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  2. Glioblastoma multiforme (GBM) is a highly aggressive brain tumor in which cancer cells with stem cell-like features, called cancer stem cells (CSCs), were identified. Two CSC populations have been previously i...

    Authors: Bianca Maria Scicchitano, Silvia Sorrentino, Gabriella Proietti, Gina Lama, Gabriella Dobrowolny, Angela Catizone, Elena Binda, Luigi Maria Larocca and Gigliola Sica
    Citation: Cancer Cell International 2018 18:136
    Content type: Primary research Published on:

  3. Lung, breast, and colorectal malignancies are the leading cause of cancer-related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite efforts to improve prevention methods, early...

    Authors: Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Velazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison and Kim L. O’Neill
    Citation: Cancer Cell International 2018 18:135
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2019 19:29

  4. High prevalence of hepatocellular carcinoma (HCC) and typically poor prognosis of this disease that lead to late stage diagnosis when potentially curative therapies are least effective; therefore, development ...

    Authors: Faezeh Hosseinzadeh, Javad Verdi, Jafar Ai, Saieh Hajighasemlou, Iman Seyhoun, Frzad Parvizpour, Fatemeh Hosseinzadeh, Abolfazl Iranikhah and Sadegh Shirian
    Citation: Cancer Cell International 2018 18:133
    Content type: Review Published on:

  5. Non-small cell lung cancer (NSCLC), the most prevalent type of human lung cancer, is characterized by many molecular abnormalities. SH2B1, a member of the SH2-domain containing family, have recently been shown...

    Authors: Shaoqiang Wang, Yingying Zheng, Zhiwei He, Wolong Zhou, Yuanda Cheng and Chunfang Zhang
    Citation: Cancer Cell International 2018 18:132
    Content type: Primary research Published on:

  6. No data is available on the molecular background of the extra-nodal extension (ENE) of lymph node metastasis (LN) in colorectal cancer (CRC).

    Authors: Matteo Fassan, Luca Vianello, Diana Sacchi, Giuseppe N. Fanelli, Giada Munari, Marco Scarpa, Rocco Cappellesso, Fotios Loupakis, Cristiano Lanza, Roberta Salmaso, Claudia Mescoli, Nicola Valeri, Marco Agostini, Edoardo D’Angelo, Sara Lonardi, Salvatore Pucciarelli…
    Citation: Cancer Cell International 2018 18:131
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2019 19:244

  7. Colorectal cancer (CRC) is one of the most common cancers diagnosed and among the commonest causes of cancer-related mortality globally. Despite the various available treatment options, millions of people stil...

    Authors: Adewale Oluwaseun Fadaka, Babajide A. Ojo, Olusola Bolaji Adewale, Temitope Esho and Ashley Pretorius
    Citation: Cancer Cell International 2018 18:130
    Content type: Review Published on:

  8. SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism e...

    Authors: Marie Saghaeian Jazi, Nader Mansour Samaei, Seyed Javad Mowla, Babak Arefnezhad and Morteza Kouhsar
    Citation: Cancer Cell International 2018 18:129
    Content type: Primary research Published on:

  9. Multidrug resistance (MDR) is a major obstacle in breast cancer treatment. The predominant mechanism underlying MDR is an increase in the activity of adenosine triphosphate (ATP)-dependent drug efflux transpor...

    Authors: Shao-hsuan Wen, Shey-chiang Su, Bo-huang Liou, Cheng-hao Lin and Kuan-rong Lee
    Citation: Cancer Cell International 2018 18:128
    Content type: Primary research Published on:

  10. MicroRNAs are small RNAs (~ 22 nt) that modulate the expression of thousands of genes in tumors and play important roles in the formation of multidrug resistance. In this study, we firstly investigated that miR-4...

    Authors: Fan Feng, Xiaolan Zhu, Chunyan Wang, Liang Chen, Weiping Cao, Yueqin Liu, Qi Chen and Wenlin Xu
    Citation: Cancer Cell International 2018 18:127
    Content type: Primary research Published on:

  11. Recent studies have suggested that B7-H6, a new member of the B7 family of ligands, not only is a crucial regulator of NK cell-mediated immune responses but also has important clinical implications due to its ...

