao Wang, Cheng Zhang and Haijuan Xiao
    Citation: Cancer Cell International 2021 21:202
    Content type: Primary research Published on:

  7. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01905-z

    Authors: Hongwang Song, Xiaojun Fu, Chenxing Wu and Shouwei Li
    Citation: Cancer Cell International 2021 21:201
    Content type: Retraction Note Published on:

    The original article was published in Cancer Cell International 2020 20:489

  8. VEGF and its receptor family (VEGFR) members have unique signaling transduction system that play significant roles in most pathological processes, such as angiogenesis in tumor growth and metastasis. VEGF-VEGF...

    Authors: Farnaz Khodabakhsh, Parnaz Merikhian, Mohammad Reza Eisavand and Leila Farahmand
    Citation: Cancer Cell International 2021 21:200
    Content type: Review Published on:

  9. Breast cancer (BC) is one of the commonest female cancers, which is characterized with high incidence. Although treatments have been improved, the prognosis of BC patients in advanced stages remains unsatisfac...

    Authors: Dilihumaer Tuluhong, Tao Chen, Jingjie Wang, Huijuan Zeng, Hanjun Li, Wangmu Dunzhu, Qiurong Li and Shaohua Wang
    Citation: Cancer Cell International 2021 21:199
    Content type: Primary research Published on:

  10. Acute myeloid leukaemia (AML) is an aggressive blood cancer. In approximately 30% of the cases, driver mutations in the FLT3 gene are identified. FLT3 inhibitors are used in treatment of such patients together...

    Authors: Jingmei Yang, H. Jonathan G. Lindström and Ran Friedman
    Citation: Cancer Cell International 2021 21:198
    Content type: Primary research Published on:

  11. Osteosarcoma is an aggressive malignant tumor which has attracted worldwide attention. MEX3A may be associated with tumors while has not yet seen its coverage on osteosarcoma. Herein, this study was to investi...

    Authors: Bangmin Wang, Zheping Hong, Chen Zhao, Qing Bi, Junhui Yuan, Jihang Chen and Yi Shen
    Citation: Cancer Cell International 2021 21:197
    Content type: Primary research Published on:

  12. High tumor mutation burden (TMB) has gradually become a sensitive biomarker for predicting the response to immunotherapy in many cancers, including lung, bladder and head and neck cancers. However, whether hig...

    Authors: Rong Tang, Xiaomeng Liu, Wei Wang, Jie Hua, Jin Xu, Chen Liang, Qingcai Meng, Jiang Liu, Bo Zhang, Xianjun Yu and Si Shi
    Citation: Cancer Cell International 2021 21:196
    Content type: Primary research Published on:

  13. Non-germinal center B-cell-like diffuse large B-cell lymphoma (non-GCB-DLBCL) has worse clinical outcome than GCB-DLBCL, and some relapsed/refractory non-GCB-DLBCL (R/R non-GCB-DLBCL) are even resistant to CD2...

    Authors: Xin Xu, Ting Wei, Weijie Zhong, Rosalind Ang, Ye Lei, Hui Zhang and Qingshan Li
    Citation: Cancer Cell International 2021 21:195
    Content type: Primary research Published on:

  14. Colorectal cancer (CRC) is the third most common cause of cancer globally and the fourth attributable cause of mortality and morbidity due to cancer. An emerging factor contributing to CRC is the gut microbiot...

    Authors: Maryam Ranjbar, Rasoul Salehi, Shaghayegh Haghjooy Javanmard, Laleh Rafiee, Habibollah Faraji, Sima jafarpor, Gordon A. Ferns, Majid Ghayour-Mobarhan, Mostafa Manian and Reza Nedaeinia
    Citation: Cancer Cell International 2021 21:194
    Content type: Review Published on:

    The Correction to this article has been published in Cancer Cell International 2022 22:134

  15. Ovarian epithelial cancer is one of the leading malignant tumors in gynecology and lacks effective diagnostic and prognostic markers. Our study aims to screen and verify ovarian epithelial cancer biomarkers.

    Authors: Xiaoying Chang, Dan Li, Chang Liu, Zhe Zhang and Tao Wang
    Citation: Cancer Cell International 2021 21:193
    Content type: Primary research Published on:

  16. Osteosarcoma (OS) is the most common primary malignant bone tumor in young people. Tumor-associated macrophages (TAMs) have been reported to play an important role in the development of osteosarcoma. However, ...

    Authors: Hongliang Zhang, Yiyang Yu, Jun Wang, Yu Han, Tingting Ren, Yi Huang, Chenglong Chen, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou and Wei Guo
    Citation: Cancer Cell International 2021 21:192
    Content type: Primary research Published on:

  17. Prostate cancer (PCa) is the most common malignant tumor in developed countries, which has seriously threatened men’s lifestyle and quality of life. The up-regulation of EZH2 is associated with advanced PCa an...

