Featured article: Chemotherapy and tumor microenvironment of pancreatic cancer

New Content ItemIn this article, Liu et al. review the following four aspects; (1) clinical landmark advances of chemotherapy in pancreatic cancer, since 2000; (2) interactions and mechanisms between stromal cells and pancreatic cancer cells; (3) remodeling effects and mechanisms of chemotherapy on TME; (4) targeting stromal components in pancreatic cancer.

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Aims and scope

Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from work using cell culture techniques. 

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Featured article: Differential expression of VEGFR2 protein in HER2 positive primary human breast cancer

In this study, Nasir et al. aim to characterize the patterns of pathologic angiogenesis in various therapeutically relevant molecular breast cancer subtypes (HR+, HER2+, TNBC) by evaluation of vascular density and immunohistochemical expression of VEGFR2 protein in a retrospective series of primary human breast cancer tissues.

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Featured article - HOTAIR: a key regulator in gynecologic cancers

New Content ItemHOTAIR (HOX transcript antisense) promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and signaling pathways. HOTAIR is deregulated in many human cancers; despite its critical roles in health and disease, the underlying mechanisms governing HOTAIR function are unknown. In this review, Li et al. summarize the recent findings on the roles of HOTAIR in gynecologic cancers.

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