Regulator | Effect on m6A modification | Expression change | (Refs.) |
---|---|---|---|
METTL3 | Catalytic core of methyltransferase | Up | |
METTL14 | Forms a heterodimer with METTL3 without catalytic action, enhancing the activity of METTL3 | Down | |
WTAP | Anchors the methyltransferase complex in the nuclear speckles | Up | |
RBM15/15B | Binding to the U-rich region to recruit m6A complexes | Up | |
KIAA1429(VIRMA) | Interacts with WTAP and recruits m6A to the 3’UTR | Up | 36,41 |
METTL16 | Catalyzes m6A installation in the 3’UTR in mRNA and on A43 of U6 small nuclear RNA | Up | |
HAKAI | Necessary for the methylation of m6A | Up | |
ZC3H13 | Promotes the WTAP localization and m6A deposition | Down |