    Authors: Lujun Chen, Jun Feng, Bin Xu, You Zhou, Xiao Zheng, Changping Wu and Jingting Jiang
    Citation: Cancer Cell International 2018 18:126
    Content type: Primary research Published on:

    The Correction to this article has been published in Cancer Cell International 2018 18:134

  12. Long non-coding RNAs (lncRNA) are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that lncRNAs are involv...

    Authors: Dan Dong, Zhongyi Mu, Chenghai Zhao and Mingli Sun
    Citation: Cancer Cell International 2018 18:125
    Content type: Review Published on:

  13. Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role ...

    Authors: Yong-Xia Wang, Hui-Fang Zhu, Zhe-Ying Zhang, Feng Ren and Yu-Han Hu
    Citation: Cancer Cell International 2018 18:124
    Content type: Primary research Published on:

  14. To investigate the efficacy and safety of concurrent chemoradiotherapy with capecitabine or oxaliplatin in locally advanced (T3-4/N + M0) rectal cancer.

    Authors: Wanghua Chen, Wenling Wang, Yuxin Li, Hongmin Dong, Gang Wang and Xiaokai Li
    Citation: Cancer Cell International 2018 18:123
    Content type: Primary research Published on:

  15. LncRNAs can regulate miRNAs and mRNAs by sequestering and binding them. Indeed, many researchers have reported lncRNA mediated-competing endogenous RNAs (ceRNAs) could regulate the progression of solid tumors....

    Authors: Xuejiao Yin, Sui Huang, Ruiqi Zhu, Fengjuan Fan, Chunyan Sun and Yu Hu
    Citation: Cancer Cell International 2018 18:122
    Content type: Primary research Published on:

  16. Local or distant metastasis remains the main course of death in head and neck squamous cell carcinoma (HNSCC) patients. MicroRNAs (miRNAs) have been implicated in metastasis of HNSCC, but the mechanisms of the...

    Authors: Yibo Dong, Yang Zheng, Chundi Wang, Xu Ding, Yifei Du, Laikui Liu, Wei Zhang, Wei Zhang, Yi Zhong, Yunong Wu and Xiaomeng Song
    Citation: Cancer Cell International 2018 18:121
    Content type: Primary research Published on:

  17. Alternatively activated macrophages in tumor microenvironment is defined as M2 tumor-associated macrophages (M2 TAMs) that promote cancer progression. However, communicative mechanisms between M2 TAMs and canc...

    Authors: Li She, Yuexiang Qin, Juncheng Wang, Chao Liu, Gangcai Zhu, Guo Li, Ming Wei, Changhan Chen, Guancheng Liu, Diekuo Zhang, Xiyu Chen, Yunyun Wang, Yuanzheng Qiu, Yongquan Tian, Xin Zhang, Yong Liu…
    Citation: Cancer Cell International 2018 18:120
    Content type: Primary research Published on:

  18. The neutrophil-to-lymphocyte ratio (NLR), a biomarker for systematic inflammation, has been recently identified as a prognostic factor for various types of both solid and hematologic malignancies. Here we cond...

    Authors: Shidai Mu, Lisha Ai, Fengjuan Fan, You Qin, Chunyan Sun and Yu Hu
    Citation: Cancer Cell International 2018 18:119
    Content type: Primary research Published on:

  19. Basal/human epidermal growth factor receptor (HER)2-positive (HER2+) breast cancer is resistant to monoclonal antibody (herceptin) treatment. There are currently only three basal/HER2+ breast cancer cell lines...

    Authors: Fei Zhou, Yanhua Zhang, Xiufang Xu, Jingfeng Luo, Fang Yang, Linbo Wang, Shuduo Xie, Jihong Sun and Xiaoming Yang
    Citation: Cancer Cell International 2018 18:118
    Content type: Primary research Published on:

  20. Cytokine-based cancer therapies have attracted a great deal of attention in recent years. Unfortunately, resistance to treatment limits the efficacy of these therapeutics. Therefore, the aim of our study was t...

    Authors: Kaihua Ji, Kaili Lin, Yan Wang, Liqing Du, Chang Xu, Ningning He, Jinhan Wang, Yang Liu and Qiang Liu
    Citation: Cancer Cell International 2018 18:117
    Content type: Primary research Published on:

  21. Accumulating data indicated that circRNA plays important roles in regulating many biological processes of the tumor, the present study is designated for exploring roles of the circ-ZEB1.33-miR-200a-3p-CDK6 reg...

    Authors: Yuhua Gong, Jinzhong Mao, Di Wu, Xuemei Wang, Long Li, Liang Zhu and Rong Song
    Citation: Cancer Cell International 2018 18:116
    Content type: Primary research Published on:

  22. Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance ...

