Fig. 3
From: MiR-145 functions as a tumor suppressor via regulating angiopoietin-2 in pancreatic cancer cells
MiR-145 inhibited tumor growth and angiogenesis in vivo. a, b MiR-145 significantly inhibited the growth of xenografts formed by Panc-1 when compared with saline or vector control group; c miR-145 treatment decreased microvessels density in xenografts isolated 45 days after subcutaneous injection when compared to saline or vector control group; d the expression levels of Ang-2 in xenografts treated with miR-145 were lower than that in the saline or vector control group. Data represents the mean ± SEM, n = 8, significant differences between groups are indicated as ***P < 0.001 (one-way ANOVA followed by Bonferroni test)