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Fig. 4 | Cancer Cell International

Fig. 4

From: Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma

Fig. 4

Effect of K73-03 on mitochondria of HepG2 cells. (A) Changes of HepG2 ∆Ψm induced by K73-03 were detected by JC-1. (B) Effect of excessive ROS generation in K73-03-treated HepG2 cells using flow cytometry. (C) Results of and FCCP/ MRC, coupling efficiency, respiration driving ATP synthesis/Oligomycin sensitive OCR and spare respiratory capacity in HepG2 cells. (D) After pretreatment with 10 µg/mL NAC for 1 h, the expression of cleaved- caspase-9 was analyzed by Western blotting. The data were presented as the mean ± SD of three independent experiments. (*p < 0.05, **p < 0.01, significantly different from control group)

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Cancer Cell International

ISSN: 1475-2867

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