Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation

Table 1 Eight microRNA expression profiling studies included in the systematic review

Reference	Year	Platform	No. of differential miRNA	Up-regulated	Down-regulated
Kim et al. [7]	2010	MiRNA microarray (human-miRNA-V1 bead chips)	Not reported	2^*	3^*
Zhang et al. [8]	2008	TaqMan miRNA Assay (PE Applied biosystems, Foster City, CA)	35	4	31
Nam et al. [9]	2008	mirVana miRNA Probe Set (Ambion)	23	11	12
Iorio et al. [10]	2007	MiRNA microarray (Ohio State comprehensive cancer center, version 2.0)	29	4	25
Dahiya et al. [11]	2008	MiRCURY^TM LNA miRNA Arrays (Exiqon)	70	27	43
Yang et al. [12]	2008	Oligonucleotide arrays	14	7	7
Wyman et al. [13]	2009	454 Life sciences	58	37	21
Chao et al. [14]	2011	TaqMan miRNA Assay (PE Applied Biosystems, Foster City, CA)	17	15	2

* The authors did not showed the total number of the differently expressed miRNAs and they only selected two up-regulated and three down-regulated miRNAs for the follow-up experiments.

ISSN: 1475-2867