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  1. Immune checkpoint inhibitors are the most studied forms of immunotherapy for triple-negative breast cancer (TNBC). The Cancer Genome Map (TCGA) and METABRIC project provide large-scale cancer samples that can ...

    Authors: Ying Zhong, Fangyuan Li, Sumei Zhang, Zhenli Yang, Xinyu Ren, Xi Cao, Yali Xu, Dan Guo, Yidong Zhou, Feng Mao, Songjie Shen and Qiang Sun
    Citation: Cancer Cell International 2023 23:76
    Content type: Research Published on:

  2. KRAS mutations are fraught with the progression of colorectal cancer and resistance to chemotherapy. There are pathways such as extracellular regulated protein kinase 1/2 (ERK1/2) and Akt downstream and farnes...

    Authors: Masanobu Tsubaki, Tomoya Takeda, Takuya Matsuda, Kana Kishimoto, Honoka Takefuji, Yuzuki Taniwaki, Misa Ueda, Tadafumi Hoshida, Kazufumi Tanabe and Shozo Nishida
    Citation: Cancer Cell International 2023 23:73
    Content type: Research Published on:

  3. Accumulating evidence demonstrated that nuclear factor erythroid 2-related factor 2 (NRF2) expression plays a crucial role in the proliferation, invasion and metastasis of hepatocellular carcinoma (HCC). Howev...

    Authors: Yanqiong Liu, Qiulian Wu, Fuyong Zhang and Xue Qin
    Citation: Cancer Cell International 2023 23:72
    Content type: Research Published on:

  4. Lung cancer is one of the most frequently diagnosed cancers and the leading cause of cancer-related deaths worldwide. Deep understanding of chemoresistance will lead to remarkable progress in lung cancer treat...

    Authors: Hongmei Yuan, Hongge Wu, Jing Cheng and Jie Xiong
    Citation: Cancer Cell International 2023 23:71
    Content type: Research Published on:

  5. Cancer-associated fibroblasts (CAFs) play an essential role in tumorigenesis and development of cancers. Nevertheless, the specific molecular mechanism of tumorigenesis and development in Laryngeal squamous ce...

    Authors: Liyun Yang, Shiqi Gong, Peipei Qiao, Runyu Zhao, Shuixian Huang, Jieyu Zhou and An Hu
    Citation: Cancer Cell International 2023 23:70
    Content type: Research Published on:

  6. Stomach adenocarcinoma (STAD) is the third leading cause of cancer-related deaths and the fifth most prevalent malignancy worldwide. Mitochondrial respiratory chain complexes play a crucial role in STAD pathog...

    Authors: Jing Yang, Feifan Jin, Huanjuan Li, Yuhuan Shen, Weilin Shi, Lina Wang, Lei Zhong, Gongqiang Wu, Qiaoliang Wu and Yanchun Li
    Citation: Cancer Cell International 2023 23:69
    Content type: Research Published on:

  7. Phosphoenolpyruvate carboxykinase 1 (PCK1) is the rate-limiting enzyme in gluconeogenesis. PCK1 is considered an anti-oncogene in several human cancers. In this study, we aimed to determine the functions of PC...

    Authors: Xiangyan Zhang, Geru Tao, Jie Jiang, Tingting Qu, Shuchao Zhao, Ping Xu, Ya’nan Zhao, Xiaoming Xing and Shucun Qin
    Citation: Cancer Cell International 2023 23:68
    Content type: Research Published on:

  8. Nuclear factor-ĸB (NF-ĸB) is an important transcriptional regulator of key cellular processes, including cell cycle, immune response, and malignant transformation. We found that the ubiquitin ligase Kip1 ubiqu...

    Authors: Yelena Kravtsova-Ivantsiv, Gilad Goldhirsh, Ciprian Tomuleasa, Eli Pikarsky and Aaron Ciechanover
    Citation: Cancer Cell International 2023 23:67
    Content type: Review Published on:

  9. Reprogrammed lipid metabolism is a hallmark of cancer that provides energy, materials, and signaling molecules for rapid cancer cell growth. Cancer cells acquire fatty acids primarily through de novo synthesis...

    Authors: Jie Hong, Jie Liu, Yanan Zhang, Lihua Ding and Qinong Ye
    Citation: Cancer Cell International 2023 23:66
    Content type: Research Published on:

  10. Sphingosine-1-phosphate (S1P) is a lipid mediator and its binding to the S1P receptor 2 (S1PR2) is reported to regulate cytoskeletal organization. Epidermal growth factor (EGF) has been shown to induce migrati...