    Authors: Ling Wang, Fu-biao Kang, Guo-chuan Zhang, Juan Wang, Ming-fang Xie and Ying-ze Zhang
    Citation: Cancer Cell International 2018 18:115
    Content type: Primary research Published on:

  23. Increasing numbers of studies have examined the correlation between specific miRNAs and tumours to enable their diagnosis and treatment. However, there are few reports regarding the concrete role and mechanism...

    Authors: Ming Zhuang, Xubin Qiu, Dong Cheng, Chenlei Zhu and Liang Chen
    Citation: Cancer Cell International 2018 18:114
    Content type: Primary research Published on:

  24. Triple-negative breast cancer (TNBC) is one of the most difficult subtypes of breast cancer to treat due to its aggressive, metastatic behavior, and a lack of a targeted therapy. Trivalent arsenic derivatives ...

    Authors: Bo Yuan, Mingjiang Yao, Xiao Wang, Ai Sato, Ayane Okazaki, Hana Komuro, Hideki Hayashi, Hiroo Toyoda, Xiaohua Pei, Xiaomei Hu, Toshihiko Hirano and Norio Takagi
    Citation: Cancer Cell International 2018 18:113
    Content type: Primary research Published on:

  25. Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternal...

    Authors: Tian Xie, Shan Pan, Hang Zheng, Zilv Luo, Kingsley M. Tembo, Muhammad Jamal, Zhongyang Yu, Yao Yu, Jing Xia, Qian Yin, Meng Wang, Wen Yuan, Qiuping Zhang and Jie Xiong
    Citation: Cancer Cell International 2018 18:112
    Content type: Review Published on:

  26. Glioblastoma (GBM) is a tumor of the central nervous system. After surgical removal and standard therapy, recurrence of tumors is observed within 6–9 months because of the high migratory behavior and the infil...

    Authors: Henry Oppermann, Johannes Dietterle, Katharina Purcz, Markus Morawski, Christian Eisenlöffel, Wolf Müller, Jürgen Meixensberger and Frank Gaunitz
    Citation: Cancer Cell International 2018 18:111
    Content type: Primary research Published on:

  27. The aim of the study was to investigate the effect associated with the protein expression of VEGF, JAK2 and STAT3 on the clinicopathologic characteristics and prognosis in the development and progression of na...

    Authors: Jin-Zhang Cheng, Jun-Jun Chen, Kai Xue, Zong-Gui Wang and Dan Yu
    Citation: Cancer Cell International 2018 18:110
    Content type: Primary research Published on:

  28. The aberrant regulation of MALAT1 has been indicated to be involved in various carcinogenic pathways contributing to the tumourigenesis and progression of cancers. The current meta-analysis summarized the rese...

    Authors: Juan Li, Zhigang Cui, Hang Li, Xiaoting Lv, Min Gao, Zitai Yang, Yanhong Bi, Ziwei Zhang, Shengli Wang, Baosen Zhou and Zhihua Yin
    Citation: Cancer Cell International 2018 18:109
    Content type: Primary research Published on:

  29. The prognostic significance of galectin-1 (Gal-1) expression in cancerous patients has been assessed for several years while the results remain controversial. Thus, we performed the first comprehensive meta-an...

    Authors: Rongzu Wu, Tingchun Wu, Kai Wang, Shicheng Luo, Zhen Chen, Min Fan, Dong Xue, Hao Lu, Qianfeng Zhuang and Xianlin Xu
    Citation: Cancer Cell International 2018 18:108
    Content type: Review Published on:

  30. Increasing evidence has shown that long non-coding RNAs (lncRNAs) are important prognostic biomarkers and epigenetic regulators with critical roles in cancer initiation and progression. However, the expression...

    Authors: Fan Wu, Zheng Zhao, Ruichao Chai, Yuqing Liu, Kuanyu Wang, Zhiliang Wang, Guanzhang Li, Ruoyu Huang, Haoyu Jiang and Kenan Zhang
    Citation: Cancer Cell International 2018 18:107
    Content type: Primary research Published on:

  31. Cajal body (CB) is a nucleic organelle where small nuclear ribonucleoproteins undergo modification, maturation, splicing and/or assembly. Coilin is the marker structural protein of CBs. The expression level an...

