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  1. Hypoxia, which affects the development, metastasis and prognosis of cancer, represents a key feature of cancer. This study describe a hypoxia risk factor model, with predicting the prognosis of cervical cancer.

    Authors: Yang Yang, Yaling Li, Ruiqun Qi and Lan Zhang

    Citation: Cancer Cell International 2021 21:345

    Content type: Primary research

    Published on:

  2. Although immunotherapy for colon cancer has made promising progress, only a few patients currently benefit from it. A recent study revealed that infiltrating immune cells are highly relevant to tumor prognosis...

    Authors: Hao Xu, Qianhui Xu and Lu Yin

    Citation: Cancer Cell International 2021 21:344

    Content type: Primary research

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  3. Long non-coding RNAs (lncRNAs) are increasingly recognized as the crucial mediators in the regulation of ferroptosis and iron metabolism. A systematic understanding of ferroptosis and iron-metabolism related l...

    Authors: Jie Yao, Xiao Chen, Xiao Liu, Rui Li, Xijia Zhou and Yiqing Qu

    Citation: Cancer Cell International 2021 21:340

    Content type: Primary research

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  4. Osteosarcoma (OS) is a common type of bone malignancy that often occurs in children and adolescents. Chemoresistance is a huge barrier to cancer therapy. This study aimed to investigate the role and potential ...

    Authors: Huapeng Guan, Hao Xu, Jinshui Chen, Weishan Wu, Dongfeng Chen, Yungang Chen and Jianzhong Sun

    Citation: Cancer Cell International 2021 21:336

    Content type: Primary research

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  5. Gastric cancer (GC) is one of the most common cancer worldwide. It is essential to identify non-invasive diagnostic and prognostic biomarkers of GC. The aim of the present study was to screen candidate biomark...

    Authors: Lei Liu, Honglin Pang, Qiao He, Biran Pan, Xiaobin Sun, Jing Shan, Liping Wu, Kaiwen Wu, Xue Yao and Yuanbiao Guo

    Citation: Cancer Cell International 2021 21:335

    Content type: Primary research

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  6. Lung cancer is one of the most common malignant tumours worldwide. however, emerging immunotherapy and targeted therapies continue to show limited efficacy. In the search for new targets for lung cancer treatm...

    Authors: Runzhi Qi, Yuwei Zhao, Qiujun Guo, Xue Mi, Mengqi Cheng, Wei Hou, Honggang Zheng and Baojin Hua

    Citation: Cancer Cell International 2021 21:333

    Content type: Review

    Published on:

  7. BCL2L13 belongs to the BCL2 super family, with its protein product exhibits capacity of apoptosis-mediating in diversified cell lines. Previous studies have shown that BCL2L13 has functional consequence in severa...

    Authors: Fei Meng, Luojin Zhang, Mingjun Zhang, Kaiqin Ye, Wei Guo, Yu Liu, Wulin Yang, Zhimin Zhai, Hongzhi Wang, Jun Xiao and Haiming Dai

    Citation: Cancer Cell International 2021 21:332

    Content type: Primary research

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  8. Emerging evidence shows that abnormal expression of long non-coding RNA is involved in the occurrence and development of various tumors. LncRNA MONC is abnormally expressed in head and neck squamous cell carci...

    Authors: Yibing Li, Jianing Huo, Junjian He and Xiaoxin Ma

    Citation: Cancer Cell International 2021 21:331

    Content type: Primary research

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  9. Hepatocellular carcinoma (HCC) has a poor prognosis and has become the sixth most common malignancy worldwide due to its high incidence. Advanced approaches to therapy, including immunotherapeutic strategies, ...

    Authors: Qiuxian Zheng, Qin Yang, Jiaming Zhou, Xinyu Gu, Haibo Zhou, Xuejun Dong, Haihong Zhu and Zhi Chen

    Citation: Cancer Cell International 2021 21:330

    Content type: Primary research

    Published on:

  10. Patients with nasopharyngeal cancer (NPC) differ in prognosis, even at the same stage; therefore, new biomarkers are urgently required to identify early-stage NPC patients at high risk of poor prognosis. Altho...

