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Fig. 3 | Cancer Cell International

Fig. 3

From: Sparassis latifolia and exercise training as complementary medicine mitigated the 5-fluorouracil potent side effects in mice with colorectal cancer: bioinformatics approaches, novel monitoring pathological metrics, screening signatures, and innovative management tactic

Fig. 3

Generation of a gene expression panel associated with Colorectal carcinoma risk based on common genes between RNA-seq and microarray data. A The VENN diagram bioinformatics tool was used to discover common genes that were rough across RNA-seq and Microarray datasets, revealing 1582 common genes from significant gene lists based on adj p-values. B The 104 hub genes interactions network is generated in Gephi software 0.9.2 based on network parameters (Degree: 20, Betweenness Centrality: 0.005, and Closeness Centrality: 0.2), eigenvector, and modularity class. Through bioinformatics research, we have found important biomarkers in this network that might serve as valuable indicators for prognosis, diagnosis, and monitoring. C According to the enrichment facts, 104 hub genes correspond with colorectal cancer, cancer metastasis, collagen formation, extracellular matrix organization, PI3K/Akt signaling pathway, ECM receptors, Cytokine-cytokine receptor interaction, IL18 signaling pathway, and Hippo signaling pathway

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Cancer Cell International

ISSN: 1475-2867

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