    Authors: Zhi-Xia Yue, Rui-qi Gao, Chao Gao, Shu-Guang Liu, Xiao-Xi Zhao, Tian-Yu Xing, Jing Niu, Zhi-Gang Li, Hu-Yong Zheng and Wei Ding
    Citation: Cancer Cell International 2018 18:106
    Content type: Primary research Published on:

  32. MicroRNAs (miRNAs) have been reported to play crucial roles in multiple cancers including non-small cell lung cancer (NSCLC). Here, we investigated the role of miR-145 and miR-497 in TGF-β-induced epithelial–m...

    Authors: Qi Yin, Yang Han, Dongyi Zhu, Zhanxia Li, Shan Shan, Wenjing Jin, Qingchun Lu and Tao Ren
    Citation: Cancer Cell International 2018 18:105
    Content type: Primary research Published on:

  33. Cancer-associated fibroblasts (CAFs) play important roles in tumor progression. However, the behaviors of activated CAFs in gastric cancer remain to be determined. The aim of the present study was to investiga...

    Authors: Yongchen Ma, Jing Zhu, Shanwen Chen, Tengyu Li, Ju Ma, Shihao Guo, Jianwen Hu, Taohua Yue, Junling Zhang, Pengyuan Wang, Xin Wang, Guowei Chen and Yucun Liu
    Citation: Cancer Cell International 2018 18:104
    Content type: Primary research Published on:

  34. Triple-negative breast cancer (TNBC) is a particular breast cancer subtype with poor prognosis due to its aggressive biological behavior and lack of targets for therapy. This study aimed to explore the express...

    Authors: Tian Tian, Zhouqing Gong, Meng Wang, Ruohan Hao, Shuai Lin, Kang Liu, Feng Guan, Peng Xu, Yujiao Deng, Dingli Song, Na Li, Ying Wu and Zhijun Dai
    Citation: Cancer Cell International 2018 18:103
    Content type: Primary research Published on:

  35. Ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA) is a hydroxycinnamic acid derived from a rich polyphenolic compound. This study aimed to investigate the effect of ferulic acid (4-hydroxy-3-methoxycinnamic ...

    Authors: Jinhua Gao, Hui Yu, Weikang Guo, Ying Kong, lina Gu, Qi Li, Shanshan Yang, Yunyan Zhang and Yaoxian Wang
    Citation: Cancer Cell International 2018 18:102
    Content type: Primary research Published on:

  36. MicroRNAs (miRNAs), which are endogenous about 20–23 nucleotides non-coding RNAs, have been acted as post-transcriptional regulators of gene expression. Current studies demonstrated that miRNAs are promising c...

    Authors: Hairong Wang, Shiming Liu, Li Jia, Fengyun Chu, Ya Zhou, Zhixu He, Mengmeng Guo, Chao Chen and Lin Xu
    Citation: Cancer Cell International 2018 18:101
    Content type: Review Published on:

  37. The expression of the immunoregulatory protein B7-H4 has been reported in many types of cancer, including breast cancer. However, its role in triple-negative breast cancer (TNBC), especially its correlation wi...

    Authors: Ling Wang, Chao Yang, Xin-bo Liu, Li Wang and Fu-biao Kang
    Citation: Cancer Cell International 2018 18:100
    Content type: Primary research Published on:

  38. Gastro-esophageal adenocarcinomas (GEA) represent a severe global health burden and despite improvements in the multimodality treatment of these malignancies the prognosis of patients remains poor. HER2 overex...

    Authors: Francesca Battaglin, Madiha Naseem, Alberto Puccini and Heinz-Josef Lenz
    Citation: Cancer Cell International 2018 18:99
    Content type: Review Published on:

  40. MicroRNAs (miRNAs) are small non-coding RNAs which play important roles in the carcinogenesis of gastric cancer (GC). Expression profiling of miRNAs in paired gastric cancer and adjacent normal gastric tissues...

    Authors: Haiqun Chen, Gang Dai, Yiting Cai, Qinhao Gong, Wei Wu, Min Gao and Zhewei Fei
    Citation: Cancer Cell International 2018 18:97
    Content type: Primary research Published on:

  41. As a disease of hematopoietic stem cell, chronic myeloid leukemia (CML) possesses unique biological and clinical features. However, the biologic mechanism underlying its development remains poorly understood. ...

    Authors: Xiao-Fang Wei, You-Fan Feng, Qiao-Lin Chen and Qi-Ke Zhang
    Citation: Cancer Cell International 2018 18:96
    Content type: Primary research Published on:

  42. Tumor-associated macrophages (TAMs) are generally recognized as a promoter of tumor progression. miR-98 has been shown to suppress the proliferation, migration, invasion and epithelial–mesenchymal transition (...