    Authors: Adjabhak Wongviriya, Richard M. Shelton, Paul R. Cooper, Michael R. Milward and Gabriel Landini
    Citation: Cancer Cell International 2023 23:65
    Content type: Research Published on:

  11. Cancer is still the leading cause of death globally. The approval of the therapeutic use of monoclonal antibodies against immune checkpoint molecules, notably those that target the proteins PD-1 and PD-L1, has...

    Authors: Hany E. Marei, Anwarul Hasan, Giacomo Pozzoli and Carlo Cenciarelli
    Citation: Cancer Cell International 2023 23:64
    Content type: Review Published on:

  12. Autophagy related protease 4B (ATG4B) is a protease required for autophagy processing, which is strongly implicated in cancer progression.  Phosphorylation of ATG4B is crucial for activation of its protease ac...

    Authors: Wan-Hsiang Hu, Ting-Ting Liu, Pei-Feng Liu, Paul Morgan, I-Ling Lin, Wei-Lun Tsai, Yi-Yun Cheng, Ang-Tsen Hsieh, Tsung-Hui Hu and Chih-Wen Shu
    Citation: Cancer Cell International 2023 23:63
    Content type: Research Published on:

  13. Glioblastoma (GBM) is the most common and lethal brain tumor. The current treatment is surgical removal combined with radiotherapy and chemotherapy, Temozolomide (TMZ). However, tumors tend to develop TMZ resi...

    Authors: Pei-Chi Chang, Yu-Chieh Lin, Hui-Ju Yen, Dueng-Yuan Hueng, Shih-Ming Huang and Yao-Feng Li
    Citation: Cancer Cell International 2023 23:62
    Content type: Research Published on:

  14. Chronic myeloid leukemia (CML) is a hematological tumor derived from hematopoietic stem cells. The aim of this study is to analyze the biological characteristics and identify the diagnostic markers of CML. We ...

    Authors: Fang-Min Zhong, Fang-Yi Yao, Yu-Lin Yang, Jing Liu, Mei-Yong Li, Jun-Yao Jiang, Nan Zhang, Yan-Mei Xu, Shu-Qi Li, Ying Cheng, Shuai Xu, Bo Huang and Xiao-Zhong Wang
    Citation: Cancer Cell International 2023 23:61
    Content type: Research Published on:

  15. The alpha-fetoprotein receptor (AFPR) is a novel target for cancer therapeutics. It is expressed on most cancers and myeloid derived suppressor cells (MDSCs) but generally absent on normal tissues. Studies wer...

    Authors: Patricia Griffin, Wendy A. Hill, Fabio Rossi, Rebecca Boohaker, Karr Stinson and Igor Sherman
    Citation: Cancer Cell International 2023 23:60
    Content type: Research Published on:

  16. Non-homologous DNA end joining (NHEJ) is the predominant DNA double-strand break (DSB) repair pathway in human. However, the relationship between NHEJ pathway and hepatocellular carcinoma (HCC) is unclear. We ...

    Authors: Zhu Lin, Zhenkun Huang, Yunxing Shi, Yichuan Yuan, Yi Niu, Binkui Li, Yunfei Yuan and Jiliang Qiu
    Citation: Cancer Cell International 2023 23:59
    Content type: Research Published on:

  17. The incidence of lung cancer (LC) in chronic obstructive pulmonary disease (COPD) patients is dozens of times higher than that in patients without COPD. Elevated activity of nuclear factor-k-gene binding (NF-κ...

    Authors: Jingjing Lu, Yan Shi, Feng Zhang, Ying Zhang, Xiangwang Zhao, Haiyan Zheng, Lingyu Li, Shiqiao Zhao and Liming Zhao
    Citation: Cancer Cell International 2023 23:58
    Content type: Research Published on:

  18. In vivo investigations with cancer cells have powerful tools to discover cancer progression mechanisms and preclinical candidate drugs. Among these in vivo experimental models, the establishment of highly mali...

