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  1. The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malign...

    Authors: Hany E. Marei, Asmaa Althani, Nahla Afifi, Anwarul Hasan, Thomas Caceci, Giacomo Pozzoli, Andrea Morrione, Antonio Giordano and Carlo Cenciarelli
    Citation: Cancer Cell International 2021 21:703
  2. Post-resistance progress in paclitaxel (PTX) treatment remains a major challenge in tumor treatment. A high dose of PTX was used for cell lines to analyze the changes in molecular expression. The miR-378d was ...

    Authors: Jie Peng, Susu Shi, Juan Yu, Jianli Liu, Haixiang Wei, Haixia Song, Shaoqiang Wang, Zhejie Li, Shujin He, Lei Li, Hongyan Zhang, Zhizhen Yan, Ran Zhao, Yukun Liu, Yanrong Liu, Junjun Li…
    Citation: Cancer Cell International 2021 21:702
  3. Epigenetic alterations contribute greatly to metastasis and dissemination in hepatocellular carcinoma (HCC). SMARCC1, as a SWI/SNF chromatin remodeling factor, has been reported to play important roles in many...

    Authors: Xiaopeng Cai, Jiaming Zhou, Jingwen Deng and Zhi Chen
    Citation: Cancer Cell International 2021 21:701
  4. Nowadays, acute leukemia (AL) among children has favorable outcome, yet some of them get refractory or relapse mainly due to drug resistance. High-mobility group box 1 (HMGB1) has been proven to have a importa...

    Authors: Weixin Lai, Xinyu Li, Qian Kong, Han Chen, Yunyao Li, Lu-Hong Xu and Jianpei Fang
    Citation: Cancer Cell International 2021 21:700
  5. Cholangiocarcinoma (CCA) is one of the deadliest cancers of the digestive tract. The prognosis of CCA is poor and the 5-year survival rate is low. Bioinformatic analysis showed that early mitotic inhibitor 2 (...

    Authors: Shuai Zhou, Kang Lin Qu, Jin Ang Li, Shi Lei Chen, Yi Gang Zhang, Chao Zhu, Hao Jin, Yong Wang, Qing Pang and Hui Chun Liu
    Citation: Cancer Cell International 2021 21:699
  6. Pancreatic cancer is one of the most common malignancies worldwide. In recent years, specific metabolic activities, which involves the development of tumor, caused wide public concern. In this study, we wish t...

    Authors: Weiyang Cai, Wenming Bao, Shengwei Chen, Yan Yang and Yanyan Li
    Citation: Cancer Cell International 2021 21:698
  7. Ovarian cancer is the leading cause of death from gynaecologic illnessed worldwide. Platelet-activating factor acetyl hydrolase IB2 (PAF-AH IB2) is an intracellular serine esterase that hydrolyzes platelet-act...

    Authors: YingYing He, Zhicheng He, Xiaoyu Zhang and Shubai Liu
    Citation: Cancer Cell International 2021 21:697
  8. Head and neck squamous cell carcinoma (HNSCC) are one of the most common types of head and neck cancer, and it is urgent to find effective treatment for advanced patients. Exploring developing and progressing ...

    Authors: You Fu, Guocai Tian, Zhiyuan Zhang and Xiao Yang
    Citation: Cancer Cell International 2021 21:696
  9. Thyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of grea...

    Authors: Xiaoyu Zhu, Xiaoping Wang, Yifei Gong and Junlin Deng
    Citation: Cancer Cell International 2021 21:695
  10. Skin cutaneous melanoma (SKCM) is the most common skin tumor with high mortality. The unfavorable outcome of SKCM urges the discovery of prognostic biomarkers for accurate therapy. The present study aimed to e...

    Authors: Hanwen Wang, Xiaoxia Xie, Junyou Zhu, Shaohai Qi and Julin Xie
    Citation: Cancer Cell International 2021 21:694
  11. Researches indicated the process of Endothelial-Mesenchymal-Transition (EndMT) of vascular endothelial cells (ECs) was critically involved in the progression of tumor. ECs demonstrated functional and phenotypi...

    Authors: Jingyuan Chen, Shengbo Han, Jinhuang Chen, Ping Hu, Zhu Zeng, Yuhang Hu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Fengyu Xu and Gang Zhao
    Citation: Cancer Cell International 2021 21:692
  12. Patients with small-cell lung cancer (SCLC) are burdened by limited treatment options and the disease’s dismal prognosis. Long non-coding RNAs (lncRNAs) are essential regulators of genetic alteration and are a...