    Authors: Tianhao Liang, Weixing Liu, Junyang Xie, Yiyan Wang, Gui Chen, Wenjing Liao, Lijuan Song and Xiaowen Zhang

    Citation: Cancer Cell International 2021 21:329

    Content type: Review

    Published on:

  11. Small non‐coding RNAs (sncRNAs) are a subgroup of non‐coding RNAs, with less than 200 nucleotides length and no potential for coding proteins. PiRNAs, a member of sncRNAs, were first discovered more than a dec...

    Authors: Fatemeh Sadoughi, Seyyed Mehdi Mirhashemi and Zatollah Asemi

    Citation: Cancer Cell International 2021 21:328

    Content type: Review

    Published on:

  12. CD58 has been demonstrated to be abnormally expressed in multiple hematopoietic malignancies and solid tumors and plays an essential role in tumorigenesis and progression; however, its clinical significance an...

    Authors: Yalu Zhang, Qiaofei Liu, Jingkai Liu and Quan Liao

    Citation: Cancer Cell International 2021 21:327

    Content type: Primary research

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  13. RNA binding protein (RBP) is an active factor involved in the occurrence and development of colorectal cancer (CRC). Therefore, the potential mechanism of RBP in CRC needs to be clarified by dry-lab analyses o...

    Authors: Qinglian He, Ziqi Li, Xue Lei, Qian Zou, Haibing Yu, Yuanlin Ding, Guangxian Xu and Wei Zhu

    Citation: Cancer Cell International 2021 21:325

    Content type: Primary research

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  14. Circular RNAs (circRNAs) have been reported to be important regulators of the development and progression of various carcinomas. However, the role of circRNA_100290 in gastric cancer (GC) is still unclear. Thi...

    Authors: Gang Wang, Dan Sun, Wenhui Li and Yan Xin

    Citation: Cancer Cell International 2021 21:324

    Content type: Primary research

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  15. The dysfunction of myc-related zinc finger protein (MAZ) has been proven to contribute to tumorigenesis and development of multiple cancer types. However, the biological roles and clinical significance of MAZ ...

    Authors: Li-Xin Ren, Jin-Chun Qi, An-Ning Zhao, Bei Shi, Hong Zhang, Dan-Dan Wang and Zhan Yang

    Citation: Cancer Cell International 2021 21:323

    Content type: Primary research

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  16. It have been proven that long non-coding RNAs (lncRNAs) serve as regulators in carcinogenesis. Interleukin enhancer binding factor 3 antisense RNA 1 (ILF3-AS1) has been illuminated as a prognostic factor in so...

    Authors: Zhaohui Zeng, Qiangfeng Teng and Jinhong Xiao

    Citation: Cancer Cell International 2021 21:322

    Content type: Primary research

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  17. Long non-coding RNAs (lncRNAs), a class of non-coding RNAs (ncRNAs) associated with diverse biological processes of cells. Over the past decades, cumulating research evidences revealed that abnormal expression...

    Authors: Md Zahirul Islam Khan and Helen Ka Wai Law

    Citation: Cancer Cell International 2021 21:321

    Content type: Primary research

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  18. Rho GTPase activating protein 10 (ARHGAP10) has been implicated as an essential element in multiple cellular process, including cell migration, adhesion and actin cytoskeleton dynamic reorganization. However, ...

    Authors: Lan-Lan Lin, Fan Yang, Dong-Huan Zhang, Cong Hu, Sheng Yang and Xiang-Qi Chen

    Citation: Cancer Cell International 2021 21:320

    Content type: Primary research

    Published on:

  19. Angiogenic switch is a hallmark feature of transition from low-grade to high-grade cervical intraepithelial neoplasia (CIN) in cervical cancer progression. Therefore, early events leading to locally-advanced c...

    Authors: Anjali Bhat, Joni Yadav, Kulbhushan Thakur, Nikita Aggarwal, Tanya Tripathi, Arun Chhokar, Tejveer Singh, Mohit Jadli and Alok Chandra Bharti

    Citation: Cancer Cell International 2021 21:319

    Content type: Primary research

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  20. The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of ...