    Authors: Yusuke Hayashi, Jun Nakayama, Mizuki Yamamoto, Masashi Maekawa, Shinya Watanabe, Shigeki Higashiyama, Jun-ichiro Inoue, Yusuke Yamamoto and Kentaro Semba
    Citation: Cancer Cell International 2023 23:57
    Content type: Research Published on:

  19. Authors: Nouf S. Al‑Numair, Abdulrahman Theyab, Faisal Alzahrani, Anwar M. Shams, Ibrahim O. Al‑Anazi, Atif Abdulwahab A. Oyouni, Osama M. Al‑Amer, Charalampos Mavromatis, Islam M. Saadeldin, Wed A. Abdali and Yousef M. Hawsawi
    Citation: Cancer Cell International 2023 23:56
    Content type: Correction Published on:

    The original article was published in Cancer Cell International 2022 22:279

  21. Metastasis is the leading cause of mortality in patients with breast cancer (BC). Studies demonstrate that circular RNAs (circRNAs) were involved in BC progression, while the molecular mechanisms remain largel...

    Authors: Ran Hao, Lei Zhang, Yangming Si, Peng Zhang, Yipeng Wang, Bangchao Li, Jie Hu and Yixin Qi
    Citation: Cancer Cell International 2023 23:54
    Content type: Research Published on:

  23. Abnormal miRNA and mRNA expression and dysregulated immune microenvironment have been found to frequently induce the progression of hepatocellular carcinoma (HCC) in recent reports. In particular, the immune-r...

    Authors: Xia-Hui Lin, Dong-ping Li, Zhi-Yong Liu, Si Zhang, Wen-qing Tang, Rong-xin Chen, Shu-qiang Weng, Yu-jen Tseng, Ru-yi Xue and Ling Dong
    Citation: Cancer Cell International 2023 23:52
    Content type: Primary research Published on:

  24. Non-small cell lung cancer is a heterogeneous disease driven by extensive molecular alterations. Exosomes are small vesicles with diameters ranging from 30 to 150 nm released by various cell types and are impo...

    Authors: Jingwei Xu, Hui Wang, Baoyu Shi, Ning Li, Guopeng Xu, Xiaopei Yan and Li Xu
    Citation: Cancer Cell International 2023 23:51
    Content type: Research Published on:

  25. As an oncogene, SETD8 can promote tumour growth and tumour cell proliferation. This study aims to reveal the relationship between SETD8 and ferroptosis in pancreatic cancer and its role in pancreatic cancer to pr...

    Authors: Zekun Lu, Qiangsheng Hu, Yi Qin, Hao Yang, Bingkai Xiao, Weibo Chen, Shunrong Ji, Guangchen Zu, Zhiliang Wang, Guixiong Fan, Xiaowu Xu and Xuemin Chen
    Citation: Cancer Cell International 2023 23:50
    Content type: Research Published on:

  26. Glioblastoma multiforme (GBM) is characterized by an unfavorable prognosis for patients affected. During standard-of-care chemotherapy using temozolomide (TMZ), tumors acquire resistance thereby causing tumor ...

    Authors: Maren Nicole Stillger, Chia-Yi Chen, Zon Weng Lai, Mujia Li, Agnes Schäfer, Axel Pagenstecher, Christopher Nimsky, Jörg Walter Bartsch and Oliver Schilling
    Citation: Cancer Cell International 2023 23:49
    Content type: Research Published on:

  27. Long non-coding RNAs (lncRNAs) have been confirmed to play important roles in various cancers including bladder cancer (BC). The precise expression pattern of lncRNA small nucleolar RNA host gene 18 (SNHG18) i...

    Authors: Meixia Ke, Ning Sun, Zhenni Lin, Peipei Zhang, Yan Hu, Shuilian Wu, Zhijian Zheng, Yongyong Lu and Honglei Jin
    Citation: Cancer Cell International 2023 23:48
    Content type: Research Published on:

  28. The disruption of epithelial features represents a critical step during breast cancer spread. In this context, the dysregulation of desmosomal proteins has been associated with malignant progression and metast...

    Authors: Francesca Reimer, Sarah Bryan, Karen Legler, Thomas Karn, Serenella Eppenberger-Castori, Jakob Matschke, Thais Pereira-Veiga, Harriet Wikman, Isabell Witzel, Volkmar Müller, Barbara Schmalfeldt, Karin Milde-Langosch, Udo Schumacher, Christine Stürken and Leticia Oliveira-Ferrer
    Citation: Cancer Cell International 2023 23:47
    Content type: Research Published on:

  29. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Its invasiveness and ability to metastasize contributes to an extremely high patient mortality. However, the molecular mechanisms tha...

