Fig. 4

A miRNA target genes. We analyzed 302 target genes for GO annotation and KEGG pathway using the Enrichr database. B The y-axis represents -log10 (p-value), where a larger -log10 value corresponds to a smaller p-value, indicating a more significant pathway. The x-axis represents the path name. The size of the dots indicated the number of genes. Yellow represents the biological process (BP). Green represents the cellular component (CC). Red represents molecular function (MF). C The circle color represents the KEGG path. The color of the left circle from black to light orange represents different genes. The color of the left circle from light red to deep red represents -log10 (p-value). A larger -log10 (p-value) represents a smaller p-value, indicating that the gene is more significant. D Nine target genes in all candidate miRNAs (A). Using the GEPIA database, we analyzed the differential expression of nine target genes in KIRC and found that CREB5 was most significantly related to KIRC based on: match TCGA normal and GTEx data and |log2FC|> 1, p < 0.01. T tumor, N normal control