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  1. Content type: Primary research

    Incidence of endometrial cancer are rising both in the United States and worldwide. As endometrial cancer becomes more prominent, the need to develop and characterize biomarkers for early stage diagnosis and t...

    Authors: Michelle H. Townsend, Zac E. Ence, Abigail M. Felsted, Alyssa C. Parker, Stephen R. Piccolo, Richard A. Robison and Kim L. O’Neill

    Citation: Cancer Cell International 2019 19:19

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  2. Content type: Primary research

    The mechanism of pancreatic cancer metastasis remains poorly understood. Recently, lncRNA CASC2 has been demonstrated to be a tumor suppressor in various types of cancer. This study aimed to explore the mechan...

    Authors: Hui Zhang, Xielin Feng, Mingyi Zhang, Aixiang Liu, Lang Tian, Wentao Bo, Haiqing Wang and Yong Hu

    Citation: Cancer Cell International 2019 19:18

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  3. Content type: Primary research

    In our previous study, we demonstrated that Sirtuin 6 (SIRT6) is upregulated and associated with papillary thyroid cancer (PTC) progression (Qu et al. in Int J Oncol 50(5):1683–92, 2017). This study examined whet...

    Authors: Zhou Yang, Weiping Yu, Renhong Huang, Min Ye and Zhijun Min

    Citation: Cancer Cell International 2019 19:17

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  4. Content type: Primary research

    Head and Neck Squamous Cell Carcinoma (HNSCC) tumors are often resistant to therapies. Therefore searching for predictive markers and new targets for treatment in clinically relevant in vitro tumor models is e...

    Authors: Styliani Melissaridou, Emilia Wiechec, Mustafa Magan, Mayur Vilas Jain, Man Ki Chung, Lovisa Farnebo and Karin Roberg

    Citation: Cancer Cell International 2019 19:16

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  5. Content type: Primary research

    Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mec...

    Authors: Junsheng Gu, Xiaorui Liu, Juan Li and Yuting He

    Citation: Cancer Cell International 2019 19:15

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  6. Content type: Correction

    Following publication of the original article [1], we have been notified that the data in Fig. 1 was wrongly presented. The correct Fig. 1 is presented below.

    Authors: Xin-xin Cao, Hao Cai, Yue-ying Mao, Qi Wu, Lu Zhang, Dao-bin Zhou and Jian Li

    Citation: Cancer Cell International 2019 19:14

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    The original article was published in Cancer Cell International 2018 18:215

  7. Content type: Primary research

    Rosiglitazone metformin adduct (RZM) is a novel compound, synthesized from rosiglitazone (Ros) and metformin (Met) combined at a molar mass ratio of 1:1. Met and Ros are widely used together for treating type ...

    Authors: Yuyang Liu, Xiangnan Hu, Xuefeng Shan, Ke Chen and Hua Tang

    Citation: Cancer Cell International 2019 19:13

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  8. Content type: Review

    Genome editing allows for the precise manipulation of DNA sequences in a cell making this technology essential for understanding gene function. CRISPR/Cas9 is a targeted genome-editing platform derived from ba...

    Authors: Debarati Ghosh, Prabhadevi Venkataramani, Saikat Nandi and Sonali Bhattacharjee

    Citation: Cancer Cell International 2019 19:12

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  9. Content type: Primary research

    Estrogen exposure is a widely known risk factor for BC. And the interaction of estrogen with estrogen receptor (ER) plays an important role in breast cancer development. This case–control study aims to assess ...

    Authors: Zhijun Dai, Tian Tian, Meng Wang, Tielin Yang, Hongtao Li, Shuai Lin, Qian Hao, Peng Xu, Yujiao Deng, Linghui Zhou, Na Li and Yan Diao

    Citation: Cancer Cell International 2019 19:11

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  10. Content type: Primary research

    Although low-grade serous ovarian cancer (LGSC) is rare, case-fatality rates are high as most patients present with advanced disease and current cytotoxic therapies are not overly effective. Recognizing that t...

    Authors: Marta Llaurado Fernandez, Amy Dawson, Joshua Hoenisch, Hannah Kim, Sylvia Bamford, Clara Salamanca, Gabriel DiMattia, Trevor Shepherd, Mattia Cremona, Bryan Hennessy, Shawn Anderson, Stanislav Volik, Colin C. Collins, David G. Huntsman and Mark S. Carey

    Citation: Cancer Cell International 2019 19:10

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  11. Content type: Primary research

    T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiolog...