    Authors: Jian-Hua Chang, Bo-Wen Xu, Di Shen, Wei Zhao, Yue Wang, Jia-liang Liu, Guang-Xiao Meng, Guang-Zhen Li and Zong-Li Zhang
    Citation: Cancer Cell International 2023 23:46
    Content type: Research Published on:

  30. Breast cancer is a prevalent disease in women, with high prevalence worldwide. The hypoxic microenvironment of solid tumors develops during the progress of carcinogenesis and leads to greater malignancy and tr...

    Authors: Kuan-Yi Lee, Chia-Ming Liu, Li-Han Chen, Chien-Yueh Lee, Tzu-Pin Lu, Li-Ling Chuang and Liang-Chuan Lai
    Citation: Cancer Cell International 2023 23:45
    Content type: Research Published on:

  31. STIL centriolar assembly protein (STIL) is a cytoplasmic protein implicated in cellular growth and proliferation as well as chromosomal stability, which abnormal condition affected tumor immunity and tumor pro...

    Authors: Longwen Xu, Shirong Zhang, Jinteng Feng, Deli Tan, Hong Sun and Hui Guo
    Citation: Cancer Cell International 2023 23:44
    Content type: Research Published on:

  32. In addition to their lipid-lowering functions, statins elicit additional pleiotropic effects on apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. Many of these effects have been reported...

    Authors: Yasin Ahmadi, Javad Khalili Fard, Dlzar Ghafoor, Ali H. Eid and Amirhossein Sahebkar
    Citation: Cancer Cell International 2023 23:43
    Content type: Review Published on:

  33. Hepatocellular carcinoma (HCC) accounts for almost 80% of all liver cancer cases and is the sixth most common cancer and the second most common cause of cancer-related death worldwide. The survival rate of sor...

    Authors: Hung-Wen Tsai, Yi-Li Chen, Chun-I Wang, Ching‑Chuan Hsieh, Yang-Hsiang Lin, Pei-Ming Chu, Yuh-Harn Wu, Yi-Ching Huang and Cheng-Yi Chen
    Citation: Cancer Cell International 2023 23:42
    Content type: Research Published on:

  34. Radiotherapy is the first-line regimen for treating oral squamous cell carcinoma (OSCC) in current clinics. However, the development of therapeutic resistance impacts the anticancer efficacy of irradiation in ...

    Authors: Tsu-Zong Yuan, Hui-Yu Lin, Chia-Hao Kuei, Che-Hsuan Lin, Hsun-Hua Lee, Hsin-Lun Lee, Hsiao-Wei Lu, Chia-Yi Su, Hui-Wen Chiu and Yuan-Feng Lin
    Citation: Cancer Cell International 2023 23:41
    Content type: Research Published on:

  35. The aim of this study was to establish a nomogram graph model to accurately predict the venous thromboembolism (VTE) risk probability in the general population with lung cancer.

    Authors: Haike Lei, Dan Tao, Ningning Zhang, Mao Sun, Lisi Sun, Dingyi Yang, Yong Jiang, Wei Zhou, Yue Xie and Ying Wang
    Citation: Cancer Cell International 2023 23:40
    Content type: Research Published on:

  36. The neutrophil-to-lymphocyte ratio is used to reflect body's inflammatory status with prognostic value in different cancers. We aimed to investigate the influence of preoperative NLR in the prognosis of CRLM p...

    Authors: Yanqing Li, Tianxiang Xu, Xin Wang, Xiangdong Jia, Meng Ren and Xiaoxia Wang
    Citation: Cancer Cell International 2023 23:39
    Content type: Review Published on:

  37. Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity again...

    Authors: Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Björn Schneider, Wendy Bergmann, Carl Friedrich Classen and Claudia Maletzki
    Citation: Cancer Cell International 2023 23:38
    Content type: Research Published on:

  38. Head and neck squamous cell carcinoma (HNSCC) remains an unmet medical challenge. Metabolic reprogramming is a hallmark of diverse cancers, including HNSCC.