    Authors: Zhihui Zhang, Yuejun Luo, Chaoqi Zhang, Peng Wu, Guochao Zhang, Qingpeg Zeng, Lide Wang, Liyan Xue, Zhaoyang Yang, Hua Zeng, Bo Zheng, Fengwei Tan, Qi Xue, Shugeng Gao, Nan Sun and Jie He
    Citation: Cancer Cell International 2021 21:691
  13. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and one of the most common cancers. While survival for localized ccRCC is good, the survival of metastatic disease is not, and...

    Authors: Sigrid Nakken, Øystein Eikrem, Hans-Peter Marti, Christian Beisland, Leif Bostad, Andreas Scherer, Arnar Flatberg, Vidar Beisvag, Eleni Skandalou, Jessica Furriol and Philipp Strauss
    Citation: Cancer Cell International 2021 21:690
  14. Osteosarcoma is the third most common cancer in adolescence and the first common primary malignant tumor of bone. The long-term prognosis of osteosarcoma still remains unsatisfactory in the past decades. There...

    Authors: Minchao Lv, Qingxin Xu, Bei Zhang, Zhiqiang Yang, Jun Xie, Jinku Guo, Feixiong He and Wei Wang
    Citation: Cancer Cell International 2021 21:689
  15. The neutrophil-to-lymphocyte ratio (NLR) as an inflammatory marker may represent changes between inflammation and host immunity that affect the prognosis of peripheral T-cell lymphoma (PTCL). To comprehensivel...

    Authors: Jia Liu, Shengnan Zhang, Ruihua Mi, Lin Chen and Qingsong Yin
    Citation: Cancer Cell International 2021 21:688
  16. Thyroid cancer remains the most prevailing endocrine malignancy, and a progressively increasing incidence rate has been observed in recent years, with 95% of thyroid cancer represented by differentiated thyroi...

    Authors: Guo Huang, Juan Chen, Jun Zhou, Shuai Xiao, Weihong Zeng, Jiliang Xia and Xi Zeng
    Citation: Cancer Cell International 2021 21:687
  17. Accumulating studies indicated that dysregulated long non-coding RNA human histocompatibility leukocyte antigen (HLA) Complex P5 (HCP5) may functions as an potential prognostic predictor in multiple cancers. T...

    Authors: Shao-pu Hu, Meng-xue Ge, Lei Gao, Min Jiang and Kai-wen Hu
    Citation: Cancer Cell International 2021 21:686
  18. Classical von Hippel Lindau (VHL) disease/syndrome includes CNS hemangioblastoma, renal or pancreatic cysts, pheochromocytoma, renal carcinoma and exodermic cystadenoma. The syndrome is caused by mutation of V...

    Authors: Dali Tong, Yao Zhang, Jun Jiang and Gang Bi
    Citation: Cancer Cell International 2021 21:685
  19. Angiogenesis provides essential nutrients and oxygen for tumor growth and has become the main mechanism of tumor invasion and metastasis. Exosomes are nanoscale membrane vesicles containing proteins, lipids, m...

    Authors: Xuewu You, Wenxiong Sun, Ying Wang, Xiaoli Liu, Aihong Wang, Lu Liu, Sai Han, Yu Sun, Junhua Zhang, Lingyu Guo and Youzhong Zhang
    Citation: Cancer Cell International 2021 21:684
  20. Multiple myeloma (MM) is the most common malignant hematological disease in the people worldwide. Glaucocalyxin A (GLA) is a bioactive ent-kauranoid diterpenoid, that is derived from Rabdosia japonica var. GLA ha...

    Authors: Mei Li, Cailong Chen, Qian Wang, Xiaolu Jiang, Lanlan Tan, Ying Huang, Yan Zhang and Zubin Zhang
    Citation: Cancer Cell International 2021 21:683
  21. One of the obstacles in treating different cancers, especially solid tumors, is cancer stem cells (CSCs) with their ability in resistance to chemo/radio therapy. The efforts for finding advanced treatments to ...

    Authors: Alireza Shokouhifar, Javad Firouzi, Masoumeh Nouri, Gholamreza Anani Sarab and Marzieh Ebrahimi
    Citation: Cancer Cell International 2021 21:682
  22. Several treatments are available for treatment of early and very early-stage Hepatocellular Carcinoma, also known as small Hepatocellular Carcinoma (SHCC). However, there is no consensus with regards to the ef...

    Authors: Sha Yang, Huapeng Lin and Jianning Song
    Citation: Cancer Cell International 2021 21:681
  23. Eukaryotic initiation factor 3a (EIF3A), a “reader” protein for RNA methylation, has been found to be involved in promoting tumorigenesis in a variety of cancers. The impact of EIF3A in clear cell renal cell c...

