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  1. Review

    Pepsinogen C expression, regulation and its relationship with cancer

    Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC’s functions ...

    Shixuan Shen, Jingyi Jiang and Yuan Yuan

    Cancer Cell International 2017 17:57

    Published on: 23 May 2017

  2. Research article

    DMD transcripts in CRL-2061 rhabdomyosarcoma cells show high levels of intron retention by intron-specific PCR amplification

    The DMD gene encoding dystrophin is mutated in Duchenne muscular dystrophy, a fatal progressive muscle wasting disease. DMD has also been shown to act as a tumor suppressor gene. Rhabdomyosarcoma (RMS) is a mesod...

    Emma Tabe Eko Niba, Ryo Yamanaka, Abdul Qawee Mahyoob Rani, Hiroyuki Awano, Masaaki Matsumoto, Hisahide Nishio and Masafumi Matsuo

    Cancer Cell International 2017 17:58

    Published on: 23 May 2017

  3. Primary Research

    Growth of MCF-7 breast cancer cells and efficacy of anti-angiogenic agents in a hydroxyethyl chitosan/glycidyl methacrylate hydrogel

    Breast cancer negatively affects women’s health worldwide. The tumour microenvironment plays a critical role in tumour initiation, proliferation, and metastasis. Cancer cells are traditionally grown in two-dim...

    Hejing Wang, Junmin Qian, Yaping Zhang, Weijun Xu, Juxiang Xiao and Aili Suo

    Cancer Cell International 2017 17:55

    Published on: 16 May 2017

  4. Primary Research

    Hypoxia and TGF-β1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation

    Intra-tumoral hypoxia and increases in extracellular level of transforming growth factor β1 (TGF-β1), which are common findings in cancer, are associated with an increased risk of metastasis and mortality. Mor...

    Feifei Xu, Jialu Zhang, Guolin Hu, Lei Liu and Weijiang Liang

    Cancer Cell International 2017 17:54

    Published on: 12 May 2017

  5. Primary Research

    The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells

    For every six men, one will be diagnosed with prostate cancer (PCa) in their lifetime. Estrogen receptors (ERs) are known to play a role in prostate carcinogenesis. However, it is unclear whether the estrogeni...

    Shaneabbas Raza, Megan Meyer, Casey Goodyear, Kimberly D. P. Hammer, Bin Guo and Othman Ghribi

    Cancer Cell International 2017 17:52

    Published on: 11 May 2017

  6. Primary Research

    Secretory phospholipase-A2 and fatty acid composition in oral reactive lesions: a cross-sectional study

    Oral reactive lesions are the most common lesions of oral cavity. Phospholipases and fatty acids play key roles in the creation of inflammation by change in metabolic activities and production of lipid mediato...

    Ali Hossein Mesgarzadeh, Abolfazl Akbarzadeh, Ali Rasipour, Tannaz Rasipour, Amir Mehdizadeh and Maghsod Shaaker

    Cancer Cell International 2017 17:50

    Published on: 27 April 2017

  7. Primary Research

    pATM and γH2AX are effective radiation biomarkers in assessing the radiosensitivity of 12C6+ in human tumor cells

    Tumour radiosensitivity would be particularly useful in optimizing the radiation dose during radiotherapy. The aim of the current study was to evaluate the potential value of phosphorylated H2AX (γH2AX) and AT...

    Jin Zhao, Zhong Guo, Shuyan Pei, Lei Song, Chenjing Wang, Jianxiu Ma, Long Jin, Yanqing Ma, Renke He, Jianbin Zhong, Ying Ma and Hong Zhang

    Cancer Cell International 2017 17:49

    Published on: 26 April 2017

  8. Primary Research

    Metformin exhibits the anti-proliferation and anti-invasion effects in hepatocellular carcinoma cells after insufficient radiofrequency ablation

    The mechanisms and prevention of progression of hepatocellular carcinoma (HCC) after insufficient radiofrequency ablation (RFA) has been preliminarily investigated, therefore, new strategy needs to be investig...

    Qingyun Zhang, Jian Kong, Shuying Dong, Wenlei Xu and Wenbing Sun

    Cancer Cell International 2017 17:48

    Published on: 24 April 2017

  9. Primary Research

    Establishment and characterization of 6 novel patient-derived primary pancreatic ductal adenocarcinoma cell lines from Korean pancreatic cancer patients

    Pancreatic ductal adenocarcinomas are among the most malignant neoplasms and have very poor prognosis. Our understanding of various cancers has recently improved the survival of patients with cancer, except fo...

    Mi-Ju Kim, Min-Sun Kim, Sung Joo Kim, Soyeon An, Jin Park, Hosub Park, Jae Hoon Lee, Ki-Byung Song, Dae Wook Hwang, Suhwan Chang, Kyu-pyo Kim, Seong-Yun Jeong, Song Cheol Kim and Seung-Mo Hong

    Cancer Cell International 2017 17:47

    Published on: 20 April 2017

  10. Primary Research

    MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2

    Lung cancer is the major cause of cancer-related death worldwide, and 80% patients of lung cancer are non-small-cell lung cancer (NSCLC) cases. MicroRNAs are important gene regulators with critical roles in di...

    Guowei Zhang, Hao Zheng, Guojun Zhang, Ruirui Cheng, Chunya Lu, Yijie Guo and Guoqiang Zhao

    Cancer Cell International 2017 17:46

    Published on: 17 April 2017

  11. Primary Research

    MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma

    MYCN gene amplification is related to risk stratification. Therefore it is important to identify accurately the level of the MYCN gene as early as possible in neuroblastoma (NB); howev...

