Table 1 List of the VOCs obtained from the culture medium of A549 cell line that were increased or decreased
A | Â | Â | Â | Â |
|---|---|---|---|---|
Increased compound | CAS No. | Classification | fold | p -value |
1-Dodecanol | 112-53-8 | alcohols | ++ | < 0.01 |
1-Methoxy-2-propanol | 107-98-2 | ethers | +++ | 0.02 |
2,2,4-Trimethyl-1,3-pentanediol diisobutyrate | 6846-50-0 | esters | + | 0.09 |
2,5-Hexanedione | 110-13-4 | ketones | + | 0.08 |
2-Butanone | 78-93-3 | ketones | + | 0.06 |
2-Phenyl-2-propanol | 617-94-7 | alcohols | +++ | 0.02 |
3,3,5-Trimethylcyclohexanone | 873-94-9 | ketones | ++ | 0.04 |
3-Butene-2-one | 78-94-4 | ketones | + | 0.03 |
4-Cyanocyclohexene | 100-45-8 | nitriles | + | 0.07 |
Acetonitrile | 75-05-8 | nitriles | + | 0.03 |
Cyclohexanone | 108-94-1 | ketones | + | 0.04 |
Diethyl ether | 60-29-7 | ethers | ++ | < 0.01 |
Dimethyl succinate | 106-65-0 | esters | ++ | 0.06 |
Ethanol | 64-17-5 | alcohols | +++ | 0.01 |
Isobutyric acid 2-ethyl-3-hydroxyhexyl ester | 74367-31-0 | esters | + | < 0.01 |
Isophorone | 78-59-1 | ketones | ++ | 0.02 |
Orthoformic acid tri-sec-butyl ester | 16754-48-6 | esters | +++ | 0.02 |
tert-Butanol | 75-65-0 | alcohols | + | < 0.01 |
Decreased compound | CAS No. | Classification | fold | p-value |
1,3-Di-tert-butylbenzene | 1014-60-4 | hydrocarbons | --- | 0.07 |
2,4-Dimethyl-1-heptene | 19549-87-2 | hydrocarbons | --- | 0.04 |
2,4-Di-tert-butylphenol | 96-76-4 | phenols | - | 0.06 |
2,5-Dimethyl-2,5-hexanediol | 110-03-2 | alcohols | -- | 0.02 |
2-Methyl-1-propanol | 78-83-1 | alcohols | -- | 0.06 |
4,6-Dimethyl-2-heptanone | 19549-80-5 | ketones | -- | 0.05 |
5-Methylnonane | 15869-85-9 | hydrocarbons | - | 0.01 |
Acetophenone | 98-86-2 | ketones | - | 0.08 |
Benzophenone | 119-61-9 | ketones | --- | 0.04 |
Benzyl alcohol | 100-51-6 | alcohols | -- | 0.02 |
Dichloromethane | 75-09-2 | halogens | - | < 0.01 |
Maltol | 118-71-8 | pyrans | --- | < 0.01 |
Styrene | 100-42-5 | hydrocarbons | -- | 0.05 |
B | Â | Â | Â | Â |
Increased compound | CAS No. | Classification | fold | p-value |
1-Dodecanol | 112-53-8 | alcohols | +++ | < 0.01 |
2,2,4-Trimethyl-1,3-pentanediol diisobutyrate | 6846-50-0 | esters | + | 0.03 |
2,2,5,5-Tetramethyltetrahydrofuran | 15045-43-9 | furans | + | < 0.01 |
2,2-Dimethyloxetane | 6245-99-4 | ethers | + | < 0.01 |
2,3-Dihydro-4-methylfuran | 34314-83-5 | furans | + | < 0.01 |
2,4,6-Trimethylpyridine | 108-75-8 | pyridines | + | 0.01 |
2,4-Di-tert-butylphenol | 96-76-4 | phenols | + | 0.01 |
2,5-Dimethyl-2,5-hexanediol | 110-03-2 | diols | + | 0.03 |
2-Butanone | 78-93-3 | ketones | ++ | < 0.01 |
2-Hexanone | 591-78-6 | ketones | + | 0.04 |
2-Methoxyfuran | 25414-22-6 | furans | + | 0.02 |
2-Methyl-1-propanol | 78-83-1 | alcohols | + | 0.02 |
2-Octanone | 111-13-7 | ketones | + | 0.03 |
2-Pentanone | 107-87-9 | ketones | + | < 0.01 |
3-Aminopyrazole-4-carboxylic acid | 24447-68-5 | carboxylic acids | + | < 0.01 |
3-Methyl-3-buten-1-ol | 763-32-6 | alcohols | + | 0.01 |
4-Isopropoxy-2-butanone | 32541-58-5 | ketones | + | 0.02 |
4-Methylbenzyl alcohol | 589-18-4 | alcohols | + | < 0.01 |
Acetonylacetone | 110-13-4 | ketones | ++ | < 0.01 |
Acetophenone | 98-86-2 | ketones | ++ | < 0.01 |