    Authors: Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu and Mingzhi Zhang
    Citation: Cancer Cell International 2021 21:191
    Content type: Primary research Published on:

  18. Hepatocellular carcinoma (HCC) ranks the sixth prevalent tumors with high mortality globally. Alternative splicing (AS) drives protein diversity, the imbalance of which might act an important factor in tumorig...

    Authors: Qianhui Xu, Hao Xu, Rongshan Deng, Nanjun Li, Ruiqi Mu, Zhixuan Qi, Yunuo Shen, Zijie Wang, Jingchao Wen, Jiaxin Zhao, Di Weng and Wen Huang
    Citation: Cancer Cell International 2021 21:190
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:448

  19. Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In recent years, there has been a keen interest towards the development of natural extracts-based cancer therapeutics with ...

    Authors: Zeeshan Javed, Haleema Sadia, Muhammad Javed Iqbal, Shazia Shamas, Kausar Malik, Rais Ahmed, Shahid Raza, Monica Butnariu, Natalia Cruz-Martins and Javad Sharifi-Rad
    Citation: Cancer Cell International 2021 21:189
    Content type: Review Published on:

  20. Cancers are serious life-threatening diseases which annually are responsible for millions of deaths across the world. Despite many developments in therapeutic approaches for affected individuals, the rate of m...

    Authors: Saeed Mehrzadi, Mohammad Hossein Pourhanifeh, Alireza Mirzaei, Farid Moradian and Azam Hosseinzadeh
    Citation: Cancer Cell International 2021 21:188
    Content type: Review Published on:

  21. Myeloma bone disease (MBD) is a severe complication of multiple myeloma (MM) mainly due to an imbalance between enhanced osteoclast activity and reduced osteoblast function. Previous studies have demonstrated ...

    Authors: Zheyu Wu, Yufeng Zhang, Zhiqiang Yang, Yufan Zhu, Yuanlong Xie, Fuling Zhou and Lin Cai
    Citation: Cancer Cell International 2021 21:187
    Content type: Primary research Published on:

  22. To our knowledge, LncRNA SNHG15 exerted its tumor-promoting effects to facilitate the development of breast cancer (BC), but there still needed more data to elucidate the potential underlying mechanisms.

    Authors: Jiang Du, Hong Zhong and Binlin Ma
    Citation: Cancer Cell International 2021 21:186
    Content type: Primary research Published on:

  23. Early diagnosis of nasopharyngeal carcinoma (NPC) is vital to improve the prognosis of these patients. However, early diagnosis of NPC is typically challenging. Therefore, we explored the pathogenetic roles an...

    Authors: Wei Zheng, Wangzhong Ye, Zijie Wu, Xinyi Huang, Yuanji Xu, Qinyan Chen, Zhizhong Lin, Yanyu Chen, Penggang Bai and Chuanben Chen
    Citation: Cancer Cell International 2021 21:185
    Content type: Primary research Published on:

  24. Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which repres...

    Authors: Li Dai, Mao Li, Wei-long Zhang, Ya-Jie Tang, Ya-ling Tang and Xin-hua Liang
    Citation: Cancer Cell International 2021 21:184
    Content type: Review Published on:

  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jihui Chen, Zhipeng Wang, Shouhong Gao, Kejin Wu, Fang Bai, Qiqiang Zhang, Hongyu Wang, Qin Ye, Fengjing Xu, Hong Sun, Yunshu Lu and Yan Liu
    Citation: Cancer Cell International 2021 21:183
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2021 21:136

  26. Previous studies have found that the microenvironment of cervical cancer (CESC) affects the progression and treatment of this disease. Thus, we constructed a multigene model to assess the survival of patients ...

    Authors: Qian Chen, Bingqing Qiu, Xiaoyun Zeng, Lang Hu, Dongping Huang, Kaihua Chen and Xiaoqiang Qiu
    Citation: Cancer Cell International 2021 21:182
    Content type: Primary research Published on:

  27. Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide. However, the molecular mechanism of LUAD tumorigenesis and development remains unclear. The purpose of this study was to comprehensi...

    Authors: Guoshu Bi, Donglin Zhu, Yunyi Bian, Yiwei Huang, Cheng Zhan, Yong Yang and Qun Wang
    Citation: Cancer Cell International 2021 21:181
    Content type: Primary research Published on:

  28. Long noncoding RNAs (lncRNAs) have recently identified as essential gene modulators in numerous cancers. Previous studies have confirmed the oncogenic role of long intergenic nonprotein-coding RNA 00514 (LINC0...

