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Fig. 6 | Cancer Cell International

Fig. 6

From: MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2

Fig. 6

Inhibitory effect of miR-338-3p on NSCLC is mediated by downregulating SphK2. GAPDH was an endogenous reference; NC, cells transfected with negative control. a SphK2 protein was measured using Western blot which showed that transfection of SphK2-siRNAs and miR-338-3p inhibited expression of SphK2 in A549 cells, respectively. b SphK2 protein (Western blot) indicated that transfection of SphK2-siRNAs and miR-338-3p inhibited expression of SphK2 in H1299 cells, respectively. c CCK-8 assay showed that SphK2-siRNA and miR-338-3p inhibited A549 cell proliferation. d CCK-8 array showed that SphK2-siRNA and miR-338-3p inhibited H1299 cell proliferation. e Colony formation assay showed that SphK2-siRNA and miR-338-3p reduced A549 and H1299 cell colony growth. f Flow cytometry showed that SphK2-siRNA and miR-338-3p induced A549 and H1299 apoptosis

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Cancer Cell International

ISSN: 1475-2867

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