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Table 2 Ngb, Cygb and CA IX expression in tissue microarrays of human primary brain tumors

From: Hypoxic regulation of cytoglobin and neuroglobin expression in human normal and tumor tissues

Pathology

Grade

Ngb

Cygb

CA IX

Astrocytoma of right temporal lobe

II

2

1

0

Ganglioglioma of right frontal lobe

-

3

1

0

Astrocytoma of left temporal lobe

II

3

1

0

Astrocytoma of right frontal lobe

I

2

2

0

Astrocytoma

II

1

2

0

Astrocytoma

I

3

2

0

Astrocytoma of frontal lobe

I

3

1

0

Astrocytoma

I

3

1

0

Astrocytoma of right temporal lobe

II

2

1

0

Astrocytoma of brain

I

2

1

0

Astrocytoma of left occipital parietal lobe

II

2

3

0

Astrocytoma of right occipital lobe

II

3

2

0

Ganglioglioma of left temporoparietal lobe

-

3

2

1

Astrocytoma of fourth ventricle

II

3

1

1

Astrocytoma of left temporal lobe

II

5

2

0

Astrocytoma

II

5

2

0

Astrocytoma of left parietal lobe

III

3

2

0

Colloid cell hyperplasia of left brain

-

5

3

0

Astrocytoma of right temporoparietal lobe

III

4

2

0

Astrocytoma of frontal lobe

III

3

1

0

Astrocytoma of foramen magnum

III

1

0

2

Astrocytoma of left temporal lobe

II

3

2

0

Astrocytoma

II

3

2

0

Brain tissue

-

3

4

1

Astrocytoma of right temporal lobe

II

3

2

0

Astrocytoma of fourth ventricle

II

3

1

0

Astrocytoma of right temporal lobe

II

3

1

0

Astrocytoma

III

2

3

0

Astrocytoma of left temporoparietal lobe

II

3

2

0

Astrocytoma of right cerebral ventricle

II

4

3

0

Oligodendroglioma of right frontal lobe

-

4

4

0

Astrocytoma of brain

III

4

2

0

Astrocytoma of brain

III

3

4

0

Astrocytoma of left temporal lobe

II

3

2

0

Astrocytoma of left temporal lobe

II

2

2

0

Astrocytoma of intracranial

II

3

2

0

Astrocytoma of cerebellum

III

1

1

0

Astrocytoma of left temporal lobe

III

1

1

0

Astrocytoma with necrosis of left frontal lobe

III

3

2

1

Astrocytoma of left temporal lobe

III

3

1

0

Astrocytoma of temporoparietal lobe

III

4

2

0

Astrocytoma of right cerebelli

III

2

2

0

Astrocytoma

III

3

2

0

Astrocytoma

III

4

4

0

Brain tissue with colloid cell hyperplasia of right temporal lobe

-

4

NE

0

Astrocytoma

III

2

2

0

Astrocytoma of brain

III

2

2

0

Astrocytoma of left frontal lobe

III

3

1

0

Astrocytoma of brain

II

4

3

0

Astrocytoma of left frontal lobe

III

2

1

0

Astrocytoma of left temporal lobe

II

4

4

1

Astrocytoma of left occipital

III

3

3

0

Astrocytoma of left temporal lobe

III

4

4

0

Astrocytoma of right temporal lobe

IV

3

4

0

Astrocytoma of left temporal lobe

III

2

1

0

Astrocytoma of right temporal lobe

III

1

1

0

Astrocytoma of right temporal lobe

III

3

1

0

Astrocytoma of fourth ventricle

IV

3

2

0

Astrocytoma

II

3

3

0

Astrocytoma of temporal lobe

IV

4

2

0

Tumor necrosis tissue of right frontal region

-

4

5

1

Astrocytoma of left occipital parietal lobe

III

4

5

1

Malignant oligodendroglioma

-

2

2

0

Desmoplastic astrocytoma of left temporoparietal lobe

-

3

5

0

Astrocytoma of intracranial

II

3

2

0

Ependymoblastoma of posterior fossa

-

3

2

0

Ependymoma of brain parietooccipital

-

3

3

0

Ependymoma of brain

-

3

2

0

Ependymoma of right parietal lobe

-

4

4

0

Ependymoma of intracranial

-

3

3

0

Matched cerebrum tissue of 1st tumor

-

2

2

0

Matched cerebrum tissue of 2nd tumor

-

3

3

0

Matched cerebrum tissue of 3rd tumor

-

4

4

1

Matched cerebrum tissue of 4th tumor

-

1

2

0

Normal cerebrum tissue

-

1

2

0

Normal cerebrum tissue

-

1

1

0

Normal cerebrum tissue

-

5

2

0

Normal cerebrum tissue

-

2

3

0

Normal cerebrum tissue

-

3

4

0

Normal cerebellum tissue

-

3

1

0

  1. Tissue microarrays constructed from cores obtained from various human primary brain cancers and normal adjacent brain were purchased from IMGENEX Corporation (San Diego, CA). Immunopositive staining for Ngb, Cygb and CA IX was assessed by two observers who noted the overall tissue staining and the presence of positively stained focal regions. Each section was assigned an overall score, where 0 = absence of positively stained cells; 1 = a few positive cells/regions ( < 10%); 2 = weak positive staining, occasional positive foci; 3 = intermediate staining, occasional positive foci ( < 50%); 4 = strongly positive in most of the section, several positive foci; and 5 = strongly positive throughout with many intensely
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Cancer Cell International

ISSN: 1475-2867

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