    Authors: Xiao Luo and Hui Wang
    Citation: Cancer Cell International 2021 21:180
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:561

  29. Studies have discussed long noncoding RNA DDX11-AS1 (DDX11-AS1)-mediated downstream mechanism in hepatocellular carcinoma (HCC). The goal of this study was to investigate the regulatory mechanism of DDX11-AS1-...

    Authors: Gangqiang Ding, Yanli Zeng, Dongqiang Yang, Can Zhang, Chongshan Mao, Erhui Xiao, Yi Kang and Jia Shang
    Citation: Cancer Cell International 2021 21:179
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:659

  30. Aberrantly expressed microRNAs play important roles in gastric tumorigenesis. However, use of miRNAs as a therapeutic option in gastric cancer still remains as a challenging problem.

    Authors: Narjes Jafari, Saeid Abediankenari and Hadi Hossein-Nataj
    Citation: Cancer Cell International 2021 21:178
    Content type: Primary research Published on:

  31. Chemo-resistance is still a major obstacle in leukemia treatment. Accumulating evidence indicates that cancer-associated fibroblasts (CAFs), the most abundant stromal cells in tumor microenvironment (TME), pla...

    Authors: Yuanyuan Li and Ling Gu
    Citation: Cancer Cell International 2021 21:177
    Content type: Primary research Published on:

  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhao‑liang Yu, Yu‑feng Chen, Bin Zheng, Ze-rong Cai, Yi‑feng Zou, Jia Ke, Ping Lan, Feng Gao and Xiao‑jian Wu
    Citation: Cancer Cell International 2021 21:176
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2021 21:94

  33. Transcription factors (TFs) may be engaged in reciprocal regulatory circuits with certain miRNAs to maintain cellular homeostasis. Disequilibrium of the reciprocities by certain tumor-related stimuli may give ...

    Authors: Wenjing Zhang, Haitao Yang, Zhongqiu Wang, Yanting Wu, Jingzhai Wang, Guihua Duan, Qiang Guo and Yu Zhang
    Citation: Cancer Cell International 2021 21:175
    Content type: Primary research Published on:

  34. The incidence and mortality rates of hepatocellular carcinoma are among the highest of all cancers all over the world. However the survival rates are relatively low due to lack of effective treatments. Efforts...

    Authors: Fan Zhang, Mengjuan Xue, Xin Jiang, Huiyuan Yu, Yixuan Qiu, Jiaming Yu, Fan Yang and Zhijun Bao
    Citation: Cancer Cell International 2021 21:174
    Content type: Primary research Published on:

  35. Gastric intestinal metaplasia (GIM) is a significant risk factor for gastric cancer. Risk of gastric cancer/dysplasia between complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (IIM) was...

    Authors: Ning Wei, Mengyue Zhou, Siyu Lei, Zhiheng Zhong and Ruihua Shi
    Citation: Cancer Cell International 2021 21:173
    Content type: Review Published on:

  37. As a tissue-specific proangiogenic or antiangiogenic agent, angiopoietin-like 4 (ANGPTL4) has recently gained attention in many diseases, such as metabolic syndrome, cardiovascular disease and cancer. However,...

    Authors: Yuxian Wu, Jinghai Gao and Xiaojun Liu
    Citation: Cancer Cell International 2021 21:171
    Content type: Primary research Published on:

  38. Neuroblastoma is a childhood neural crest tumor showing large clinical and genetic heterogeneity, one form displaying 11q-deletion is very aggressive. It has been shown that 11q-deletion results in decreased e...

    Authors: Simon Keane, Tommy Martinsson, Per Kogner and Katarina Ejeskär
    Citation: Cancer Cell International 2021 21:170
    Content type: Primary research Published on:

  39. Nowadays, colorectal cancer (CRC) is one of the most commonly diagnosed malignant tumors worldwide, the incidence rate of which is still increasing year by year. Herein, the objective of this study is to inves...

    Authors: Qiang Feng, Dongkui Xu, Mingyao Zhou, Zijian Wu, Zhiyuan Wu, Zheng Wang, Jianjun Bi and Wei Pei
    Citation: Cancer Cell International 2021 21:169
    Content type: Primary research Published on:

  40. Long non-coding RNA (lncRNA) has been confirmed to exert a critical effect on the progression of tumors, including prostate cancer. Previous literature has demonstrated LINC01116 involves in activities of mult...

    Authors: Shengjie Yu, Huihong Yu, Yuanfeng Zhang, Chuan Liu, Weili Zhang and Yunyun Zhang
    Citation: Cancer Cell International 2021 21:168
    Content type: Primary research Published on:

  41. Head and neck squamous cell carcinoma (HNSCC) is a common tumor worldwide with poor prognosis. The pathogenesis of human papillomavirus (HPV)-positive and HPV-negative HNSCCs differs. However, few studies have...