    Authors: Zekun Zhou, Jianfei Tang, Yixuan Lu, Jia Jia, Tiao Luo, Kaixin Su, Xiaohan Dai, Haixia Zhang and Ousheng Liu
    Citation: Cancer Cell International 2023 23:37
    Content type: Research Published on:

  39. Mixed lineage leukemia 1-rearranged (MLL1-r) acute leukemia patients respond poorly to currently available treatments and there is a need to develop more effective therapies directly disrupting the Menin‒MLL1 com...

    Authors: Masashi Numata, Noriyasu Haginoya, Machiko Shiroishi, Tsuyoshi Hirata, Aiko Sato-Otsubo, Kenji Yoshikawa, Yoshimi Takata, Reina Nagase, Yoshinori Kashimoto, Makoto Suzuki, Nina Schulte, Gernot Polier, Akiko Kurimoto, Yumiko Tomoe, Akiko Toyota, Tomoko Yoneyama…
    Citation: Cancer Cell International 2023 23:36
    Content type: Research Published on:

  40. Aberrant expression of circRNAs is closely associated with the progression of gastric cancer; however, the specific mechanisms involved remain unclear. Our aim was to identify new gastric cancer biomarkers and...

    Authors: Haoying Wang, Hao Yuan, Qinghong Guo, Xi Zeng, Mengxiao Liu, Rui Ji, Zhaofeng Chen, Quanlin Guan, Ya Zheng, Yuping Wang and Yongning Zhou
    Citation: Cancer Cell International 2023 23:35
    Content type: Research Published on:

  41. The chorioallantoic membrane (CAM) assay is a well-established technique to evaluate tumor invasion and angiogenesis and may overcome the shortcoming of the patient-derived xenograft (PDX) mouse model. Current...

    Authors: Kenji Miura, Michiyo Koyanagi-Aoi, Yoshimasa Maniwa and Takashi Aoi
    Citation: Cancer Cell International 2023 23:34
    Content type: Research Published on:

  45. Cancer immunotherapy is a major breakthrough in the history of tumor therapy in the last decade. Immune checkpoint inhibitors blocking CTLA-4/B7 or PD-1/PD-L1 pathways have greatly prolonged the survival of pa...

    Authors: Xuan Pan, Chenchen Li and Jifeng Feng
    Citation: Cancer Cell International 2023 23:30
    Content type: Review Published on:

  46. MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological f...

    Authors: Mahboobeh Faramin Lashkarian, Nasrin Hashemipour, Negin Niaraki, Shahrad Soghala, Ali Moradi, Sareh Sarhangi, Mahsa Hatami, Fatemehsadat Aghaei-Zarch, Mina Khosravifar, Alireza Mohammadzadeh, Sajad Najafi, Jamal Majidpoor, Poopak Farnia and Seyed Mohsen Aghaei-Zarch
    Citation: Cancer Cell International 2023 23:29
    Content type: Review Published on:

  48. Long non-coding RNAs (lncRNAs) play important roles in the biology of colorectal cancer (CRC). There are several lncRNAs associated with invasion and metastasis have been characterized in CRC. However, studies...

    Authors: Mingzhou Li, Chengmei Huang, Yuanyuan Wu, Lina Zhu, Yaxin Zhang, Yi Zhou, Huali Li, Zhihao Liu, Xinyan Pan, Xin Wang, Junfeng Qiu, Fengtian Li and Wenting Liao
    Citation: Cancer Cell International 2023 23:27
    Content type: Research Published on:

  49. Mounting evidence supports that matrix metalloproteinase (MMPs) are highly associated with tumor progression and that targeting MMPs may overcome the barrier of immune suppression. Among these, whether MMP2 fu...

    Authors: Kunwei Peng, Yanyan Zhang, Deyi Liu and Jingqi Chen
    Citation: Cancer Cell International 2023 23:26
    Content type: Research Published on:

  50. Pituitary neuroendocrine tumours (PitNETs) are neoplasms of the pituitary that overproduce hormones or cause unspecific symptoms due to mass effect. Growth hormone overproducing GH-producing PitNETs cause acro...

    Authors: Rihards Saksis, Olesja Rogoza, Helvijs Niedra, Kaspars Megnis, Ilona Mandrika, Inga Balcere, Liva Steina, Janis Stukens, Austra Breiksa, Jurijs Nazarovs, Jelizaveta Sokolovska, Ilze Konrade, Raitis Peculis and Vita Rovite
    Citation: Cancer Cell International 2023 23:25
    Content type: Research Published on:
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Cancer Cell International

ISSN: 1475-2867

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