    Authors: Javad Sharifi-Rad, Cristina Quispe, Monica Butnariu, Lia Sanda Rotariu, Oksana Sytar, Simona Sestito, Simona Rapposelli, Muhammad Akram, Mehwish Iqbal, Akash Krishna, Nanjangud Venkatesh Anil Kumar, Susana S. Braga, Susana M. Cardoso, Karolina Jafernik, Halina Ekiert, Natália Cruz-Martins…

    Citation: Cancer Cell International 2021 21:318

    Content type: Review

    Published on:

  21. Circular RNAs (circRNAs) are RNAs that have an important role in various pathological processes, including cancer. After the usage of high-throughput RNA sequencing, many circRNAs were found to be differential...

    Authors: Pranavi Garlapati, Jinjie Ling, Paul J. Chiao and Jie Fu

    Citation: Cancer Cell International 2021 21:317

    Content type: Review

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  22. Laryngeal carcinoma is a primary malignant tumor originating from the laryngeal mucosa, and its pathogenesis is not fully understood. It is a rare type of cancer that shows a downward trend in the 5-year survi...

    Authors: Yan Huang, Min Gu, Yiting Tang, Zhiqiang Sun, Judong Luo and Zhe Li

    Citation: Cancer Cell International 2021 21:316

    Content type: Review

    Published on:

  23. RSF1, remodelling and spacing factor 1, is an important interphase centromere protein and is overexpressed in many types of cancers and correlated with poor overall survival. RSF1 has functions mainly in maint...

    Authors: Guiyang Cai, Qing Yang and Wei Sun

    Citation: Cancer Cell International 2021 21:315

    Content type: Review

    Published on:

  24. Epithelial ovarian cancer remains one of the leading causes of cancer deaths among women worldwide, and advanced epithelial ovarian cancer frequently metastasizes to the omentum. The characteristics of metasta...

    Authors: Kosuke Yoshida, Nobuhisa Yoshikawa, Kazuhisa Kitami, Satoshi Tamauchi, Yoshiki Ikeda, Akira Yokoi, Kimihiro Nishino, Kaoru Niimi and Hiroaki Kajiyama

    Citation: Cancer Cell International 2021 21:314

    Content type: Primary research

    Published on:

  25. Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or...

    Authors: Jieyu He, Lin Ling, Zhongyue Liu, Xiaolei Ren, Lu Wan, Chao Tu and Zhihong Li

    Citation: Cancer Cell International 2021 21:313

    Content type: Review

    Published on:

  26. Circular RNAs (circRNAs) have been implicated in the initiation and development of breast cancer as functional non-coding RNAs (ncRNA). The roles of circRNAs as the competing endogenous RNAs (ceRNAs) to sponge...

    Authors: Farzaneh Darbeheshti, Elham Zokaei, Yaser Mansoori, Sima Emadi Allahyari, Zeeba Kamaliyan, Sepideh Kadkhoda, Javad Tavakkoly Bazzaz, Nima Rezaei and Abbas Shakoori

    Citation: Cancer Cell International 2021 21:312

    Content type: Primary research

    Published on:

  27. Myocardial damage is a mostly incurable complication of multiple myeloma (MM) that seriously affects the treatment outcome and quality of life of patients. Exosomal circular RNAs (exo-circRNAs) play an importa...

    Authors: Runjie Sun, Wei Liu, Yangang Zhao, Haoyu Chen, Zhenzhen Wang, Yanyu Zhang, Xiaoqi Sun and Xing Cui

    Citation: Cancer Cell International 2021 21:311

    Content type: Primary research

    Published on:

  28. Tumor-infiltrating B lymphocytes (TIL-Bs) is a heterogeneous population of lymphocytes. The prognostic value of TIL-Bs in patients with breast cancer remains controversial. Here we conducted this meta-analysis...

    Authors: You Qin, Fei Peng, Lisha Ai, Shidai Mu, Yuting Li, Chensu Yang and Yu Hu

    Citation: Cancer Cell International 2021 21:310

    Content type: Review

    Published on:

  29. High-risk human papillomaviruses (HPVs) are present and can cooperate with Epstein–Barr virus (EBV) to initiate and/or enhance the progression of several types of human carcinomas including cervical as well as...