    Authors: Yanfei Jia, Yan Qi, Yunshan Wang, Xiaoli Ma, Yihui Xu, Jun Wang, Xiaoqian Zhang, Meihua Gao, Beibei Cong and Shuyi Han

    Citation: Cancer Cell International 2019 19:9

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  12. Content type: Primary research

    Cervical carcinoma is a major gynecological cancer and causes cancer-related deaths in worldwide, the latent pathogenesis and progress of cervical cancer is still under research. ClC-3 may be an important prom...

    Authors: Yu-tao Guan, Yong Xie, Hui Zhou, Hai-yan Shi, Yu-yuan Zhu, Xiao-lu Zhang, Yi Luan, Xi-ming Shen, Yang-ping Chen, Li-jiang Xu, Zhong-qiu Lin and Gang Wang

    Citation: Cancer Cell International 2019 19:8

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  13. Content type: Primary research

    Gambogic acid is a natural component isolated from gamboge that possesses anticancer properties. Our previous study suggested that gambogic acid might be involved in autophagy; however, its role in pancreatic ...

    Authors: Hongcheng Wang, Zhi Zhao, Shizhou Lei, Shaoli Li, Zhen Xiang, Xiaoyu Wang, Xiuyan Huang, Guanggai Xia and Xinyu Huang

    Citation: Cancer Cell International 2019 19:7

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  14. Content type: Primary research

    Many studies have aimed to clarify the relationship between Notch1 signaling and papillary thyroid carcinoma (PTC), but the results have been inconsistent to date. In the present study, a systematic review and...

    Authors: Libing Yuan, Lei Ma, Haibo Xue and Shoujun Song

    Citation: Cancer Cell International 2019 19:5

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  15. Content type: Primary research

    The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-med...

    Authors: Shi-chun Du, Lan Zhu, Yu-xing Wang, Jie Liu, Die Zhang, Yu-lu Chen, Qing Peng, Wei Liu and Bin Liu

    Citation: Cancer Cell International 2019 19:4

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  16. Content type: Primary research

    Previous studies have demonstrated that the expression of homeobox8 (HOXB8) is higher in colorectal cancer (CRC) tissues than in normal tissues; however, the precise role of HOXB8 in human CRC cells remains to...

    Authors: Tingting Wang, Feiyan Lin, Xuecheng Sun, Lei Jiang, Ruibo Mao, Shenyue Zhou, Wenjing Shang, Ruichun Bi, Fengying Lu and Shaotang Li

    Citation: Cancer Cell International 2019 19:3

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  17. Content type: Primary research

    The estrogen metabolite 2-methoxyestradiol (2ME2) and a number of synthesised derivatives have been shown to bind to microtubules thereby arresting cancer cells in mitosis which leads to apoptosis. In interpha...

    Authors: Rustelle Janse van Vuuren, Mandie Botes, Tamarin Jurgens, Anna Margaretha Joubert and Iman van den Bout

    Citation: Cancer Cell International 2019 19:1

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  18. Content type: Primary research

    ESPN (Espin), an actin filament-binding protein, plays an important role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializati...

    Authors: Shau-Hsuan Li, Hung-I Lu, Wan-Ting Huang, Yen-Hao Chen, Chien-Ming Lo, Ya-Chun Lan, Wei-Che Lin, Hsin-Ting Tsai and Chang-Han Chen

    Citation: Cancer Cell International 2018 18:219

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  19. Content type: Primary research

    Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it’s essential to...

    Authors: Jun Shang, Qian Song, Zuyi Yang, Xiaoyan Sun, Meijuan Xue, Wenjie Chen, Jingcheng Yang and Sihua Wang

    Citation: Cancer Cell International 2018 18:218

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  20. Content type: Review

    Many studies have investigated the prognostic role of biomarkers in colorectal liver metastases (CRLM). However, no biomarker has been established in routine clinical practice. The aim of this study was to scr...

    Authors: William Torén, Daniel Ansari and Roland Andersson

    Citation: Cancer Cell International 2018 18:217

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  21. Content type: Primary research

    Metastatic cancer to bone is well-known to produce extreme pain. It has been suggested that the magnitude of this perceived pain is associated with disease progression and poor prognosis. These data suggest a ...

    Authors: Silvia Gutierrez and M. Danilo Boada

    Citation: Cancer Cell International 2018 18:216

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  22. Content type: Primary research

    Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecula...

    Authors: Xin-xin Cao, Hao Cai, Yue-ying Mao, Qi Wu, Lu Zhang, Dao-bin Zhou and Jian Li

    Citation: Cancer Cell International 2018 18:215

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    The Correction to this article has been published in Cancer Cell International 2019 19:14

  23. Content type: Primary research

    Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid tumors. The rapid progression of PDAC results in an advanced stage of patients when diagnosed. However, the dynamic molecular mechanism und...

