A 6-gene signature identifies four molecular subgroups of neuroblastoma

Table 2 Characteristics of cluster p4

Progn. factor	p4 vs p1			p4 vs p2			p4 vs p3
High stage (3-4)	0,047988	*	↑	0,48968			0,375645
Stage 4	0,002127	**	↑	0,583591			0,506192
DOD	0,009569	**	↑	0,296618			0,600782
Del1p	0,039341	*	↑	0,009569	*	↑	0,071035
MNA	0,566667			0,35			0,00905	**	↓
Del11q	0,181631			0,291194			0,165635
Gain17q	0,212934			0,428148			0,31448
Transcript	p4 vs p1			p4 vs p2			p4 vs p3
ALK	0,696703			0,403066			0,005545	**	↓
BIRC5	0,042222	*	↓	1,06E-06	**	↓	4,78E-06	**	↓
CCND1	5,43E-05	**	↓	0,000243	**	↓	0,046452	*	↓
MYCN	0,036238	*	↓	0,055719	**	↓	0,002016	**	↓
NTRK1	0,001017	**	↓	0,03105	*	↓	0,093904
PHOX2B	0,004037	**	↓	0,002773	**	↓	0,006196	**	↓

Progn. Factor: Fischer's exact test of frequency occurrence of prognostic factors in group p4 compared to the other groups separately. High stage = INSS stage 3 and 4; DOD = Dead of disease; Del = deletion; MNA = MYCN amplification. Transcript: T-test by Welch of differential expression in p4 compared to the other groups separately. p-values from each data-set are combined (see text for details). The arrows marks the direction: ↑ Higher frequency or higher expression in p4, ↓ Lower frequency or lower expression in p4.

ISSN: 1475-2867