    Authors: Yi Zhang, Xiaoliang Hua, Haoqiang Shi, Li Zhang, Haibing Xiao and Chaozhao Liang
    Citation: Cancer Cell International 2021 21:680
  24. Growing evidence has shown that the prognosis for colon cancer depends on changes in microenvironment. The purpose of this study was to elucidate the prognostic value of long noncoding RNAs (lncRNAs) related t...

    Authors: Yilin Lin, Xiaoxian Pan, Zhihua Chen, Suyong Lin, Zhanlong Shen and Shaoqin Chen
    Citation: Cancer Cell International 2021 21:679
  25. Cervical cancer (CC) is the second most common cancer among women with high morbidity and mortality. TKTL1 is a key protein in glucose metabolism in cancer cells and controls the pentose phosphate pathway (PPP...

    Authors: Yingping Zhu, Yu Qiu and Xueqin Zhang
    Citation: Cancer Cell International 2021 21:678
  26. M2 macrophages are associated with a poor prognosis in a variety of malignancies. There are, however, few relevant investigations in clear cell renal cell carcinoma (ccRCC).

    Authors: Yingwei Xie, Zhiliang Chen, Qiyu Zhong, Zaosong Zheng, Yuqing Chen, Wentai Shangguan, Yishan Zhang, Jingying Yang, Dingjun Zhu and Wenlian Xie
    Citation: Cancer Cell International 2021 21:677
  27. Ferroptosis, an iron-dependent form of non-apoptotic cell death, is believed to strongly contribute to the pathogenesis of multiple cancers. Recently, the positive association between ferroptosis and urologic ...

    Authors: Shankun Zhao, Peng Li, Weizhou Wu, Qinzhang Wang, Biao Qian, Xin Li and Maolei Shen
    Citation: Cancer Cell International 2021 21:676
  28. Liquid biopsy (LB) has boosted a remarkable change in the management of cancer patients by contributing to tumour genomic profiling. Plasma circulating cell-free tumour DNA (ctDNA) is the most widely searched ...

    Authors: Maria Gabriela O. Fernandes, Natália Cruz-Martins, José Carlos Machado, José Luís Costa and Venceslau Hespanhol
    Citation: Cancer Cell International 2021 21:675
  29. Pancreatic cancer (PCa) is a fatal malignancy with poor prognosis, high recurrence and mortality. Substantial reports have suggested long non-coding RNAs (lncRNAs) are implicated in development of numerous mal...

    Authors: Jin Xu, Weixue Xu, Xuan Yang, Zhen Liu, Yiya Zhao and Qinyun Sun
    Citation: Cancer Cell International 2021 21:674
  30. Circular RNA (circRNA), producing by special selective splicing, was widely expressed in the cytoplasm of eukaryotic cells as a newly non-coding RNAs. It played different roles in a variety of diseases includi...

    Authors: Yankun Chen, Simiao Xu, Xinyuan Liu, Xueyi Jiang and Jianxin Jiang
    Citation: Cancer Cell International 2021 21:671
  31. Owing to the lack of effective treatment options, early metastasis remains the major cause of pancreatic ductal adenocarcinoma (PDAC) recurrence and mortality. However, the molecular mechanism of early metasta...

    Authors: Yuchong Zhao, Yun Wang, Wei Chen, Shuya Bai, Wang Peng, Mengli Zheng, Yilei Yang, Bin Cheng and Zhou Luan
    Citation: Cancer Cell International 2021 21:670
  32. Metabolic reprogramming has been reported in various kinds of cancers and is related to clinical prognosis, but the prognostic role of pyrimidine metabolism in gastric cancer (GC) remains unclear.

    Authors: Zhengxin Wu, Jinshui Tan, Yifan Zhuang, Mengya Zhong, Yubo Xiong, Jingsong Ma, Yan Yang, Zhi Gao, Jiabao Zhao, Zhijian Ye, Huiwen Zhou, Yuekun Zhu, Haijie Lu and Xuehui Hong
    Citation: Cancer Cell International 2021 21:668
  33. Increasing evidence has indicated that pyroptosis could regulate the tumor immune microenvironment (TIME) to affect the tumor development. As a highly immunogenic tumor, clear cell renal cell carcinoma (ccRCC)...