    Authors: Zongfu Pan, Lu Li, Qilu Fang, Yiwen Zhang, Xiaoping Hu, Yangyang Qian and Ping Huang

    Citation: Cancer Cell International 2018 18:214

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  24. Content type: Primary research

    Tumor suppressor epigenetic silencing plays an important role in non-small cell lung cancer (NSCLC) development and progression. Previously, the expression of speckle-type POZ protein (SPOP) has been found to ...

    Authors: Sumei Yao, Xinming Chen, Jinliang Chen, Yangbo Guan, Yifei Liu, Jianrong Chen and Xuedong Lv

    Citation: Cancer Cell International 2018 18:213

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  25. Content type: Primary research

    CXC chemokine receptor 7 (CXCR7) is frequently overexpressed in a variety of tumors. Nevertheless, whether CXCR7 can be used as a tumor prognosis marker has not been systematically assessed. The current meta-a...

    Authors: Huiqian Fan, Weijun Wang, Jingjing Yan, Li Xiao and Ling Yang

    Citation: Cancer Cell International 2018 18:212

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  26. Content type: Primary research

    Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tu...

    Authors: Gábor Petővári, Zoltán Hujber, Ildikó Krencz, Titanilla Dankó, Noémi Nagy, Fanni Tóth, Regina Raffay, Katalin Mészáros, Hajnalka Rajnai, Enikő Vetlényi, Krisztina Takács-Vellai, András Jeney and Anna Sebestyén

    Citation: Cancer Cell International 2018 18:211

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  27. Content type: Primary research

    It has been demonstrated that bufadienolides exert potent anti-cancer activity in various tumor types. However, the mechanisms that underlie their anti-cancer properties remain unclear. Yes-associated protein,...

    Authors: Li-Juan Deng, Ming Qi, Qun-Long Peng, Min-Feng Chen, Qi Qi, Jia-Yan Zhang, Nan Yao, Mao-Hua Huang, Xiao-Bo Li, Yin-Hui Peng, Jun-Shan Liu, Deng-Rui Fu, Jia-Xu Chen, Wen-Cai Ye and Dong-Mei Zhang

    Citation: Cancer Cell International 2018 18:209

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  28. Content type: Primary research

    TRIP13 is highly expressed in several cancers and is closely connected with cancer progression. However, its roles on the growth and metastasis of hepatocellular carcinoma (HCC), and the underlying mechanism a...

    Authors: Jianning Yao, Xuexiu Zhang, Jiaheng Li, Dongyao Zhao, Bing Gao, Haining Zhou, Shilin Gao and Lianfeng Zhang

    Citation: Cancer Cell International 2018 18:208

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  29. Content type: Primary research

    To investigate the potential prognostic role of pre-treatment prognostic nutritional index (PNI) in urinary cancers.

    Authors: Feng Qi, Xiang Zhou, Yi Wang, Yamin Wang, Yichun Wang, Qijie Zhang, Rong Cong, Jie Yang and Ninghong Song

    Citation: Cancer Cell International 2018 18:207

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  30. Content type: Primary research

    Chromophobe renal cell carcinoma (ChRCC) is the second common subtype of non-clear cell renal cell carcinoma (nccRCC), which accounting for 4–5% of renal cell carcinoma (RCC). However, there is no effective bi...

    Authors: Xiaomao Yin, Jianfeng Wang and Jin Zhang

    Citation: Cancer Cell International 2018 18:206

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  31. Content type: Hypothesis

    The origin of cancer cells is the most fundamental yet unresolved problem in cancer research. Cancer cells are thought to be transformed from the normal cells. However, recent studies reveal that the primary c...

    Authors: Qing-lin Dong and Xiang-ying Xing

    Citation: Cancer Cell International 2018 18:205

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  32. Content type: Primary research

    Homeobox C6 (HOXC6) plays a part in malignant progression of some tumors. However, the expression of HOXC6 and its clinical significance remains unclear in cervical carcinoma (CC). The purpose of this study is...

    Authors: Feng Zhang, Chen-Chen Ren, Ling Liu, Yan-Nan Chen, Li Yang and Xiao-An Zhang

    Citation: Cancer Cell International 2018 18:204

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  33. Content type: Primary research

    Colorectal cancer (CRC) is one of the most lethal malignancies. Tripartite Motif Containing 14 (TRIM14) is a member of TRIM family proteins, which are involved in the pathogenesis of various cancers. This stud...

