Fig. 2From: Significance of PSCA as a novel prognostic marker and therapeutic target for cancerPSCA controls cell cycle and differentiation regulators through modulating RB1CC1 protein stability and nuclear translocation. The binding of PSCA to RB1CC1 in cytoplasm results in stabilization and translocation of RB1CC1, which in turn increases levels of p53, Rb14 and decreases cyclin D1. As a result, proliferation decreases while differentiation increasesBack to article page