    Authors: Karim Nagi, Ishita Gupta, Nawaf Jurdi, Ayesha Jabeen, Amber Yasmeen, Gerald Batist, Semir Vranic and Ala-Eddin Al-Moustafa

    Citation: Cancer Cell International 2021 21:308

    Content type: Primary research

    Published on:

  30. An increasing number of studies have shown that circular RNAs (circRNAs) play important roles in the regulation of tumor progression. Therefore, we explored the expression characteristics, function, and relate...

    Authors: Yi Liu, Simin Chen, Gang Peng, Yiwei Liao, Xuegong Fan, Zuping Zhang and Chenfu Shen

    Citation: Cancer Cell International 2021 21:307

    Content type: Primary research

    Published on:

  31. Drug resistance is always a great obstacle in any endocrine therapy of breast cancer. Although the combination of endocrine therapy and targeted therapy has been shown to significantly improve prognosis, refra...

    Authors: Jing Chen, Runlan Wan, Qinqin Li, Zhenghuan Rao, Yanlin Wang, Lei Zhang and Alexander Tobias Teichmann

    Citation: Cancer Cell International 2021 21:306

    Content type: Review

    Published on:

  32. This study incorporates fundamental research referring to considerable amounts of gene-sequencing data and bioinformatics tools to analyze the pathological mechanisms of diffuse large B-cell lymphoma (DLBCL).

    Authors: Yuying Cui, Hui Xu, Yu Yang, Dongmei Zhao, Yu Wen, Chao Lv, Hongbin Qiu and Chennan Wang

    Citation: Cancer Cell International 2021 21:305

    Content type: Primary research

    Published on:

  33. Echinacoside (ECH) is the main active ingredient of Cistanches Herba, which is known to have therapeutic effects on metastatic tumors. However, the effects of ECH on liver cancer are still unclear. This study was...

    Authors: Wen Li, Jing Zhou, Yajie Zhang, Jing Zhang, Xue Li, Qiao Yan, Jiabing Han and Fangdi Hu

    Citation: Cancer Cell International 2021 21:304

    Content type: Primary research

    Published on:

  34. Various diagnostic and prognostic tools exist in colorectal cancer (CRC) due to multiple genetic and epigenetic alterations causing the disease. Today, the expression of RNAs is being used as prognostic marker...

    Authors: Fahimeh Fattahi, Jafar Kiani, Mahdi Alemrajabi, Ahmadreza Soroush, Marzieh Naseri, Mohammad Najafi and Zahra Madjd

    Citation: Cancer Cell International 2021 21:303

    Content type: Primary research

    Published on:

  35. Malignant tumours of the female reproductive system threaten the lives and health of women worldwide, with ovarian cancer having the highest mortality rate. Based on previous work, this study analysed the expr...

    Authors: Xiao Li, Caixia Wang, Shuang Wang, Yuexin Hu, Shan Jin, Ouxuan Liu, Rui Gou, Xin Nie, Juanjuan Liu and Bei Lin

    Citation: Cancer Cell International 2021 21:302

    Content type: Primary research

    Published on:

  36. Osteosarcoma (OS) is a common malignant bone tumor with poor prognosis. We previously reviewed that CD146 is correlated with multiple cancer progression, while its impact on OS is currently not systematically ...

    Authors: Xing Lei, Kewei Wang, Wenbo Wang, Hao Jin, Wenguang Gu, Zhiguo Chen, Wei Wang, Kaituo Gao and Huan Wang

    Citation: Cancer Cell International 2021 21:300

    Content type: Primary research

    Published on:

  37. Colorectal cancer (CRC) is the leading cause of cancer deaths and most common malignant tumors worldwide. Immune-related genes (IRGs) can predict prognoses of patients and the effects of immunotherapy. A serie...

    Authors: Xuankun Yang, Jia Yan, Yahui Jiang and Yaxu Wang

    Citation: Cancer Cell International 2021 21:299

    Content type: Primary research

    Published on:

  38. The natural killer (NK) cells differentiated from umbilical cord blood (UCB) hematopoietic stem cells (HSCs) may be more suitable for cell-based immunotherapy compared to the NK cells from adult donors. This i...

