Overexpression of suppressor of zest 12 is associated with cervical node metastasis and unfavorable prognosis in tongue squamous cell carcinoma

Table 3 Univariate and multivariate survival analyses for patients with primary TSCC using proportional hazards methods

Variable	Univariate survival analysis			Multivariate survival analysis
Variable	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
Gender (male, female)	1.651	0.739–3.688	0.221	1.428	0.599–3.405	0.422
Age (≤60, >60)	0.753	0.338–1.680	0.489	1.374	0.601–3.141	0.452
Smoking (no, yes)	1.253	0.653–1.835	0.524	1.372	0.665–1.732	0.536
Alcohol use (no, yes)	1.121	0.547–1.538	0.753	1.231	0.557–1.861	0.643
Tumor size (T1–T2, T3–T4)	1.331	0.528–3.357	0.544	1.447	0.505–4.147	0.491
Pathological grade (I, II–III)	1.258	0.490–1.994	0.117	1.246	0.444–3.496	0.676
Cervical nodal metastasis (N0, N+)	1.759	1.240–3.291	0.042	1.696	1.104–3.067	0.056
Clinical stage (I–II, III–IV)	1.203	0.688–1.824	0.095	0.922	0.524–1.622	0.778
SUZ12 expression (low^a, high)	3.023	1.216–7.516	0.017	2.848	1.121–7.240	0.028

The numbers in italic indicate statistical significance with p values <0.05
^aBoth of patients with low and negative SUZ12 staining are stratified into low SUZ12 category for simplicity

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