Fig. 1From: Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cellsMelatonin promotes apoptosis of SGC-7901 gastric cancer cells. SGC-7901 cells were incubated with melatonin for the indicated doses and periods. a The morphological figures of apoptosis were monitored by fluorescence microscopy after staining with Hoechst 33258. Images are representative of at least three independent determinations. Scale bar 50 μm. b Melatonin-induced apoptosis of SGC-7901 gastric cancer cells. Values were presented as mean ± SD of three independent experiments. c Cell proliferation was measured by MTT assay. d Apoptosis was evaluated for up to 48 h by Hoechst 33258 staining. Images are representative of at least three independent determinations. Scale bar 50 μm. **P < 0.01Back to article page