    Authors: Yan Zhang, Xianwu Chen, Qinghe Fu, Feifan Wang, Xuejian Zhou, Jiayong Xiang, Ning He, Zhenghui Hu and Xiaodong Jin
    Citation: Cancer Cell International 2021 21:667
  34. C1QTNF6 (CTRP6), a member of the CTRP family, has recently been implied to play a role in the tumorigenesis of for a variety of cancer types. However, the role of C1QTNF6 in oral squamous cell carcinoma (OSCC)...

    Authors: Xiaobin Song, Longjie Li, Liang Shi, Xinyu Liu, Xun Qu, Fengcai Wei and Ketao Wang
    Citation: Cancer Cell International 2021 21:666
  35. Lung cancer is one of the most lethal malignant tumors that endangers human health. Lung adenocarcinoma (LUAD) has increased dramatically in recent decades, accounting for nearly 40% of all lung cancer cases. ...

    Authors: Bai-Quan Qiu, Xia-Hui Lin, Song-Qing Lai, Feng Lu, Kun Lin, Xiang Long, Shu-Qiang Zhu, Hua-Xi Zou, Jian-Jun Xu, Ji-Chun Liu and Yong-Bing Wu
    Citation: Cancer Cell International 2021 21:665
  36. m6A (N6-methyladenosine) methylation, a well-known modification in tumour epigenetics, dynamically and reversibly fine tunes the entire process of RNA metabolism. Aberrant levels of m6A and its regulators, whi...

    Authors: Lin-Lin Chang, Xia-Qing Xu, Xue-Ling Liu, Qian-Qian Guo, Yan-Nan Fan, Bao-Xia He and Wen-Zhou Zhang
    Citation: Cancer Cell International 2021 21:663
  37. Gastric cancer is a highly aggressive malignant tumor with heterogeneity and is still a global health problem. The present study aimed to investigate the role of Cyclin I-like (CCNI2) in the regulation of phen...

    Authors: Wenchao Chen, Yang Zhou, Gang Wu and Peichun Sun
    Citation: Cancer Cell International 2021 21:661
  38. In bladder cancer, up to 70% of patients will relapse after resection within 5 years, in which the mechanism underlying the recurrence remains largely unclear.

    Authors: Junhao Zhou, Hu Tian, Xi Zhi, Zhuoyu Xiao, Taoyi Chen, Haoyu Yuan, Qi Chen, Mingkun Chen, Jiankun Yang, Qizhao Zhou, Kangyi Xue, Wenbin Guo, Ming Xia, Jiming Bao, Cheng Yang, Haifeng Duan…
    Citation: Cancer Cell International 2021 21:660
  39. Prodigiosin (PG), a natural red pigment produced by numerous bacterial species, has been a eye-catching research point in recent years for its anticancer activity. However, the role of PG in the cancer biology...

    Authors: Dijie Zheng, Shiyu Chen, Kun Cai, Linhan Lei, Chunchen Wu, Chengyi Sun, Yazhu Deng and Chao Yu
    Citation: Cancer Cell International 2021 21:658
  40. Intrahepatic cholangiocarcinoma (ICC) is a fatal primary liver cancer, and its long-term survival rate remains poor. RNA-binding proteins (RBPs) play an important role in critical cellular processes, failure o...

    Authors: Wenbo Zou, Zizheng Wang, Xiuping Zhang, Shuai Xu, Fei Wang, Lincheng Li, Zhaoda Deng, Jing Wang, Ke Pan, Xinlan Ge, Chonghui Li, Rong Liu and Minggen Hu
    Citation: Cancer Cell International 2021 21:657
  41. Accumulating evidence has demonstrated the close relation of SOX1 with tumorigenesis and tumor progression. Upregulation of SOX1 was recently shown to suppress growth of human cancers. However, the expression ...

    Authors: Da Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Bing Wang and Yongjun Chen
    Citation: Cancer Cell International 2021 21:656
  42. Tumor migration and invasion is a complex and diverse process that involves the epithelial–mesenchymal transition (EMT) of tumor cells and degradation of the extracellular matrix by matrix metalloproteases (MM...

    Authors: Mengying Teng, Chunyan Hu, Bingmo Yang, Wei Xiao, Qian Zhou, Yuan Li and Zhong Li
    Citation: Cancer Cell International 2021 21:654
  43. MYB is often overexpressed in malignant tumors and plays a carcinogenic role in the initiation and development of cancer. Deletion of the MYB regulatory C-terminal domain may be a driving mutation leading to t...

    Authors: Dingyu Hu, Wenjun Shao, Li Liu, Yanyan Wang, Shunling Yuan, Zhaoping Liu, Jing Liu and Ji Zhang
    Citation: Cancer Cell International 2021 21:653

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