    Authors: Zhonghai Jin, Hongguang Li, Xiaofei Hong, Guangrong Ying, Xiaofeng Lu, Lilei Zhuang and Shenbao Wu

    Citation: Cancer Cell International 2018 18:202

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  34. Content type: Review

    There is increasing evidence that inflammation-based biomarkers are associated with tumor microenvironment which plays important roles in cancer progression. A high lymphocyte-to-monocyte ratio (LMR), has been...

    Authors: Yiming Mao, Donglai Chen, Shanzhou Duan, Yuhuan Zhao, Changjiang Wu, Feng Zhu, Chang Chen and Yongbing Chen

    Citation: Cancer Cell International 2018 18:201

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  35. Content type: Primary research

    Apoptosis and autophagy are known to play important roles in cancer development. It has been reported that HVJ-E induces apoptosis in cancer cells, thereby inhibiting the development of tumors. To define the m...

    Authors: Tao Wang, Ning Yu, Miao Qian, Jie Feng, Shuyang Cao, Jun Yin and Quan Zhang

    Citation: Cancer Cell International 2018 18:200

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  36. Content type: Primary research

    To get insight into the molecular mechanisms underlying the anti-tumor activity of S-adenosyl-l-methionine (AdoMet), we analyzed AdoMet-induced modulation of microRNAs (miRNAs) expression profile in MCF-7 breast ...

    Authors: Concetta Paola Ilisso, Donatella Delle Cave, Laura Mosca, Martina Pagano, Alessandra Coppola, Luigi Mele, Michele Caraglia, Giovanna Cacciapuoti and Marina Porcelli

    Citation: Cancer Cell International 2018 18:197

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  37. Content type: Primary research

    RNA editing by adenosine deaminases acting on RNA (ADARs) converts adenosines to inosines (A-to-I) in RNA, that alters gene expression and generates protein diversity. Dysregulation of A-to-I editing has been ...

    Authors: Ying Zhang, Kuanyu Wang, Zheng Zhao, Si Sun, Kenan Zhang, Ruoyu Huang, Fan Zeng and Huimin Hu

    Citation: Cancer Cell International 2018 18:196

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  38. Content type: Primary research

    MicroRNAs play crucial roles in tumorigenesis and tumor progression. miR-770 has been reported to be downregulated in several cancers and affects cancer cell proliferation, apoptosis, metastasis and drug resis...

    Authors: Jun-feng Zhang, Jian-shui Zhang, Zhao-hua Zhao, Peng-bo Yang, Sheng-feng Ji, Nan Li, Qin-dong Shi, Jing Tan, Xi Xu, Cang-bao Xu and Ling-yu Zhao

    Citation: Cancer Cell International 2018 18:195

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  39. Content type: Primary research

    As one of the most common malignant tumors in humans, lung cancer has experienced a gradual increase in morbidity and mortality. This study examined prognosis-related methylation-driven genes specific to lung ...

    Authors: Chundi Gao, Jing Zhuang, Huayao Li, Cun Liu, Chao Zhou, Lijuan Liu and Changgang Sun

    Citation: Cancer Cell International 2018 18:194

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  40. Content type: Primary research

    Anoikis resistance has been demonstrated to facilitate distant metastases of cancers. MicroRNA-133b (miR-133b) is found to be down-regulated in various tumors, including esophageal squamous cell carcinoma (ESC...

    Authors: Jin-Feng Zhu, Yi Liu, He Huang, Li Shan, Zhi-Gang Han, Jun-Yuan Liu, Ying-Long Li, Xiang Dong and Wei Zeng

    Citation: Cancer Cell International 2018 18:193

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  41. Content type: Primary research

    The response of soft tissue sarcomas to cytotoxic chemotherapy is inconsistent. Biomarkers of chemoresistance or chemosensitivity are needed in order to identify appropriate patients for treatment. Given that ...

    Authors: Yike Bing, Zacharie Wund, Tina Abratte, Lucia Borlle, Susie Kang, Teresa Southard and Kelly R. Hume

    Citation: Cancer Cell International 2018 18:192

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  42. Content type: Primary research

    Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune respons...

    Authors: Bangshun He, Tao Xu, Bei Pan, Yuqin Pan, Xuhong Wang, Jingwu Dong, Huiling Sun, Xueni Xu, Xiangxiang Liu and Shukui Wang

    Citation: Cancer Cell International 2018 18:191

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  43. Content type: Primary research

    Rhabdoid tumors (RTs) are aggressive tumors that occur most frequently in children under 2 years old, which often invade kidney (KRTs) and Center Nervous System, named Atypical teratoid/rhabdoid tumors (AT/RTs...

    Authors: Yanming Ren, Chuanyuan Tao, Xiliang Wang and Yan Ju

    Citation: Cancer Cell International 2018 18:190

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