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Table 4 Mutations in colon compared to all cancers (including colon) in p53 codons 210–290

From: Mechanisms of genotoxin-induced transcription and hypermutation in p53

 

A

C

G

T

Total number of all mutations in 240 nt (6662)

865

1875

3375

547

Percent of total

13.0%

28.1%

50.7%

8.2%

Number of colon mutations in 240 nt (651)

42

260

317

32

Percent of colon

6.4%

40.0%

48.7%

4.9%

Difference in total mutations compared to colon mutations

-6.6%

+11.9%

-2.0%

-3.3%

  1. Analyzed as in Tables 1-3 for colon cancer.
  2. Table 4 shows the total number of all mutations (including colon) compared to colon mutations and the propensity of each of the four bases to mutate to any other base (with mutations of both G and C in bold).