Regulator | Effect on m6A modification | Expression change | (Refs.) |
---|---|---|---|
YTH domain family | |||
YTHDF1 | Enhances m6A-modified RNA translation | Up | |
YTHDF2 | Promotes m6A-modified RNA degradation | Up | |
YTHDF3 | Accelerates m6A-modified RNA translation and degradation | Up | |
YTHDC1 | Regulates m6A-modified RNA splicing and export | Up | |
YTHDC2 | Promotes m6A-modified RNA translation efficiency | Up | |
HNRNP family | |||
HNRNPC and HNRNPG | Regulates the abundance and alternative splicing of target genes | Up | |
HNRNPA2B1 | Promotes the processing of primary miRNA | Up | |
IGF2BP1-3 | Stabilizes m6A-modified mRNA | Up |