Fig. 3
From: Melanoma biology and treatment: a review of novel regulated cell death-based approaches
Schematic diagram of necroptosis and its effects on melanoma. Necroptosis can be triggered by activation of death receptors or Toll-like receptors. Through interaction of activated RIPK1 with RIPK3, and subsequently, RIPK3 phosphorylates MLKL. Pore formation on cell membrane is the final step of necroptosis. Research of necroptosis on melanoma was expressed in white squares with reference number in parenthesis. The exogenous molecules are marked in blue squares especially. While unsure effect of RIPK1 inhibition on melanoma metastasis, direct intratumor delivery of MLKL mRNA can inhibit melanoma tumor growth and metastasis and augment the efficiency of immune blockade therapy. Besides, NTiO2, BAY 87–2243 and CBL0137 are the agents with the ability to induce necroptosis in melanoma cells