Fig. 3

Development and evaluation of a nomogram integrating the PyroScore in the entire cohort. A, B Univariate (A) and multivariate (B) Cox regression analyses for validating the independent prognostic value of the PyroScore. C A nomogram to predict the 1-, 3-, and 5-year TCFi. The red dot shows the nomogram points of patients with barcode TCGA-DE-A4MD (recurrence in 267 days). D Time-dependent ROC curves of the nomogram to predict the 1-, 3-, 5-, and 10-year TCFi. E ROC curves of the nomogram and four THCA staging systems to predict the 5-year TCFi. F AUC for the nomogram and four staging systems based on the time-dependent ROC curves. G C-indexes of the nomogram and four staging systems. H Calibration curves of 1-, 3- and 5-year TCFi probability for the nomogram. I DCA curves of the nomogram and four staging systems for predicting the net benefit of the 5-year TCFi.