Micropeptides: potential treatment strategies for cancer

Zhou, He; Wu, Yan; Cai, Ji; Zhang, Dan; Lan, Dongfeng; Dai, Xiaofang; Liu, Songpo; Song, Tao; Wang, Xianyao; Kong, Qinghong; He, Zhixu; Tan, Jun; Zhang, Jidong

doi:10.1186/s12935-024-03281-w

Cancer Cell International

Table 2 The function of ncRNA-encoded micropeptides in human cancer

From: Micropeptides: potential treatment strategies for cancer

Subcellular localization	NcRNAs	Micropeptide	Size	Cancer types	Function	Reference
Membrane	LncRNARP11-469H8.6	MIAC	51 aa	HNSCC	Interacts with AQP2 and reduces the expression of ITGB4 and SEPT2, inhibiting tumour growth and metastasis	61
	LINC00998	SMIM30	59 aa	HCC	Activates the MAPK pathway to promote proliferation and metastasis of tumour	54
	lncRNA DLEU1	ORF1,ORF8	-	Glioma	Forms a pentameric structure with ion channel activity, increases brain oedema and the risk of cancer cell development	63
Cytoplasm	LINC00665	CIP2A-BP	52 aa	TNBC	Directly binds to the oncogene CIP2A and inhibits the PI3K/AKT signalling pathway, thus inhibiting the migration and invasion of TNBC.	67
	LINC00278	YY1BM	21 aa	ESCC	Inhibits the interaction of YY1 and androgen receptor and reduces the expression of Eef2k	70
	LINC00908	ASRPS	60 aa	TNBC	Inhibits STAT3 phosphorylation, reduces VEGF expression, and then inhibits tumour angiogenesis	58
	LINC01420	NOBODY	7 kDa	Lung cancer	Affect underlying cancer cells processes by regulating the decay of mRNA	66
	lncRNA NCBP2-AS2	KRASIM	99 aa	HCC	Inhibits the growth and proliferation of HCC cells	68
	Circ-AKT3	AKT3-174aa	174 aa	GBM	Inhibits AKT-thr308 phosphory-lation and PI3K/AKT signalling pathway activation	69
Endoplasmic reticulum	lncRNA ASH1L-AS1	APPLE	90 aa	AML	Promotes the development of different subtypes of AML	72
Endoplasmic reticulum	LINC00675	FORCP	79 aa	CRC	Inhibits basal cell proliferation and tumorigenesis	73
Endosomes	-	CASIMO1	83 aa	BC	Interacts with squalene epoxidase (SQLE) to influence cell proliferation and cycle progression	79
Endosomes	lncRNA LINC00961	SPAR	90 aa	Lymphoma	Reduces the effects of amino acid-sensing pathway activated by mTORC1 and exerts antitumour effects	80
Mitochondria	LINC00467	ASAP	94 aa	CRC	Promotes cancer cell proliferation by regulating the production of ATP	85
	LINC00116	MPM	56 aa	HCC	Promotes hepatocellular carcinoma metastasis by increasing mitochondrial complex I activity and the NAD+/NADH ratio	86
	-	PIGBOS	54 aa	-	Regulates the unfolded protein response and cell death	87
	-	STMP1	47 aa	HCC	Promotes G1/S conversion and cell proliferation by enhancing the activity of mitochondrial complex IV	89,90
	5’UTR of PTEN	MP31	31 aa	GBM	Limits lactate-pyruvate conversion in mitochondria	32
	miR-34a	miPEP133	133 aa	NPC	Binds HSPA9 to reduce mitochondrial membrane potential and mitochondrial mass, and inhibits tumour growth	93
Nucleus	lncRNA CTD-2256P15.2	PACMP	44 aa	BC	Maintains nucleolus homeostasis and promotes the DNA damage response	95
	LOC90024	SRSP	130 aa	CRC	Incerases SRSP levels, which are positively correlated with a malignant phenotype and poor prognosis	96
	LINC00266-1	RBRP	71 aa	CRC	Promotes proliferation, colony formation, migration and invasion of cancer cells	57
	lncRNA HOXB-AS3	HOXB-AS3	53 aa	CRC	Inhibits the proliferation, migration and invasion of cancer cells	101
	Linc013026	Linc013026-68AA	68 aa	HCC	Promotes the proliferation of cancer cells	103
	lncRNA	UBAP1-AST6	117 aa	Lung cancer	When overexpressed promotes the proliferation of lung cancer cells	60
	Linc00176 C20orf204	C20orf204-189AA	189 aa	HCC	Stabilizes nucleolin and promotes nucleosomal DNA transcription	105
	circ-0000437	CORO1C-47aa	47 aa	Endometrial cancer	Inhibits endothelial cell proliferation and tumour angiogenesis	20

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ISSN: 1475-2867

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