    Authors: Lei Li, Pengfei Sun, Chengsheng Zhang, Zongchao Li, Kai Cui and Wuyuan Zhou
    Citation: Cancer Cell International 2018 18:95
    Content type: Primary research Published on:

  43. The DNA methyltransferase 1 inhibitor, 5-Aza-2′-deoxycytidine (5-Aza-dC) is a potential treatment for breast cancer. However, not all breast tumors will respond similarly to treatment with 5-Aza-dC, and little...

    Authors: Stephanie M. Zimmers, Eva P. Browne, Kristin E. Williams, Rahul M. Jawale, Christopher N. Otis, Sallie S. Schneider and Kathleen F. Arcaro
    Citation: Cancer Cell International 2018 18:94
    Content type: Primary research Published on:

  44. Breast cancer (BC) is the most frequent malignancy among females worldwide. Despite several efforts and improvements in early diagnosis and treatment, there are still tumors characterized by an aggressive beha...

    Authors: Jessica Iorio, Icro Meattini, Simonetta Bianchi, Marco Bernini, Virginia Maragna, Luca Dominici, Donato Casella, Vania Vezzosi, Lorenzo Orzalesi, Jacopo Nori, Lorenzo Livi, Annarosa Arcangeli and Elena Lastraioli
    Citation: Cancer Cell International 2018 18:93
    Content type: Primary research Published on:

  45. Glycolysis is an important metabolic oncogenic change also play a pivot role in the Warburg effect. Glycolysis related gene PKM2 expressed differently individually. Presently, we sought to investigate the effe...

    Authors: Na Cao, Meng Li, Jun Han, Yongren Wang and Xiaowei Wang
    Citation: Cancer Cell International 2018 18:92
    Content type: Primary research Published on:

  46. Long non-coding RNAs play pivotal roles in the carcinogenesis of multiple types of cancers. This study is firstly to evaluate influence of rs4848320 and rs1110839 polymorphisms in long non-coding RNA AC016683....

    Authors: Juan Li, Hang Li, Xiaoting Lv, Zitai Yang, Min Gao, Yanhong Bi, Ziwei Zhang, Shengli Wang, Zhigang Cui, Baosen Zhou and Zhihua Yin
    Citation: Cancer Cell International 2018 18:91
    Content type: Primary research Published on:

  47. Recent studies showed that benzimidazoleisoquinolinone derivatives exhibit anticancer activity against human cancer cell lines. The aim of this study is to evaluate the anti-tumor effects and mechanisms of ben...

    Authors: Ya-Jun Zhang, Zhi-Gang Xu, Shi-Qiang Li, Liu-Jun He, Yan Tang, Zhong-Zhu Chen and Dong-Lin Yang
    Citation: Cancer Cell International 2018 18:90
    Content type: Primary research Published on:

  48. Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-...

    Authors: Peter Y. Yu, Gonzalo Lopez, Danielle Braggio, David Koller, Kate Lynn J. Bill, Bethany C. Prudner, Abbie Zewdu, James L. Chen, O. Hans Iwenofu, Dina Lev, Anne M. Strohecker, Joelle M. Fenger, Raphael E. Pollock and Denis C. Guttridge
    Citation: Cancer Cell International 2018 18:89
    Content type: Primary research Published on:

  49. Lung cancer is a leading public health issue worldwide. Although therapeutic approaches have improved drastically in the last decades, the prognosis of lung cancer patients remains suboptimal. The canonical nu...

    Authors: Hualong Qin, Jun Zhou, Jingjing Xu, Li Cheng, Zaixiang Tang, Haitao Ma and Feng Guo
    Citation: Cancer Cell International 2018 18:88
    Content type: Primary research Published on:

  50. Semaphorin 5A has been linked to tumor growth, invasion, and metastasis in pancreatic cancer. However, the role of semaphorin 5A in cervical cancer is not known. Our aim is to investigate the prognostic value ...

    Authors: Jian-Bing Xiao, Xin-Lei Li, Le Liu, Geng Wang, Song-Nan Hao, Hui-Juan Dong, Xue-Min Wang, Ya-Fang Zhang and Hui-Dong Liu
    Citation: Cancer Cell International 2018 18:87
    Content type: Primary research Published on:
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Cancer Cell International

ISSN: 1475-2867

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