    Authors: Alireza Shokouhifar, Gholamreza Anani Sarab, Mahboubeh Yazdanifar, Mohammad Fereidouni, Masoumeh Nouri and Marzieh Ebrahimi

    Citation: Cancer Cell International 2021 21:298

    Content type: Primary research

    Published on:

  39. Although many biomarkers have been reported for detecting glioma, the prognosis for the disease remains poor, and therefore, new biomarkers need to be identified. GNG5, which is part of the G-protein family, has ...

    Authors: Wang Zhang, Zhendong Liu, Binchao Liu, Miaomiao Jiang, Shi Yan, Xian Han, Hong Shen, Meng Na, Yanbiao Wang, Zhishuai Ren, Binfeng Liu, Zhenfeng Jiang, Yanzheng Gao and Zhiguo Lin

    Citation: Cancer Cell International 2021 21:297

    Content type: Primary research

    Published on:

  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai, Yanqing Wang, Yaqi Fan, Mengqin Yuan, Dongyong Yang, Yajing Zheng, Zhimin Deng, Yeqiang Liu and Yanxiang Cheng

    Citation: Cancer Cell International 2021 21:296

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2020 20:519

  41. As the essential sexual hormone, estrogen and its receptor has been proved to participate in the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor immunity is related to the ...

    Authors: Tiecheng Wang, Jiakang Jin, Chao Qian, Jianan Lou, Jinti Lin, Ankai Xu, Kaishun Xia, Libin Jin, Bing Liu, Huimin Tao, Zhengming Yang and Wei Yu

    Citation: Cancer Cell International 2021 21:295

    Content type: Review

    Published on:

  42. Lung adenocarcinoma (LUAD) is one of the most common types in the world with a high mortality rate. Despite advances in treatment strategies, the overall survival (OS) remains short. Our study aims to establis...

    Authors: Aisha Al-Dherasi, Qi-Tian Huang, Yuwei Liao, Sultan Al-Mosaib, Rulin Hua, Yichen Wang, Ying Yu, Yu Zhang, Xuehong Zhang, Chao Huang, Haithm Mousa, Dongcen Ge, Sufiyan Sufiyan, Wanting Bai, Ruimei Liu, Yanyan Shao…

    Citation: Cancer Cell International 2021 21:294

    Content type: Primary research

    Published on:

  43. The expression of forkhead box protein H1 (FOXH1) is frequently upregulated in various cancers. However, the molecular mechanisms underlying the association between FOXH1 expression and lung cancer progression...

    Authors: Jun Zhang, Xian Zhang, Shasha Yang, Yanqiu Bao, Dongyuan Xu and Lan Liu

    Citation: Cancer Cell International 2021 21:293

    Content type: Primary research

    Published on:

  44. Lung adenocarcinoma (LAD) is one of the most frequently diagnosed pathological categories of human lung cancer. Nevertheless, the link between long non-coding RNA (lncRNA) LINC01116 and LAD remains poorly inve...

    Authors: Ping Ren, Liang Chang, Xiaodong Hong, Lei Xing and Hong Zhang

    Citation: Cancer Cell International 2021 21:292

    Content type: Primary research

    Published on:

  45. Pancreatic cancer (PC) is a highly fatal and aggressive disease with its incidence and mortality quite discouraging. An effective prediction model is urgently needed for the accurate assessment of patients’ pr...

    Authors: Yuan Chen, Ruiyuan Xu, Rexiati Ruze, Jinshou Yang, Huanyu Wang, Jianlu Song, Lei You, Chengcheng Wang and Yupei Zhao

    Citation: Cancer Cell International 2021 21:291

    Content type: Primary research

    Published on:

  46. Interferon regulatory factor-1 (IRF1) affects the proliferation of colorectal cancer (CRC). Recombinant interferon inducible protein 35 (IFI35) participates in immune regulation and cell proliferation. The aim...

    Authors: Yan Hu, Bing Wang, Ke Yi, Qingjun Lei, Guanghui Wang and Xiaohui Xu

    Citation: Cancer Cell International 2021 21:290

    Content type: Primary research

    Published on:

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