Diethyl ether | 60-29-7 | ethers | ++ | < 0.01 |
Dimethyl succinate | 106-65-0 | esters | +++ | < 0.01 |
DL-1-Phenylethyl alcohol | 98-85-1 | alcohols | + | 0.01 |
Ethanol | 64-17-5 | alcohols | ++ | 0.01 |
Furfural | 98-01-1 | aldehydes | + | 0.02 |
Isobutyric acid 2-ethyl-3-hydroxyhexyl ester | 74367-31-0 | esters | + | 0.01 |
Methyl vinyl ketone | 78-94-4 | ketones | + | < 0.01 |
Orthoformic acid tri-sec-butyl ester | 16754-48-6 | esters | + | < 0.01 |
o-Xylene | 95-47-6 | hydrocarbons | + | 0.05 |
Pyrrole | 109-97-7 | pyrroles | ++ | < 0.01 |
trans-4-Methyl-2-pentene | 674-76-0 | hydrocarbons | + | 0.01 |
Decreased compound | CAS No. | Classification | fold | p-value |
1,2-Dihydro-2,2,4-trimethylquinoline | 147-47-7 | quinolines | - | 0.01 |
1-Butanol | 71-36-3 | alcohols | - | 0.05 |
2,3-Butanediol | 19132-06-0 | diols | - | < 0.01 |
2-Ethyl-1-hexanol | 104-76-7 | alcohols | - | 0.06 |
2-Methyl-2-hepten-6-one | 110-93-0 | ketones | -- | < 0.01 |
3,5-Lutidine | 591-22-0 | pyridines | - | < 0.01 |
Acetonitrile | 75-05-8 | nitriles | -- | < 0.01 |
Benzophenone | 119-61-9 | ketones | -- | < 0.01 |
Cyclohexanone | 108-94-1 | ketones | - | 0.01 |
Dimethyl disulfide | 624-92-0 | Sulfurs | --- | 0.09 |
Isophorone | 78-59-1 | ketones | - | 0.02 |
Maltol | 118-71-8 | pyrans | --- | < 0.01 |
Methanethiol | 74-93-1 | thiols | --- | 0.1 |
Tributyl phosphate | 126-73-8 | esters | -- | 0.03 |
C | Â | Â | Â | Â |
Increased compound | CAS No. | Classification | fold | p-value |
1,4-Diacetylbenzene | 1009-61-6 | ketones | ++ | < 0.01 |
1-Hydroxycyclohexanecarboxylic acid | 1123-28-0 | carboxylic acids | +++ | < 0.01 |
2,2,4-Trimethyl-1,3-pentanediol diisobutyrate | 6846-50-0 | esters | ++ | < 0.01 |
2,4,6-Trimethylpyridine | 108-75-8 | pyridines | ++ | 0.02 |
2,6-Di-tert-butylphenol | 128-39-2 | phenols | + | 0.08 |
2-Butanone | 78-93-3 | ketones | ++ | < 0.01 |
2-Octanone | 111-13-7 | ketones | + | < 0.01 |
3-Methyl-3-buten-1-ol | 763-32-6 | alcohols | + | 0.01 |
3-Octanol | 589-98-0 | alcohols | + | 0.01 |
4-Cyanocyclohexene | 100-45-8 | nitriles | + | < 0.01 |
4-Methylbenzyl alcohol | 589-18-4 | alcohols | ++ | < 0.01 |
Acetophenone | 98-86-2 | ketones | + | < 0.01 |
Benzaldehyde | 100-52-7 | aldehydes | + | 0.07 |
Benzophenone | 119-61-9 | ketones | +++ | < 0.01 |
Benzyl alcohol | 100-51-6 | alcohols | ++ | < 0.01 |
Bisisobutyric acid 2,4,4-trimethylpentane-1,3-diyl ester | 74381-40-1 | esters | ++ | 0.02 |
Carbamic acid, 4-methylphenyl ester | 1850-13-1 | esters | +++ | < 0.01 |
Cyclohexanone | 108-94-1 | ketones | + | 0.02 |
Diethyl ether | 60-29-7 | ethers | ++ | < 0.01 |
Dimethyl succinate | 106-65-0 | esters | +++ | 0.01 |
DL-1-Phenylethyl alcohol | 98-85-1 | alcohols | ++ | < 0.01 |
Ethanol | 64-17-5 | alcohols | ++ | 0.09 |
Furfural | 98-01-1 | aldehydes | + | < 0.01 |
Isobutyric acid 2-ethyl-3-hydroxyhexyl ester | 74367-31-0 | esters | ++ | < 0.01 |
Phenol | 108-95-2 | phenols | + | 0.04 |
p-Tolualdehyde | 104-87-0 | aldehydes | + | < 0.01 |
Pyrrole | 109-97-7 | pyrroles | + | < 0.01 |
omega-Caprolactam | 105-60-2 | amides | ++ | < 0.01 |
Decreased compound | CAS No. | Classification | fold | p-value |
2,4-Dimethyl-1-heptene | 19549-87-2 | hydrocarbons | -- | 0.01 |
Maltol | 118-71-8 | pyrans | --- | 0.01 |