    Authors: Guocai Tian, You Fu, Dahe Zhang, Jiang Li, Zhiyuan Zhang and Xi Yang
    Citation: Cancer Cell International 2021 21:167
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2021 21:248

  42. Tumor metastasis is one of the leading reasons of the dismal prognosis of hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) is closely associated with tumor metastasis including HCC. The ...

    Authors: Gongmin Zhu, Hongwei Xia, Qiulin Tang and Feng Bi
    Citation: Cancer Cell International 2021 21:166
    Content type: Primary research Published on:

  43. Radiotherapy is a major treatment for esophageal squamous cell carcinoma (ESCC). However, HPV infection related radioresistance caused poor prognosis of ESCC. The function of SOCS6, which has been shown to be ...

    Authors: Xuanzi Sun, Yuchen Sun, Jing Li, Xu Zhao, Xiaobo Shi, Tuotuo Gong, Shupei Pan, Zhongqiang Zheng and Xiaozhi Zhang
    Citation: Cancer Cell International 2021 21:165
    Content type: Primary research Published on:

  44. Numerous individual studies have investigated the diagnostic value of EBV-DNA, EA-IgA, VCA-IgA, EBNA1-IgA and Rta-IgG detection for nasopharyngeal carcinoma (NPC), but the conclusions remain controversial. Thi...

    Authors: Weixing Liu, Gui Chen, Xin Gong, Yingqi Wang, Yaoming Zheng, Xiao Liao, Wenjing Liao, Lijuan Song, Jun Xu and Xiaowen Zhang
    Citation: Cancer Cell International 2021 21:164
    Content type: Review Published on:

  45. Slug (Snai2) is a pivotal player in initiating epithelial-mesenchymal transition (EMT) through its trans-suppression effect on E-cadherin in various normal and malignant cells. In this study, the positive effe...

    Authors: Xian Liu, Qian Feng, Yanru Zhang, PengSheng Zheng and Nan Cui
    Citation: Cancer Cell International 2021 21:163
    Content type: Primary research Published on:

  46. Patients with type 2 diabetes mellitus (T2DM) have an increased risk of suffering from various malignancies. This study aimed to identify specific biomarkers that can detect lung adenocarcinoma (LAC) in T2DM p...

    Authors: Jiayue Yang, Cheng Yang, Hong Shen, Wenjun Wu, Zhen Tian, Qinghua Xu, Cuiping Cao, Shugao Ye, Le Ban, Xin Tong and Jie Mei
    Citation: Cancer Cell International 2021 21:162
    Content type: Primary research Published on:

  47. Cholangiocarcinoma (CCA) is the second most common primary liver malignancy worldwide. Several microRNAs (miRNAs) have been implicated as potential tumor suppressors in CCA. This study aims to explore the pote...

    Authors: Xin Pan, Gang Wang and Baoming Wang
    Citation: Cancer Cell International 2021 21:161
    Content type: Primary research Published on:

  48. CDC27 is one of the core components of Anaphase Promoting complex/cyclosome. The main role of this protein is defined at cellular division to control cell cycle transitions. Here we review the molecular aspect...

    Authors: Golnaz Ensieh Kazemi-Sefat, Mohammad Keramatipour, Saeed Talebi, Kaveh Kavousi, Roya Sajed, Nazanin Atieh Kazemi-Sefat and Kazem Mousavizadeh
    Citation: Cancer Cell International 2021 21:160
    Content type: Review Published on:

  49. Human cell division cycle associated 8 (CDCA8) a key regulator of mitosis, has been described as a potential prognostic biomarker for a variety of cancers, such as breast, colon and lung cancers. We aimed to eval...

    Authors: Yu Shuai, Erxi Fan, Qiuyue Zhong, Qiying Chen, Guangyong Feng, Xiaoxia Gou and Guihai Zhang
    Citation: Cancer Cell International 2021 21:159
    Content type: Primary research Published on:

  50. Uterine leiomyosarcoma (ULMS) is a malignant tumor found in the smooth muscle lining the walls of the uterus. Cancer stem cells (CSCs) are responsible for metastasis, drug resistance, and relapse of cancer, re...

    Authors: Jiuping Gao, Ting Yang, Xu Wang, Yi Zhang, Jing Wang, Beilei Zhang, Dihong Tang, Yanqiong Liu, Ting Gao, Qiuhui Lin, Jun Tang and Jingting Cai
    Citation: Cancer Cell International 2021 21:157
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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