Fig. 3

Construction of the disulfidptosis-related prognostic model in HCC. A and B LASSO regression identified hub DRGs and coefficient profiles. C Histogram showing the 6 protective genes and 13 risk genes and their weighted coefficients. D Volcano plot of 19 selected hub genes between two disulfidptosis-regulated clusters. E Univariate Cox regression analysis of selected hub genes associated with overall survival in HCC patients. F Distribution of DRG scores and patient survival status in the TCGA-LIHC cohort. G and H The Kaplan–Meier OS curves G and time-dependent ROC curves H for patients in the high- and low-DRG score groups in the TCGA training cohort. The group with high DRG scores had worse survival rates, and the AUC values of DRG scores for one-year, three-year, and 5 year OS were 0.787, 0.748, and 0.711, respectively. DRGs Disulfidptosis-related genes; HCC hepatocellular carcinoma, LASSO least absolute shrinkage and selection operator, DEGs differentially expressed genes, LIHC liver cancer, ROC receiver operating characteristic