    Zhi-Xia Yue, Cheng Huang, Chao Gao, Tian-Yu Xing, Shu-Guang Liu, Xing-Jun Li, Qian Zhao, Xi-Si Wang, Wen Zhao, Mei Jin and Xiao-Li Ma

    Cancer Cell International 2017 17:43

    Published on: 31 March 2017

  12. Primary Research

    The synthetic peptide CIGB-300 modulates CK2-dependent signaling pathways affecting the survival and chemoresistance of non-small cell lung cancer cell lines

    Lung cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths worldwide. Up to 80% of cancer patients are classified as non-small-cell lung cancer (NSCLC) and cisplatin rem...

    Stéfano M. Cirigliano, María I. Díaz Bessone, Damián E. Berardi, Carolina Flumian, Elisa D. Bal de Kier Joffé, Silvio E. Perea, Hernán G. Farina, Laura B. Todaro and Alejandro J. Urtreger

    Cancer Cell International 2017 17:42

    Published on: 31 March 2017

  13. Primary Research

    Combined EphB2 receptor knockdown with radiation decreases cell viability and invasion in medulloblastoma

    Medulloblastoma is one of the most common types of pediatric brain tumor characterized by the subpopulation of cells that exhibit high invasive potential and radioresistant properties. In addition, dysregulate...

    Shilpa Bhatia, Kellen Hirsch, Sanjana Bukkapatnam, Nimrah A. Baig, Ayman Oweida, Anastacia Griego, Dylan Calame, Jaspreet Sharma, Andrew Donson, Nicholas Foreman, Christopher Albanese, Sujatha Venkataraman, Rajeev Vibhakar and Sana D. Karam

    Cancer Cell International 2017 17:41

    Published on: 29 March 2017

  14. Primary Research

    The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells

    Non-small cell lung cancer comprises the majority of lung cancer cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid,...

    Ling-Yun Ye, Song Hu, Hua-E Xu, Rong-Rong Xu, Hui Kong, Xiao-Ning Zeng, Wei-Ping Xie and Hong Wang

    Cancer Cell International 2017 17:40

    Published on: 27 March 2017

  15. Primary research

    rs35301225 polymorphism in miR-34a promotes development of human colon cancer by deregulation of 3′UTR in E2F1 in Chinese population

    Previous reports have revealed that down-regulation of miR-34a expression can promote colorectal cancer (CRC) cell growth by targeting cell cycle-related transcriptional factor E2F1. To date, the function of t...

    Haiqiang Jiang, Fengyuan Ge, Beina Hu, Lamei Wu, Huijian Yang and Huiyun Wang

    Cancer Cell International 2017 17:39

    Published on: 9 March 2017

  16. Primary Research

    miR-484 suppresses proliferation and epithelial–mesenchymal transition by targeting ZEB1 and SMAD2 in cervical cancer cells

    MicroRNAs (miRNAs) play important roles in cancer initiation and development. Epithelial–mesenchymal transition (EMT) is a form of cellular plasticity that is critical for embryonic development and metastasis....

    Yang Hu, Hong Xie, Yankun Liu, Weiying Liu, Min Liu and Hua Tang

    Cancer Cell International 2017 17:36

    Published on: 7 March 2017

  17. Primary research

    HLBT-100: a highly potent anti-cancer flavanone from Tillandsia recurvata (L.) L.

    The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, ef...

    Henry I. C. Lowe, Ngeh J. Toyang, Charah T. Watson, Kenneth N. Ayeah and Joseph Bryant

    Cancer Cell International 2017 17:38

    Published on: 7 March 2017

  18. Primary research

    Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells

    2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinoline-11-one (BPIQ), is a synthetic quinoline analog. A previous study showed the anti-cancer potential of BPIQ thr...

    Yao Fong, Chang-Yi Wu, Kuo-Feng Chang, Bing-Hung Chen, Wan-Ju Chou, Chih-Hua Tseng, Yen-Chun Chen, Hui-Min David Wang, Yeh-Long Chen and Chien-Chih Chiu

    Cancer Cell International 2017 17:37

    Published on: 7 March 2017

  19. Primary research

    Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells

    Overexpression of cyclin D1 dependent kinases 4 and 6 (CDK4/6) is a common feature of many human cancers including leukemia. LEE011 is a novel inhibitor of both CDK4 and 6. To date, the molecular function of L...

    Yan-Fang Tao, Na-Na Wang, Li-Xiao Xu, Zhi-Heng Li, Xiao-Lu Li, Yun-Yun Xu, Fang Fang, Mei Li, Guang-Hui Qian, Yan-Hong Li, Yi-Ping Li, Yi Wu, Jun-Li Ren, Wei-Wei Du, Jun Lu, Xing Feng…

    Cancer Cell International 2017 17:35

    Published on: 6 March 2017

  20. Primary research

    Transactivation of the estrogen receptor promoter by BRCA1

    Absence of the estrogen receptor-α (ER) is perhaps the most distinctive pathological feature of breast cancers arising in women who inherit a mutation in BRCA1. Two hypotheses, not necessarily mutually exclusi...

    William B. Archey and Bradley A. Arrick

    Cancer Cell International 2017 17:33

    Published on: 2 March 2017

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