Malignancy | MicroRNA | Target | N. of cases | Pattern of alteration | Application | Site of measurement | Validity | Associated determinants of prognosis | References |
---|---|---|---|---|---|---|---|---|---|
Breast cancer | miR-21 | PTEN | 102 | Up-regulation | Diagnostic, prognostic | Serum | AUC = 0.721 | Visceral metastasis (p < 0.001) | [209] |
miR-195 | Raf1 | 210 | Down-regulation | Diagnostic, treatment response | Serum | AUC = 0.859 | – | ||
miR-155 | SOCS1 | 103 | Up-regulation | Diagnostic, treatment response | Serum | AUC = 0.801 | – | ||
Colorectal cancer | miR-21 | PTEN | 200 | Up-regulation | Diagnostic | Serum | AUC = 0.802 | – | [213] |
miR-92a | PTEN | 200 | Up-regulation | Diagnostic, prognostic | Serum | AUC = 0.786 | Poor survival (p = 0.03) | ||
miR-200c | ZEB1/ZEB2 | 446 | Up-regulation | Prognostic | Serum | – | Higher disease stage, lymph node metastasis (p = 0.0026), distant metastasis (0.0023), overall survival (p = 0.0064), tumor recurrence (HR = 4.51, p = 0.005) | ||
Gastric cancer | miR-182 | FOXO1 | 47 | Down-regulation | Diagnostic | Serum | AUC = 0.898 | – | |
miR-21 | PTEN | 50 | Up-regulation | Diagnostic | Serum, PBMC | AUC = 0.912 (serum), AUC = 0.898 (PBMC) | – | [218] | |
miR-106b | ALEX1 | 90 | Up-regulation | Diagnostic | Plasma | AUC = 0.7733 | – | ||
Pancreatic cancer | miR-21 | PTEN | 49 | Up-regulation | Diagnostic | Plasma | AUC = 0.62 | – | |
miR-7 | MAP3K1 | 8 | Down-regulation | Prognostic | Plasma | – | Advanced tumor stage, poor survival | ||
200c | ZEB1/ZEB2 | 84 | Up-regulation | Prognostic | Tissue | – | Poor overall survival (p = 0.013) | ||
HCC | miR-122 | IGF1R | 50 | Up-regulation | Diagnostic, prognostic | Serum | AUC = 0.954 | Favorite prognosis (p < 0.001) | |
miR-21 | PTEN | 126 | Up-regulation | Diagnostic | Plasma | AUC = 0.953 | – | ||
NSCLC | miR-21 | PTEN | 152 | Up-regulation | Diagnostic, prognostic | Serum | AUC = 0.81 | Tumor size (p = 0.001), higher TNM stage (p = 0.004) | |
miR-126 | VEGF | 112 | Up-regulation | Diagnostic | Serum | AUC = 0.793 | – | ||
let7c | IGF1R | 120 | Down-regulation | Diagnostic | Plasma | AUC = 0.714 | – |